Three-dimensional dynamics of mesothelin-targeted CAR.CIK lymphocytes against ovarian cancer peritoneal carcinomatosis by Federica Galvagno, Valeria Leuci, Annamaria Massa, Chiara Donini, Ramona Rotolo, Sonia Capellero, Alessia Proment, Letizia Vitali, Andrea Maria Lombardi, Valentina Tuninetti, Lorenzo D’Ambrosio, Alessandra Merlini, Elisa Vigna, Giorgio Valabrega, Luca Primo, Alberto Puliafito, Dario Sangiolo

“…Abstract Intraperitoneal cellular immunotherapy with CAR-redirected lymphocytes is an intriguing approach to target peritoneal carcinomatosis (PC) from ovarian cancer (OC), which is currently evaluated in clinical trials. PC displays a composite structure with floating tumor cells within ascites and solid-like masses invading the peritoneum. …”
Get full text

Multi-objective optimization of laser spot welding parameters for enhancing mechanical properties of hard disk components using response surface methodology by K. Chimklin, S. Phuangkaew, J. Deeying

“…The parameters considered include outer diameter (OD), inner diameter (ID), penetration, and tip height. Through a central composite design matrix experiment and quadratic modeling, empirical mathematical models were established to predict the response variables. …”
Get full text

A nomogram to predict sarcopenia in middle-aged and older women: a nationally representative survey in China by Jiayi Yang, Zihao Chen, Xinxin Dai, Liyao Jiang, Liyan Dai, Yu Zhao

“…In addition, this study integrated these sarcopenia-related variables into a comprehensive index, and ROC analysis results showed that the AUC of the composite index was 0.738.ConclusionsThis study found that sarcopenia in Chinese women may be closely related to age, waist, education, marriage, area, stroke, physical pain, depression, and region. …”
Get full text

Arterial Anastomosis to Injured Vessels: Outcomes in Lower Extremity Trauma Reconstruction by Ellen Wang, BS, Jessica R. Nye, BS, Imran Rizvi, MD, Kylie R. Swiekatowski, BA, Bora Kahramangil, MD, Paul Won, MD, Noa G. Kopplin, BS, Stephen F. Parlamas, BS, Jeffrey G. Trost, MD, Mohin A. Bhadkamkar, MD

“…The primary outcome, complications attributed to the arterial anastomosis, was a composite variable defined as return to the operating room during the index hospitalization for arterial thrombosis, partial flap loss, and/or total flap loss. …”
Get full text

Integrating geostatistical methods and deep learning for enhanced 87Sr/86Sr isoscape Estimation: A case study in South Korea by Hyeongmok Lee, Go-Eun Kim, Woo-Jin Shin, Yuyoung Lee, Sanghee Park, Kwang-Sik Lee, Jina Jeong, Seung-Ik Park, Sungwook Choung

“…., lithology, tectonic settings) and geochemical compositions, are used as input variables for training a feedforward deep neural network. …”
Get full text

In situ deposition of MnO2 nanoparticles on cellulosic denim via KMnO4 reduction: Parametric optimization and functional assessment by Hamid Reza Jafari, Reza Mohammad Ali Malek, Majid Montazer

“…Considering the effect of four variables including temperature, pH, time, and concentration of KMnO4, the photocatalytic properties of the treated fabrics were compared according to MB dye discoloration under the ultraviolet A (UVA) radiation using Central Composite Design (CCD) class of Response Surface Methodology (RSM). …”
Get full text

Reversible multivalent carrier redox exceeding intercalation capacity boundary by Yuanhe Sun, Rui Qi, Qi Lei, Wei Zhang, Haitao Li, Mengru Lin, Hao Shi, Jianrong Zeng, Wen Wen, Yi Gao, Xiaolong Li, Chunyi Zhi, Daming Zhu

“…Operando X-ray absorption spectroscopy, operando synchrotron X-ray diffraction and composite ex situ characterization jointly demonstrated that intercalated divalent copper is preferentially involved in redox afforded extra electron transfer to form reversible monovalent copper pillars, thus not only ensuring stable topological de/intercalation with high capacity but also sustaining fast migration kinetic paths through reconfigurable pillar effects. …”
Get full text

The Development and Validation of a High-Performance Liquid Chromatographic Method for the Determination of Urinary Levels of Etoricoxib After Fabric Phase Sorptive Extraction by Anastasia Korpeti, Natalia Manousi, Abuzar Kabir, Constantinos K. Zacharis, Erwin Rosenberg

“…., sample amount, stirring rate, and adsorption time) were optimized using a face-centered central composite design (FC-CCD), while the remaining ones were explored by means of the one-variable-at-a-time approach. …”
Get full text

Aeromagnetic anomalies and structural model of the Chicxulub multiring impact crater, Yucatan, Mexico by Mario Rebolledo-Vieyra, Jaime Urrutia-Fucugauchi, Héctor López-Loera

“…Reduction to the pole and downward analytical continuations show the discrete composite character of the anomaly, with inverse dipolar anomalies. …”
Get full text

Multi-Objective Optimization of Steel Slag–Ceramsite Foam Concrete via Integrated Orthogonal Experimentation and Multivariate Analytics: A Synergistic Approach Combining Range–Vari... by Alipujiang Jierula, Haodong Li, Tae-Min Oh, Xiaolong Li, Jin Wu, Shiyi Zhao, Yang Chen

“…This study aims to enhance the performance of an innovative steel slag–ceramsite foam concrete (SSCFC) to advance sustainable green building materials. An eco-friendly composite construction material was developed by integrating industrial by-product steel slag (SS) with lightweight ceramsite. …”
Get full text

Multiple mush generations provide insight into the longevity of open-conduit basaltic volcanoes by Beatrice Schiavon, Chiara M. Petrone, Francesca Forni, Alessio Pontesilli, Haiyang Hu, Piergiorgio Scarlato, Daniele Andronico, Elisabetta Del Bello, Manuela Nazzari, Silvio Mollo

“…The complex zoning patterns of plagioclase phenocrysts from 2003 to 2021 eruptions have been interrogated by combining in-situ Sr isotope compositions, thermometric modelling, and Mg diffusion chronometry. …”
Get full text

Major Adverse Kidney Events in Hospitalized Older Patients With Acute Kidney Injury: Machine Learning–Based Model Development and Validation Study by Xiao-Qin Luo, Ning-Ya Zhang, Ying-Hao Deng, Hong-Shen Wang, Yi-Xin Kang, Shao-Bin Duan

“…Major adverse kidney events within 30 days (MAKE30), a composite of death, new renal replacement therapy, or persistent renal dysfunction, has been recommended as a patient-centered endpoint for clinical trials involving AKI. …”
Get full text

Primary prevention cardiovascular disease risk prediction model for contemporary Chinese (1°P-CARDIAC): Model derivation and validation using a hybrid statistical and machine-learn... by Yekai Zhou, Celia Jiaxi Lin, Qiuyan Yu, Joseph Edgar Blais, Eric Yuk Fai Wan, Emmanuel Wong, Kathryn Tan, David Chung-Wah Siu, Kai Hang Yiu, Esther Wai Yin Chan, Doris Yu, William Wong, Tak-Wah Lam, Ian Chi Kei Wong, Ruibang Luo, Celine S L Chui

“…The outcome was the first diagnosis of a composite of coronary heart disease, ischemic or hemorrhagic stroke, peripheral artery disease, and revascularization. …”
Get full text

The Impact of Digital Inequities on Nasal and Paranasal-Sinus Cancer Disparities in the United States: A Cohort Study by David J Fei-Zhang, Amelia Sherron Lawrence, Daniel C Chelius, Anthony M Sheyn, Jeffrey C Rastatter

“…Variables were categorized as infrastructure-access (ie, electronic device ownership, internet provider availability, and income-broadband subscription ratio) or sociodemographic (education, income, age, and disability), ranked, and then averaged into a composite score to encompass direct and indirect factors related to digital inequity. …”
Get full text

Increase in intimate partner violence during the COVID19 lockdown in uganda: a household survey by Freddy Eric Kitutu, Ronald Olum, Sharon Kitibwakye Nakamanya, Olivia Nakisita, Sian E. Clarke, Eleanor Hutchinson

“…Data were collected using standardized structured questionnaires adapted from UN guidelines for producing statistics on violence in women. Outcome variables were lifetime and current (measured as incidents in the past 12 months) prevalence of IPV and whether there was reported increase during the COVID-19 lockdown, assessed by several items under emotional, socio-economic, physical and sexual violence and analyzed as individual items or derived composite variables. …”
Get full text

Oakland score to identify low-risk patients with lower gastrointestinal bleeding performs well among emergency department patients by Daniel D. DiLena, Sean C. Bouvet, Madeline J. Somers, Maqdooda A. Merchant, Theodore R. Levin, Adina S. Rauchwerger, Dana R. Sax

“…The Oakland Score has not been studied among emergency department (ED) patients with LGIB. The Oakland Score composite outcome includes re-bleeding, defined as additional blood transfusion requirements and/or a further decrease in hematocrit (Hct) >/= 20% after 24 h in clinical stability; red blood cell transfusion; therapeutic intervention to control bleeding, including surgery, mesenteric embolization, or endoscopic hemostasis; in-hospital death, all cause; and re-admission with further LGIB within 28 days. …”
Get full text

Adaptive versus maladaptive coping strategies: insight from Lebanese young adults navigating multiple crises by Roni Chaaya, Michel Sfeir, Samar El Khoury, Sandrella Bou Malhab, Myriam El Khoury-Malhame

“…Abstract Background Coping strategies are composites of cognitive and behavioral efforts to manage the internal and external demands of stressful situations. …”
Get full text

Textbook Outcomes for Retroperitoneal Sarcoma Resection: A Multi-Centre Review by Skyle Murphy, Christopher Allan, Andrew Barbour, Victoria Donoghue, B. Mark Smithers

“…Textbook outcomes (TOs) are composite measures developed to compare ideal surgical outcomes for complex oncologic resections. …”
Get full text

The effect of SGLT2 inhibitor in patients with type 2 diabetes and atrial fibrillation. by Yongin Cho, Sung-Hee Shin, Min-Ae Park, Young Ju Suh, Sojeong Park, Ji-Hun Jang, Dae-Young Kim, So Hun Kim

“…A total of 4,771 patients with T2D and AF who were newly prescribed SGLT2 inhibitors or DPP4 inhibitors were selected and matched in a 1:2 ratio by propensity score with 37 confounding variables. We assessed the effect of SGLT2 inhibitors on the composite outcome of either HF hospitalization or death.…”
Get full text

Total Reflection X-Ray Fluorescence Spectroscopy (TXRF) Method Validation: Determination of Heavy Metals in Dietary Supplements by Blanca G. Beltrán, Victor Ramos-Sanchez, David Chávez-Flores, Rogelio Rodríguez-Maese, Edwin Palacio

“…Methods validation was conducted through a multivariate analysis using a central composite design (CCD) and a desirability function. …”
Get full text