A randomised trial comparing usual versus strict home blood pressure control in elderly patients with hypertension: protocol and initial progress by Dong-Yan Zhang, Yi-Qing Zhang, De-Wei An, Yi-Bang Cheng, Song-Tao Tang, Min Liu, Jue Li, Jan A. Staessen, Ji-Guang Wang, Yan Li

“…The primary outcome is a composite of cardiovascular death, non-fatal myocardial infarction, coronary revascularisation, unstable angina pectoris or heart failure requiring hospitalisation, and non-fatal stroke. …”
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Clinical Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction and With Reduced Ejection Fraction According to the Prognostic Nutritional Ind... by Simone Solano, Mingming Yang, Paolo Tolomeo, Toru Kondo, Li Shen, Pardeep S. Jhund, Inder S. Anand, Akshay S. Desai, Carolyn S. P. Lam, Aldo P. Maggioni, Felipe A. Martinez, Jean L. Rouleau, Muthiah Vaduganathan, Dirk J. van Veldhuisen, Faiez Zannad, Michael R. Zile, Milton Packer, Scott D. Solomon, John J. V. McMurray

“…The primary outcome was the composite of HF hospitalization or cardiovascular death. …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Methods Systematic optimization of the cell culture membrane insert set-up for sEV transport studies was accomplished with inserts with different pore sizes, varied coating procedures and medium compositions. Particle size distribution, quantification and zeta-potential was measured with nanoparticle tracking analysis. …”
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Prospective comparison of the digestive tract resistome and microbiota in cattle raised in grass-fed versus grain-fed production systems by Jiye Kwon, Windy Tanner, Yong Kong, Martina Wade, Chad Bitler, Marilia B. Chiavegato, Melinda M. Pettigrew

“…Beta-diversity estimates indicated overlap in the pre-weaning resistome and microbiota in both systems, which diverged post-weaning, with increases in several medically important ARGs when system B cattle transitioned to a grain diet. Analysis of compositions of microbiomes with bias correction indicated that levels of tetracycline, macrolide, aminoglycoside, beta-lactam, and bacitracin ARGs were significantly higher in system B cattle pre-harvest. …”
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Prediabetes: prevalence, associations with cardiovascular risk factors and contribution to survival in the Russian population by Yu. A. Balanova, S. A. Shalnova, A. E. Imaeva, V. A. Kutsenko, A. V. Kapustina, S. E. Evstifeeva, G. A. Muromtseva, R. V. Ievlev, R. N. Shepel, O. M. Drapkina

“…Prediabetes and T2D demonstrated a significant decrease of survival, including cardiovascular survival, and the occurrence of a composite endpoint. However, multivariate analysis adjusted for sex, age, and region of residence indicates a significant contribution of T2D, but not IFG.Conclusion. …”
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A Randomized Controlled Trial of a Biodegradable Polymer, Microcrystalline Sirolimus-Eluting Stent (MiStent) versus Another Biodegradable Polymer Sirolimus-Eluting Stent (TIVOLI):... by Bin Wang, Sicong Ma, Zhiyong Wang, Li Zhang, Hanjun Pei, Yang Zheng, Yuejin Yang, Zheng Zhang, Xinqun Hu, Ziwen Ren, Feng Zhang, Changqian Wang, Renqiang Yang, Zhiming Yang, Yuexi Wang, Guosheng Fu, Yu Cao, Zuyi Yuan, Kai Xu, Xin Zhao, Bo Xu, Miaohan Qiu, Quanmin Jing

“…The secondary endpoint was device-related clinical cardiovascular composite events (target lesion failure (TLF), composite of cardiac death, target vessel myocardial infarction (MI), and clinically driven target lesion revascularization) and 1-year outcomes. …”
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Association Between Mineralocorticoid Receptor Antagonist Use With Worsening Renal Function and Prognosis in Patients With Acute Heart Failure by Yudai Fujimoto, Yasuyuki Shiraishi, Kazutaka Nogi, Shun Kohsaka, Takashi Kohno, Mitsunobu Kitamura, Yuji Nagatomo, Tomoya Ueda, Maki Nogi, Satomi Ishihara, Yasuki Nakada, Rika Kawakami, Takeshi Kitai, Shogo Oishi, Eiichi Akiyama, Satoshi Suzuki, Masayoshi Yamamoto, Keisuke Kida, Takahiro Okumura, Tsutomu Yoshikawa, Yoshihiko Saito, Yuya Matsue

“…Methods This was a post hoc analysis using data from Japanese AHF registries (NARA‐HF [Nara Registry and Analyses for Heart Failure], WET‐HF [West Tokyo Heart Failure], REALITY‐AHF [Registry Focused on Very Early Presentation and Treatment in Emergency Department of Acute Heart Failure]). …”
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STOP-Colitis pilot trial protocol: a prospective, open-label, randomised pilot study to assess two possible routes of faecal microbiota transplant delivery in patients with ulcerat... by Ailsa L Hart, Christel McMullan, Jonathan Mathers, Laura Magill, Natalie J Ives, Tariq Iqbal, Mohammed Nabil Quraishi, Naveen Sharma, Jonathan Segal, Richard Hansen, Mehmet Yalchin, Clare Blackwell, Peter Hawkey, Victoria McCune, Daniel Gaya, Shrushma Loi, Konstantinos Gerasimidis, Nicholas James Loman, Christopher Quince, Nicola Crees

“…The primary outcome will be a composite assessment of both qualitative and quantitative data based on efficacy (clinical response), acceptability and safety. …”
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Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT by Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N Faust, Josie Henley, Lucy Hinds, Kerry Hood, Chao Huang, Sarah Jones, Sarah Kotecha, Sarah Milosevic, Helen Nabwera, Sanjay Patel, Stéphane Paulus, Colin VE Powell, Jenny Preston, Huasheng Xiang, Emma Thomas-Jones, Enitan D Carrol

“…The estimated treatment effect for the composite safety outcome was consistent with non-inferiority. …”
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Transcranial Doppler microemboli and acute brain injury in extracorporeal membrane oxygenation: A prospective observational studyCentral MessagePerspective by Giorgio Caturegli, BS, Shrey Kapoor, BS, Vladimir Ponomarev, RVS, Bo Soo Kim, MD, Glenn J.R. Whitman, MD, Wendy Ziai, MD, MPH, Sung-Min Cho, DO, MHS, Lucy Q. Zhang, MD, Yunis Mayasi, MD, Aaron Gusdon, MD, Bahattin Ergin, RVT, Steven Keller, MD, Matthew Acton, MD, Hannah Rando, MD, Diane Alejo, Kate Calligy, RN, Scott Anderson, Benjamin Shou, BS, Pedro A. Mendez-Tellez, MD, Henry Chang, MD, PhD, Marc Sussman, MD, Christopher Wilcox, DO, MS, Patricia Brown, RD-AP, CNSC, Anna Peeler, RN

“…Transcranial Doppler (TCD) allows real-time characterization of regional cerebral hemodynamics, but limited data exist on the interpretation of microembolic signals (MES) in ECMO. …”
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Features of short-term heart rate variability in internally displaced people with type 2 diabetes mellitus by V.A. Serhiyenko, V.B. Sehin, V.I. Pankiv, A.A. Serhiyenko

“…Subclini­cal CAN was diagnosed according to the results of cardiovascular reflex tests and the Composite Assessment Symptom Score 31. The results of short-term HRV lasting 5 min were studied and analyzed. …”
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Association of dietary minerals and phosphorus to protein ratio with quality of life in Iranian Hemodialysis patients: a cross-sectional study by Farnaz Shahdadian, Fatemeh Sadat Hashemi Javaheri, Fateme Shams, Fatemeh Navab, Sahar Foshati, Mohammad Bagherniya, Firouzeh Moeinzadeh, Rahele Ziaei, Mohammad Hossein Rouhani

“…Nutritionist IV software was used to calculate overall energy and nutrient intake and SPSS software version 20 was utilized for data analysis. The results showed that lower phosphorus intake increased the odds of symptoms (OR = 2.65, 95% CI: 1.07–6.59), sleep disturbances (OR = 2.82, 95% CI: 1.18–6.71), and low emotional well-being (OR = 2.63, 95% CI: 1.09–6.31) in fully adjusted model, adjusted for age, sex, BMI, energy intake, Kt-V, and URR. …”
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Considerations on the Human Body in European Art from Ancient Times to Present Day by Liviu Nedelcu

“…The French Jean Louis David and Jean Auguste Dominique Ingres were the creators of the classical nude that idealized anatomical data to render perfect human prototypes. Towards the end of the century, another French artist, Edouard Manet, breached this consecrated model, imposing, in its compositions, nudes without any mythological connotation simply inspired from real life with anatomical effects and disproportions inherent to a live model. …”
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The association of ideal cardiovascular health and its change with subclinical atherosclerosis according to glucose status: A prospective cohort study by Xiaojing Jia, Yilan Ding, Chunyan Hu, Hong Lin, Lin Lin, Xueyan Wu, Hongyan Qi, Shuangyuan Wang, Ruizhi Zheng, Jie Zheng, Min Xu, Yu Xu, Tiange Wang, Zhiyun Zhao, Yuhong Chen, Mian Li, Guang Ning, Weiqing Wang, Weiguo Hu, Yufang Bi, Jieli Lu

“…Methods We conducted a prospective analysis of 5225 participants without prior cardiovascular diseases, of whom 4768 had complete data on CVH change. …”
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Concordance and agreement between different activity scores in polymyalgia rheumatica by Bruno Fautrel, Eric Toussirot, Renaud Felten, Emmanuel Nowak, Christophe Richez, Jacques-Eric Gottenberg, Isabelle Chary-Valckenaere, Alain Saraux, Aleth Perdriger, Emanuelle Dernis, Thierry Marhadour, Marie-Elise Truchetet, Divi Cornec, Valérie Devauchelle-Pensec, Daniel Wendling, Guillaume Direz, Anne Lohse, Laurent Chiche, PASCAL HILLIQUIN, Guillermo Carvajal Alegria, Dewi Guellec, Justine D'Agostino, Aghiles Souki, Catherine Le Henaff, Benjamin Dervieux

“…Our secondary objective was to evaluate the concordance between different cutoffs of the PMR-ASs.Method Data from the Safety and Efficacy of tocilizumab versus Placebo in Polymyalgia rHeumatica With glucocORticoid dEpendence (SEMAPHORE) trial, a superiority randomised double-blind placebo-controlled trial, were subjected to post hoc analysis to compare the efficacy of tocilizumab versus placebo in patients with active PMR. …”
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Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes by Xingxi Lin, Xingxi Lin, Luhan Zhou, Luhan Zhou, Shuting Si, Haoyue Cheng, Haoyue Cheng, Xialidan Alifu, Xialidan Alifu, Yiwen Qiu, Yiwen Qiu, Yan Zhuang, Yan Zhuang, Ye Huang, Ye Huang, Libi Zhang, Libi Zhang, Diliyaer Ainiwan, Diliyaer Ainiwan, Hui Liu, Yunxian Yu, Yunxian Yu

“…GDM+HDP was significantly associated with a higher risk of composite adverse neonatal outcomes (OR=1.82, 95%CI: 1.02-3.04), including preterm birth, placenta previa, and/or neonatal jaundice, a higher risk of small for gestational age (SGA) (OR=2.2, 95% CI: 1.24 3.92) and large for gestational age (LGA) (OR=2.33, 95% CI: 1.64 3.31) compared with the normal group. …”
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Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation by Agnieszka Prytula, Rukshana Shroff, Ineke van Gremberghe, Kai Krupka, Justine Bacchetta, Elisa Benetti, Ryszard Grenda, Isabella Guzzo, Nele Kanzelmeyer, Bahar Büyükkaragöz, Birgitta Kranz, Hülya Nalçacıoğlu, Jun Oh, Lars Pape, Mohan Shenoy, Anne-Laure Sellier-Leclerc, Burkhard Tönshoff, Gema Ariceta, Atif Awan, Sevcan Bakkaloğlu, Marjolein Bonthuis, Charlotte Bootsma Robroeks, Antonia Bouts, Martin Christian, Marlies Cornelissen, Ali Duzova, Nasrin Esfandiar, Luciana Ghio, Ryszard Grenda, Isabella Guzzo, Maria Herrero Goni, Julien Hogan, Nattaphorn Hongsawong, Nele Kanzelmeyer, Aysun Karabay Bayazit, Gülşah Kaya Aksoy, Noel Knops, Linda Koster Kamphuis, Daniella Levy Erez, Victor Lopez-Baez, Alvaro Madrid, Stephen Marks, Anette Melk, Luisa Murer, Lars Pape, Licia Peruzzi, Edita Petrosyan, Evgenia Preka, Nikoleta Printza, Andreea Liana Rachisan, Ann Raes, Mohan Shenoy, Oguz Soylemezoglu, Luca Dello Strologo, Ana Teixeira, Rezan Topaloglu, Markus Weitz, Jakub Zieg, Galia Zlatanova, Christian Patry, Jerome Harambat, Ayşe Ağbaş, Varvara Askiti, Marina Avramescu, Justine Bacchetta, Sevcan Bakkaloglu, Marjolein Bontuis, Caroline Booth, Laurene Dehoux, Giacomo Dizazzo, Dorota Drozdz, Ismail Dursun, Michaela Gessner, Jaap Groothoff, Giuliana Guido, Isabella Guzzo, Aysun Karabay Bayazit, Guenter Klaus, Linda Koster-Kamphuis, Alexander Lalayiannis, Maren Leifheit-Nestler, Sinha Manish, Chiara Matteucci, Jun Oh, Ozan Ozkaya, Edita Petrosyan, Christine Pietrement, Agnieszka Prytula, George Reusz, Franz Schaefer, Claus Peter Schmitt, Anne Schön, Fatma Lale Sever, Stella Stabouli, Serra Sürmeli Döven, Camilla Tondel, Enrico Verrina, Enrico Vidal, Dean Wallace, Zainab Arslan, M. Bald, H. Fehrenbach, D. Haffner, M. Hansen, C. Hempel, U. John, G. Klaus, J. König, B. Lange-Sperandio, D. Müller, J. Oh, L. Pape, M. Pohl, K. Sauerstein, G. Schalk, H. Staude, P. Strotmann, L.T. Weber, M. Weitz, L. Berta, K. Heindl-Rusai

“…Methods: This registry study collected data up to 10 years posttransplant. Survival analysis for a composite end point of graft loss or estimated glomerular filtration rate (eGFR) ≤ 30 ml/min per 1.73 m2 or ≥50% decline from eGFR at month 3 posttransplant was performed. …”
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Risk factors for severe outcomes in people with diabetes hospitalised for COVID-19: a cross-sectional database study by Kamlesh Khunti, Pere Domingo, Josep Franch-Nadal, Manel Mata-Cases, Jordi Real, Didac Mauricio, Esmeralda Castelblanco, Emilio Ortega, Rosa Corcoy, Mònica Gratacòs, Francesc Xavier Cos Claramunt, Ramon Puig-Treserra, Bogdan Vlacho

“…Aim This study’s objective was to assess the risk of severe in-hospital complications of patients admitted for COVID-19 and diabetes mellitus (DM).Design This was a cross-sectional study.Settings We used pseudonymised medical record data provided by six general hospitals from the HM Hospitales group in Spain.Outcome measures Multiple logistic regression analyses were used to identify variables associated with mortality and the composite of mortality or invasive mechanical ventilation (IMV) in the overall population, and stratified for the presence or absence of DM. …”
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Older Patients With Interstitial Lung Disease Feature a Distinct Clinical Profile by Laura Feltrer-Martínez, Sandra Orozco, Ana Alonso, Paloma Millan-Billi, Silvia Barril, Gisela Ruibal, Joel Francesqui, David Lobo-Prat, Ana Gimenez, Laura Lopez, Laura Martinez-Martinez, Ivan Castellvi, Diego Castillo

“…Gender-age-physiology (GAP) stage, composite physiologic index (CPI) and Charlson index was calculated. …”
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Timely post-discharge medication reviews to Improve Continuity—the Transitions Of Care stewardship (TIC TOC) study in rural and regional Australia: a parallel-group randomised cont... by Sepehr Shakib, Manya Angley, Jonathan Penm, Charley Budgeon, Kim Nguyen, Rebekah Jane Moles, Faye McMillan, Rohan A Elliott, Paul Yates, Katie Phillips, Jenny Chen, Stephen Ross Carter, Kingston Yeung, Deirdre Criddle, Deborah Rigby, Frank Mario Sanfilippo, Jerry Yik, Deborah Hawthorne, Cristen Fleming, Anna Packer, Linda Krogh, Simon K Poon, Brett Chambers, Shania Liu, Fatemeh Emadi, Klaudia Englezos, Ganga Ratnanayagam, Michelle Penm, Andrew Hawthorne, Alexander Khlentzos, Jilian Khlentzos

“…Usual care will include informing the patient’s clinical inpatient treating team that the patient is at high risk of medication misadventure and may benefit from a post-discharge Home Medicines Review (a GP-referred pharmacist medication review funded by the Australian Government).Data analysis will be performed on a modified intent-to-treat basis. …”
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