Real-world effectiveness and safety of oral azvudine versus Paxlovid in patients with COVID-19 and pre-existing hypertension: a multicentre, retrospective, cohort study in Henan Pr... by Ling Wang, Zhigang Ren, Xiaoli Jin, Hong Luo, Donghua Zhang, Ming Cheng, Fuwei Wang, Bohan Jia, Guotao Li, Mengzhao Yang, Guangming Li, Shixi Zhang, Guowu Qian, Silin Li, Hongxia Liang

“…The objective of this study was to assess their effectiveness and safety among those patients in a real-world context.Design Retrospective cohort study.Setting Electronic medical record data of COVID-19 patients with pre-existing hypertension were extracted from nine hospitals in Henan Province from 5 December 2022 to 31 January 2023.Participants Following 2:1 propensity score matching (PSM), 996 individuals who received treatment with azvudine and 498 individuals who received treatment with Paxlovid were included in the analysis.Primary and secondary outcome measures The primary outcome was all-cause death and the secondary outcome was the composite disease progression.Results Following adherence to the inclusion and exclusion criteria and 2:1 PSM, 996 individuals were included in the azvudine group and 498 in the Paxlovid group. …”
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Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions by Anna Gabele, Maximilian Sprang, Mert Cihan, Mareen Welzel, Assel Nurbekova, Karolina Romaniuk, Sarah Dietzen, Matthias Klein, Georg Bündgen, Maxim Emelianov, Gregory Harms, Krishnaraj Rajalingam, Tanja Ziesmann, Katrin Pape, Beatrice Wasser, David Gomez-Zepeda, Kathrin Braband, Michael Delacher, Niels Lemmermann, Stefan Bittner, Miguel A. Andrade-Navarro, Stefan Tenzer, Katja Luck, Tobias Bopp, Ute Distler

“…This allowed the characterization of subtype-specific molecular programs and the identification of IRF4 interactors in the Th17/Treg context. Our data reveal that IRF4-interacting transcription factors are recruited to IRF composite elements for the regulation of cell-type-specific transcriptional programs as exemplarily demonstrated for FLI1, which, in cooperation with IRF4, promotes Th17-specific gene expression. …”
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Gait speed after mild stroke/transient ischemic attack was associated with long‐term adverse outcomes: A cohort study by Ning Li, Jia Zhang, Yang Du, Jing Li, Anxin Wang, Xingquan Zhao

“…Additional outcomes included all‐cause death, ambulate dependency (mRS score 4–6), cognitive impairment (Montreal Cognitive Assessment <26), stroke recurrence, and composite vascular events. Results The study sample included a total of 1542 stroke patients with a median age of 60 (53–68). …”
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Clinically Important Improvements and Disease Stability with Fluticasone Furoate/Umeclidinium/Vilanterol Once-Daily Single-Inhaler Triple Therapy in the ELLITHE Trial: A Post Hoc R... by Kai-Michael Beeh, Karl Scheithe, Heike Schmutzler, Saskia Krüger

“…Conclusions Despite overlapping responses to single and composite outcomes with odSITT, individual patterns support a multidimensional approach to evaluate benefits in COPD. …”
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Interactions Between SDG 6 and Sustainable Development Goals: A Case Study from Chenzhou City, China’s Sustainable Development Agenda Innovation Demonstration Area by Penglong Wang, Xiao Yu, Bingxin Xu, Qinhua Wang, Xuhong Wei, Bao Wang, Xueyan Zhao, Feng Gao

“…The results show that (1) from 2015 to 2022, the SDG6 composite index has significantly increased over time, with the establishment of the demonstration area (2019–2022) more than twice compared to before (2015–2018), particularly in water environment and water quantity; (2) the SDG composite index and individual SDG indexes have shown a fluctuating upward trend, with an increase of about 89.74% after the establishment of the demonstration area (2019–2022) compared to before (2015–2018), with the most significant progress in the society dimension; and (3) there were significant synergy effects between the improvements in SDG6 and related SDGs. …”
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Modeling and predicting growth and growth boundary of Bacillus cereus s.l. from phylogroups II, IV, V, and VI in starchy foods at or below 12°C by Veronica Martinez-Rios, Resadije Idrizi, Paw Dalgaard, Lisbeth Truelstrup Hansen, Tina Beck Hansen

“…The study focused on isolates belonging to psychrotolerant or mesophilic-psychrotolerant intermediary thermotypes in panC-groups II, IV, V, or VI and generated data for growth kinetics for various pH (4.8–7.8), aw (0.935–0.999) and storage temperatures (6.0–11.7°C) in 42 starchy foods (bulgur, couscous, pasta, potatoes, rice) and eight composite foods containing at least one starchy ingredient. …”
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Mapping subtidal seagrass in the turbid Baltic Sea: Rethinking satellite sensor selection using a sensor-agnostic pipeline by Eike M. Schütt, Florian Uhl, Philipp R. Schubert, Thorsten B.H. Reusch, Natascha Oppelt

“…Conservation and restoration of seagrass ecosystems critically depend on accurate habitat distribution data. Traditional monitoring methods for subtidal seagrass meadows are costly and labour-intensive for large-scale, repetitive mapping efforts. …”
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Environmental contamination and horizontal transmission of Salmonella Enteritidis among experimentally infected layer pullets in indoor cage-free housing by Richard K. Gast, Javier S. Garcia, Rupa Guraya, Deana R. Jones, Darrin M. Karcher

“…Flooring substrate composites were the most efficient environmental sample type for all 3 trials combined (72 % positive), providing significantly better S. …”
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Association between tonsillectomy plus steroid pulse therapy and renal outcomes in patients with IgA nephropathy: a retrospective cohort study by Ayano Hayashi, Kayoko Mizuno, Kanna Shinkawa, Kazunori Sakoda, Satomi Yoshida, Masato Takeuchi, Motoko Yanagita, Koji Kawakami

“…The primary outcome was the composite outcome of a 30% decline in eGFR and initiation of dialysis, and the secondary outcomes comprised the composite outcome of end-stage renal failure and initiation of dialysis and eGFR slope. …”
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Current status and influencing factors of mild renal function decline in elders aged over 60 years by Xue Jian-qiang, He Na, Shuai Ping, Liu Yu-ping

“…With lowered renal function as adependent variable，compositions of hematuria and hyperuricemia，age，diastolic blood pressure，hemoglobin，urea nitrogen，low density lipoprotein and uric acid value were included for multivariate Logstic regression analysis. …”
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Recent advancements in metal oxide‐based hybrid nanocomposite resistive random‐access memories for artificial intelligence by Anirudh Kumar, Kirti Bhardwaj, Satendra Pal Singh, Youngmin Lee, Sejoon Lee, Mohit Kumar, Sanjeev K. Sharma

“…Finally, the challenges, limitations, and future outlooks of the fabrication of MOx–polymer hybrid composite ReRAMs over the conventional von Neumann computing systems are discussed.…”
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Clinical outcomes of multivessel disease patients after off-pump minimally invasive coronary surgery by Lixue Zhang, Qing Gao, Simeng Zhang, Gang Liu, Bo Lian, Yu Chen, Yi Shi

“…Clinical characteristics, surgical data, postoperative outcomes and graft patency were analyzed between the two groups. …”
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A selective NH3 gas sensor based on (Ag2O)1-x(SnO2)x nanocomposites thin films at various operating temperatures by Nada Mohammed Abas, Anwar Ali Baqer

“…Energy Dispersive X-Ray Analysis (EDX) is used to confirm the elements in composite films. Atomic Force Microscopy (AFM) analysis shows that the produced films had grains size between 37.68 - 49.57nm and root mean square (RMS) roughness of 4.92-8.22nm. …”
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HIV risk screening and HIV testing among orphans and vulnerable children in community settings in Tanzania: Acceptability and fidelity to lay-cadre administration of the screening... by Michelle M Gill, Ola Jahanpour, Roland van de Ven, Asheri Barankena, Peris Urasa, Gretchen Antelman

“…In-depth interviews were conducted with older adolescents and caregivers in their homes following screening and testing. A composite score was developed for the checklist. Qualitative data were thematically analyzed to address screening and testing perceptions and experiences.…”
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In-depth study and optimization of process parameters to enhance tensile and compressive strengths of PETG in FDM technology by Rajan Kumaresan, Kumaran Kadirgama, Mahendran Samykano, Wan Sharuzi Wan Harun, Arunkumar Thirugnanasambandam, Krishnan Kanny

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Characterization of Java Island's volcanoes based on volcano density and quantification of volcanic products using Landsat imagery by Supriyadi, Asep Saepuloh, Harry Mahardika, Wahyu Srigutomo

“…The Landsat 8 and 9 OLI data were processed and displayed in False Color Composite (FCC) R, G, B for Band 5, 6, 7 to identify volcanic products distribution. …”
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Association between the fibrosis-4 and the risk of left ventricular aneurysm formation in acute ST-segment elevation myocardial infarction by Kai Zhang, Lihong Yang, Yonghui Zhao

“…The ROC curve was used to determine the predictive capability of the FIB-4 index and composite variable for LVA formation.ResultsLVA occurred in 12.7% of the population. …”
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Simulating the methodological bias in the ATLS classification of hypovolemic shock: a critical reappraisal of the base deficit renaissance by M. L. A. Heldeweg, T. T. R. Heldeweg, J. A. H. Stohlmann, P. Freire Jorge, R. Boer, L. A. Schwarte, P. Schober

“…Results Applying the original imbalanced grouping and composite allocation strategies caused a systematic overestimation of shock class for traditional ATLS parameters, favoring the association between BD and transfusion. …”
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Whitening Efficiency of Papain and Bromelain Gels in Removing Dental Stains by Stanca Cuc, Codruta Sarosi, Ioan Petean, Amalia Moldovan, Cecilia Bacali, Sorin Claudiu Man

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Impact of controlled physical training on clinicopathological and psychophysiological features of patients with chronic heart failure and type 2 diabetes by M. N. Sinkova, L. K. Isakov, E. Yu. Plotnikova, O. L. Barbarash

“…The incidence of the composite endpoint was 55.2% and 80.9% in main and control group, respectively (p = 0.038). …”
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