The use of implementation science theoretical approaches in hybrid effectiveness-implementation type 1 randomised trials of healthcare interventions: A scoping review by Orly Atzmon, Meagan E. Crowther, Bei Bei, Denise A. O’Connor

“…Theoretical approaches were most often applied (62%) to justify the implementation study design, guide selection of study materials or analyse implementation outcomes. …”
Get full text

Impact of Standardised Order Sets on Functional Outcome of Acute Ischaemic Stroke Patients: A Research Protocol by Sarang Dilip Videkar, Tushar Patil

“…The data collection process for this study will be divided into three phases: the pre-implementation phase, the implementation phase, and the post-implementation phase. …”
Get full text

The relationship between serum CTRP-5, C3a/desArg, and complement-C3 levels and hypothyroidism in women with polycystic ovary syndrome by Fatima Abdul-ameer, Itlal Jummha AbudlRasool AlAsadi, Asieh Hosseini, Elham Bahreini

“…Methods This case-control study involved three groups: healthy women (control group), women with PCOS and hypothyroidism, and women with PCOS without hypothyroidism. …”
Get full text

Practice of balanced scorecard implementation and its contributing factors among public primary hospital professionals in Central Gondar zone, Northwest Ethiopia by Seid Yeshaw, Seid Yeshaw, Geta Asrade, Asebe Hagos, Muluken Genetu Chanie, Nigusu Worku

“…The health sector’s healthcare provision, customer satisfaction, customer retention, organizational profit, changes and improvements in the healthcare delivery practice are affected by the implementation of BSC tools. However, no evidence or study indicates the implementation of BSC practice in the Ethiopian context. …”
Get full text

Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery by Massimo Nunes, Mare Vlok, Amy Proal, Douglas B. Kell, Etheresia Pretorius

“…To build on these findings, and to identify potential biomarkers that can be related to pathophysiology, we measured differences in protein expression in platelet-poor plasma (PPP) samples from 15 ME/CFS study participants and 10 controls not previously infected with SARS-CoV-2, using DIA LC-MS/MS. …”
Get full text

Efficacy and safety of complement inhibitors in patients with geographic atrophy associated with age-related macular degeneration: a network meta-analysis of randomized controlled... by Huan Wang, Jiaqi Zheng, Qing Zhang, Zhongping Tian, Yuhang Sun, Tianyi Zhu, Yanlong Bi, Yanlong Bi, Li Zhang, Li Zhang

“…Two complement inhibitor drugs have been approved by the Food and Drug Administration (FDA).Objectiveto compare and rank the different complement inhibitors in the treatment of GA secondary to age-related macular degeneration (AMD).Data sourcesA systematic literature search was conducted in the Cochrane Central, Web of Science Core Collection, PubMed, LWW Medical Journals, ClinicalTrials.gov, and WHO ICTRP from inception to October 2023.Study selectionAll randomized clinical trials evaluating the effectiveness of complement inhibitors in patients diagnosed with secondary GA in AMD were identified.Data extraction and synthesisThis study followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) network meta-analysis Checklist of Items and the Cochrane Risk of Bias Assessment Tool for assessing the study quality. …”
Get full text

How PrEP delivery was integrated into public ART clinics in central Uganda: A qualitative analysis of implementation processes. by Monique A Wyatt, Emily E Pisarski, Alisaati Nalumansi, Vicent Kasiita, Brenda Kamusiime, Grace K Nalukwago, Dorothy Thomas, Timothy R Muwonge, Andrew Mujugira, Renee Heffron, Norma C Ware, Partners PrEP Program Study Team

Get full text

Does Brand Attitude Complement Influencer Credibility in Shaping Purchase Intention of Indian GenZ Consumers? [version 1; peer review: 2 approved] by Varalakshmi Alapati, Pranav Vilas Chavare, Smitha Nayak, Ramona Birau

Get full text

Does Brand Attitude Complement Influencer Credibility in Shaping Purchase Intention of Indian GenZ Consumers? [version 3; peer review: 2 approved] by Varalakshmi Alapati, Pranav Vilas Chavare, Smitha Nayak, Ramona Birau

Get full text

Polymorphic factor H-binding activity of CspA protects Lyme borreliae from the host complement in feeding ticks to facilitate tick-to-host transmission. by Thomas Hart, Ngoc Thien Thu Nguyen, Nancy A Nowak, Fuming Zhang, Robert J Linhardt, Maria Diuk-Wasser, Sanjay Ram, Peter Kraiczy, Yi-Pin Lin

“…However, the role that CspA plays in the Bbsl enzootic cycle remains unclear. In this study, we demonstrated that different CspA variants promote spirochete binding to FH to inactivate complement and promote serum resistance in a host-specific manner. …”
Get full text

External relationships as implementation determinants in community-engaged, equity-focused COVID-19 vaccination events by Ramey Moore, Jennifer Callaghan-Koru, Jennifer L. Vincenzo, Susan K. Patton, Marissa J. Spear, Sheldon Riklon, Eldon Alik, Alan Padilla Ramos, Stephanie Takamaru, Pearl A. McElfish, Geoffrey M. Curran, Geoffrey M. Curran

“…This exploratory study makes a significant contribution to the literature by describing the types of external relationships that facilitate equitable implementation and identifying the mechanisms through which they may work. …”
Get full text

Improving MPCitH with Preprocessing: Mask Is All You Need by Guowei Liu, Guoxiao Liu, Kaijie Jiang, Qingyuan Yu, Keting Jia, Puwen Wei, Meiqin Wang

Get full text

Implementing psychosocial guidelines into specialized spinal cord injury rehabilitation services to strengthen person-centred health care: protocol for a mixed methods study by Candice McBain, Candice McBain, Anne Marie Sarandrea, Anne Marie Sarandrea, Anne Marie Sarandrea, Ilaria Pozzato, Ilaria Pozzato, Mohit Arora, Mohit Arora, Daniel Myles, Daniel Myles, John Bourke, John Bourke, Yvonne Tran, Ian D. Cameron, Ian D. Cameron, James W. Middleton, James W. Middleton, James W. Middleton, Ashley Craig, Ashley Craig

“…To capture lived experience insight, 10 patients with SCI currently undergoing rehabilitation will be interviewed.DiscussionThis study will establish the success of implementing psychosocial guidelines into three specialist SCI services. …”
Get full text

Strategies for implementing long‐acting cabotegravir for PrEP in US clinics serving Black women: interim healthcare provider findings from the EBONI study by Katherine L. Nelson, Tammeka Evans Cooper, Yolanda Lawson, Dylan Baker, Satish Mocherla, Megan Dieterich, Theo Hodge, Alftan Dyson, Denise Sutherland‐Philips, Heidi Swygard, Lisa Petty, Peter Jeffery, Kenneth Sutton, Courtney Peasant Bonner, Sara M. Andrews, Samantha Chang, Piotr Budnik, Kimberly Smith, Annemiek deRuiter, Maggie Czarnogorski, Nanlesta Pilgrim

“…EBONI (NCT05514509) is a Phase 4 implementation study evaluating the implementation of CAB LA delivery to Black cis‐ and transgender (cis‐and‐trans) women in clinics located in the United States, including infectious disease (ID), primary care (PC) and women's health (WH) clinics. …”
Get full text

Systematic review and meta-analysis of the association between complement factor H I62V polymorphism and risk of polypoidal choroidal vasculopathy in Asian populations. by Zhao-Yang Wang, Keke Zhao, Jingwei Zheng, Brian Rossmiller, Cristhian Ildefonso, Manas Biswal, Pei-quan Zhao

“…A system review and meta-analysis of the association between I62V and PCV and/or nAMD were performed from 8 studies involving 5,062 subjects. The following data from individual studies were extracted and analyzed: 1) comparison of I62V polymorphisms between PCV and controls; 2) comparison of I62V polymorphisms between PCV and nAMD. …”
Get full text

N-terminomics profiling of host proteins targeted by excretory-secretory proteases of the nematode Angiostrongylus vasorum identifies points of interaction with canine coagulation... by Nina Germitsch, Tobias Kockmann, Manuela Schnyder, Lucienne Tritten

“…Further studies are needed to validate their substrate specificity.…”
Get full text

Which indoor residual spraying insecticide best complements standard pyrethroid long-lasting insecticidal nets for improved control of pyrethroid resistant malaria vectors? by Thomas Syme, Augustin Fongnikin, Damien Todjinou, Renaud Govoetchan, Martial Gbegbo, Mark Rowland, Martin Akogbeto, Corine Ngufor

“…<h4>Background</h4>Where resources are available, non-pyrethroid IRS can be deployed to complement standard pyrethroid LLINs with the aim of achieving improved vector control and managing insecticide resistance. …”
Get full text

Fine Mapping of <i>BrTCP1</i> as a Key Regulator of Branching in Flowering Chinese Cabbage (<i>Brassica rapa</i> subsp. <i>chinensis</i>) by Chuanhong Liu, Xinghua Qi, Shuo Fu, Chao Zheng, Chao Wu, Xiaoyu Li, Yun Zhang, Xueling Ye

Get full text

Addressing Hypertension and Diabetes through Community-Engaged Systems (ANDES) in Puno, Peru: rationale and study protocol for a hybrid type 2 effectiveness and implementation randomized controlled trial by Lindsay J. Underhill, Kendra N. Williams, Lucy Cordova-Ascona, Karina Campos, Lisa de las Fuentes, Mark D. Huffman, Joel Gittelsohn, Kenneth B. Schechtman, Zoila Vela-Clavo, Carla Tarazona-Meza, Laura K. Beres, Parker K. Acevedo, Abigail Barker, Nishadi Rajapakse, Makeda Williams, Veronica Tonwe, Aaloke Mody, Raquel Hurtado, Juan Carlos Mendoza, Gonzalo Cuentas, Elvin H. Geng, William Checkley, Victor G. Dávila-Román, Stella M. Hartinger-Peña

“…Here we describe the rationale and study design for a hybrid type 2 randomized controlled trial to test the implementation and effectiveness of a community health worker (CHW)-led hypertension control program within the national primary care system in Puno, Peru. …”
Get full text

Multifarious approaches of implementation to transfer gender sensitivity in health care practice: a scoping review by Judith Mollenhauer, Sophia Sgraja, Ute Seeland, Martina Kloepfer, Volker E. Amelung, Clarissa Kurscheid

“…Learning from international best-practice concepts and promoting career advancement facilitates the implementation. (ii) Generating evidence by conducted studies enables the integration of GSC+ content through professional associations in guidelines. …”
Get full text