CTSL-2 upon specifically recognizing Vibrio splendidus directly cleaves complement C3 to promote the bacterial phagocytosis and degradation in oyster by Qiuyan Guo, Wenwen Yang, Weishuai Shan, Hongsheng Yao, Xiangqi Shi, Lingling Wang, Jiejie Sun, Linsheng Song

“…Abstract Cathepsin L (CTSL) as a cysteine cathepsin protease mediates complement C3 cleavage and pathogen degradation. In the present study, a CTSL homolog was identified from Crassostrea gigas (designated as CgCTSL-2). …”
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Time course of organ and hematological response to complement blockage in transplant-associated thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation by Tatiana A. Rudakova, Julia Yu Vlasova, Olesya V. Paina, Olga A. Slesarchuk, Marina A. Gorodnova, Tatiana S. Schegoleva, Oleg V. Goloshchapov, Tatiana A. Bykova, Elena V. Morozova, Lyudmila S. Zubarovskaya, Ivan S. Moiseev, Alexander D. Kulagin

“…BackgroundHematopoietic stem cell transplantation (HSCT) offers a potential cure for various hematologic malignancies and non-malignant disorders but is often accompanied by severe complications, one of the most challenging being transplant-associated thrombotic microangiopathy (TA-TMA). Eculizumab, a complement inhibitor, has emerged as an effective therapeutic option for TA-TMA.MethodsThis single-center retrospective study was conducted at Pavlov University, St. …”
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Normothermic Machine Perfusion Reconstitutes Porcine Kidney Tissue Metabolism But Induces an Inflammatory Response, Which Is Reduced by Complement C5 Inhibition by Eline de Boer, Eline de Boer, Marina Sokolova, Marina Sokolova, Neeltina M. Jager, Camilla Schjalm, Camilla Schjalm, Marc G. Weiss, Olav M. Liavåg, Hanno Maassen, Hanno Maassen, Harry van Goor, Ebbe Billmann Thorgersen, Ebbe Billmann Thorgersen, Kristin Pettersen, Dorte Christiansen, Judith Krey Ludviksen, Bente Jespersen, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Henri G. D. Leuvenink, Henri G. D. Leuvenink, Søren E. Pischke, Søren E. Pischke, Søren E. Pischke

“…Microdialysis was used to evaluate renal metabolism. This study aimed to assess the effect of complement inhibition on NMP induced inflammatory responses. …”
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Challenges in Implementing Kurikulum Merdeka for EFL Teachers by Fahrani Reza, Zuliati Rohmah, Nur Nabilah Abdullah

“…This article explores the challenges the English teachers face in executing Kurikulum Merdeka. This study employed a mixed-method approach to examine the challenges faced by English teachers when implementing Kurikulum Merdeka. …”
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Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging by Feng Zhang, Rong Li, Yasong Liu, Jinliang Liang, Yihang Gong, Cuicui Xiao, Jianye Cai, Tingting Wang, Qiang You, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Yingcai Zhang, Yang Yang, Hua Li, Jia Yao, Qi Zhang, Jun Zheng

“…Our findings revealed widespread aging‐rewired chronic inflammation, characterized by complement system activation in plasma and universal immunoglobulins accumulation across multiple solid tissues. …”
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Real-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohortResearch in context by Aleksandra Vujović, Anne-Laure Sellier-Leclerc, Maria Cristina Mancuso, Olivia Boyer, Atif Awan, Antonio Gargiulo, Sebastian Loos, Marc Fila, Augustina Jankauskiene, Gema Ariceta, Nele Kanzelmeyer, Enrico Vidal, Maria Van Dyck, Tanja Kersnik Levart, Naděžda Šimánková, Stephane Decramer, Jonas Hofstetter, Marina Vivarelli, Savino Sciascia, Nicole C.A.J. van de Kar, Franz Schaefer, Nicole C.A.J. van de Kar, Marina Vivarelli, Savino Sciascia, David Kavanagh, René Andersen, Mia Faerch, Soren Rittig, Miquel Blasco, Pedro Arango Sancho, Alvaro Madrid, Gema Ariceta, Loreto Gesualdo, Camillo Carrara, Piero Ruggenenti, Kai-Uwe Eckardt, Jan Halbritter, Dominik Müller, Adrian Schreiber, Evelyn Seelow, Yahsou Delmas, Jerome Harambat, Brigitte Llanas, Nathalie Godefroid, Eric Goffin, Johann Morelle, Adrian Catalin Lungu, George Reusz, Péter Sallay, Attila Szabo, Kalman Tory, Jan Ulrich Becker, Kathrin Burgmaier, Volker Burst, Sandra Habbig, Max Liebau, Roman-Ulrich Mueller, Lutz Weber, Mette Damholt, Anne-Lise Kamper, Karl Emil Nelveg-Kristensen, Hanne Nørgaard, Ida Maria Schmidt, Soeren Soerensen, Wladimir Szpirt, Agnieszka Jaskólska, Monika Miklaszewska, Anna Moczulska, Elżbieta Szczęsny-Choruz, Katarzyna Zachwieja, Peter Conlon, Atif Awan, Michael Wiesener, Anja Büscher, Rainer Büscher, Lars Pape, Francesca Becherucci, Paola Romagnani, Ann Raes, Thomas Renson, Evelien Snauwaert, Johan Vande Walle, Jill Vanmassenhove, Mark Eijgelsheim, Casper Franssen, Coen Stegeman, Florian Grahammer, Thomas Henne, Tobias Huber, Christian Krebs, Sebastian Loos, Anne Mühlig, Jun Oh, Ulf Panzer, Raphael Schild, Jessica Kaufeld, Stefanie Haeberle, Franz Schaefer, Tanja Wlodkowski, Juuso Tainio, Elisa Ylinen, Obbo Bredewold, Wieneke Michels, Dorien Peters, Antonius Rabelink, Arghya Ray, Joris Rotmans, Siebe Spijker, Y.K. Onno Teng, Kathleen Claes, Noel Knops, Tanja Kersnik Levart, Anamarija Meglič, Gregor Novljan, Agnieszka Gach, Monika Pawlak-Bratkowska, Małgorzata Stańczyk, Marcin Tkaczyk, Pierre Cochat, Anne-Laure Sellier-Leclerc, Teresa Cavero, Eduardo Guiterrez, Joaquin Martinez, Enrique Morales, Hernando Trujillo, Gianluigi Ardissino, Valentina Capone, Sara Testa, Denis Morin, Martin Konrad, Ilaria Luongo, Gabriele Malgieri, Luigi Annicchiarico Petruzzelli, Wilbert van der Meijden, Jack Wetzels, Mattia Parolin, Enrico Vidal, Thérésa Kwon, Olivia Boyer, Aude Servais, Laurent Mesnard, Alena Parikova, Silvie Rajnochova-Bloudickova, Janka Slatinska, Ondrej Viklicky, Martin Bezdicka, Nadezda Simankova, Dana Thomasova, Jakub Zieg, Francesco Emma, Rocco Baccaro, Giuseppe Grandaliano, Alessandro Naticchia, Francesco Pesce, Margherita Baldassarri, Andrea Guarnieri, Anna Maria Pinto, Alessandra Renieri, Stephane Decramer, Stanislas Faguer, David Ribes, Thomas Simon, Stephanie Tellier, Daniel Gale, Christoph Licht, Michal Malina, Candice Roufosse, Neil Sheerin, Susana Carvajal Arjona, Renée de Wildt, Uwe Korst, Christiane Mockenhaupt, Francisco Monfort, Mireya Vicenta Rios Carratala

“…Occasionally, complement inhibition is applied in infectious (i)HUS. …”
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Academic leadership during the time of crisis: Success story of implementation success from traditional to online mode of education in a low-resource context by Saima Hamid, Shaheryar Naveed, Huma Ayub, Shoaib Akhtar

“…The study provides evidence that AIFs are effective for implementing evidence-based models by promoting the development and deployment of innovations through implementation teams in a resource-constraint setting. …”
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Understanding implementation determinants of universal school meals through an equity-driven mixed methods approach by Gabriella M. McLoughlin, Molly Kerstetter, Yerusalem Yohannes, Omar Martinez, Resa M. Jones, Ross C. Brownson, Jennifer O. Fisher

“…Grounded in implementation science and health equity frameworks, this study aimed to: 1) investigate the determinants of implementing USM in a large, urban school district and 2) assess key challenges and supports across schools with varying levels of participation in USM. …”
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Advancing the selection of implementation science theories, models, and frameworks: a scoping review and the development of the SELECT-IT meta-framework by Guillaume Fontaine, Meagan Mooney, Joshua Porat-Dahlerbruch, Katherine Cahir, Moriah Ellen, Anne Spinewine, Natalie Taylor, Rachael Laritz, Ève Bourbeau-Allard, Jeremy M. Grimshaw

“…This study aimed to (1) identify and categorize the reported purposes and attributes of TMFs, as well as the practical considerations of TMF users, and (2) synthesize these findings into a meta-framework that supports implementation practitioners and researchers in selecting TMFs. …”
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Restrictive points of entry into abortion care in Ireland: a qualitative study of expectations and experiences with the service by Dyuti Chakravarty, Joanna Mishtal, Lorraine Grimes, Karli Reeves, Bianca Stifani, Deirdre Duffy, Mark Murphy, Mary Favier, Patricia Horgan, Wendy Chavkin, Antonella Lavelanet

“…The interviews were part of a wider mixed-methods study from 2020-2021 examining the barriers and facilitators to the implementation of abortion policy in Ireland. …”
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Challenges in adopting health technology assessment for evidence-based policy in Iran: a qualitative study by Meysam Behzadifar, Saeed Shahabi, Ahad Bakhtiari, Samad Azari, Mohammad Yarahmadi, Mariano Martini, Masoud Behzadifar

“…The findings also offer valuable lessons for other low- and middle-income countries facing similar challenges, contributing to the global discourse on HTA implementation in resource-constrained settings.…”
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Predictive Value of Excision Repair Cross Complementation Group 1 (ERCC1) by Immunohistochemistry for Determining Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancer... by Atif Ali Hashmi, Yumna Ajaz, Muhsana Sajjad, Fazail Zia, Muhammad Irfan, Syed Muhammad Abu Bakar, Erum Yousuf Khan, Naveen Faridi

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Pilot feasibility and staff acceptability of adding question prompt list links to SMS appointment reminders: a mixed methods study by Marguerite Tracy, Gur Kanwal Singh, Heather L. Shepherd

“…Website access data were collected, implementation costs measured, and clinic staff completed interviews about the impact on service delivery and consultation content.Results The website was accessed 22 times via the link during the study period by 13 people (388 SMS sent, additional cost AUD$15.52). …”
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Artificial Intelligence and Modern Technology in Dentistry: Attitudes, Knowledge, Use, and Barriers Among Dentists in Croatia—A Survey-Based Study by Ana Ivanišević, Antonija Tadin

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Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3′ untranslated region in MCF7 cells by Xin Yan, Qianyin Li, Dongsheng Ni, Yajun Xie, Qingling He, Qianya Wan, Yamin Liu, Zhongshi Lyu, Zhaomin Mao, Qin Zhou

“…A1CF (apobec-1 complementation factor) acts as a component of the apolipoprotein-B messenger RNA editing complex. …”
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A phase 3 study of ravulizumab to protect patients with chronic kidney disease from cardiac surgery-associated acute kidney injury and major adverse kidney events (ARTEMIS) by Marlies Ostermann, David C. Corteville, Kent Doi, Jay L. Koyner, Andre Lamy, Gerry Li, Christine M. Solinsky, Pamela D. Winterberg, William T. Smith, Ravindra L. Mehta, Patrick T. Murray, Andrew D. Shaw, Alexander Zarbock, Daniel T. Engelman

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Implementing electronic health record-based anxiety and depression screening in an epilepsy clinic: Theory-based implementation strategy and pre-post quantitative outcomes using Re... by Heidi M. Munger Clary, Halley B. Alexander, Sabina Gesell, Mingyu Wan, Kelly R. Conner, Cormac O’Donovan, Jane Boggs, Christian Robles, Maria Sam, Jerryl Christopher, Christina Marini, Beverly M. Snively

“…Screening with validated measures at every epilepsy visit is a quality measure, yet screening remains limited due to time constraints. Methods: This study aimed to develop an implementation strategy for anxiety and depression screening at an epilepsy center and evaluate it in a pre-post design with RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance). …”
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A pharmacist-led educational and audit & feedback strategy to reduce antibiotic prescription in primary care: the AFA study by A. Soler, A. Huguet, A. Leiva, C. Vicens, F. Bejarano-Romero, E. Sempere, T. Izquierdo, M. M. Parera, R. Seco, M. Fages, A. Medina, L. Castillo-Palomares, E. López-Guerrero, B. A. Ferrer, L. Ugarriza, M. Llarena, L. Gallardo-Alfaro, AFA study investigators

“…Methods A randomized, multicentre, parallel-group clinical trial with a hybrid type I (effectiveness-implementation) design to reduce antibiotic prescriptions in primary care. …”
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Effectiveness of 5E Instructional Model Implementation in Mathematics Education: A Case Study of Two Selected Advanced Level Public Secondary Schools in Gasabo District, Rwanda by Onesme Niyibizi

“…This qualitative research study explored the effectiveness of implementing the 5E instructional model in mathematics education within the context of two selected advanced-level public secondary schools in Gasabo District, Rwanda. …”
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School life during COVID-19: a qualitative study exploring English secondary school staff and pupils’ experiences of the school-based mitigation measures by Sarah Bell, Jane Williams, Sabi Redwood, Jeremy Horwood

“…Methods This qualitative study explored secondary school staff and pupils’ views and experiences of COVID-19 guidance and mitigation measures. …”
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