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Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies
Published 2025-01-01“…In this study, the glomerular proteome, especially the profiles of the complement proteins, was analyzed in kidney biopsies from 40 DKD patients and 10 normal controls using laser microdissection-assisted liquid chromatography-tandem mass spectrometry (LMD-LC-MS/MS). …”
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943
Complement C1q is associated with neuroinflammation and mediates the association between amyloid-β and tau pathology in Alzheimer’s disease
Published 2025-07-01“…Abstract Complement C1q initiates the classical complement pathway and becomes activated in Alzheimer’s disease (AD), contributing to the association between amyloid-β (Aβ) and tau pathologies. …”
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944
Proteomic analysis of laser captured tubular tissues reveals complement activation and mitochondrial dysfunction in autoimmune related kidney diseases
Published 2024-08-01“…Notably, significant alterations in CFB in tubular ARKD patients were revealed, implicating it as a therapeutic target. This study underscores the importance of complement activation and mitochondrial dysfunction in the pathogenesis of ARKDs, and proposes CFB as a potential therapeutic target to inhibit complement activation and mitigate tubular damage. …”
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945
Reduced synaptic tagging by complement protein C3 is associated with elevated extracellular matrix in the middle-aged cerebellum of mice
Published 2025-06-01“…Furthermore, we show an increased expression of cytokines and complement factors upon aging and a decline of C3-tagged VGLUT1+ presynaptic puncta in the CB. …”
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947
Complement-mediated hemolytic uremic syndrome associated with postpartum hemorrhage: case series and systematic review of individual participant data
Published 2024-11-01“…Background: Postpartum hemorrhage is considered a risk factor for pregnancy-associated complement-mediated hemolytic uremic syndrome (CM-HUS; previously known as atypical hemolytic uremic syndrome) but has not been systematically studied. …”
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948
Challenges of Blockchain Implementation in Construction
Published 2024-01-01“…The purpose of this study is to check the difficulties attached with the implementation of blockchain technology in extensive building undertakings. …”
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949
The Politics of Curriculum Implementation in Africa.
Published 2024“…The objectives of the study were to explore how politics influences the curriculum implementation process in Africa and establish strategies that can improve the curriculum implementation process amidst the political dynamics. …”
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950
Implementation of school-based management
Published 2024-12-01“…This study examined the influence of teachers' perceptions of management, principals' leadership styles, and teachers' work motivation on the implementation of school-based management in Batang Gansal. …”
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951
Insights and proposals for RPA implementations
Published 2024-05-01“…By analyzing a large dataset of scientific papers, this study aims to identify trends and gaps of this subject. …”
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952
On Toeplitz matrices construction algorithm with a given number of connected components of the limitary spectrum complement<sup>[1]</sup>
Published 2015-12-01“…The simplest topological properties of the approximate spectrum, namely the connectivity of its complement in the complex plane, are studied. A numerical verification of the lower bounds for the maximum number of the connected components of the limitary spectrum complement of the band Toeplitz matrices whose symbol is Laurent polynomial of the specified degree, is carried out. …”
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Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis
Published 2018-01-01“…The complement system plays an important role in innate immunity inducing liver diseases as well as signaling immune cell activation in local inflammation regulating immunomodulatory effects such as liver damage and/or liver regeneration. …”
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Mechanism of implementation of an enterprise strategy
Published 2018-12-01“…The purpose of the article is to develop the methodological basis for the development and implementation of an enterprise strategy. The methodological basis of the study is presented by a system-activity approach, which allows to explore the process of strategic management of an enterprise, taking into account the interrelationships of the functions of developing and implementing an organizational strategy. …”
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956
Brazil's experience in IPSAS implementation
Published 2019-03-01“… Considering the small number of empirical studies on the adoption of the IPSAS in Latin American countries, this article aims to understand the implementation of IPSAS in Brazil, presenting the national institutional arrangements, the progress made since the beginning of the reform, the challenges encountered in the Brazilian scenario and the results observed until 2017. …”
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Implementation of Nitrate Directive to Poland
Published 2006-04-01“…Action programmes have been prepared for each vulnerable zone separately and the implementation of these programmes is in progress. The case study for one vulnerable zone was included.…”
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Therapists perspectives on the Early Intervention after Rape study: a qualitative process evaluation of a randomized controlled trial
Published 2025-12-01“…The Early Intervention after Rape (EIR) study is a multisite randomized controlled trial designed to assess the efficacy and effectiveness of training SAC nurses and social workers to deliver a modified version of prolonged exposure therapy shortly after rape.Objective: This article aims to present a qualitative process evaluation of the implementation of the EIR study across three SACs in Norway, from the perspective of nurses and social workers.Method: We conducted semi-structured interviews with fifteen nurses and social workers, ten of whom received training in prolonged exposure therapy (mPE). …”
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An Effectiveness Trial of an Exercise Physiologist Service to Improve Quality of Life in Adults with Severe Mental Illness: Protocol for the MOVEMENT Study
Published 2025-07-01“…Participants will be invited to a study in which they may self-select to access an AEP service for six months. …”
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