Complement inhibition rapidly blocks lesion extension and facilitates remyelination in neuromyelitis optica by Katherine S Given, Elizabeth G Acker, Wendy B Macklin, Dan Carlin, Gregory P. Owens, Jeffrey L Bennett

“…Complement inhibition may offer multiple benefits for the treatment of acute NMOSD attacks.…”
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Complement Factor C7 Contributes to Lung Immunopathology Caused by Mycobacterium tuberculosis by Kerry J. Welsh, Cole T. Lewis, Sydney Boyd, Michael C. Braun, Jeffrey K. Actor

“…Increasing evidence indicates a critical role of the complement system in the development of host protection against the bacillus, but few studies have specifically explored the function of the terminal complement factors. …”
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Targeting the Roots of Kidney Disease: Systematic Review of the Therapies Targeting the Complement System by Maja Roman, Michał Nowicki

“…<i>Results</i>: A systematic review of complement-targeted therapies was conducted, analysing studies from 2013 to 2023 that address unmet medical needs in primary and secondary glomerular diseases. …”
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Complement Modulation Mitigates Inflammation-Mediated Preterm Birth and Fetal Neural Inflammation by Eliza R. McElwee, Devin Hatchell, Mohammed Alshareef, Khalil Mallah, Harriet Hall, Hannah Robinson, Ramin Eskandari, Eugene Chang, Scott Sullivan, Stephen Tomlinson

“…Preterm birth and the neonatal pathological sequelae that follow spontaneous preterm labor are closely associated with maternal and fetal inflammatory activation. Previous studies have indicated a role for the complement system in this inflammatory response. …”
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Emerging role of complement system in the induction of neuroinflammation in adenylosuccinate lyase deficiency disorder by Albert Frank Magnusen, Robert James Hopkin, Charles Vorhees, Elizabeth Wilson, Molly Moehlman, Barbara Hallinan, Craig Erickson, Melissa P. DelBello, Luca Marsili, Nicole G. Coufal, Manoj Kumar Pandey

“…We highlight emerging hypotheses implicating activation of the alternative complement pathway as a key driver of inflammation, blood-brain barrier disruption, and progressive neurodegeneration.By synthesizing recent findings, this review underscores the urgent need for mechanistic studies and therapeutic exploration, particularly targeting complement activation, as a promising strategy to mitigate inflammation and improve clinical outcomes in ADSLDD.…”
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Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic... by Evan Mulvihill, Stacy Ardoin, Susan D Thompson, Bi Zhou, Gakit Richard Yu, Emily King, Nora Singer, D M Levy, Hermine Brunner, Yee Ling Wu, Haikady N Nagaraja, Laura Eve Schanberg, Chack-Yung Yu

“…Objective Systemic lupus erythematosus (SLE) features high frequency of cardiovascular disease (CVD) and fluctuating complement levels. The clinical trial Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) aimed to evaluate whether atorvastatin treatment reduced the progression of atherosclerosis in 221 patients with childhood-onset SLE (cSLE), using carotid intima media thickness (CIMT) as surrogates. …”
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Implementing the IA stage and developing an instrument to assess the fidelity of critical time interventional: task shifting by Tatiana Fernandes Carpinteiro Silva

Subjects: “…intervention studies…”
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Implementation of Social Studies Learning at Cimahi City Junior High School Post-Covid-19 Pandemic by ARNIE FAJAR

Subjects: “…implementation , social studies learning, post covid-19 pandemic…”
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Adaptive reuse of cultural built heritage: towards the implementation of the circular city model by M. Angrisano, M. Bottero, G. Cavana, F. Fabbrocino, A. Gravagnuolo, L. Fusco Girard, L. Fusco Girard

“…Particular attention in the selection of case studies has been given to the co-planning and co-design experiences activated, to highlight the social innovation capacity of the analysed adaptive reuse projects.…”
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The Implementation of Emotionally-Valuable Component of the Content of Foreign-Language Education (on the Material of Study Course “Spotlight”). Part II by M. N. Tatarinova, O. V. Sungurova

“…There is broad agreement that the compliance of its criteria today is the most important prerequisite of foreign languages viability.The aim of this article is to provide a scientific answer to the question if there is necessary background for the implementation of the EVC of the content of foreign-language education in the current study course “Spotlight”.Methodology and research methods. …”
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Scaling up low barrier wound care for people who use drugs: a mixed methods study by Eleanor Turi, Shoshana V. Aronowitz, Amanda Bettencourt, Allison Li, Jessica Lin, Rachel McFadden, David Mandell, Courtney Benjamin Wolk

“…We also generated evidence-based implementation strategies using the Expert Recommendations for Implementing Change compilation. …”
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Integrating a Mobile App to Enhance Atrial Fibrillation Care: Key Insights From an Implementation Study Guided by the Consolidated Framework for Implementation Research by Sumudu Hewage, Sanjeewa Kularatna, William Parsonage, Tomos Walters, Steven McPhail, David Brain, Michelle J Allen

“… BackgroundDespite the growing use of mobile health apps in managing chronic heart disease, their integration into routine care remains challenging due to dynamic, context-specific barriers. ObjectiveThis study aimed to identify the key enablers and challenges of implementing a mobile app for cardiac rehabilitation and healthy lifestyles in patients with atrial fibrillation at an Australian cardiology clinic. …”
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What work is required to implement and sustain the National Surgical Quality Improvement Program (NSQIP)? A qualitative study of NSQIP implementation in Alberta, Canada by Denise Campbell-Scherer, Mary Brindle, Thea Luig, Jill Robert, Dawn Schroeder, Sanjay Beesoon

“…Objectives Hospitals introducing the National Surgical Quality Improvement Program (NSQIP) face implementation challenges. To understand the work of embedding NSQIP into routine practice, we explored interactions between contextual factors and the work among implementation teams at the individual, team and organisational level to illuminate how to support and sustain NSQIP implementation.Design Qualitative interpretative study using thematic analysis.Setting Five contextually diverse hospital sites in Alberta, Canada, for in-depth interviewing and four additional hospitals for observation of NSQIP meetings.Participants 9 Surgeon and Anaesthesiologist Champions; 6 Surgical Clinical Reviewers; 4 Directors and 1 Surgical Site Manager; 3 Operating Room Managers; 3 Quality Improvement Consultants; 1 Surgeon and 1 Provincial NSQIP Lead.Methods To capture context, process and the dynamic interplay between the two, we integrated the Consolidated Framework for Implementation Research (CFIR) and Normalisation Process Theory (NPT) to guide data collection and analysis. 28 individual semi-structured interviews with key informants and observations with field notes of 10 NSQIP meetings were conducted. …”
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Phase one of a hybrid effectiveness-implementation study to assess the feasibility, acceptability and effectiveness of implementing seasonal malaria chemoprevention in Nampula Province, Mozambique by Kevin Baker, Ivan Alejandro Pulido Tarquino, Pedro Aide, Craig Bonnington, Christian Rassi, Sol Richardson, Chuks Nnaji, Arantxa Roca-Feltrer, Maria Rodrigues, Mercia Sitoe, Sonia Enosse, Caitlin McGugan, Francisco Saute, Gloria Matambisso, Baltazar Candrinho

“…Methods A pragmatic type II hybrid effectiveness-implementation study design was adopted, using mixed methods. …”
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Can theory-driven implementation interventions help clinician champions promote opioid stewardship after childbirth? Protocol for a pragmatic implementation study by Michelle H. Moniz, Michelle H. Moniz, Michelle H. Moniz, Amy M. Kilbourne, Amy M. Kilbourne, Alex F. Peahl, Alex F. Peahl, Alex F. Peahl, Jennifer F. Waljee, Jennifer F. Waljee, Jennifer F. Waljee, Shelytia Cocroft, Carey Simpson, Carey Simpson, Lisa Kane Low, Lisa Kane Low, Lisa Kane Low, Mark C. Bicket, Mark C. Bicket, Mark C. Bicket, Michael J. Englesbe, Michael J. Englesbe, Michael J. Englesbe, Molly J. Stout, Molly J. Stout, Vidhya Gunaseelan, Vidhya Gunaseelan, Althea Bourdeau, Althea Bourdeau, May Hu, Carrie Miller, Carrie Miller, Shawna N. Smith, Shawna N. Smith, Shawna N. Smith

“…BackgroundOur objective is to determine the effect of a new national clinical practice guideline (CPG) for pain management after childbirth, as implemented with less vs. more intensive implementation support, on postpartum opioid prescribing.MethodsA quasi-experimental analysis will measure the impact of post-childbirth pain management guidelines on opioid prescribing in a statewide hospital collaborative, overall and among key patient subgroups at risk for inequitable care and outcomes. …”
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Effectiveness-implementation hybrid type 2 trial evaluating two psychoeducational programmes for severe hypoglycaemia in type 1 diabetes: implementation study protocol by Nick Sevdalis, Tayana Soukup, Ioannis Bakolis, Stephanie A Amiel, Emma Lauretta Smith, Louise Hull, Andy Healey, PWD Group

“…While both programmes are aimed at reducing hypoglycaemia, SH and IAH, it is the former that integrates behavioural change techniques.The aim of the current (implementation) study is to evaluate delivery of both HARPdoc and BGAT and explore associations between implementation outcomes and trial endpoints; as well as to develop an evidence-based implementation blueprint to guide implementation, sustainment and scale-up of the effective programmes.Methods and analysis Guided by the implementation science tools, frameworks, methods and principles, the current study was designed through a series of focus groups (n=11) with the key intervention stakeholders (n=28)—including (1) individuals with lived experience of T1D, IAH and a pilot version of the HARPdoc (n=6) and (2) diabetes healthcare professionals (n=22). …”
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Properties of adaptive, cluster-randomised controlled trials with few clusters: a simulation study by Erin Nolan, Joshua Dizon, Christopher Oldmeadow, Elizabeth Holliday, Alix Hall, Daniel Barker

“…Adaptive designs offer increased efficiency, when compared to “fixed trial” approaches. A simulation study was conducted to assess whether adaptive designs are feasible (acceptable operating characteristics and adaptive interim decisions) for implementation cRCTs with few clusters. …”
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An Analytical Study of Qur'anic Tafsir: Interpretation of Qur'anic Verses on Moral Education by Ilzam Hubby Dzikrillah Alfani, Khoirul Umam Addzaky, Mukhsin Mukhsin, Jimmy Malintang, Ari Yudhanto Prabowo

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Artificial intelligence in wellbeing services counties: management and experts’ perspectives on opportunities, challenges and AI readiness by Marketta Niemelä, Tommi Kemppainen, Jenny Vuollet

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Co-design as a participatory approach for enhancing HPV health literacy among youths: a program evaluation by Jessica Dennehy, Lauren Rauh, Kamrun Nahar

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