Associations Between Serum Autoantibodies, Cytokines, Complements, and Clinical Manifestations in SLE Patients by Vikas Kailashiya, Usha Singh, Jyotsna Kailashiya

“…However, the role of these autoantibodies in the pathogenesis and clinical symptoms remains unclear. Objectives: This study aimed to explore the associations between autoantibodies, clinical symptoms, complement levels, and cytokine levels in SLE patients. …”
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Comediation of Erythrocyte Haemolysis by Erythrocyte-Derived Microparticles and Complement during Malaria Infection by Ransford Kyeremeh, Samuel Antwi-Baffour, Max Annani-Akollor, Jonathan Kofi Adjei, Otchere Addai-Mensah, Margaret Frempong

“…The issue of malaria anaemia has to do with why uninfected RBCs get destroyed and even more so than infected ones. Studies have proposed that cytophilic anti-RSP2 (ring surface protein 2—merozoite rhoptry protein 2) antibodies present in sera enhance phagocytosis of RSP2-tagged RBCs by macrophages either directly or via complement, while others have proposed transfer of RSP2 to both infected and uninfected RBCs which may render them susceptible to phagocytosis. …”
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Potential for online crowdsourced biological recording data to complement surveillance for arthropod vectors. by Benjamin Cull

“…Online platforms such as iNaturalist accumulate crowdsourced biological observations from around the world and these data could also be useful for monitoring vectors. The aim of this study was to explore the availability of observations of important vector taxa on the iNaturalist platform and examine the utility of these data to complement existing vector surveillance activities. …”
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Complement protein and Immunoglobulins Serum levels in Normal Pregnant and Spontaneous Aborted Women by Hiwa Abdulrahman Ahmad, Mehri Mirhaj Muhammd salih, Kamal Ahmed Khidir

“…Disorder of maternal immune responses during pregnancy triggers immunological rejection of fetus antigens by maternal immune components, contribute to spontaneous abortion or miscarriage. The study was designed to concentrated on immunoglobulins (IgM, IgG and IgA) and complement elements (C3 and C4)   serum levels changes in normal pregnant and abortion women. …”
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Legislation on Agrivoltaics in Germany: Changes and Complements Towards a Comprehensive Legal Framework by Max Trommsdorff, Jens Vollprecht, Till Sterzenbach

“… Following the authors’ two contributions “Legal Framework of Agrivoltaics in Germany” [1] and “New Legal Framework of Agrivoltaics in Germany” [2] in previous proceedings of the AgriVoltaics conference series, this study summarizes changes of and complements to the legal framework for agrivoltaics in Germany that have been implemented after April 2023. …”
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Why not both? Complementing explanations with uncertainty, and self-confidence in human-AI collaboration by Ioannis Papantonis, Vaishak Belle, Vaishak Belle

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Tocilizumab modulates the activity of the classical and alternative complement pathways in rheumatoid arthritis patients by Iván Ferraz-Amaro, Iván Ferraz-Amaro, Sergio Santos-Concepción, Javier Castro-Hernández, Maria Vanesa Hernández-Hernández, Beatriz Tejera Segura, Cristina Luna, Esmeralda Delgado-Frias, Federico Díaz-González, Federico Díaz-González, Federico Díaz-González

“…BackgroundTocilizumab (TCZ) is a monoclonal antibody that neutralizes interleukin (IL)-6 and is indicated for diseases characterized by markedly elevated inflammatory markers, such as rheumatoid arthritis (RA). The complement system has been implicated in the etiopathogenesis of RA.ObjectiveTo evaluate the effect of systemic IL-6 inhibition on complement pathways functional activity in RA patients treated with TCZ.DesingProspective non-interventional study.MethodsTwenty-seven RA patients included in the TOCRIVAR study who received TCZ (8mg/kg IV/q4w) were evaluated at baseline and at weeks 12, 24 and 52 of treatment. …”
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Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury by Sofie Vandendriessche, Matheus Silvério Mattos, Emilia Laura Bialek, Sara Schuermans, Paul Proost, Pedro Elias Marques

“…The clearance of necrotic cell debris is crucial for tissue recovery and injury resolution, however, the underlying mechanisms are still poorly understood, especially in vivo. This study examined the role of complement proteins in promoting clearance of necrotic cell debris by leukocytes and their influence on liver regeneration. …”
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Free anteromedial thigh perforator flap: Complementing and completing the anterolateral thigh flap by Dushyant Jaiswal, Amol Ghalme, Prabha Yadav, Vinaykant Shankhdhar, Akshay Deshpande

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Low serum complements in idiopathic inflammatory myositis: clinical features and impact on the prognosis by Shun Nomura, Yasuhiro Shimojima, Dai Kishida, Takanori Ichikawa, Akira Matsushima, Yoshiki Sekijima

“…This study investigated the clinical features and prognostic relevance of decreased serum complement levels in patients with idiopathic inflammatory myositis (IIM). …”
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Targeting the complement-mTOR-autophagy axis: the role of apolipoprotein E in depression by Yong Li, Chengyuan Xu, Jing Liu, Mengru Guo, Jia Wang, Xianbing Bai, Yujie Cheng, Xinyue Luan, Huailong Pei, Chenlei Zhang, Huan Liu, Ming Chen, Binliang Tang

“…Mechanistically, ApoE knockout triggered microglial hyperactivation and complement C3 elevation, leading to sustained mTOR pathway activation and subsequent impairment of autophagy. …”
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Long-term GABA supplementation mitigates anxiety by modulating complement and neuroinflammatory pathways by Jiyi Xu, Ziyu Ge, Han Wang, Chenhui Zhang, Jinjie Xu, Ying Li, Xiangyun Yang, Ling Zhang, Zhanjiang Li, Zhe Liu, Gang Wang, Jing Du

“…Proteomic analysis and validation revealed GABA reversed complement dysregulation (C3, C4b, Cfh, Cfi). These findings suggest GABA alleviates anxiety by modulating immune homeostasis and complement activation, highlighting its therapeutic potential.…”
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Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy by Liu JunFei, Qian XiaoPing, Wang TaoXia, Liu XiaoLi, Liu WeiGang, Wang LiJie, Zhang HuiFang, Han Li, Li GuiYing, Yu XiaoJuan

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Profile of antiphospholipid antibodies and complement system in COVID-19 patients of different severity by N. V. Dolgushina, I. V. Menzhinskaya, O. S. Beznoshchenko, S. M. Mullabayeva, E. A. Gorodnova, L. V. Krechetova

“…IgM and IgG antibodies to cardiolipin (CL), phosphatidylserine (PS), β2-glycoprotein-I (β2-GP-I), prothrombin (PT), annexin V (An V), as well as C1q complement component, content of its C3 and C4 components and total complement activity were determined in blood serum using ELISA approach. 141 patients with COVID-19 were included in the study. …”
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Clinical value of the renal pathologic scoring system in complement-mediated thrombotic microangiopathy by Fei-Fei Chen, Xiao-Juan Yu, Hui Wang, Xu Zhang, Ying Tan, Zhen Qu, Su-Xia Wang, Feng Yu, Min Chen, Ming-Hui Zhao

“…Objectives This study was initiated to establish a renal thrombotic microangiopathy (TMA) scoring system based on clinical needs and investigate its predictive value for patients’ long-term outcomes.Methods Kidney biopsy-proven Complement-mediated TMA (C-TMA) patients from January 2000 to December 2017 in Peking University First Hospital were retrospectively studied. …”
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Shedding of membrane complement inhibitors CD59 and CD46 into the circulation is associated with poor prognosis in acute coronary syndrome patients: a cohort study by Baojun Zhong, Ben King, Homa Waziri, Troels Yndigegn, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Isabel Goncalves, Anna M. Blom, Alexandru Schiopu

“…Abstract Introduction The role of the complement inhibitory proteins CD46 and CD59 in the immune response to an acute coronary syndrome (ACS) is unknown. …”
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WCN25-716 EFFECT OF IPTACOPAN ON PROTEINURIA AND COMPLEMENT BIOMARKERS IN IgA NEPHROPATHY (IgAN): INTERIM ANALYSIS OF THE PHASE 3 APPLAUSE-IgAN STUDY by Dmitrij Kollins, Olympia Papachristofi, Thomas Hach, Marie-Anne Valentin, Tobias Merkel, Ronny Renfurm, Vlado Perkovic

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The Influence of Donor and Recipient Complement C3 Polymorphisms on Liver Transplant Outcome by Maria Pires, James Underhill, Abdel Douiri, Alberto Quaglia, Wayel Jassem, William Bernal, Nigel Heaton, Phillip Morgan, Richard Thompson, J. Michael Tredger

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Genetic variants in complement-related genes: potential implications for cancer risk and progression by Jenny N. Fung, Ruben Pio

“…While genetic and epigenetic regulation of complement-related genes has been studied in various diseases, its influence on cancer remains underexplored. …”
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Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs. by Zoltán Bánki, Wilfried Posch, Asim Ejaz, Verena Oberhauser, Suzanne Willey, Christoph Gassner, Heribert Stoiber, Ulf Dittmer, Manfred P Dierich, Kim J Hasenkrug, Doris Wilflingseder

“…Previous studies have demonstrated the involvement of complement (C) in induction of efficient CTL responses against different viral infections, but the exact role of complement in this process has not been determined. …”
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