Development of a new high-yield integration site assay reveals disease-specific patterns across HTLV-1-associated pathologies by Vincent Guiraud, Jérôme Alexandre Denis, Sofia Ben Attia, Erwan Ablin, Ronan Legrand, Véronique Morel, Claire Lacan, Sylvain Choquet, Rabab Debs, Margaux Cheval, Cindy Marques, Alexandre Le Joncour, Jean-Christophe Corvol, Olivier Benveniste, Valérie Pourcher, Anne-Geneviève Marcelin, Agnès Gautheret-Dejean, Clotilde Bravetti, Vincent Calvez

“…As a conclusion, we present an easy-to-implement integration site assay for HTLV-1 that allows a relatively unbiased IS analysis regarding clonal populations. …”
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In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination by Martin Glas, Florian Battke, Dirk Hadaschik, Martin Schulze, Saskia Biskup, David Reardon, Christina Kyzirakos, Simone Kayser, Oliver Bartsch, Armin Rabsteyn, Henning Zelba, Borong Shao, Annekathrin Reinhardt, Carsten Greve, Lisa Oenning, Pauline Latzer, Tabea Riedlinger, Julian Wünsche, Johannes Harter, Magdalena Feldhahn, Yannick Bantel, Janina Johänning, Jiri Ködding, Olga Maksimovic, Veit Scheble, Alexandra M Miller, Michael Castro, Deborah T Blumenthal

“…Immunogenicity against mutIDH1 was high (89%). We implemented an assay which allowed us to isolate functional antigen-specific CD4+T cells in an HLA-independent manner. …”
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Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets by Simin Delalat, Innas Sultana, Hersh Osman, Marcel Sieme, Saltanat Zhazykbayeva, Melissa Herwig, Heidi Budde, Árpád Kovács, Mustafa Kaçmaz, Eda Göztepe, Natalie Borgmann, Gelareh Shahriari, Benjamin Sasko, Jan Wintrich, Peter Haldenwang, Wolfgang E. Schmidt, Wiebke Fenske, Muchtiar Khan, Kornelia Jaquet, Andreas Mügge, Domokos Máthé, Viktória E. Tóth, Zoltán V. Varga, Péter Ferdinandy, Ibrahim El-Battrawy, Loek van Heerebeek, Nazha Hamdani

“…The passive stiffness of cardiomyocytes (Fpassive) was assessed in demembranated cardiomyocytes before and after implementing treatments aimed at reducing inflammation (IL-6 inhibition), oxidative stress (Mito-TEMPO), and enhancing PQC (HSP27, HSP70). …”
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LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer by Mark Samuels, Christos Karakostas, Simoni Besta, Andrea Lauer Betrán, Katerina Tsilingiri, Charlotte Turner, Reza Shirazi Nia, Niloufar Poudine, Richard Goodyear, William Jones, Apostolos Klinakis, Georgios Giamas

“…Bioinformatics analysis of clinical data along with in vitro and cell-based assays were implemented to explore the effects of LMTK3-dependent EV protein cargo on the tumour immune microenvironment. …”
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Nationwide analysis of COVID-19 complications, outcomes, and costs of childbirth in Spain by Blanca Álvarez-del Río, Laura Sánchez-de Prada, Laura Sánchez-de Prada, Irene Arroyo-Hernantes, F. Javier Álvarez, F. Javier Álvarez, F. Javier Álvarez, F. Javier Álvarez, Eduardo Tamayo, Eduardo Tamayo, Eduardo Tamayo, Eduardo Tamayo, Eduardo Gutiérrez-Abejón, Eduardo Gutiérrez-Abejón, Eduardo Gutiérrez-Abejón, Eduardo Gutiérrez-Abejón, Eduardo Gutiérrez-Abejón

“…Our evaluation should be useful for health authorities to allocate resources and professionals to implement preventive measures, such as vaccination and screening, due to the increased morbidity, mortality and costs in this group.…”
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AIRWAVE-SLSTR—An Algorithm to Estimate the Total Column of Water Vapour from SLSTR Measurements over Liquid Surfaces by Elisa Castelli, Stefano Casadio, Enzo Papandrea, Paolo Pettinari, Massimo Valeri, Andrè Achilli, Bojan R. Bojkov, Alessio Di Roma, Camilla Perfetti, Bianca Maria Dinelli

“…The new algorithm, named AIRWAVE-SLSTR, has been implemented in both IDL and Python languages. In the frame of an EUMETSAT contract, AIRWAVE-SLSTR has been applied to a full year of SLSTR measurements (2021) and the retrieved TCWV have been validated with the help of both satellite- and ground-based measurements. …”
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MALDI-TOF lipidomics rapidly detects modification of 2-hydroxymyristate lipid A, a potential virulence trait in Enterobacter bugandensis by Rémy A. Bonnin, Aymeric Jacquemin, Jade Pizzato, Delphine Girlich, Cecile Emeraud, Markus Kostrzewa, Thierry Naas, Gerald Larrouy-Maumus, Laurent Dortet

“…Accordingly, the MALDIxin test might help clinicians detect the presence of lpxO-positive E. bugandensis, which can be considered a risk factor for the newborn, and implement measures to avoid potentially fatal septicemia.…”
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People living with chronic pain in Canada face difficult decisions and decisional conflict concerning their care: data from the national DECIDE-PAIN survey by Florian Naye, France Légaré, Chloé Cachinho, Thomas Gérard, Karine Toupin-April, Maxime Sasseville, Jean-Sébastien Paquette, Annie LeBlanc, Isabelle Gaboury, Marie-Eve Poitras, Linda C. Li, Alison M. Hoens, Marie-Dominique Poirier, Yannick Tousignant-Laflamme, Simon Décary

“…Our findings will guide future development of interventions to implement shared decision-making, especially to support primary care where discussions about difficult decisions often occur.…”
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Global perspectives on challenges, coping strategies, and future preparedness of nursing home staff during COVID-19: a systematic review and meta-synthesis by Xiu-fen Yang, Jia-yi Guo, Wei-si Peng, Bing-dong Wang, Chao-ran Qv, Si-jia Zhou, Rui Sun, Lulu Liao, Wei-wei Zhang, Ling-Yan Liu, Lian-chi Ren, Lin Zou, Shi-hai Xu

“…Three synthesized findings were identified: Challenges (sub-findings: challenges implementing epidemic prevention and control, resource shortage, negative emotions, inadequate departmental communication and coordination, lack of support, physical strain); coping strategies (sub-findings: role adaptation and redefinition, innovative solutions and technology, work organisation and cooperation, positive psychological service, seeking community and organisational support, Improving infection prevention awareness), and suggestions for future preparedness (sub-findings: Enhancing communication and decision-making in response to COVID-19 changes, Optimizing material supply channels and physical space, and increasing medical related team and training). …”
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Effect of aspirin on small for gestational age neonates in pregnancies at high-risk for preeclampsia: a secondary analysis of a cluster randomised clinical trialResearch in context by Yunyu Chen, Long Nguyen-Hoang, Linh Thuy Dinh, Duy-Anh Nguyen, Ritsuko K. Pooh, Arihiro Shiozaki, Mingming Zheng, Yali Hu, Runmei Ma, Aditya Kusuma, Tuangsit Wataganara, Mahesh A. Choolani, Mayumi Kaneko, Suchaya Luewan, Tung-Yao Chang, Noppadol Chaiyasit, Tongta Nanthakomon, Yanmin Jiang, Steven W. Shaw, Wing Cheong Leung, Ainaa Syazana Mohamad, Angela Aguilar, So Ling Lau, Nikki M.W. Lee, Jiao Liu, Daljit S. Sahota, Marc K.C. Chong, Ioannis Papastefanou, Liona C. Poon

“…These findings underscore the importance of implementing the screen-and-prevent program for preterm-PE to reduce early-SGA, and emphasizing the heightened alert in follow-up to optimize the outcomes for late-SGA. …”
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Evidence of the correlation between air pollution and different types of birth defects: based on a distribution-lag non-linear model by Wen Sun, Qingqing Dong, Yingying Zhang, Hui Wang, Youqiang Wang, Wenjie Yuan, Leyao Wang, Xianhong Shi, Yuhong Feng, Haiwei Wang, Xiaodan Wang, Yingbin Ren, Lihong Wang, Lijian Lei, Wenxia Song

“…In light of these findings, we recommend that, while overall regional air quality improvements remain essential, specific targeted measures should be implemented for pregnant women, who represent a particularly vulnerable population. …”
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Feasibility of a tailored, combined intervention with mind-body elements to prevent burnout in healthcare professionals (LAGOM) in a mixed-methods multicenter single-arm trial by Marleen Schröter, Anna K. Koch, Julia Berschick, Julia K. Schiele, Martin Bogdanski, Melanie Steinmetz, Judith Czakert, Wiebke Stritter, Christian S. Kessler, Georg Seifert

“…The study supports the acceptability and feasibility of implementing LAGOM in the healthcare setting, with initial indications of effectiveness. …”
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Profile of molecular markers of Sulfadoxine-Pyrimethamine-resistant Plasmodium falciparum in individuals living in southern area of Brazzaville, Republic of Congo by Jean Claude Djontu, Marcel Tapsou Baina, Jacque Dollon Mbama Ntabi, Abel Lissom, Dieu Merci Umuhoza, Naura veil Assioro Doulamo, Christevy Jeanney Vouvoungui, Reauchelvy Kamal Boumpoutou, Alain Maxime Mouanga, Etienne Nguimbi, Francine Ntoumi

“…Background: Although the seasonal and perennial malaria chemopreventions are not implemented in the Republic of Congo, resistance to Sulfadoxine-pyrimethamine (SP) threatens the intermittent preventive treatment during pregnancy (IPTp-SP) and others treatments using the drug. …”
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Pre-assembled ECMO: Enhancing efficiency and reducing stress in refractory cardiac arrest care by Tharusan Thevathasan, Sonia Lech, Andreas Diefenbach, Elisa Bechthold, Tim Gaßmann, Sebastian Fester, Georg Girke, Wulf Knie, Benjamin T. Lukusa, Sebastian Kühn, Steffen Desch, Ulf Landmesser, Carsten Skurk

“…Conclusion: Aseptically pre-assembled and pre-primed ECMO circuits maintain sterility for multiple weeks, significantly reducing ECMO initiation times and alleviating psychological strain on the ECPR team. Consequently, implementing these circuits in ECPR centers could enhance both patient outcomes and healthcare provider well-being.…”
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A colloidal gold immunochromatographic test strip based on mAbs anti-N protein to detect feline coronavirus by Zhe Liu, Yupeng Yang, Ruibin Qi, Haorong Gu, Mengru Chen, Kexin Feng, Qian Jiang, Honglin Jia, Hongtao Kang, Jiasen Liu

“…The detection of feline enteric coronavirus (FECV) excreted by cats can effectively implement treatment, reduce the coronavirus load, and further prevent the risk of FECV infection evolving into feline infectious peritonitis virus. …”
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High-risk neuroblastoma in Mexico: from multimodal treatment to immunotherapy. Regarding the first case treated with naxitamab by Alberto Olaya Vargas, Haydee Salazar-Rosales, Marcela Caballero-Palacios, Nideshda Ramírez-Uribe, Gerardo López-Hernández, Erika Morales-Martinez, María Cervantes-Delgado, Liliana Velasco Hidalgo, Araceli Castellanos-Toledo, Rocío Cárdenas-Cardos, Rocío Cárdenas-Cardos, Ana Niembro-Zúñiga, Roberto Rivera-Luna, Alberto Olaya-Nieto, Jesús Ponce-Cruz, Jaime Shalkow-Klincovstein, Yadira Melchor-Vidal, Rodrigo Díaz-Machorro

“…Despite intensive care, he progressed to brain death, with neurotoxicity suspected as the cause.DiscussionThe primary objective of implementing novel immunotherapeutic strategies, in addition to improving event-free survival (EFS) and overall survival (OS) in patients diagnosed with high-risk neuroblastoma, is to reduce adverse effects and lower both short- and long-term mortality. …”
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Identifying most important predictors for suicidal thoughts and behaviours among healthcare workers active during the Spain COVID-19 pandemic: a machine-learning approach by Itxaso Alayo, Oriol Pujol, Jordi Alonso, Montse Ferrer, Franco Amigo, Ana Portillo-Van Diest, Enric Aragonès, Andrés Aragon Peña, Ángel Asúnsolo Del Barco, Mireia Campos, Meritxell Espuga, Ana González-Pinto, Josep Maria Haro, Nieves López-Fresneña, Alma D. Martínez de Salázar, Juan D. Molina, Rafael M. Ortí-Lucas, Mara Parellada, José Maria Pelayo-Terán, Maria João Forjaz, Aurora Pérez-Zapata, José Ignacio Pijoan, Nieves Plana, Elena Polentinos-Castro, Maria Teresa Puig, Cristina Rius, Ferran Sanz, Cònsol Serra, Iratxe Urreta-Barallobre, Ronny Bruffaerts, Eduard Vieta, Víctor Pérez-Solá, Philippe Mortier, Gemma Vilagut

“…Conclusions Machine learning-based prediction models for STBs in HCWs during the COVID-19 pandemic trained on web-based survey data present high discrimination and classification capacity. Future clinical implementations of this model could enable the early detection of HCWs at the highest risk for developing adverse mental health outcomes. …”
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HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals by Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, Maria-Cruz Martin Delgado, Yaseen Arabi, Carole Boulanger, Giovanni Mistraletti, Maria Theodorakopoulou, Vernon Van Heerden, José-Artur Paiva, Oktay Demirkýran, Gabriel Heras La Calle, Abdulrahman Al Fares, Gaston Burghi, Guy Francois, Anita Barth, Jan De Waele, Samir Jaber, Michael Darmon, Maurizio Cecconi

“…Intervention clusters will implement the 6-component Hello Bundle between October 14 and November 10, 2024, while control clusters will be wait-listed to receive the intervention in January 2025 after the RCT concludes. …”
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Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology by Elliot Gould, Hannah S. Fraser, Timothy H. Parker, Shinichi Nakagawa, Simon C. Griffith, Peter A. Vesk, Fiona Fidler, Daniel G. Hamilton, Robin N. Abbey-Lee, Jessica K. Abbott, Luis A. Aguirre, Carles Alcaraz, Irith Aloni, Drew Altschul, Kunal Arekar, Jeff W. Atkins, Joe Atkinson, Christopher M. Baker, Meghan Barrett, Kristian Bell, Suleiman Kehinde Bello, Iván Beltrán, Bernd J. Berauer, Michael Grant Bertram, Peter D. Billman, Charlie K. Blake, Shannon Blake, Louis Bliard, Andrea Bonisoli-Alquati, Timothée Bonnet, Camille Nina Marion Bordes, Aneesh P. H. Bose, Thomas Botterill-James, Melissa Anna Boyd, Sarah A. Boyle, Tom Bradfer-Lawrence, Jennifer Bradham, Jack A. Brand, Martin I. Brengdahl, Martin Bulla, Luc Bussière, Ettore Camerlenghi, Sara E. Campbell, Leonardo L. F. Campos, Anthony Caravaggi, Pedro Cardoso, Charles J. W. Carroll, Therese A. Catanach, Xuan Chen, Heung Ying Janet Chik, Emily Sarah Choy, Alec Philip Christie, Angela Chuang, Amanda J. Chunco, Bethany L. Clark, Andrea Contina, Garth A. Covernton, Murray P. Cox, Kimberly A. Cressman, Marco Crotti, Connor Davidson Crouch, Pietro B. D’Amelio, Alexandra Allison de Sousa, Timm Fabian Döbert, Ralph Dobler, Adam J. Dobson, Tim S. Doherty, Szymon Marian Drobniak, Alexandra Grace Duffy, Alison B. Duncan, Robert P. Dunn, Jamie Dunning, Trishna Dutta, Luke Eberhart-Hertel, Jared Alan Elmore, Mahmoud Medhat Elsherif, Holly M. English, David C. Ensminger, Ulrich Rainer Ernst, Stephen M. Ferguson, Esteban Fernandez-Juricic, Thalita Ferreira-Arruda, John Fieberg, Elizabeth A. Finch, Evan A. Fiorenza, David N. Fisher, Amélie Fontaine, Wolfgang Forstmeier, Yoan Fourcade, Graham S. Frank, Cathryn A. Freund, Eduardo Fuentes-Lillo, Sara L. Gandy, Dustin G. Gannon, Ana I. García-Cervigón, Alexis C. Garretson, Xuezhen Ge, William L. Geary, Charly Géron, Marc Gilles, Antje Girndt, Daniel Gliksman, Harrison B. Goldspiel, Dylan G. E. Gomes, Megan Kate Good, Sarah C. Goslee, J. Stephen Gosnell, Eliza M. Grames, Paolo Gratton, Nicholas M. Grebe, Skye M. Greenler, Maaike Griffioen, Daniel M. Griffith, Frances J. Griffith, Jake J. Grossman, Ali Güncan, Stef Haesen, James G. Hagan, Heather A. Hager, Jonathan Philo Harris, Natasha Dean Harrison, Sarah Syedia Hasnain, Justin Chase Havird, Andrew J. Heaton, María Laura Herrera-Chaustre, Tanner J. Howard, Bin-Yan Hsu, Fabiola Iannarilli, Esperanza C. Iranzo, Erik N. K. Iverson, Saheed Olaide Jimoh, Douglas H. Johnson, Martin Johnsson, Jesse Jorna, Tommaso Jucker, Martin Jung, Ineta Kačergytė, Oliver Kaltz, Alison Ke, Clint D. Kelly, Katharine Keogan, Friedrich Wolfgang Keppeler, Alexander K. Killion, Dongmin Kim, David P. Kochan, Peter Korsten, Shan Kothari, Jonas Kuppler, Jillian M. Kusch, Malgorzata Lagisz, Kristen Marianne Lalla, Daniel J. Larkin, Courtney L. Larson, Katherine S. Lauck, M. Elise Lauterbur, Alan Law, Don-Jean Léandri-Breton, Jonas J. Lembrechts, Kiara L’Herpiniere, Eva J. P. Lievens, Daniela Oliveira de Lima, Shane Lindsay, Martin Luquet, Ross MacLeod, Kirsty H. Macphie, Kit Magellan, Magdalena M. Mair, Lisa E. Malm, Stefano Mammola, Caitlin P. Mandeville, Michael Manhart, Laura Milena Manrique-Garzon, Elina Mäntylä, Philippe Marchand, Benjamin Michael Marshall, Charles A. Martin, Dominic Andreas Martin, Jake Mitchell Martin, April Robin Martinig, Erin S. McCallum, Mark McCauley, Sabrina M. McNew, Scott J. Meiners, Thomas Merkling, Marcus Michelangeli, Maria Moiron, Bruno Moreira, Jennifer Mortensen, Benjamin Mos, Taofeek Olatunbosun Muraina, Penelope Wrenn Murphy, Luca Nelli, Petri Niemelä, Josh Nightingale, Gustav Nilsonne, Sergio Nolazco, Sabine S. Nooten, Jessie Lanterman Novotny, Agnes Birgitta Olin, Chris L. Organ, Kate L. Ostevik, Facundo Xavier Palacio, Matthieu Paquet, Darren James Parker, David J. Pascall, Valerie J. Pasquarella, John Harold Paterson, Ana Payo-Payo, Karen Marie Pedersen, Grégoire Perez, Kayla I. Perry, Patrice Pottier, Michael J. Proulx, Raphaël Proulx, Jessica L Pruett, Veronarindra Ramananjato, Finaritra Tolotra Randimbiarison, Onja H. Razafindratsima, Diana J. Rennison, Federico Riva, Sepand Riyahi, Michael James Roast, Felipe Pereira Rocha, Dominique G. Roche, Cristian Román-Palacios, Michael S. Rosenberg, Jessica Ross, Freya E. Rowland, Deusdedith Rugemalila, Avery L. Russell, Suvi Ruuskanen, Patrick Saccone, Asaf Sadeh, Stephen M. Salazar, Kris Sales, Pablo Salmón, Alfredo Sánchez-Tójar, Leticia Pereira Santos, Francesca Santostefano, Hayden T. Schilling, Marcus Schmidt, Tim Schmoll, Adam C. Schneider, Allie E. Schrock, Julia Schroeder, Nicolas Schtickzelle, Nick L. Schultz, Drew A. Scott, Michael Peter Scroggie, Julie Teresa Shapiro, Nitika Sharma, Caroline L. Shearer, Diego Simón, Michael I. Sitvarin, Fabrício Luiz Skupien, Heather Lea Slinn, Grania Polly Smith, Jeremy A. Smith, Rahel Sollmann, Kaitlin Stack Whitney, Shannon Michael Still, Erica F. Stuber, Guy F. Sutton, Ben Swallow, Conor Claverie Taff, Elina Takola, Andrew J. Tanentzap, Rocío Tarjuelo, Richard J. Telford, Christopher J. Thawley, Hugo Thierry, Jacqueline Thomson, Svenja Tidau, Emily M. Tompkins, Claire Marie Tortorelli, Andrew Trlica, Biz R. Turnell, Lara Urban, Stijn Van de Vondel, Jessica Eva Megan van der Wal, Jens Van Eeckhoven, Francis van Oordt, K. Michelle Vanderwel, Mark C. Vanderwel, Karen J. Vanderwolf, Juliana Vélez, Diana Carolina Vergara-Florez, Brian C. Verrelli, Marcus Vinícius Vieira, Nora Villamil, Valerio Vitali, Julien Vollering, Jeffrey Walker, Xanthe J. Walker, Jonathan A. Walter, Pawel Waryszak, Ryan J. Weaver, Ronja E. M. Wedegärtner, Daniel L. Weller, Shannon Whelan, Rachel Louise White, David William Wolfson, Andrew Wood, Scott W. Yanco, Jian D. L. Yen, Casey Youngflesh, Giacomo Zilio, Cédric Zimmer, Gregory Mark Zimmerman, Rachel A. Zitomer

“…We expanded the scope of this prior work by implementing a large-scale empirical exploration of the variation in effect sizes and model predictions generated by the analytical decisions of different researchers in ecology and evolutionary biology. …”
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Xenomonitoring as an epidemiological tool supporting post-stop surveillance of albendazole-ivermectin mass drug distribution in the Bougouni-Yanfolila evaluation unit, Sikasso, Mal... by Lamine Soumaoro, Housseini Dolo, Yaya Ibrahim Coulibaly, Siaka Yamoussa Coulibaly, Salif Seriba Doumbia, Moussa Sangaré, Abdallah Amadou Diallo, Abdoul Fatah Diabaté, Michel Emmanuel Coulibaly, Ibrahima Dolo, Massitan Dembélé, Alpha Seydou Yaro, Thomas Nutman

“…Mali is currently in the LF transmission assessment survey phase (TAS), while Guinea continues to implement mass drug administration (MDA). As the populations of these two countries are closely related, and vectors are present, the emergence of LF is theoretically possible in the Bougouni-Yanfolila evaluation unit (EU). …”
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