The chronic heart failure evolutions: Different fates and routes by Piergiuseppe Agostoni, Mattia Chiesa, Elisabetta Salvioni, Michele Emdin, Massimo Piepoli, Gianfranco Sinagra, Michele Senni, Alice Bonomi, Stamatis Adamopoulos, Dimitris Miliopoulos, Massimo Mapelli, Jeness Campodonico, Umberto Attanasio, Anna Apostolo, Emanuele Pestrin, Agostino Rossoni, Damiano Magrì, Stefania Paolillo, Ugo Corrà, Rosa Raimondo, Antonio Cittadini, Annamaria Iorio, Andrea Salzano, Rocco Lagioia, Carlo Vignati, Roberto Badagliacca, Pasquale Perrone Filardi, Michele Correale, Enrico Perna, Marco Metra, Gaia Cattadori, Marco Guazzi, Giuseppe Limongelli, Gianfranco Parati, Fabiana De Martino, Maria Vittoria Matassini, Francesco Bandera, Maurizio Bussotti, Federica Re, Carlo M. Lombardi, Angela B. Scardovi, Susanna Sciomer, Andrea Passantino, Caterina Santolamazza, Davide Girola, Claudio Passino, Marlus Karsten, Savina Nodari, Giulio Pompilio, MECKI score research group

“…Methods and results From a bulk of 7948 HF patients included in the MECKI registry, we selected patients with a minimum 2‐year follow‐up. We implemented a topological data analysis (TDA), based on 43 variables derived from clinical, biochemical, cardiac ultrasound, and exercise evaluations, to identify several patients' clusters. …”
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High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study by Leyla A. Ovchinnikova, Igor E. Eliseev, Igor E. Eliseev, Samir S. Dzhelad, Taras O. Simaniv, Ksenia M. Klimina, Maria Ivanova, Elena N. Ilina, Maria N. Zakharova, Sergey N. Illarioshkin, Yury P. Rubtsov, Alexander G. Gabibov, Alexander G. Gabibov, Alexander G. Gabibov, Yakov A. Lomakin

“…We concluded that the combination of particular peptides from SPTAN1, PTK6, PRX and LMP1 could be implemented as a four-peptide biomarker panel for MS diagnosis (area under the curve (AUC) of 0.818 for discriminating between HD and MS).ConclusionsThis study supports the concept that the specificity of autoreactive IgG in MS is highly heterogeneous. …”
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Malaria parasite burden and heterogeneity of risk factors among Central African Republic refugees: a cross-sectional study in the Gado-Badzere refugee camp in Eastern Cameroon by Zidedine Nematchoua Weyou, Felicite Djemna Djieyep, Rene Ning Teh, Michel Lontsi-Demano, Cheikh Cambel Dieng, Roland Bamou, Eugenia Lo, Helen Kuokuo Kimbi, Helen Kuokuo Kimbi, Irene Ule Ngole Sumbele

“…Seasonal chemoprevention mainly during the rainy season and Indoor Residual Spraying (IRS) might be implemented for effective malaria control in refugee settings.…”
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Systematic review of multidrug-resistant Klebsiella pneumoniae in the Arabian Peninsula: molecular epidemiology and resistance patterns by Enaam K. Idrees, Enaam K. Idrees, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Marwh G. Aldriwesh, Manal M. Alkhulaifi, Majed F. Alghoribi, Majed F. Alghoribi, Majed F. Alghoribi

“…Limited molecular and genome-based investigations hinder comprehensive AMR surveillance. Implementing standardized methodologies and fostering molecular and genome-based AMR surveillance programs at both national and regional levels within the GHC are essential for effectively combating the spread of MDR K. pneumoniae and improving public health outcomes in the region.…”
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SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response by Richard Carvajal, Akiva Mintz, Fatemeh Momen-Heravi, Alison Taylor, Kranthi Kiran Kishore Tanagala, Joshua Morin-Baxter, Maryum Cheema, Sunil Dubey, Angela Yoon, Yi-Shing L Cheng, Jeffrey Nickerson

“…SP140 overexpression or knockdown was implemented to identify the role of SP140 in downstream signaling and production of inflammatory cytokine and chemokines. …”
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Morphological, functional and biochemical differences in cardiac adaptation to endurance exercise among male and female amateur marathon runners by Zofia Lasocka-Koriat, Zofia Lasocka-Koriat, Zuzanna Lewicka-Potocka, Zuzanna Lewicka-Potocka, Anna Kaleta-Duss, Nikola Bulman, Ewelina Marciniak, Leszek Kalinowski, Leszek Kalinowski, Ewa Lewicka, Alicja Dąbrowska-Kugacka

“…Cardiovascular screening in amateur runners should be implemented to identify subjects requiring further evaluation.…”
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Analysis of characteristics among unemployed callers to the psychological support hotline in Beijing by Xingxue Li, Xingxue Li, Xingxue Li, Zikang Liu, Zikang Liu, Zikang Liu, Tong Wu, Tong Wu, Tong Wu, Zhe Yuan, Zhe Yuan, Zhe Yuan, Wei Wang, Liting Zhao, Liting Zhao, Shuchang Yang, Hong Liang, Hong Liang

“…These findings warrant attention, and hotline services should implement timely identification, psychological support, and targeted interventions to effectively alleviate psychological distress and reduce potential suicide risk in these high-risk groups.…”
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The impact of continuous positive airway pressure therapy on the recurrence of atrial fibrillation in patients with obstructive sleep apnea after pulmonary vein isolation by Jun Fan, Cui-Jin Tan, Li-li Cao, Shao-ling Luo, Shao-Xi Sun, Shao-hua Wang, Wei-jie Li, Yi-chao Pan, Tian-yuan Wu, Qi-shan Dai, Zhen Liu, Jian Liu, Bing-Bo Yu

“…These results highlight the necessity of phenotypic stratification when designing and implementing CPAP-based preventive strategies.…”
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Characterization of insecticide resistance mechanisms in the Anopheles gambiae population of Sierra Leone by Kevin Ochieng’ Opondo, Evelyne Alyko, Samuel Smith, Rebecca Levine, Jenny Donnelly, Tony Hughes, David Schnabel, Ramlat Jose, Alpha Jalloh, Umaru Lolleh, Samuel Conteh, Laurent Iyikirenga, Djenam Jacob, Miriam Mokuena, Frederick Yamba, Yemane Yihdego

“…Abstract Background Information on the status of insecticide resistance in malaria vectors is critical for implementing effective malaria vector control. The Sierra Leone National Malaria Control Programme, in collaboration with the PMI VectorLink project, assessed the resistance status to insecticides commonly used in public health, and associated resistance mechanisms in Anopheles gambiae, the main vector of malaria in Sierra Leone. …”
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Epidemiological Analysis of Pathogens in Acute Respiratory Infections During the 2023—2024 Autumn-Winter Season in Beijing: A Case Series of 5556 Patients at Peking Union Medical C... by CAO Yan, CHEN Yu, YI Jie, KONG Lingjun, WANG Ziyi, ZHANG Rui, YU Qi, LIU Yiwei, MULATIJIANG Maimaiti, YANG Chenglin, SUN Yujie, XU Yingchun, YANG Qiwen, DU Juan

“…Targeted preventive measures should be implemented in different seasons and for key populations.…”
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Comprehensive genomic surveillance reveals transmission profiles of extensively drug-resistant tuberculosis cases in Pará, Brazil by Davi Josué Marcon, Davi Josué Marcon, Abhinav Sharma, Alex Brito Souza, Alex Brito Souza, Rafaella Bonfim Barros, Valnete das Graças Dantas Andrade, Ricardo José de Paula Souza Guimarães, Luana Nepomuceno Gondim Lima, Luana Nepomuceno Gondim Lima, Lúcia Helena Martins Tavares Monteiro, Ana Judith Pires Garcia Quaresma, Ana Judith Pires Garcia Quaresma, Layana Rufino Ribeiro, Layana Rufino Ribeiro, Philip Noel Suffys, Robin Mark Warren, Carlos Augusto Abreu Alberio, Karla Valéria Batista Lima, Karla Valéria Batista Lima, Emilyn Costa Conceição

“…Monitoring the emergence and transmission of DR-TB is crucial for implementing public health to control the spread of DR strains of Mycobacterium tuberculosis. …”
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Characteristics of individuals who received post‐exposure prophylaxis and HIV seroconversion in Malawi: an analysis of national routine HIV testing data by Hannock Tweya, Tiwonge Chimpandule, William Wu, Leah Goeke, Zhouyun Zheng, Stone Mbiriyawanda, Tobias Masina, Washington Ozitiosauka, Martha Muyaso, Anna Drabko, Dominik Bilicki, Jiehua Chen, Rose Nyirenda, Andreas Jahn

“…Abstract Introduction In Malawi, where HIV prevalence remains high at 6.7%, post‐exposure prophylaxis (PEP) has been implemented as one of the HIV prevention strategies. …”
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Over a decade of HIV infection prevalence and incidence among Mozambican pregnant women: a secondary analysis of prospectively collected data by Anete Mendes-Muxlhanga, Arsénio Nhacolo, Antia Figueroa-Romero, Maura Mazuze, Alfredo Mayor, Anifa Vala, Esperança Sevene, Aleny Couto, Namita Eliseu, Llorenç Quintó, Gloria Matabisso, Eusebio Macete, Paula Vaz, Pedro Alonso, Clara Menendez, Raquel González, Tacilta Nhampossa

“…However, both estimates remain unacceptably high, which indicates the need to revise current preventive policies and implement effective ones to improve HIV control among pregnant women.…”
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Explainable clinical diagnosis through unexploited yet optimized fine-tuned ConvNeXt Models for accurate monkeypox disease classification by Muhammad Waqar, Zeshan Aslam Khan, Shanzey Tariq Khawaja, Naveed Ishtiaq Chaudhary, Saadia Khan, Khalid Mehmood Cheema, Muhammad Farhan Khan, Syed Sohail Ahmed, Muhammad Asif Zahoor Raja

“…Fortunately, due to the developments in artificial intelligence approaches, it can be implemented to promptly and accurately identify monkeypox disease using visual data information. …”
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Effects on perceived pain and somatosensory function after transcutaneous neuromodulation in patients with chronic low back pain: a quasi-experimental study with a crossover interv... by Francisco Selva-Sarzo, Francisco Selva-Sarzo, Francisco Selva-Sarzo, Eleuterio A. Sánchez Romero, Eleuterio A. Sánchez Romero, Eleuterio A. Sánchez Romero, Eleuterio A. Sánchez Romero, Juan Nicolás Cuenca-Zaldívar, Juan Nicolás Cuenca-Zaldívar, Juan Nicolás Cuenca-Zaldívar, Juan Nicolás Cuenca-Zaldívar, Beatriz García-Haba, Claudio Akiyama, Claudio Akiyama, Claudio Akiyama, Rob Sillevis, Samuel Fernández-Carnero, Samuel Fernández-Carnero

“…A one-week washout period was implemented between the interventions. TMP was applied at the lumbar spinal levels for 48 h, following standard recommendations for neuromodulation frequency (constant exposure via magnetic particles), intensity (low-energy field), and time (continuous exposure over two days). …”
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Management of non-traumatic abdominal pain in the emergency department: a multicentre, stepped-wedge, cluster-randomised trialResearch in context by Anna Slagman, Liane Schenk, Dörte Huscher, Lisa Arnold, Harald Dormann, Johannes Drepper, Larissa Eienbröker, Antje Fischer-Rosinský, Johann Frick, Lukas Helbig, Dirk Horenkamp-Sonntag, Freddy Irorutola, Tim Klinge, Thomas Reinhold, Peter Schily, Britta Stier, Katharina Verleger, Andreas Wagenknecht, Yves Noel Wu, Martin Möckel

“…The new care pathway was implemented at randomly assigned time points (every four months) within a 24-month recruitment period and consisted of a structured care pathway for the management of abdominal pain patients in the emergency department. …”
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Bridging the gap in mental health literacy: co-adapting and feasibility testing a digital intervention to improve mental health literacy amongst young people aged 12–14 in the UK by Emily Vicary, Helen Brierley, Jack Wilkinson, Melody Adesina, Penny Bee, Karina Lovell, Naz Uzun, Emily Bee, Helen Brooks

“…Exploratory analyses suggested potential improvements in mental health literacy and well-being, although these results require confirmation in a well-powered trial.ConclusionThis study highlights the feasibility of co-adapting and implementing digital interventions to improve mental health literacy among YP within community settings. …”
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The risk of repeated self-harm and suicide after emergency department presentation with self-harm in mental health presenters: a retrospective cohort study with data linkage in Que... by Richard A.F. Pellatt, David R. Painter, Jesse T. Young, Kairi Kõlves, Gerben Keijzers, Stuart A. Kinner, Ed Heffernan, Julia Crilly, Marc Broadbent, Amy Johnston, Melinda Martin-Khan, Paul Scuffham, Marianne Wallis, Ping Zhang

“…Suicide was particularly associated with older males. Implementing evidence-based interventions to support people presenting to ED with self-harm should be a public health priority. …”
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Music therapy for the treatment of anxiety: a systematic review with multilevel meta-analysesResearch in context by Martina de Witte, Sonja Aalbers, Annemieke Vink, Stijn Friederichs, Anne Knapen, Thomas Pelgrim, Amit Lampit, Felicity A. Baker, Susan van Hooren

“…Music therapy involves personally tailored music interventions that are designed and implemented by qualified music therapists to meet the specific health needs of individual patients. …”
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Myo‐Guide: A Machine Learning‐Based Web Application for Neuromuscular Disease Diagnosis With MRI by Jose Verdu‐Diaz, Carla Bolano‐Díaz, Alejandro Gonzalez‐Chamorro, Sam Fitzsimmons, Jodi Warman‐Chardon, Goknur Selen Kocak, Debora Mucida‐Alvim, Ian C. Smith, John Vissing, Nanna Scharff Poulsen, Sushan Luo, Cristina Domínguez‐González, Laura Bermejo‐Guerrero, David Gomez‐Andres, Javier Sotoca, Anna Pichiecchio, Silvia Nicolosi, Mauro Monforte, Claudia Brogna, Eugenio Mercuri, Jorge Alfredo Bevilacqua, Jorge Díaz‐Jara, Benjamín Pizarro‐Galleguillos, Peter Krkoska, Jorge Alonso‐Pérez, Montse Olivé, Erik H. Niks, Hermien E. Kan, James Lilleker, Mark Roberts, Bianca Buchignani, Jinhong Shin, Florence Esselin, Emmanuelle Le Bars, Anne Marie Childs, Edoardo Malfatti, Anna Sarkozy, Luke Perry, Sniya Sudhakar, Edmar Zanoteli, Filipe Tupinamba Di Pace, Emma Matthews, Shahram Attarian, David Bendahan, Matteo Garibaldi, Laura Fionda, Alicia Alonso‐Jiménez, Robert Carlier, Ali Asghar Okhovat, Shahriar Nafissi, Atchayaram Nalini, Seena Vengalil, Kieren Hollingsworth, Chiara Marini‐Bettolo, Volker Straub, Giorgio Tasca, Jaume Bacardit, Jordi Díaz‐Manera, the Myo‐Guide Consortium

“…The diagnostic tool has been implemented as a free web platform, providing global access to the medical community. …”
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