Assessing the accuracy of the recording and reporting of malaria rapid diagnostic test results in four African countries: methods and key results by Kim A. Lindblade, Arthur Mpimbaza, Corine Ngufor, William Yavo, Sunday Atobatele, Ese Akpiroroh, Abibatou Konaté-Touré, Idelphonse Ahogni, Nelson Ssewante, Bosco Agaba, Augustin Kpemasse, Jacques Agnon, Onyebuchi Okoro, Godwin Ntadom, Antoine Tanoh, Cyriaque Affoukou, Jimmy Opigo, Shawna Cooper, John J. Aponte, Kevin Griffith, Radina Soebiyanto, Michael Humes

“…Methods A mixed-methods observational study was implemented in Benin, Côte d'Ivoire, Nigeria, and Uganda in 2023. …”
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Evaluating SinergiAPS, an intervention based on patient feedback to improve patient safety in primary care: a cluster randomized trial by Maria Antònia Fiol-deRoque, José María Valderas, María Jesús Serrano-Ripoll, Montserrat Gens-Barbarà, Francisco Martín-Luján, Encarna Sánchez-Freire, Juan José Montaño, Sofía Mira-Martínez, Guadalupe Pastor-Moreno, Rocío Zamanillo-Campos, Pau Riera-Serra, Ignacio Ricci-Cabello

“…The qualitative interviews evidenced that the onset of the COVID-19 pandemic 6–9 weeks after initiating the follow-up period severely limited PHC’s capacity of developing and implementing safety improvement action plans, despite high levels of acceptability and perceived utility of the SinergiAPS intervention. …”
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Enhancing Wind Turbine Efficiency: An Experimental Investigation of a Sensorless Three-Vector Finite Set Predictive Torque Control Approach for PMSG-Based Systems by Marouane Ahmed Ghodbane, Toufik Mohamed Benchouia, Mohamed Chebaani, Mohamed Becherif, Yassine Himeur, Amar Golea, Abdelmoumen Ghilani, Zakaria Alili, Shadi Atalla, Wathiq Mansoor

“…The proposed FS-PTC strategy was implemented experimentally, and its performance was evaluated under varying wind speeds using MATLAB/SIMULINK, ControlDesk, dSPACE DS1104, and the DSP LAUNCHXL-F28379D real-time platform.…”
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Accurate Indentification of Pathogenic Mutations Conferring α1-Antitrypsin Deficiency by a Novel Multiplexed Molecular AssayTake-home Points by Emily K. DeCurtis, BSc, Sharon K. Kuss-Duerkop, PhD, Iara M.P. Machado, PhD, Zoe P. Stewart, BSc, Matt Jackson, MS, Ellie Hasenohr, BSc, Jessica L. Crumby, BSc, Steve D. Groshong, MD, PhD, Claire M. Coeshott, PhD, Ronald J. Harbeck, PhD, James P. Woodrow, MD, Robert A. Sandhaus, MD, PhD, Yongbao Wang, PhD

“…The 23-SNP AAT assay was successfully implemented using AATD indication patient samples to evaluate the most common SERPINA1 mutations indicative of AATD. …”
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Establishing and mapping heat-sensitive disease spectrum in eastern China: A comprehensive analysis of 1.4 million deaths involving 14 major disease categories by Yiming Gai, Hong Su, Yinguang Fan, Wenjun Cheng, Xiaojie Zou, Yarui Fan, Yuefang Li, Zhen Ding, Jintao Liu, Yongmei Su, Zien Jin, Liwei Zhang, Yanan Ouyang, Yujia Zhai, Yiyun Ding, Chun Zhao, Jian Cheng, Hao Zheng

“…Our findings may have implications for implementing heat-health action plans to mitigate the adverse effects of heat-sensitive diseases.…”
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Development of a multiplex loop-mediated isothermal amplification (LAMP) method for differential detection of Mycobacterium bovis and Mycobacterium tuberculosis by dipstick DNA chr... by Mwangala L. Akapelwa, Thoko F. Kapalamula, Lavel C. Moonga, Precious Bwalya, Eddie S. Solo, Joseph Y. Chizimu, Jeewan Thapa, Kyoko Hayashida, Bernard M. Hang'ombe, Musso Munyeme, Aki Tamaru, Takayuki Wada, Shiomi Yoshida, Takuya Kodera, Mistuo Kawase, Stephen V. Gordon, Keiko Yamada, Chie Nakajima, Yasuhiko Suzuki

“…The LAMP method does not require sophisticated high-cost equipment and can be easily implemented in resource-limited settings. Our LAMP facilitates rapid and accurate tuberculosis diagnosis, enabling appropriate therapeutic agents to be selected in areas where bovine and human tuberculosis coexist. …”
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Starfield’s 4Cs of NCD management in primary healthcare: a conceptual framework development from a case study of 19 countries by Helena Legido-Quigley, Eva Turk, Juan Carlos Rivillas, Tiara Marthias, Darius Erlangga, Jasper Tromp, Pami Shrestha, Chuan De Foo, Kim Bao Giang, Maria Eugenia Esandi, Laura Antonietti, Shangzhi Xiong, Likke Prawidya Putri, Aungsumalee Pholpark, Natchaya Ritthisirikul, Piya Hanvoravongchai, Krishaa Logan, Elliot Eu, Ewa Kosycarz, Marcela Schenck, Wilson Benia, Doan Thi Thuy Duong, Supri Shrestha

“…Introduction Faced with a backdrop of an increasing chronic disease burden from an ageing global population compounded with rising healthcare costs, health systems are required to implement cost-effective, safe and equitable care through efficient service delivery models. …”
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Machine learning-based risk prediction model for pertussis in children: a multicenter retrospective study by Juan Xie, Run-wei Ma, Yu-jing Feng, Yuan Qiao, Hong-yan Zhu, Xing-ping Tao, Wen-juan Chen, Cong-yun Liu, Tan Li, Kai Liu, Li-ming Cheng

“…Conclusion The pertussis prediction model devised in this study was validated using multicenter data, exhibited high prediction performance, and was successfully implemented online. Future research should broaden the data sources and incorporate dynamic data to enhance the model's accuracy and applicability.…”
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Targeted next-generation sequencing: a promising approach for Mycobacterium tuberculosis detection and drug resistance when applied in paucibacillary clinical samples by Wenting Jin, Meixia Wang, Yang Wang, Beidi Zhu, Qingqing Wang, Chunmei Zhou, Pei Li, Chaohui Hu, Jun Liu, Jue Pan, Jiachang Chen, Bijie Hu

“…It was concluded that the tNGS assay was a promising approach in the initial diagnostic test of MTB and DR-related genes in different clinical samples, even for the smear- and culture-negative paucibacillary samples.IMPORTANCEtNGS combines gene-specific amplification with next-generation sequencing to detect MTB and drug-resistant genes by amplifying numerous loci directly from clinical samples. The WHO implemented tNGS for the purpose of monitoring respiratory specimens for MTB detection and DR-TB due to its high sensitivity and specificity, culture independence, and ability to report heterogeneous/silent mutations. …”
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Water quality improvements and ecological inertia: a basin-wide assessment of ecosystem recovery in the Yangtze River system (2005–2022) by Xingchen Zhao, Yunlin Zhang, Haoran Tang, Qingji Zhang, Chixiao Cui, Boqiang Qin

“…Since the 2000s, China has implemented extensive pollution‑control and restoration policies targeting both rivers and lakes. …”
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A holistic approach to promoting early child development: a cluster randomised trial of a group-based, multicomponent intervention in rural Bangladesh by Stephen P Luby, Mahbubur Rahman, Fahmida Tofail, Lia CH Fernald, Esther O Chung, Helen O Pitchik, Fahmida Akter, Jesmin Sultana, Abul Kasham Shoab, Tarique Md. Nurul Huda, Tania Jahir, Md Ruhul Amin, Md Khobair Hossain, Jyoti Bhushan Das, Kendra A Byrd, Farzana Yeasmin, Laura H Kwong, Jenna E Forsyth, Malay K Mridha, Peter J Winch

“…Data collectors were independent from implementers.Results In July–August 2017, 621 pregnant women and primary caregivers of children<15 months were enrolled (group n=160, combined n=160, control n=301). …”
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Downsizing chronic disease management programs for type 2 diabetes patients during the COVID-19 pandemic: changes in healthcare utilization patterns by Corinne Rijpkema, Corinne Rijpkema, Lotte Ramerman, Lilian Peters, Lilian Peters, Jean Muris, Tim Olde Hartman, Maarten Homburg, Isabelle Bos, Robert Verheij, Robert Verheij, Robert Verheij

“…In future pandemics, it will be essential to implement adaptations such as telemedicine to mitigate health deterioration and alleviate pressure on other healthcare services.…”
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Safety and immunogenicity of PHH-1V booster against SARS-CoV-2 variants, including omicron subvariants: Results from a phase IIb open-label extension study by María Jesús López, Maria Del Mar Vazquez, Melchor Alvarez-Mon, José Ramón Arribas, Eunate Arana-Arri, Patricia Muñoz, Jorge Navarro-Pérez, Rafael Ramos, José Molto, Susana Otero-Romero, Elena Aurrecoechea, Roc Pomarol, Laia Bernad, Ignasi Esteban, Raúl Pérez-Caballero, Montserrat Plana, Júlia G. Prado, Álex Soriano

“…As conclusion, PHH-1V booster induced sustained humoral and cellular immune response against Beta, Delta variants and cross reactivity against distant Omicron subvariants and could be an appropriate strategy for implementing heterologous vaccination campaigns.…”
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Community perceptions and acceptability of insecticide-treated screens for mosquito proofing of unimproved houses in Chalinze district, Tanzania: a mixed-methods study by Fadhila Kihwele, Olukayode G. Odufuwa, Olukayode G. Odufuwa, Olukayode G. Odufuwa, Olukayode G. Odufuwa, Joseph B. Muganga, Emmanuel Mbuba, Emmanuel Mbuba, Emmanuel Mbuba, Rose Philipo, Jason Moore, Jason Moore, Jason Moore, Ole Skovmand, Rune Bosselmann, John Bradley, Sarah Moore, Sarah Moore, Sarah Moore, Sarah Moore, Zawadi Mageni Mboma, Zawadi Mageni Mboma

“…This study assessed the community perceptions and the acceptability of insecticide-treated screens (ITS), previously described as insecticide-treated eave nets (ITENs) and insecticide-treated window screens (ITWS).MethodologyA mixed-methods approach was implemented in three villages of the Chalinze District in Tanzania. …”
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Psychological distress and its impact on glycemic control in patients with diabetes, Northwest Ethiopia by Ashenafi Kibret Sendekie, Ashenafi Kibret Sendekie, Liknaw Workie Limenh, Gizachew Kassahun Bizuneh, Asmamaw Emagn Kasahun, Samuel Agegnew Wondm, Fasil Bayafers Tamene, Ephrem Mebratu Dagnew, Kalab Yigermal Gete, Abebe Tarekegn Kassaw, Abera Dessie Dagnaw, Yabibal Berie Tadesse, Biruk Beletew Abate, Biruk Beletew Abate

“…Interventions incorporating mental health and psychosocial support should be implemented to relieve psychological distress and improve glycemic control.…”
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Bioinformatic identification of signature miRNAs associated with fetoplacental vascular dysfunction in gestational diabetes mellitus by Yulan Lu, Chunhong Liu, Xiaoxia Pang, Xinghong Chen, Chunfang Wang, Huatuo Huang

“…The receiver operator characteristic curve (ROC), the nomogram diagram, gene set enrichment analysis (GSEA), and signature miRNAs-target genes interaction network were implemented further to explore the features and functions of signature genes. …”
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Clinical characteristics, management approaches, and outcomes of patients with heart failure: the Jordan Heart Failure Registry by Hadi Abu-Hantash, Yousef Khader, Akram AL-Saleh, Hanna Al-Makhamreh, Rasheed Ibdah, Muhannad Ababneh, Asem Nammas, Amr Rasheed, Ahmad Toubasi, Sarah Al-Qalalweh, Mohammad Y. Mahmoud, Farah Albustanji, Yazan Y. Obaid, Hind B. Abu Tawileh, Toqa Awaisheh, Louis Elias Hobeika, Ala Banihamdan, Abdullah Al-Kasasbeh, Sukaina Rawashdeh, Mohammad Abu-hantash, Ali Shakhatreh, Mahmoud Izraiq

“…These findings should guide healthcare policymakers and practitioners in the country to enhance the quality of management of HF patients and implement interventions to reduce the burden of comorbidities accompanying HF.…”
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The national and subnational burden of falls and its attributable risk factors among older adults in Iran from 1990 to 2021: findings from the global burden of disease study by Hoomaan Ghasemi, Mohammad Amin Kharaghani, Ali Golestani, Morvarid Najafi, Sepehr Khosravi, Mohammad-Reza Malekpour, Ozra Tabatabaei-Malazy, Nazila Rezaei, Afshin Ostovar, Seyyed-Hadi Ghamari

“…Conclusions From 1990 to 2021, the incidence rate of falls has increased significantly among older adults in Iran, necessitating urgent interventions. Implementing nationwide, cost-effective strategies such as exercise programs to improve strength and balance, home hazard modifications, medication reviews to reduce fall-related risks, and routine screening programs for osteoporosis and fall risk assessment can help protect and support older people, minimizing their risk of falls.…”
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A Coherent Approach-Based Fine-Tuning of Segment Anything Model Plus Watershed Algorithm for Instance Segmentation of Mitochondria in Electron Microscopy Images by Zahra Faska, Lahbib Khrissi, Imadeddine Mountasser, Khalid Haddouch, Nabil El Akkad, Samah Alshathri, Walid El-Shafai

“…This research tackles the complex task of implementing domain adaptation for task of mitochondria segmentation in electron microscopy images obtained from various tissues and species, employing deep learning methodologies. …”
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A Delphi-based framework for optimizing nurse staffing in Chinese hospitals by Waner Wang, Waner Wang, Gege Li, Jiangfeng Pu, Tiemei Shen, Zhanghao Xie, Lifang Chen, Hong Cui, Peng Xu, Huigen Huang, Huigen Huang

“…Based on the results, we recommend that hospitals implement the evaluation system to regularly monitor and optimize their nursing staffing levels. …”
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