A comparative study of the implementation of the doughnut round teaching and the lecture method on self-regulation and motivation of medical students' academic progress: A semi-experimental study by Elmira Khodabakhsh, Ali Keramati, Azizeh Barry, Rastegar Rahmani Tanha, Maryam Babazadeh, Ghadir Pourbairamian, Ghobad Ramezani

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Fine Mapping of <i>BrTCP1</i> as a Key Regulator of Branching in Flowering Chinese Cabbage (<i>Brassica rapa</i> subsp. <i>chinensis</i>) by Chuanhong Liu, Xinghua Qi, Shuo Fu, Chao Zheng, Chao Wu, Xiaoyu Li, Yun Zhang, Xueling Ye

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Complement Evasion Protects FCoV from Virus Clearance Within Prototypic FIP Lesions by Anne Hönl, Sandra Felten, Katharina Erber, Michèle Bergmann, Sven Reese, Regina Hofmann-Lehmann, Marina L. Meli, Andrea M. Spiri, Katrin Hartmann, Kaspar Matiasek

“…This study aimed to investigate the involvement of complement-regulating factors (CRFs). CRFs help modulate the immune response and prevent host tissue damage. …”
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Chemokine–complement cascade in glial–vascular units protects neurons from non-biogenic nanoparticles by Ari Ogaki, Shinichi Kinoshita, Yuji Ikegaya, Ryuta Koyama

“…Here, using a developing mouse model, we show that microglia phagocytose non-biogenic NPs through a complement-dependent mechanism involving C3 tagging. …”
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Implementation of a guideline-based clinical practice teaching model to enhance learning and thinking abilities in undergraduate nursing students by Li Wang, Li-huan He, Jian-hong Wan

“…The study compared the self-regulated learning ability and critical thinking ability scores of both groups before and after clinical practice. …”
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Implementing Joint External Evaluations of the International Health Regulations (2005) capacities in all countries in the WHO African region: process challenges, lessons learnt and perspectives for the future by Ali Ahmed Yahaya, Miriam Nanyunja, Charles Njuguna, Ambrose Talisuna, Mary Stephen, Antonio Oke, Allan Mpairwe, Amadou Bailo Diallo, Daniel Yota, Roland Kimbi Wango, Zabulon Yoti, Janneth Mghamba, Ibrahima-Soce Fall, Belinda Louise Herring, Christian Massidi, Dick Chamla, Anderson Latt, Viviane Fossouo Ndoungue, Sally-Ann Ohene, Georges Alfred Kizerbo

“…Following the West Africa Ebola virus disease outbreak (2013–2016), the Joint External Evaluation (JEE) is one of the three voluntary components recommended by the WHO for evaluating the International Health Regulations (2005) capacities in countries. Here, we share experience implementing JEEs in all 47 countries in the WHO African region. …”
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Understanding patients’ perceptions of uncomplicated low back pain: a theory-informed qualitative study using the Common-Sense Self-Regulation Model by Shannon M. Ruzycki, Yamile Jasaui, Sameh Mortazhejri, Shawn Dowling, D’Arcy Duquette, Stefanie Linklater, Kelly Mrklas, Gloria Wilkinson, Jeremy M. Grimshaw, Andrea M. Patey, on behalf of the De-Implementing Wisely Research Group

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Spatial transcriptomics in focal cortical dysplasia type IIb by Yujiao Wang, Yihe Wang, Linai Guo, Chunhao Shen, Yongjuan Fu, Penghu Wei, Yongzhi Shan, Qian Wu, Yue-Shan Piao, Guoguang Zhao

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Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization. by Margarita V Brovkina, Rachel Duffié, Abbigayl E C Burtis, E Josephine Clowney

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Evaluation of the implementation and the associated operating costs of a medicine regulatory harmonisation model in Africa: the case of ZaZiBoNa, a SADC work-sharing initiative by S. Dube-Mwedzi, F. Suleman

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Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective by Didar Murad, Rehan Zafar Paracha, Maryum Nisar

“…It directly interacts with the complement system, which is key to innate immunity. …”
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Implementation of the Deposit System in Poland as a Tool for Implementing the Circular Economy by Andrzej Zarębski, Joanna Zarębska, Konrad Marosek

“…An extensive literature review and survey research indicate that Polish society views the deposit system favorably and Poland is ready to implement it. Specific regulations from the Minister of Climate and Environment need to be implemented as well as special machine need to be put in stores to start the deposit system. …”
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Specific surface-modified iron oxide nanoparticles trigger complement-dependent innate and adaptive antileukaemia immunity by Yuanyuan Li, Wen Wu, Qihui Liu, Qiong Wu, Ping Ren, Xi Xi, Haiyan Liu, Jiarui Zhao, Wei Zhang, Zizhun Wang, Yuanyuan lv, Bin Tian, Shuang Sun, Jiaqi Cui, Yangyang Zhao, Jingyuan Wu, Mingyuan Gao, Fangfang Chen

“…Mechanistically, IONP-COOH indirectly binds to C3b after activating the complement alternative pathway, subsequently enhancing phagocytosis of macrophages and activating adaptive immunity mediated by complement corona. …”
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The specific contributions of factor H and factor I in controlling fluid phase activation of the alternative complement pathway by Nancy A. Turner, Joel L. Moake

“…Abstract The immediate defense provided by the alternative complement pathway (AP) is under constant control by fluid phase regulators, factor H (FH) and factor I (FI), to prevent nonessential activation. …”
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Genotypic and phenotypic diversity of Lactobacillus rhamnosus clinical isolates, their comparison with strain GG and their recognition by complement system. by Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos

“…All L. rhamnosus strains activated complement in serum and none of them bound complement regulators. …”
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Target complement factor H / serum amyloid a signaling in trichloroethylene-induced immune kidney injury by Haibo Xie, Bo Liang, Jingyi Zhao, Chen You, Qirui Bai, Rui Li, Jian Chen, Pengcheng Zhou, Luolun Dong, Ruixuan Cheng, Jiaxiang Zhang, Qixing Zhu

“…The aberrant activation of the intracellular complement system is a significant characteristic of trichloroethylene (TCE) -induced immune kidney injury. …”
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Venom from Bothrops lanceolatus, a Snake Species Native to Martinique, Potently Activates the Complement System by Marie Delafontaine, Isadora Maria Villas-Boas, Giselle Pidde, Carmen W. van den Berg, Laurence Mathieu, Joël Blomet, Denise V. Tambourgi

“…Here, we investigated the ability of B. lanceolatus venom to activate the Complement system (C) in order to improve the understanding of venom-induced local inflammation. …”
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KLF4 overexpression protects against complement-mediated endothelial injury in transplant-associated thrombotic microangiopathy by Shuhui Jiang, Jiaqian Qi, Tingting Pan, Zhenzhen Yao, Siyi Lu, Yifei Han, Depei Wu, Yue Han

“…Mechanistic analyses using CUT&Tag, RNA sequencing, luciferase assays, and quantitative real-time PCR revealed that KLF4 binds to the CD46 promoter, enhancing its transcription and thus restraining complement activation in endothelial cells. These results identify KLF4 as a key negative regulator of complement-mediated endothelial injury in TA-TMA. …”
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Moss-derived human complement factor H modulates retinal immune response and attenuates retinal degeneration by Mandy Hector, Verena Behnke, Paulina Dabrowska-Schlepp, Andreas Busch, Andreas Schaaf, Thomas Langmann, Anne Wolf

“…Conclusion Modulating the alternative complement pathway using moss-derived recombinant human full-length CFH variant CPV-101 and CPV-104 counter-regulate gliosis and attenuates light-induced retinal degeneration, highlighting a promising concept for the treatment of AMD patients.…”
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Understanding Perceptions of Hepatitis C and Its Management Among People with Experience of Incarceration in Quebec, Canada: A Qualitative Study Guided by the Common Sense Self-Reg... by Andrea Mambro, Sameh Mortazhejri, David Ortiz-Paredes, Andrea Patey, Guillaume Fontaine, Camille Dussault, Joseph Cox, Jeremy M. Grimshaw, Justin Presseau, Nadine Kronfli

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