Osimertinib plus anlotinib for advanced NSCLC with acquired EGFR T790M mutation: results from a multicenter phase II study with ctDNA analysis by Xinyue Wang, Zhaona Li, Liuchun Wang, Yan Liang, Chun Huang, Peng Chen, Dingzhi Huang, Xia Song, Cuimin Ding, Changli Wang, Richeng Jiang

“…Clearance of ctDNA, particularly of EGFR mutations, could serve as a valuable predictive biomarker, supporting the implementation of personalized treatment strategies. Trial registration ClinicalTrials.gov, NCT04029350.…”
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Intra-hospital patient-specific 3D printed surgical guide for patients with thoracic scoliotic deformities, the collaboration between engineer and surgeon by M. Suffo, M. Quiroga-De Castro, L Galán-Romero, P Andrés-Cano

“…The intra-hospital collaboration between engineers and surgeons was identified as a key factor in improving outcomes and reducing error risks, showcasing the benefits of interdisciplinary teamwork. …”
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Influence of wetted perimeters variation of physical cover porosity on the evaporation suppression effect of plains reservoirs in arid zones by Shaolei Wang, Kebin Shi, Kewu Han, Xueying Zhou, Xinjun Yan

“…Study focus: The implementation of anti-evaporation materials (e.g., foam boards, PE floats, etc.) on the water surface can be an effective strategy to mitigate ineffective evaporation losses. …”
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Impacts of Sandstorms on Chemistries of Ambient PAHs in a Small City in North China by Zhiyong Li, Zhen Zhai, Jixiang Liu, Lan Chen, Zhuangzhuang Ren, Chen Liu, Ziyi Zhan, Ziyuan Yue, Wenjia Zhu, Jihong Wei, Huiying Gao, Songtao Guo

“…Coal burning (CB) still held a high contribution to PAHs regardless of the implementation of “coal to gas” law in the sampling area. …”
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Impact of educational videos and user guide on indwelling pleural catheter caregiver training and unplanned healthcare encounters by Si Ling Young, Brian Lee Wei Chua, Qiao Li Tan, Carrie Kah-Lai Leong, Ivana Gilcrist Chiew Sian Phua, Jane Jing Yi Wong, Wen Ting Lim, Kendra Jing Ying Tang, Aaron Jun Jie Tan, Fena Ming Qin Lee, Ken Junyang Goh

“…There was no difference in overall complication and IPC-related infection rates between groups.Conclusion IPC-specific educational videos and resources, which are readily accessible and easily implemented into CGT programmes, reduce UHEs due to IPC-related issues and may improve caregiver knowledge and competency in IPC care and drainage.…”
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Machine learning-based integration identifies plasma cells-related gene signature ST6GAL1 in idiopathic pulmonary fibrosis by Fanjie Lin, Ken Lin, Donglei Li, Weiguo Kong, Jiayu Zhuang, Wei He, Xinguang Wei, Tianchi Xiao, Hao Zu, Zili Zhang, Wenju Lu

“…Finally, the network pharmacology analysis for the core gene was implemented. Results The established PCRGS, based on the seven genes (SLAMF7, JCHAIN, PNOC, POU2AF1, MEI1, ST6GAL1, and VOPP1), was identified as an independent prognostic factor for overall survival. …”
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Indoor air quality and airborne transmission under the One Health lens: A scoping review by Gil Correia, Daniela Calheiros, Nuno Rosa, Lisa Rodrigues, Sandra Cunha, Luiz Miguel Santiago, José Costa, Manuel Gameiro da Silva, Teresa Gonçalves

“…The World Health Organization defines One Health as “an approach to designing and implementing programmes, policies, legislation and research in which multiple sectors communicate and work together to achieve better public health outcomes”. …”
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Construction and validation of renal cell carcinoma tumor cell differentiation-related prognostic classification (RCC-TCDC): an integrated bioinformatic analysis and clinical study by Yifan Liu, Keqin Dong, Yuntao Yao, Bingnan Lu, Lei Wang, Guo Ji, Haoyu Zhang, Zihui Zhao, Xinyue Yang, Runzhi Huang, Wang Zhou, Xiuwu Pan, Xingang Cui

“…Subsequently, we conducted consensus clustering to construct the RCC tumor cell differentiation-related prognostic classification (RCC-TCDC) and implemented prognostic and multi-omics analyses. Moreover, we utilized Lasso regression to help develop a multivariable prognostic model. …”
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Diagnostic, Therapeutic, and Prognostic Applications of Artificial Intelligence (AI) in the Clinical Management of Brain Metastases (BMs) by Kyriacos Evangelou, Panagiotis Zemperligkos, Anastasios Politis, Evgenia Lani, Enrique Gutierrez-Valencia, Ioannis Kotsantis, Georgios Velonakis, Efstathios Boviatsis, Lampis C. Stavrinou, Aristotelis Kalyvas

“…Despite these advancements and the promising landscape, multiple challenges—including data availability and variability, decision-making interpretability, and ethical, legal, and regulatory concerns—limit the broader implementation of AI into the everyday clinical management of BMs. …”
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Curing using the minimal – Strategies for treatment reduction in childhood acute lymphoblastic leukemia by Bernice LZ Oh, Stephen P. Hunger, Allen EJ Yeoh, Shawn HR Lee

“…Future directions include potential implementation of immunotherapy upfront to low-risk ALL, which may allow for even further reducing toxic chemotherapy or treatment duration. …”
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Sources and Health Risks of PM2.5-bound PAHs in a Small City along with the “Clean Heating” Policy by Zhiyong Li, Ziyuan Yue, Jixiang Liu, Zhen Zhai, Jianwei Meng, Lei Wang, Jihong Wei, Dingyuan Yang, Ailian Hu, Wenjia Zhu, Ning Ding, Xiaoxia Lu, Chunhao Lin

“…The far lower PAHs in this study than those of small cities before CH implementation indicated the CH effectiveness. Higher diagnostic ratios (DRs) of FA/(FA + PY), BaA/(BaA + CHR), and IP/(IP + BgP) in the HS were in agreement with the increased coal/biomass usage. …”
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Measurement-Based Prediction of mmWave Channel Parameters Using Deep Learning and Point Cloud by Hang Mi, Bo Ai, Ruisi He, Anuraag Bodi, Raied Caromi, Jian Wang, Jelena Senic, Camillo Gentile, Yang Miao

“…Last, the deployment and implementation method of the proposed model is recommended to the readers.…”
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Effect of super absorbent polymer on quantitative and qualitative traits of cowpea (Vigna unguiculata L.) in low irrigation management conditions by Parvaneh Mombani, Seyed Keyvan Marashi

“…The second factor included three levels of super absorbent polymers: 1) Absence of super absorbent (control), 2) 75 Kg/ha and 3) 150 Kg/ha. …”
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The Effect of Different Tillage Methods and Application of Plant Residues on Yield, Protein and Nitrogen Percentage of Triticale Plant (X Triticosecale Wittmack) and Physical and C... by S. Hosseinzadeh, E. Fateh, A. Aynehband, M. Farzaneh, J. Habibi Asl

“…One of the key challenges in sustainable agriculture is the lack of organic matter and its associated consequences. Implementing conservation tillage and managing plant residues-critical elements of agricultural production-can help address this issue. …”
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Water quality index modelling and its application on artificial intelligence (AI) in conjunction with machine learning (ML) methodologies for mapping surface water potential zones... by Abhijeet Das

“…On the other hand, the degree of FA, were implemented to reduce inconsistencies, involving WQI index. …”
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Design and validation of consumer behavior model based on user-generated content in the banking industry by Sepahdar Rahnama, Marzieh ZendehDel, Mir Hadi Moazen Jamshidi

“…According to its purpose, the research method is practical, and in terms of implementation method, it is mixed (qualitative-quantitative), and descriptive-exploratory in terms of the implementation strategy of research. …”
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Expression of scavenger receptors CD163, CD204, and CD206 on macrophages in patients with pulmonary tuberculosis by E. G. Churina, A. V. Popova, O. I. Urazova, M. R. Patysheva, Ju. V. Kolobovnikova, S. P. Chumakova

“…Monocytes were cultured in the X-VIVO 10 medium with gentamicin and phenol red with the addition of macrophage colony-stimulating factor (M-CSF) (5 ng / ml) at a concentration of 1×106 cells / ml with stimulators: interleukin (IL)-4 (10 ng / ml) and interferon (IFN) γ (100 ng / ml). …”
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Is joint hypermobility linked to self-reported non-recovery from COVID-19? Case–control evidence from the British COVID Symptom Study Biobank by Hugo D Critchley, Dorina Cadar, Claire J Steves, Kevin A Davies, Alan J Hakim, Nicholas Gall, Jessica A Eccles, Vicky Bowyer, Lisa Quadt, Nathan Cheetham

“…More generally, greater awareness of GJH and its extra-articular associations is needed for effective patient stratification and implementation of personalised medicine.…”
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Oncotype DX Recurrence Score and Germline BRCA Variants in Patients with HR-Positive/HER2-Negative Early Breast Cancer: A Retrospective Observational Study by Stefania Morganti, Rabia A. Khan, Luis C. Berrocal-Almanza, Miguel Miranda, Linlin Luo, Xiaoqing Xu, Ann H. Partridge, Filipa Lynce

“…Abstract Introduction The Oncotype DX (ODX) recurrence score (RS) is prognostic and predictive of chemotherapy benefit in patients with hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative early breast cancer. …”
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Association of cardiometabolic index with all-cause and cardiovascular mortality among middle-aged and elderly populations by Mengya Zhu, Hui Jin, Yujie Yin, Ya Xu, Yangang Zhu

“…Abstract The Cardiometabolic Index (CMI) is a well-recognized risk factor for a range of cardiovascular diseases and diabetes mellitus. …”
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