SARS-CoV-2 Protein Deposition Enhances Renal Complement Activation and Aggravates Kidney Injury in Membranous Nephropathy After COVID-19 by Guoqin Wang, Lei Yang, Xiaoyi Xu, Weiyi Guo, Lijun Sun, Yanyan Wang, Wenrong Cheng, Nan Ye, Lingqiang Kong, Xiaoyi Zhao, Hong Cheng

Subjects: “…complement…”
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Scaling evidence-based interventions: Examining factors promoting and limiting the dissemination of research mentor training by Kimberly Spencer, Melissa McDaniels, So Hee Hyun, Jenna Griebel Rogers, Emily Utzerath, Christine Pfund

“…Data analyses included t-tests to compare differences between the implementer and non-implementer groups and binary logistic regression to determine which factors best predict implementation status. …”
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Reduced hemolytic complement activity in the classical pathway (CH50) is a risk factor for poor clinical outcomes of patients with infections: a retrospective analysis of health insurance claims in Japan by Hiroyuki Koami, Hiroyuki Koami, Yutaro Furukawa, Yuri Hirota, Akira Sasaki, Hirotaka Ogawa, Ayaka Matsuoka, Kota Shinada, Kento Nakayama, Ryota Sakurai, Sachiko Iwanaga, Takayuki Onohara, Shogo Narumi, Mayuko Koba, Hirotaka Mori, Hirotaka Mori, Yutaka Umemura, Yutaka Umemura, Kazuma Yamakawa, Kazuma Yamakawa, Kohji Okamoto, Kohji Okamoto, Yuichiro Sakamoto, Yuichiro Sakamoto

“…Moreover, patients with low levels of both CH50 and C3 had an extremely high mortality rate (25.0%).ConclusionLow CH50 after infection is not only significantly associated with multiple organ failure and coagulopathy but is also an independent risk factor for poor prognosis. Complement activation after infection may help to avert organ damage and to improve clinical outcomes.…”
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Value of prothrombotic state molecules and the serum level of complement C1q tumor necrosis factor-related protein 1 in predicting the prognosis of patients after percutaneous coronary intervention by WEN Bo

“…Objective To investigate the value of prethrombotic state molecules and the serum level of complement C1q tumor necrosis factor-related protein 1 (CTRP1) in predicting the prognosis of patients after percutaneous coronary intervention (PCI). …”
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Protein koji vezuje manozu - činilac urođenog imunskog odgovora by Gruden-Movsesijan Alisa A.

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Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy by Liu JunFei, Qian XiaoPing, Wang TaoXia, Liu XiaoLi, Liu WeiGang, Wang LiJie, Zhang HuiFang, Han Li, Li GuiYing, Yu XiaoJuan

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NADPH Oxidase 4: Crucial for Endothelial Function under Hypoxia—Complementing Prostacyclin by Heike Brendel, Jennifer Mittag, Anja Hofmann, Helene Hempel, Sindy Giebe, Patrick Diaba-Nuhoho, Steffen Wolk, Christian Reeps, Henning Morawietz, Coy Brunssen

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Curriculum Fidelity of English Language Teaching Teachers and Factors Affecting Teachers’ Implementation at Ethiopian Public Universities’ Context by Baye Ashebir Anteneh, Alemu Hailu Anshu

“…Personal/teacher factors (teachers’ beliefs, confidence, knowledge, and skills in improving the curriculum) and student factors (motivation and interest) also had significant influence. …”
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Experience in implementing workplace wellbeing programs in Russia: results of a survey of employers on the ATRIA platform by A. A. Antsiferova, A. V. Kontsevaya, M. B. Khudyakov, P. V. Ipatov, O. M. Drapkina

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Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue by Milosz P. Kawa, Anna Machalinska, Dorota Roginska, Boguslaw Machalinski

“…Although the prevalence, risk factors, and clinical course of the disease are well described, its pathogenesis is not entirely elucidated. …”
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A Kinetic Model of Antigen‐Dependent IgG Oligomerization and Complement Binding by Jürgen Strasser, Nikolaus Frischauf, Lukas Schustereder, Andreas Karner, Sieto Bosgra, Aran F. Labrijn, Frank J. Beurskens, Johannes Preiner

“…The classical complement pathway (CCP) is an essential part of the immune system, activated when complement protein C1 binds to IgG antibody oligomers on the surface of pathogens, infected or malignant cells, culminating in the formation of the membrane attack complex and subsequent cell lysis. …”
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Long-term GABA supplementation mitigates anxiety by modulating complement and neuroinflammatory pathways by Jiyi Xu, Ziyu Ge, Han Wang, Chenhui Zhang, Jinjie Xu, Ying Li, Xiangyun Yang, Ling Zhang, Zhanjiang Li, Zhe Liu, Gang Wang, Jing Du

“…Results showed that GABA significantly alleviated anxiety-like behaviors, increased GABA levels in the prefrontal cortex, and elevated anti-inflammatory factors IL-10 and TGF-β1. Proteomic analysis and validation revealed GABA reversed complement dysregulation (C3, C4b, Cfh, Cfi). …”
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Clinical value of the renal pathologic scoring system in complement-mediated thrombotic microangiopathy by Fei-Fei Chen, Xiao-Juan Yu, Hui Wang, Xu Zhang, Ying Tan, Zhen Qu, Su-Xia Wang, Feng Yu, Min Chen, Ming-Hui Zhao

“…Objectives This study was initiated to establish a renal thrombotic microangiopathy (TMA) scoring system based on clinical needs and investigate its predictive value for patients’ long-term outcomes.Methods Kidney biopsy-proven Complement-mediated TMA (C-TMA) patients from January 2000 to December 2017 in Peking University First Hospital were retrospectively studied. …”
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Key Factors Influencing Building Components’ Remanufacturing Strategy: A Comprehensive Literature Review by Can Miao Gao, Kuan Yew Wong

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Humoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression by Margot Revel, Mikel Rezola Artero, Houcine Hamidi, Anne Grunenwald, Loris Blasco, Yann A. Vano, Stephane Marie Oudard, Rafael Sanchez-Salas, Petr Macek, Lara Rodriguez Sanchez, Xavier Cathelineau, Benoit Vedié, Catherine Sautes-Fridman, Wolf Herman Fridman, Lubka T. Roumenina, Marie-Agnes Dragon-Durey

“…Here, we propose a Humoral Complementomics approach: a work-up of assays to comprehensively evaluate complement proteins, activation fragments, and autoantibodies targeting complement proteins in plasma, which we correlated with the intratumoral complement activation, and/or local production, focusing on localized and metastatic clear cell renal cell carcinoma (ccRCC). …”
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Postoperative Atypical Hemolytic Uremic Syndrome Associated with Complement C3 Mutation by Eiji Matsukuma, Atsushi Imamura, Yusuke Iwata, Takamasa Takeuchi, Yoko Yoshida, Yoshihiro Fujimura, Xinping Fan, Toshiyuki Miyata, Takashi Kuwahara

“…Sequencing of his CFH, complement factor I, membrane cofactor protein, complement factor B, and thrombomodulin genes was normal. …”
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Targeting the Roots of Kidney Disease: Systematic Review of the Therapies Targeting the Complement System by Maja Roman, Michał Nowicki

“…<i>Materials and Methods</i>: This review aims to summarize innovative therapies targeting various pathways, including the inhibition of the terminal part of the complement pathway (mainly C5), the alternative pathway (factor B inhibitors), and the lectin pathway (MASP inhibitors. …”
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R&D investment and political connections - complements or substitutes? evidence from Russia by Natalia Lamberova

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Why not both? Complementing explanations with uncertainty, and self-confidence in human-AI collaboration by Ioannis Papantonis, Vaishak Belle, Vaishak Belle

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Proteomic profiling of saliva reveals association of complement system with primary Sjögren's syndrome by Mingde Li, Yajun Qi, Guizhen Wang, Su Bu, Ming Chen, Jiahui Yu, Tianyang Luo, Lulu Meng, Anran Dai, Yong Zhou, Shuai Liu, Xingxing Huo

“…The concentrations of Serpin family G member 1 (SERPING1), C3, complement factor H (CFH), fibrinogen alpha (FGA), and fibrinogen gamma (FGG) in saliva were determined by ELISA. …”
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