Development of a predictive model for long-term care and support eligibility certification associated with dementia-related functional impairments: the IRIDE cohort study by Daichi Yamashiro, Hiroyuki Suzuki, Susumu Ogawa, Mari Yamashita, Hiroki Moriya, Hiroyuki Sasai, Shuichi P. Obuchi, Takumi Abe, Hiroshi Murayama, Takumi Hirata, Yoshinori Fujiwara, Shuichi Awata, Masahiro Akishita, Kenji Toba, IRIDE Cohort Study Investigators

“…Two models were developed: Model 1, focused on dementia-related functional impairments factors in Japan, whereas Model 2, prioritized social implementation by limiting predictors to self-reportable items. …”
Get full text

High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study by Leyla A. Ovchinnikova, Igor E. Eliseev, Igor E. Eliseev, Samir S. Dzhelad, Taras O. Simaniv, Ksenia M. Klimina, Maria Ivanova, Elena N. Ilina, Maria N. Zakharova, Sergey N. Illarioshkin, Yury P. Rubtsov, Alexander G. Gabibov, Alexander G. Gabibov, Alexander G. Gabibov, Yakov A. Lomakin

“…BackgroundMultiple sclerosis (MS) is a neuroinflammatory disease triggered by a combination of genetic traits and external factors. Autoimmune nature of MS is proven by the identification of pathogenic T cells, but the role of autoantibody-producing B cells is less clear. …”
Get full text

Socio-economic contextual determinants and behavioral changes during pregnancy: evidence from the "MAMI-MED" cohort by Francesca Bitonti, Angelo Mazza, Martina Barchitta, Andrea Maugeri, Roberta Magnano San Lio, Giuliana Favara, Claudia La Mastra, Maria Clara La Rosa, Fabiola Galvani, Elisa Pappalardo, Carla Ettore, Giuseppe Ettore, Federico Mertoli, Carmela Elita Schillaci, Antonella Agodi

“…Mann–Whitney test, Kruskal–Wallis tests, logistic regressions and mixtures of regressions models with concomitant variables are implemented 1) to investigate the associations between contextual covariates and individual responses, 2) to assess the presence of latent sub-groups of the population reacting differently to the same contextual factors. …”
Get full text

Treatment outcomes for acute T-lymphoblastic leukemias/lymphomas: data from the ALL-2016 multicenter prospective randomized trial by O. A. Aleshina, I. V. Galtseva, E. S. Kotova, G. I. Isinova, T. N. Obukhova, V. N. Dvirnik, A. B. Sudarikov, M. E. Grishunina, O. S. Samoilova, K. D. Kaplanov, V. A. Lapin, S. N. Bondarenko, E. S. Fokina, N. V. Minaeva, T. S. Konstantinova, Yu. V. Sveshnikova, E. E. Zinina, A. S. Antipova, O. Yu. Baranova, E. A. Borisenkova, Yu. O. Davydova, N. M. Kapranov, S. M. Kulikov, Yu. A. Chabaeva, V. V. Troitskaya, E. N. Parovichnikova

“…The effectiveness of therapy for acute T-lymphoblastic leukemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) has significantly improved over the past decades, including through the implementation of hematopoietic stem cell transplantation (HSCT). …”
Get full text

Engaging the private sector as part of HIV pre-exposure prophylaxis service delivery in Vietnam: a comparative analysis of uptake, persistence and HIV seroconversion from 2018 to 2... by Bao Ngoc Vu, Kimberly Green, Huong Phan, Long Tran, Phuong Phan, Tham Tran, Linh Doan, Yen Vu, Chau Pham, Dao Nguyen, Anh Doan, Trang Ngo, Phuong Tran, Vuong Nguyen, Bieu Nguyen, Thai Phan, Ha Nguyen

“…We assessed the effectiveness of this approach to inform ongoing efforts to accelerate epidemic control by 2030.MethodsWe implemented a process evaluation with longitudinal design using retrospective programmatic data collected and uploaded onto a secure online system (HMED) from 23 public and 17 private PrEP clinics in Hanoi, Ho Chi Minh City (HCMC), and Dong Nai. …”
Get full text

Protocol of the pilot study to test and evaluate the iCARE tool: a machine learning-based e-platform tool to make health prognoses and support decision-making for the care of older... by John P Hirdes, Hao Luo, Davide L Vetrano, Graziano Onder, Jonathan Chen, Violetta Kijowska, Katarzyna Szczerbińska, Johanna Edgren, Amaia Calderón-Larrañaga, George Heckman, Ron MC Herings, Johanna de Almeida Mello, Anja Declercq, Mark Hoogendoorn, Caitlin McArthur, Mari Aaltonen, Yi Chai, Karlijn J Joling, Micaela Jantzi, Rosa Liperoti, Melissa Northwood, Ilona Barańska, Agata Stodolska, Hein P J van Hout, Margaret Saari, Luca Mariotti, Emiel O Hoogendijk, Luke Turcotte, Louk Smalbil, Elizabeth P Howard, John N Morris, Daniela Fialová, Eline CM Kooijmans, Riikka-Leena Leskelä, Jokke Häsä, Georg Ruppe, Carmen Angioletti, Olena Antonenko, Shireen Aziz, Gustavo Betini, Jovana Brkič, Roberto Da Cas, Daniel Da Cunha Leme, Lu Dai, Cecilia Damiano, Natalia Drapała, Bonaventure Egbujie, Collin JC Exmann, Harriet Finne-Soveri, Charlene France, Tiziana Grisetti, Ira Haavisto, Sophie Hogeveen, Paweł Jagielski, Laurian Jongejan, Jet E Klunder, Ingrid Kummer, Anna Lukačišinová, Matti Mäkelä, Krista Mathias, Amanda Mofina, Reem Mulla, Mikko Nuutinen, Sandra Ochwat, Paula Pennanen, Jitka Pokladníková, Bregtje Proost, Ahmer Raza, Emanuele Rocco Villani, Jindra Reissigová, Erez Schachter, Katarzyna Sekulak, Chi-Ling Joanna Sinn, Andrea Vokálová, Adrianna Ziuziakowska, Mari Lahelma, Anna-Maria Hiltunen, Anna Salminen, Mor Alon, Collin Exmann, Wiebe Boorsma, Johanna de Almeida Mello, Hein PJ van Hout

“…Two pilot modalities—decision loop and non-decision loop—were implemented to assess the effect of the iCARE tool on clinical decisions. …”
Get full text

ARTEMIS: An independently validated prognostic prediction model of breast cancer incorporating epigenetic biomarkers with main effects and gene-gene interactions by Maojie Xue, Ziang Xu, Xiang Wang, Jiajin Chen, Xinxin Kong, Shenxuan Zhou, Jiamin Wu, Yuhao Zhang, Yi Li, David C. Christiani, Feng Chen, Yang Zhao, Ruyang Zhang

“…Introduction: Breast cancer, a heterogeneous disease, is influenced by multiple genetic and epigenetic factors. The majority of prognostic models for breast cancer focus merely on the main effects of predictors, disregarding the crucial impacts of gene-gene interactions on prognosis. …”
Get full text

Residence-based disparities of composite index of anthropometric failures in East African under five children; multivariate decomposition analysis by Aznamariam Ayres, Yawkal Tsega, Abel Endawkie, Shimels Derso Kebede, Eyob Tilahun Abeje, Ermias Bekele Enyew, Chala Daba, Lakew Asmare, Amare Muche, Fekade Demeke Bayou, Mastewal Arefaynie, Asnakew Molla Mekonen, Abiyu Abadi Tareke, Awoke Keleb, Kaleab Mesfin Abera, Natnael Kebede, Endalkachew Mesfin Gebeyehu

“…Hence, identifying the main contributors of these disparities will help health policy makers, program designers and implementers for the reduction of composite index of anthropometric failures in children under-5 years old in the study areas. …”
Get full text

Assessing the global burden of interstitial lung disease and pulmonary sarcoidosis using multiple statistical models: analysis and future projections by Luna Zhao, Yue Zhou, Yun Jia, Lang Wang, Ye Liu, Guizhen Lv, Yihao Zhang, Jinyang Li, Junfeng Ren, Hongzheng Liu, Yufeng Zhang, Ning Wang, Wenwen Zhang, Wenqiang Mo, Jiaqi Liu, Yilin Wang, Junhao Ma, Chao Wu, Dong Liu, GBD Collaborator

“…Prioritizing early screening (e.g., high-resolution computed tomography and serum biomarkers), minimizing environmental and occupational exposures, and implementing gender-/age-specific interventions are critical measures. …”
Get full text

Pediatric cardiac surgical site infections: A single-center quality improvement initiativeCentral MessagePerspective by Nhat Chau, HBSc, Crystal Tran, HBSc, CCRP, Megan Clarke, MN, RN, CIC, Jennifer Kilburn, MN, RN, Cecilia St. George-Hyslop, MEd, RN, CNCCPC, Diana Young, RN, Sandra L. Merklinger, MN-NP, PhD, Erica Mosolanczki, MN-NP, Vivian Trinder, MN-NP, Jill O'Hare, MN-NP, Karen Clarke, RN, Kate McCormick, MScN, RN, Rachel D. Vanderlaan, MD, PhD, FRCSC

“…Therefore, as a quality improvement initiative, we implemented interventions with the goal of decreasing SSI rates by 30%. …”
Get full text

Preliminary effectiveness of social prescription and virtual patient information in increasing tertiary prevention among cancer patients (ESPRIT): protocol for a single-centre, ran... by Karen Steindorf, Michael Koller, Michael Leitzmann, Wolfgang Herr, Daniel Heudobler, Lisa Boyer, Anne Herrmann, Tobias Pukrop, Christine Bernardi, Sabine Einhell

“…Cost-effectiveness and the time spent in the consultation, as well as potential implementation barriers and facilitators, will also be explored as part of a mixed-methods hybrid design. …”
Get full text

Mixed-Methods Investigation of Rural Emergency Medical Services ST-Elevation Myocardial Infarction Time to Percutaneous Coronary Intervention: High- vs Low-Performing Agencies by Michael Supples, McKenna E. Gallagher, Nicklaus P. Ashburn, Anna C. Snavely, Ashley E. Strahley, Chadwick D. Miller, Simon A. Mahler, Jason P. Stopyra

Get full text

Validation Indicator Identification and Customer Ranking in Microloans: A Study at Middle East Bank in Iran by Azadeh Ahmadi Kousha, Faegh Ahmadi, Mohammad Hossein Ranjbar, Hamidreza Kordlouie

“…Naive Bayes, Meta, Attribute Selected Classifier, and j48 algorithms were implemented and WEKA software was used to classify criteria and create patterns. …”
Get full text

Impact and elastic modulus of coal mining on terrestrial ecosystems by Jihong Dong, Wenting Dai, Jiren Xu, Hui Zhang, Yunpeng Li, Fei Xie

“…Abstract The energy consumption structure is gradually evolving into a "diversified energy structure" against the backdrop of the global implementation of energy-saving and low-carbon policies. …”
Get full text

Geographic disparities in hospital readmissions: a retrospective cohort study among patients with chronic disease in rural China by Mingyue Li, Haoqing Tang, Huixian Zheng, Baisong Zhang, Haozhe Cheng, Yanshang Wang, Yuxun Zhou, Xiaotian Zhang, Pascal Geldsetzer, Xiaoyun Liu

“…Many high-income countries have implemented financial incentives to reduce readmissions. …”
Get full text

CURRENT APPROACHES TOX-RAY METHODS OF DIAGNOSTICS IN PLANNING OF DENTAL IMPLANTS AND STAGES OF SURGICAL REHABILITATION OF PATIENTS WITH A SECONDARY EDENTIA by H.B. Prots, V.P. Puryk, Y.I. Solodzhuk, G.P. Nychyporuk, I.G. Omelchuk, Y.V. Puryk, A.K. Shudjairi, S.A. Ohiyenko, I.I. Prots

“…Many periodontists recommended gradual and consistent implementation of all periodontal procedures, which significantly increases the length of treatment and is burdensome for working patients [2,3,9]. …”
Get full text

The current landscape in antibiotic access and supply issues: a qualitative study with key experts and opinion leaders by Dr Esmita Charani, Dr Vrinda Nampoothiri, Dr Ritika Kondal, Dr Avaneesh Pandey, Dr Oluchi Mbamalu, Dr Jennifer Cohn, Dr Sanjeev Singh, Dr Nusrat Shafiq

“…Mitigation strategies included moving stock between pharmacies, pharmacists being assigned to monitor antibiotic supply and shortages at the hospital level, and implementation of serious shortage protocols in the UK which enable pharmacists to dispense alternate antibiotics in case of shortages. …”
Get full text

CONHECIMENTO DE PACIENTES SOBRE O PROCESSO DE AUTO-CUIDADO EM PÓS-OPERATÓRIO DE CIRURGIA CARDÍACA by Líscia Divana P. Carvalho, Marli Villela Mamede, Maria dos Remédios Oliveira de Araujo

“…The data collection instrument validated by Hermida (2005) was used. On personal factors and basic constraints the predominance of women and the medical diagnosis of mitral valve dysfunction was observed. …”
Get full text

The main approaches to assessing the quality and effectiveness of measures for assisting persons with disabilities by S. V. Pavlova, A. M. Salogub

“…It is necessary to ensure equal access to quality support in obtaining social services for all categories of people in need, regardless of their place of residence, family income and other factors. Another important indicator is the effectiveness of the work of the specialists providing support. …”
Get full text

Empowering Aging with Dignity: The Need for Geriatric Home-based Primary Care in Pakistan by Rabeeya Saeed

“…To protect patient safety and public trust, strong regulatory frameworks and quality assurance standards must be developed and implemented. In conclusion, geriatric home-based primary care represents a critical opportunity to enhance the quality of life for older adults and alleviate the burden on hospitals. …”
Get full text