Effects of Hydrogen Sulfide at Normal Body Temperature and in the Cold on Isolated Tail and Carotid Arteries from Rats and TRPA1 Knockout and Wild-Type Mice by Leonardo Kelava, Eszter Pakai, Kazushi Ogasawara, Kata Fekete, Gabor Pozsgai, Erika Pinter, Andras Garami

“…Sodium nitroprusside-induced vasorelaxation was not influenced by any of the investigated factors, while acetylcholine-induced dilation decreased in the cold in all vessel types. …”
Get full text

TimberTracer: a comprehensive framework for the evaluation of carbon sequestration by forest management and substitution of harvested wood products by I. Boukhris, A. Collalti, S. Lahssini, D. Dalmonech, F. Nakhle, R. Testolin, M. V. Chiriacò, M. Santini, R. Valentini

“…Furthermore, this study evaluates the consequences of disregarding landfill methane emissions and relying on static substitution factors, assessing their impact on the mitigation potential of various options. …”
Get full text

Unequal disease burdens: exploring the intersection of gender, health and disease dynamics in China by Xueneng Yang, Ruijuan Li, Junfei Liu, Jun Shu, Hanbo Chen, Minglin Dong, Jia Lv, Yong Yuan, Qiangqiang Song, Limin Guo, Ming Zeng, Bo Li

“…Conclusion Over the past 30 years, gender differences in disease burden in China have changed dynamically, influenced by biological, behavioral, and sociocultural factors. Public health policies should focus on high-risk behaviors in males, such as smoking, drinking, and occupational exposure, by implementing cardiovascular disease and cancer screening programs. …”
Get full text

What Matters Most to Veterans When Deciding to Use Technology for Health: Cross-Sectional Analysis of a National Survey by Bella Etingen, Bridget M Smith, Stephanie L Shimada, Stephanie A Robinson, Robin T Higashi, Ndindam Ndiwane, Kathleen L Frisbee, Jessica M Lipschitz, Eric Richardson, Dawn Irvin, Timothy P Hogan

“…ConclusionsUnderstanding what matters most to patients when they are deciding to adopt a technology for their health can, and should, inform implementation strategies and other approaches to enhance health-related technology use. …”
Get full text

Lung Cancer Screening in Family Members and Peers of Patients With Lung Cancer: Protocol for a Prospective Cohort Study by Isabelle Pitrou, Adriano Petrangelo, Charlotte Besson, Carmela Pepe, Annika Helen Waschke, Jason Agulnik, Anne V Gonzalez, Nicole Ezer

“… BackgroundLow-dose computed tomography (LDCT) screening is promising for the early detection of lung cancer (LC) and the reduction of LC-related mortality. Despite the implementation of LC screening programs worldwide, recruitment is challenging. …”
Get full text

Relative Influence of Salinity in the Flow and Accumulation of Organic Carbon in Open-Water Karstic Mangroves by Angélica Paola Quintero Alvarado, Jairo Humberto Medina Calderón, José Ernesto Mancera-Pineda

“…To this end, an experimental design was implemented on San Andrés Island, where an edaphic salinity gradient exists due to the water regime. …”
Get full text

Analysis of young students' perception of loneliness: a cross-sectional study by Rogelio Hernández-Díaz, Rogelio Hernández-Díaz, Lucas Navarro-Vásquez, Alejandra Aguilar-Latorre, Alejandra Aguilar-Latorre, Alejandra Aguilar-Latorre, Fátima Méndez-López, Fátima Méndez-López, Fátima Méndez-López, Santiago Gascón-Santos, Santiago Gascón-Santos, Santiago Gascón-Santos, Rosa Magallón-Botaya, Rosa Magallón-Botaya, Rosa Magallón-Botaya

“…Further research is needed to develop effective prevention, detection, and intervention strategies tailored to youth, which could be implemented through Primary Care and educational institutions.…”
Get full text

In situ endoscopic photodynamic therapy combined with immature DC vaccination induces a robust T cell response against peritoneal carcinomatosis by Davide Brusa, Caroline Bouzin, Charline Degavre, Anouk Lepez, Sebastien Ibanez, Clémence François, Katarzyna Głowacka, Céline Guilbaud, Florine Laloux-Morris, Hrag Esfahani, Olivier Feron

“…Background Immunogenic cell death (ICD) and ferroptosis have recently emerged as key factors in the anticancer immune response. Among the treatments able to induce ICD and the associated release of danger signals is photodynamic therapy (PDT). …”
Get full text

Parenting and mental health in protracted refugee situations: a systematic review by Qusai Khraisha, Nadeen Abujaber, Sadhbh Carpenter, Robert J. Crossen, Johanna Kappenberg, Ronan Kelly, Cameron Murphy, Orla Norton, Sophie Marleen Put, Kate Schnoebelen, Azza Warraitch, Stella Roney, Kristin Hadfield

“…., overcrowding) and relational factors (e.g., spousal dynamics) modulated both of these pathways. …”
Get full text

Multiple loci are associated with white blood cell phenotypes. by Michael A Nalls, David J Couper, Toshiko Tanaka, Frank J A van Rooij, Ming-Huei Chen, Albert V Smith, Daniela Toniolo, Neil A Zakai, Qiong Yang, Andreas Greinacher, Andrew R Wood, Melissa Garcia, Paolo Gasparini, Yongmei Liu, Thomas Lumley, Aaron R Folsom, Alex P Reiner, Christian Gieger, Vasiliki Lagou, Janine F Felix, Henry Völzke, Natalia A Gouskova, Alessandro Biffi, Angela Döring, Uwe Völker, Sean Chong, Kerri L Wiggins, Augusto Rendon, Abbas Dehghan, Matt Moore, Kent Taylor, James G Wilson, Guillaume Lettre, Albert Hofman, Joshua C Bis, Nicola Pirastu, Caroline S Fox, Christa Meisinger, Jennifer Sambrook, Sampath Arepalli, Matthias Nauck, Holger Prokisch, Jonathan Stephens, Nicole L Glazer, L Adrienne Cupples, Yukinori Okada, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Tatsuhiko Tsunoda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Kazuhiko Yamamoto, Naoyuki Kamatani, Michael Stumvoll, Anke Tönjes, Inga Prokopenko, Thomas Illig, Kushang V Patel, Stephen F Garner, Brigitte Kuhnel, Massimo Mangino, Ben A Oostra, Swee Lay Thein, Josef Coresh, H-Erich Wichmann, Stephan Menzel, JingPing Lin, Giorgio Pistis, André G Uitterlinden, Tim D Spector, Alexander Teumer, Gudny Eiriksdottir, Vilmundur Gudnason, Stefania Bandinelli, Timothy M Frayling, Aravinda Chakravarti, Cornelia M van Duijn, David Melzer, Willem H Ouwehand, Daniel Levy, Eric Boerwinkle, Andrew B Singleton, Dena G Hernandez, Dan L Longo, Nicole Soranzo, Jacqueline C M Witteman, Bruce M Psaty, Luigi Ferrucci, Tamara B Harris, Christopher J O'Donnell, Santhi K Ganesh

“…We studied 19,509 subjects from seven cohorts in a discovery analysis, and 11,823 subjects from ten cohorts for replication analyses, to determine genetic factors influencing variability within the normal hematological range for total WBC count and five WBC subtype measures. …”
Get full text

Biological nitrogen fixation of natural and agricultural vegetation simulated with LPJmL 5.7.9 by S. B. Wirth, S. B. Wirth, J. Braun, J. Heinke, S. Ostberg, S. Rolinski, S. Schaphoff, F. Stenzel, W. von Bloh, F. Taube, C. Müller

“…While we see the potential for further model development, for example, to separate symbiotic and free-living BNF, the C-costly approach is a major improvement over the simple Original approach because of the separate representation of important drivers and limiting factors of BNF, and the C-costly approach also improves the ability of LPJmL to project future C and N cycle dynamics.…”
Get full text

Potential of anogenital distance as a genetic selection trait in Canadian Holsteins by G.R. Dodd, F.S. Schenkel, F. Miglior, T.C. Bruinjé, M. Gobikrushanth, J.E. Carrelli, M. Oba, D.J. Ambrose, C.F. Baes

“…However, many of the traits currently implemented in breeding programs are heavily influenced by environmental factors, resulting in a slow rate of genetic improvement. …”
Get full text

Effects of effort-reward imbalance on emergency nurses’ health: a mediating and moderating role of emotional exhaustion and work-family conflict by Yuanyuan Tan, Jing Zhou, Jing Zhou, Jing Zhou, Hao Zhang, Hao Zhang, Hao Zhang, Lin Lan, Lin Lan, Lin Lan, Xiaoli Chen, Xiaoli Chen, Xiaoli Chen, Xiaomin Yu, Xiaomin Yu, Xiaomin Yu, Luying Zhong, Luying Zhong, Luying Zhong, Ling Zhu, Ling Zhu, Ling Zhu, Yongli Gao, Yongli Gao, Yongli Gao

“…As a result, interventions should be implemented to improve ERI, alleviate emotional exhaustion among nurses, monitor work–family conflict levels, and mitigate the effects of these factors on nurses’ overall well-being.…”
Get full text

Effects of pectic oligosaccharide on growth performance, organ indexes and intestinal health in broilers exposed to aflatoxin B1 by Zhengqi Ye, Yongzhi Qin, Haijun Zhang, Meitian Xian, Hui Ye, Qingyun Cao, Zemin Dong, Changming Zhang, Jianjun Zuo, Weiwei Wang

“…In vivo experiment was then implemented by allocating 320 one-day-old yellow-feathered broilers to 4 groups (8 replicates/group), according to a 2 × 2 factorial arrangement with POS addition (0 or 400 mg/kg) and AFB1 exposure (with or without) as the two factors. …”
Get full text

Utilizing multidisciplinary mobile outreach clinics to provide comprehensive diabetic foot care to patients experiencing homelessness by Kris M. Boelitz, MD, Jaeyoung Lee, BS, Michael D. Pepin, BS, Yiming Zhang, MS, Mallory Gibbons, MSN, NP, Frances J. Lagana, DPM, Shahida Balaparya, EdD, MBA, RVT, Lindsey Carr, Jessin Varghese, BS, NP, Caitlin Sorensen, MD, Jessica P. Simons, MD, MPH, Douglas Jones, MS, MD, Andres Schanzer, MD, Tammy T. Nguyen, MD, PhD

“…We sought to evaluate the feasibility of implementing a multidisciplinary mobile outreach clinic for unhoused individuals with a focus on diabetic foot care and screening to overcome the SDoH-associated barriers to care. …”
Get full text

Integrating next-generation sequencing and artificial intelligence for the identification and validation of pathogenic variants in colorectal cancer by Juliana Rodriguez-Salamanca, Mariana Angulo-Aguado, Sarah Orjuela-Amarillo, Catalina Duque, Diana Carolina Sierra-Díaz, Nora Contreras Bravo, Carlos Figueroa, Carlos M. Restrepo, Andrés López-Cortés, Rodrigo Cabrera, Adrien Morel, Dora Janeth Fonseca-Mendoza

“…BackgroundColorectal cancer (CRC) is recognized as a multifactorial disease, where both genetic and environmental factors play critical roles in its development and progression. …”
Get full text

Evidence for Coordinated Control of PM_2.5 and O₃: Long-Term Observational Study in a Typical City of Central Plains Urban Agglomeration by Chenhui Jia, Guangxuan Yan, Xinyi Yu, Xue Li, Jing Xue, Yanan Wang, Zhiguo Cao

“…The Random Forest (RF) model was employed to identify the key factors influencing O₃ concentrations during the two phases. …”
Get full text

Rationale and design of the HERZCHECK trial: Detection of early heart failure using telemedicine and cardiovascular magnetic resonance in structurally weak regions (NCT05122793) by Sebastian Kelle, Anna Clara Nolden, Maximilian Leo Müller, Rebecca Elisabeth Beyer, Henning Steen, Bjoern Andrew Remppis, Johannes Wieditz, Hannah Kentenich, Alex Tuit, Mina Cvetkovic, Undine Ella Witt, Florian André, Sein Schmidt, Alexander Huppertz, Dusan Simic, Dirk Müller, Arim Shukri, Matthias Issing, Andre Glardon, Katrin Christiane Reber, Ulf Landmesser, Norbert Frey, Burkert Pieske, Stephanie Stock, Volkmar Falk, Tim Friede, Gisela Thiede

“…The study targets asymptomatic adults aged 40–69 years without a history of HF, but with at least one of the following cardiovascular risk factors: hypertension, hypercholesterolemia, obesity, smoking/tobacco consumption, chronic diabetes mellitus, or chronic kidney disease. …”
Get full text

Predicting the risk of postoperative gastrointestinal bleeding in patients with Type A aortic dissection based on an interpretable machine learning model by Lin Li, Xing Yang, Wei Guo, Wenxian Wu, Meixia Guo, Huanhuan Li, Xueyan Wang, Siyu Che

“…SHAP analysis identified the three most influential clinical features on the RF model’s output: duration of mechanical ventilation (MV), Time to aortic occlusion, and red blood cell (RBC) transfusion.ConclusionThe machine learning-based predictive model effectively assesses postoperative GIB risk in TAAD patients, aiding healthcare providers in early identification of risk factors and implementation of targeted preventive strategies.…”
Get full text

Delirium education priorities for healthcare professional students: a modified Delphi study by Tara Anderson, Alice Coffey, James McMahon, Stephanie Craig, Heather E. Barry, Margaret Graham, Jill Murphy, Christine Brown Wilson, Pauline Boland, Dympna Tuohy, Matt Birch, Audrey Tierney, Patrick Stark, Arlene McCurtin, Laura Creighton, Elizabeth Henderson, Lana Cook, Emma Cunningham, Geoffrey M. Curran, Gary Mitchell

Get full text