Correlation between serum complement C3 levels and cognitive dysfunction in patients with end-stage renal disease by Wu Si-yang, Zhang Jin, Wang Ying, Zhang Pei, Qi Xiang-ming, Wu Yong-gui

“…ObjectiveTo explore the correlation between complement level of C3， other risk factors and cognitive dysfunction in patients with end-stage renal disease （ESRD）.MethodsFrom July 2019 to July 2021， medical records and laboratory examinations were collected from 92 ESRD patients. …”
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Real-world implementation and adaptation to local settings of first trimester preeclampsia screening in Italy: a systematic review by Silvia Amodeo, Giulia Bonavina, Anna Seidenari, Paolo Ivo Cavoretto, Antonio Farina

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Exploring factors affecting adherence to multiple micronutrient supplementation during pregnancy in Cambodia: A qualitative analysis by Jocelyne M. Labonté, Mai‐Anh Hoang, Aishwarya Panicker, Hou Kroeun, Meng Sokchea, Sreang Sambo, Vin Sokhal, Cassandra Sauer, Mary Chea, Crystal D. Karakochuk

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Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina by Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz‐Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann, Harald Neumann

“…First, polySia avDP20 prevented tumor necrosis factor‐α, vascular endothelial growth factor A, and superoxide production by SIGLEC11‐positive phagocytes. …”
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Acceptability, feasibility, and factors affecting implementation of a gender-sensitivity training for HIV providers and staff in Uganda: a mixed methods, quasi-experimental controlled pilot trial by K M. Sileo, R K. Wanyenze, A Anecho, R L. Luttinen, K Weston, B Mukasa, S C. Mukama, S H. Vermund, S L. Dworkin, J F. Dovidio, B S. Taylor, T S. Kershaw

“…Conclusions This study underscores the acceptability and feasibility of a gender-sensitivity training program for HIV providers; further evaluation of the program is warranted. Identified factors influencing implementation can inform enhancements to gender-focused training initiatives to improve the quality of HIV services and enhance client engagement and health outcomes. …”
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The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells by Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango-Gonzalez, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernandez-Godino, Berta de la Cerda, Simon J. Clark, Simon J. Clark, Simon J. Clark, Marius Ueffing

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Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study by Nicole Pinzon-Hoyos, Yibo Li, Monnie McGee, Nicholas P. Poolos, Nicola Marchi, Amy L. Brewster

“…We identified DRE-associated complement decreases, including reduced levels of C1q, Factor H, C4, C4b, C3, and C3b/iC3b, as well as elevated bFGF. …”
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Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart by Inge Van de Walle, Laura Bracke, Heidi Gytz Olesen, Tonke van Bragt, Stéphanie Cadour, Phillip De Decker, Giorgia Ciurlia, Erwin Pannecoucke, Emma K. Persson, Olivier Van de Steen, Xinghong Leng, Gregers Rom Andersen, Domenica Gandini, C. Erik Hack

“…Empasiprubart is a humanized recycling monoclonal antibody that inhibits both pathways by binding to the CCP2 domain of complement factor 2 (C2), an interaction that is dependent on both Ca2+ and pH. …”
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Impact of preoperative complement-dependent cytotoxicity crossmatch on postoperative outcomes in kidney transplant recipients: A retrospective analysis by Chonghe Xu, Siqi Xie, Meiyi Lu, Wei Xu, Mei Zhu

“…However, delayed graft function rate was highest in the complement-dependent cytotoxicity of 5%–10% group. The source of donor kidneys was the most important factor influencing delayed graft function, and a larger cohort with a longer follow-up period may be needed to verify the tendency.…”
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Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment by Guo T, Zhao Y, Liang S, Wang J, Liu H, Zhou Y, Xu H, Chen Z

“…The concentrations of 13 complement proteins and vascular endothelial growth factor A (VEGF-A) were measured using Luminex® × MAP® technology.Results: During ranibizumab treatment, a reduction in the levels of C1q (p < 0.001), C2 (p = 0.030), C4 (p = 0.001), C4b (p = 0.026), C3b/iC3b (p < 0.001), C5 (p = 0.007), C5a (p = 0.005), CFD (p = 0.022), CFH (p < 0.001), and CFI (p < 0.001) in AH was observed. …”
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Complement Activation is More Pronounced in the Kidneys of Critically Ill Patients With COVID-19 Than in Those With Bacterial Sepsis by Firas F. Alkaff, Grietje G. Talen, Marius C. van den Heuvel, Meint Volbeda, Matijs van Meurs, Jill Moser, Mohamed R. Daha, Jacob van den Born, Stefan P. Berger

“…Immunohistochemical staining was performed for complement factor properdin and complement activation products C4d, C3d, and C5b-9. …”
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Novel and established biomarkers to complement risk scores in patients with acute decompensated heart failure – a pilot study by Valentin Hähnel, Victoria Meretz, Christian Butter, Vera Paar, Christoph Edlinger, Michael Lichtenauer, Ronald Biemann, Berend Isermann, Meike Hoffmeister, Michael Haase, Anja Haase-Fielitz, Marwin Bannehr

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Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. by Matheswaran Kandasamy, Poon C Ying, Adrian W S Ho, Hermi R Sumatoh, Andreas Schlitzer, Timothy R Hughes, David M Kemeny, B Paul Morgan, Florent Ginhoux, Baalasubramanian Sivasankar

“…However, little is known about the factors that regulate lung DC migration to the dLN. …”
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A core UPS molecular complement implicates unique endocytic compartments at the parasite–host interface in Giardia lamblia by Erina A. Balmer, Corina D. Wirdnam, Carmen Faso

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Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction by T. Jadczyk, K. Baranski, M. Syzdol, E. Nabialek, W. Wanha, R. Kurzelowski, M. Z. Ratajczak, M. Kucia, B. Dolegowska, M. Niewczas, J. Zejda, W. Wojakowski

“…In both groups, levels of CC factors showed no significant changes within 48 hours of follow-up. …”
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STRATEGIC HUMAN RESOURCE MANAGEMENT AS A FACTOR IN GAINING AN ORGANIZATION’S COMPETITIVE ADVANTAGE by L. Ivanovskaya

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Rheumatoid arthritis: some components of hemostasis and inflammation by F. A. Cheldieva, T. M. Reshetnyak

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Cost management in technological processes taking into account the implementation of the resource saving policy by A. I. Shinkevich, O. V. Antipova

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Research on promotion of implementation of clinical practice guidelines(I):the status of implementation and promotion strategies by Xu-Hui LI, Qiao HUANG, Yong-Bo WANG, Si-Yu YAN, Mu-Kun CHEN, Kuang GAO, Yi-Bei SI, Jing GUO, Wen-Bin HU, Ying-Hui JIN

“…Af-fected by factors such as low operability, single form of dissemination and application, not timely update, and lack of implementation tools and implementation evaluation tools, the implementation of clinical practice guidelines is still insufficient. …”
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Exploring meso- and macro-level contextual factors associated with inequalities in program adoption during statewide scale-up of TransformUs Primary, a whole-school physical activi... by Elly Ganakas, Jo Salmon, Jiani Ma, Karen E. Lamb, Lisa Barnett, Adrian Bauman, Amanda Telford, Nicola D. Ridgers, Anna Timperio, Harriet Koorts

“…Abstract Background Contextual influences on program implementation exist across micro (individual), meso (organization), and macro (government/environment) system levels, yet macro factors are less frequently explored in implementation research. …”
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