Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective by Didar Murad, Rehan Zafar Paracha, Maryum Nisar

“…Simulation results highlight key components affected, including thrombin, tissue plasminogen activator, plasmin, fibrin degradation products, interleukin 6 (IL-6), the IL-6 and IL-6R complex, and the terminal complement complex (C5b-9). We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …”
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Genotypic and phenotypic diversity of Lactobacillus rhamnosus clinical isolates, their comparison with strain GG and their recognition by complement system. by Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos

“…Binding of complement regulators factor H and C4bp was also determined using radioligand assays. …”
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Classical Complement (CH 50 ) activity among children with some bacterial and parasitic infections in Sokoto, Nigeria by Kalgo, M.U.* , Muhammad, T.B. , Yeldu, M.H. , Garba, B.I. , Hamid, K.M. , Isiyaku, A. , Raji, H.Y. , Bello, M. , Bunza, N.M. Garba, M.R.

“…Similarly, age, gender, and residence of the participants appeared not to be a factor affecting classical complement activity of children with microbial infections. …”
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The role of complement C1q in atrial fibrillation: a marker for disease progression and surgical outcomes by Yuefeng Ju, MaoJing Wang, Yang Ji, Zhihui Wang, Wenzhuo Wang, Feiyue Liu, Qing Zhao

“…Background and objectiveThe complement system plays a crucial role in the pathogenesis and progression of cardiovascular diseases. …”
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Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle by Jonas Brorson, Lin Lin, Jakob Wang, Amanda Bæk, Tine Borum Billeskov, Frederik Forsberg Thybo, Jesper Just, János Haskó, Christen Ravn, Rehne L. Hansen, Mats Bue, Jens Otto Lunde Jørgensen, Yonglun Luo, Niels Jessen, Jean Farup

“…Spatial correlation analysis unveils FAPs and monocytes/macrophages co-localization and intercellular communication, mediated by complement factor C3. Immunostaining confirms C3 expression in FAPs and FAP secretion of C3, suggesting a role in phagocytosis of necrotic muscle cells. …”
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Successful targeting of the alternative complement cascade with iptacopan for the treatment of IgA nephropathy: a case report by Leonore Ingold, Michael Dickenmann, Thomas Menter, Helmut Hopfer, Patricia Hirt-Minkowski

“…Iptacopan is an oral inhibitor of complement factor B that effectively blocks the alternative complement pathway. …”
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Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy by Gabriel Ștefan, Eric Alamartine, Christophe Mariat, Nicolas Maillard

“…C4d, C3, C5b9, MBL, C4, and factor H-related protein 5 (FHR5) were the most frequently studied complement proteins in relation to the MEST-C classification. …”
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KLF4 overexpression protects against complement-mediated endothelial injury in transplant-associated thrombotic microangiopathy by Shuhui Jiang, Jiaqian Qi, Tingting Pan, Zhenzhen Yao, Siyi Lu, Yifei Han, Depei Wu, Yue Han

“…Therefore, plasma samples from 20 TA-TMA patients and 1:1 matched control patients (matched by age, sex, underlying diagnosis, HLA compatibility, graft source, and donor–recipient ABO blood type) were measured for krüppel-like factor 4 (KLF4), complement proteins and endothelial injury markers. …”
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Competence Method of Forming Project and Integration Teams in the Implementation of a Merger Transaction in the Banking Sector by D. S. Rukavishnikov

“…Outputs have been made regarding the transfer factor of efficiency, covering all the main stages of the implementation of the M & A project (Mergers & Acquisitions — mergers and acquisitions). …”
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137 Real-World Implementation of Latex Immunoturbidimetric Platelet Factor 4 Assay for Heparin-Induced Thrombocytopenia Diagnosis at a Large Academic Medical Center by Dareen M. Kanaan, Gabriella C. Torres, Allison L. Zhang, Katelyn W. Sylvester, Daniel Dees, Elisabeth M. Battinelli, Jean M. Connors

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Correlation between serum level of complement C3 and abdominal aortic calcification in maintenance hemodialysis patients by Zhao Xin, Bi Chun-sheng

“…Objective To explore the correlation between serum level of complement C3 and abdominal aortic calcification（AAC）in maintenance hemodialysis（MHD）patients.Methods A total of 127 MHD patients hospitalized between February 2019 and December 2019 were selected.Based upon to the points of AACs, they were divided into the groups of non-calcification（AACs<1,n=31）,mild calcification（1≤AACs<5,n=36）,moderate calcification（5≤AACs≤15,n=32）and severe calcification（AACs>15,n=28）.The relevant clinical data were collected and serum level of complement C3 was detected.The difference of serum complement C3 level with different degree of calcification and its correlation with AAC were analyzed.The influencing factors of AAC were analyzed by Logistic regression.The predictive value of serum level of complement C3 for AAC was analyzed by plotting the curve of receiver operating characteristic（ROC）.Results The levels of serum phosphorus, intact parathyroid hormone（iPTH）and complement C3 were significantly higher in mild/moderate/severe calcification group than those in non-calcification group（P<0.05）;levels of serum phosphorus, iPTH and complement C3 significantly higher in moderate/severe calcification group than those in mild calcification group（P<0.05）;the levels of serum phosphorus, iPTH and complement C3 significantly higher in severe calcification group than those in moderate calcification group（P<0.05）.Serum level of complement C3 was positively correlated with serum phosphorus, iPTH and AACs points（P<0.05）.And serum levels of phosphorus, iPTH and complement C3 were independent risk factors of AAC（P<0.05）.And the area under curve（AUC）of serum complement C3 was 0.858 for predicting AAC（P<0.05）.Conclusion Serum level of complement C3 is associated with the severity of AAC.As one of the independent risk factors for AAC,it may become an important biological marker for predicting the occurrence of AAC in MHD patients.…”
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Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model by Jakob Appel Østergaard, Marieta Milkova Ruseva, Talat Habib Malik, Ingeborg Torp Hoffmann-Petersen, Matthew Caleb Pickering, Steffen Thiel, Troels Krarup Hansen

“…Diabetes and control groups did not differ in glomerular immunofluorescence intensity obtained by antibodies against complement factors C4, C3, and C9. However, the circulating complement activation product C3a was increased in diabetes as compared to control mice (P=0.04). …”
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Visualizing interactions along the Escherichia coli twin-arginine translocation pathway using protein fragment complementation. by Jan S Kostecki, Haiming Li, Raymond J Turner, Matthew P DeLisa

“…To visualize these interactions, we have adapted bimolecular fluorescence complementation (BiFC) to detect protein-protein interactions along the Tat pathway of living cells. …”
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Bead arrays for antibody and complement profiling reveal joint contribution of antibody isotypes to C3 deposition. by Burcu Ayoglu, Eszter Szarka, Krisztina Huber, Anita Orosz, Fruzsina Babos, Anna Magyar, Ferenc Hudecz, Bernadette Rojkovich, Tamás Gáti, György Nagy, Jochen M Schwenk, Gabriella Sármay, József Prechl, Peter Nilsson, Krisztián Papp

“…Here, we present a bead array-based assay for a multiplexed determination of antigen-specific antibody levels in parallel with their properties for complement activation. We measured the deposition of C3 fragments from serum samples to reflect the degree of complement activation via all three complement activation pathways. …”
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Plasma complement proteins as biomarkers and therapeutic targets in chronic kidney disease: a Mendelian randomization analysis by Yu-Peng Xu, Zheng-Qi Song, Ming-Li Chen, Yang-Li Fang, Hui-Di Zhang

“…This study investigates the causal role of diverse plasma complement proteins in CKD and its clinical types to discover new biomarkers and therapeutic targets.Method Using two-sample Mendelian randomization (MR), we examined the causal relationships between 28 plasma complement proteins and CKD outcomes. …”
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Mapping regional implementation of ‘Making Every Contact Count’: mixed-methods evaluation of implementation stage, strategies, barriers and facilitators of implementation by Gregory Maniatopoulos, Tracy Finch, Deborah Harrison, Catherine Haighton, Jill Harland, Rob Wilson, Angela M Rodrigues, Craig Robson, Bethany Nichol, Caroline Charlton, Beckie Gibson, Emma Giles, Denise Orange

“…Qualitative findings highlighted factors that influence stakeholders to implement MECC (eg, organisational goals that were facilitated by MECC implementation, including the prevention agenda), supported resources that facilitate the implementation of MECC (eg, logic models) and enabling factors that promote MECC sustainability across the region (eg, buy-in from leadership and management).Conclusions The NENC MECC programme is built around regional leadership that supports the implementation process. …”
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Design and Implementation of 24-GHz and 48-GHz VCOs Using Noise Filtering Technique in 90-nm CMOS by Chen-Chih Ku, Sen Wang

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Pengaruh Faktor Keperilakuan Organisasi Terhadap Implementasi Sistem Akuntansi Keuangan Daerah Pada Satuan Kerja Perangkat Daerah Kabupaten Bengkalis by Muhammad Fadhil Junery, Abdullah Aziz

Subjects: “…factors of organizational behavior…”
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Commentary: Sustaining and scaling a clinic-based approach to address health-related social needs by Bo Kim, Bo Kim

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Application Of Passage Plan To Avoid Ship Aground In Barito River: Case Study On Km. Fleet Fresh by Septria Kumoro Jati, Iskandar, Indah Nurhidayati

Subjects: “…external and internal factors…”
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