Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation by Pooja Shivshankar, Stacey L. Mueller-Ortiz, Aleksey Y. Domozhirov, Weizhen Bi, Scott D. Collum, Marie-Francoise Doursout, Manish Patel, Isabella N. LeFebvre, Bindu Akkanti, Simon Yau, Howard J. Huang, Rahat Hussain, Harry Karmouty-Quintana

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C3aR1 on β cells enhances β cell function and survival to maintain glucose homeostasis by Renan Pereira de Lima, Ang Li, Ankit Gilani, Alfonso Rubio-Navarro, Charles D. Warren, Isabella Y. Kong, Jacob B. Geri, James C. Lo

“…Results: We show that the complement receptor C3aR1 on β cells plays an essential role in maintaining β cell homeostasis, especially under the metabolic duress of obesity and T2D. …”
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The relationship between serum CTRP-5, C3a/desArg, and complement-C3 levels and hypothyroidism in women with polycystic ovary syndrome by Fatima Abdul-ameer, Itlal Jummha AbudlRasool AlAsadi, Asieh Hosseini, Elham Bahreini

“…Results The results indicated that reduced blood levels of CTRP-5, along with elevated levels of ASP (C3a/desArg) and complement C3 in patients with PCOS, may be linked to dysregulation of the thyroid gland. …”
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Complement C3a promotes the formation of osteoclasts by inhibiting Sirt1 to activate the PI3K/PDK1/SGK3 pathway in patients with multiple myeloma by Fengjuan Jiang, Yunhe Zhang, Fengping Peng, Hui Liu, Kai Ding, Panpan Cao, Xiaohan Liu, Lijuan Li, Zhaoyun Liu, Rong Fu

Subjects: “…Complement C3a…”
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Clinical Value of Complement C3a, C5a, and sC5b-9 in Evaluating the Severity of Patients with Severe Fever with Thrombocytopenia Syndrome by Chen T, Liu Y, Liu Y, Hu N, Dai Y, Zhu C, Han Y, Jin K, Li J

“…The correlation analysis indicated that C3a and sC5b-9 positively correlated with SFTS RNA, CRP, PCT, ALT, AST, ALP, LDH, CK, HBDH, APPT, TT and D-dimer, while C3a negatively correlated with PLT.Conclusion: This study revealed abnormalities in complement components among patients with SFTS. …”
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Deficiency of C3a receptor attenuates the development of diabetic nephropathy by Ming-hui Zhao, Xiao-Qian Li, Dong-Yuan Chang

“…The aim of this study was to investigate the pathogenic role of C3a and C3a receptor (C3aR) in DN.Research design and methods The expression of C3aR was examined in the renal specimen of patients with DN. …”
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The complement system in human pregnancy and preeclampsia by Vijay Kumar, John H. Stewart

“…The second section discusses the CS signaling pathway, its negative regulators, and the roles of the C3a/C3aR and C5a/C5aR1/C5aR2 or C5L2 axis in immune homeostasis. …”
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Angiotensinogen and C3 compete for renin-induced complement activation by Ann-Charlotte Kristoffersson, Albin Sköld, Charlotte Welinder, Markus Wendler, Gabriella Kalliokoski, Zivile Bekassy, Diana Karpman

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Association of Proliferative Diabetic Retinopathy in the Elderly with the Blood Complement System by O. L. Fabrikantov, N. M. Agarkov, I. V. Lev, T. S. Gurko, S. I. Nikolashin

“…The highest value of the relative risk among the studied components is inherent in the C3a component of the blood complement with a reliable confidence interval of 4,451–5,103. …”
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Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina. by Matt Rutar, Krisztina Valter, Riccardo Natoli, Jan M Provis

“…We aimed to investigate the expression and localization of C3, a crucial component of the complement system, in the retina during the course of aging.…”
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Endothelial damage and complement dysregulation in fetuses from pregnancies complicated by preeclampsia by Alex Ramos, Lina Youssef, Patricia Molina, Julia Martinez‐Sanchez, Ana Belen Moreno‐Castaño, Miquel Blasco, Blanca De Moner, Marta Tortajada, Marta Camacho, Maria Borrell, Francesca Crovetto, Marc Pino, Gines Escolar, Enric Carreras, Eduard Gratacos, Maribel Diaz‐Ricart, Marta Palomo, Fatima Crispi

“…In the ex vivo approach, soluble tumor necrosis factor‐a receptor 1 (sTNFR1), vascular cell adhesion molecule‐1 (sVCAM‐1), intercellular adhesion molecule‐1 (sICAM‐1), Von Willebrand factor (sVWF), terminal complement complex (sC5b‐9), Factor H, complement component C3a and Factor Bb were analyzed in fetal cord blood samples. …”
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Complement activation by the artificial surface of cardiopulmonary bypass is a persistent clinical problem by Joel David Bierer, Roger Stanzel, Mark Henderson, Tony El-Rabahi, John Sapp, Pantelis Andreou, Jean S. Marshall, David Conrad, David Horne

“…Sequential samples were collected during forty-five ex-vivo sanguineous prime preparations of CPB circuits coated with phosphorylcholine, as a biocompatibility technology, to characterize complement activation in this context. We observed and quantified evidence of alternative and terminal complement pathway activation indicated by dynamic concentration increases of C3a, C3b, C5a and terminal complement complex. …”
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Modified Methylation Following Electrostimulation in a Standardized Setting—Complementing a Transcriptomic Analysis by Biagio Di Pietro, Simona Villata, Anna Plaksienko, Tiziana Guarnieri, Simeone Dal Monego, Margherita Degasperi, Pietro Di Lena, Danilo Licastro, Claudia Angelini, Francesca Frascella, Lucia Napione, Christine Nardini

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Complement 3a Mediates CCN2/CTGF in Human Retinal Pigment Epithelial Cells by Kang Xiao, Zhiyan Xu, Zhengyu Chen, Qin Long, Youxin Chen

“…Background. Complement 3 (C3) is the crucial component of the complement cascade when retina was exposed to external stimulus. …”
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Clinical significance of circulating immune complexes and components of the blood complement system in viral meningitis in children by G. A. Kharchenko, O. G. Kimirilova

“…As the main target laboratory parameters, the concentration of complement components: C1inh, C4, C3a in blood plasma was determined by ELISA using the kits of reagents «ELISA-Clinh», «ELISA-C4», «ELISA-C3a». …”
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Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase. by Nicola N Lynskey, Mark Reglinski, Damien Calay, Matthew K Siggins, Justin C Mason, Marina Botto, Shiranee Sriskandan

“…The complement cascade is crucial for clearance and control of invading pathogens, and as such is a key target for pathogen mediated host modulation. …”
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Functional mass spectrometry indicates anti-protease and complement activity increase with COVID-19 severity by Douglas D. Fraser, Douglas D. Fraser, Swapan Roy, Matt Kuruc, Maritza Quintero, Logan R. Van Nynatten, Gediminas Cepinskas, Gediminas Cepinskas, Haiyan Zheng, Amenah Soherwardy, Devjit Roy

“…Evaluation of the AAT/ACT ratio and C3a/C3beta ratio indicated that COVID-19 severity is associated with both neutrophil elastase neutralization and complement activation.…”
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Acute induction of interleukin-6 and biphasic changes of serum complement C3 by carrageenan in mice by K. Tateda, T. Matsumoto, K. Yamaguchi

“…Prior to the rise in complement C3, a sharp peak of serum IL-6 was observed at 6 h after carrageenan treatment. …”
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Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm by Felipe Silva de França, Felipe Silva de França, Ricardo de Oliveira Orsi, Dayanne Carla Fernandes, Dayanne Carla Fernandes, Thyago Bispo Leonel, Thyago Bispo Leonel, Denise V. Tambourgi, Denise V. Tambourgi

“…Strikingly, NHS exposed to increasing AmV concentrations varying from 5 to 1000 µg/mL presented a high generation of C3a, C4a and C5a anaphylatoxins, and sC5b-9 complexes assembly, thus reinforcing that AmV triggers complement activation.ConclusionThese results show that AmV is a strong complement activator. …”
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The specific contributions of factor H and factor I in controlling fluid phase activation of the alternative complement pathway by Nancy A. Turner, Joel L. Moake

“…Abstract The immediate defense provided by the alternative complement pathway (AP) is under constant control by fluid phase regulators, factor H (FH) and factor I (FI), to prevent nonessential activation. …”
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