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    Pathophysiological changes in patients during hemodialysis and blood reinfusion predict potential development of hemodialysis reactions by Ákos Géza Pethő, Csaba Révész, Tamás Mészáros, Orsolya Sáfár, László Rosivall, József Domán, Gábor Szénási, Tünde Gigacz, László Dézsi

    Published 2025-12-01
    “…Based on our recent animal experiments, we hypothesize that increased pulmonary arterial pressure (PAP), and increases in thromboxane B2 (TXB2) and complement 3a (C3a) plasma concentrations will likely manifest in, or at least predict, human HDRs during HD and blood reinfusion. …”
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    MECHANISMS OF CYTOKINE STORM DEVELOPMENT IN COVID-19 AND NEW POTENTIAL TARGETS OF PHARMACOTHERAPY by V. I. Petrov, A. A. Amosov, A. S. Gerasimenko, O. V. Shatalova, A. V. Ponomareva, A. N. Akinchits, I. S. Kulakova, V. S. Gorbatenko

    Published 2021-05-01
    “…The nucleocapsid protein SARS-CoV-2 triggers the activation of the complement system through the lectin pathway. It leads to the production of anaphylatoxins C3a and C5a, which stimulate the synthesis of pro-inflammatory cytokines. …”
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    Inflammatory and Immune Proteins in Umbilical Cord Blood: Association with Hearing Screening Test Failure in Preterm Neonates by Ye Ji Shim, Byung Yoon Choi, Kyo Hoon Park, Hyunju Lee, Young Mi Jung, Yu Mi Kim

    Published 2018-01-01
    “…Umbilical cord plasma at birth was assayed for interleukin (IL)-6, complement C3a and C5a, matrix metalloproteinase (MMP)-9, macrophage colony-stimulating factor (M-CSF), and endostatin levels using ELISA kits. …”
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    C3 as a predictive and prognostic biomarker in adult hemophagocytic lymphohistiocytosis: a large cohort study in China by Xuemei Shu, Xinjie Gao, Yujun Dai, Yuxiang Wang, Yilin Liu, Dawei Wang, Tao Guo

    Published 2025-04-01
    “…Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome. Complement component 3 (C3), a central effector molecule in 3 separate complement pathways, has been linked to inflammatory diseases. …”
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    Accelerated Sarcopenia Phenotype in the DJ-1/<i>Park7</i>-Knockout Zebrafish by Kristine O. Rostad, Tobias Trognitz, Ann Kristin Frøyset, Ersilia Bifulco, Kari E. Fladmark

    Published 2024-12-01
    “…A total of 68 proteins, mainly associated with inflammation and mitochondrial function, were dysregulated in the young DJ-1-null adults, with Annexin A3, Sphingomyelin phosphodiesterase acid-like 3B, Complement C3a, and 2,4-dienoyl CoA reductase 1 being the most affected. …”
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    NPC 15669 blocks neutrophil CD18 increase and lung injury during cardiopulmonary bypass in pigs by J. M. Bator, A. M. Gillinov, K. J. Zehr, J. M. Redmond, I. C. Wilson, A. Herskowitz, J. R. Connor, R. M. Burch, D. E. Cameron

    Published 1993-01-01
    “…During cardiopulmonary bypass (CPB), neutrophils become activated due to contact with extracorporeal surfaces and binding of complement fragments C3a and C5a, leading to extravasation and subsequent tissue damage. …”
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