Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model by Jakob Appel Østergaard, Marieta Milkova Ruseva, Talat Habib Malik, Ingeborg Torp Hoffmann-Petersen, Matthew Caleb Pickering, Steffen Thiel, Troels Krarup Hansen

“…Diabetes and control groups did not differ in glomerular immunofluorescence intensity obtained by antibodies against complement factors C4, C3, and C9. However, the circulating complement activation product C3a was increased in diabetes as compared to control mice (P=0.04). …”
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Genotypic and phenotypic diversity of Lactobacillus rhamnosus clinical isolates, their comparison with strain GG and their recognition by complement system. by Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos

“…The capacity of the L. rhamnosus strains to activate serum complement was studied using immunological assays for complement factor C3a and the terminal pathway complement complex (TCC). …”
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Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury by Roxana Surugiu, Bogdan Catalin, Danut Dumbrava, Andrei Gresita, Denisa Greta Olaru, Dirk M. Hermann, Aurel Popa-Wagner

“…In the lesioned area, the dying neurons release chemotactic signals, such as fractalkine/CX3CL1, which evoke “eat-me” signals that are recognized by microglia expressing complement C3a receptor (C3aR), resulting in phagocytosis of the dying but still viable neurons, known as secondary phagocytosis. …”
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Astrocyte-derived complement C3 facilitated microglial phagocytosis of synapses in Staphylococcus aureus-associated neurocognitive deficits. by Haifang Zhang, Qiyuan Jin, Jijie Li, Jiali Wang, Mengqi Li, Qiao Yin, Qi Li, Yuwan Qi, Lingling Feng, Liang Shen, Yuan Qin, Qifei Cong

“…These results indicate that S. aureus induces synapse elimination and cognitive impairment by activating microglia and astrocytes through C3-C3aR signaling. This suggests a mechanism of complement signaling bridged crosstalk between astrocyte and microglia in the S. aureus-associated post-infectious synapse loss and cognitive dysfunction, and provide potential therapeutic targets for managing pathogen-associated brain infections.…”
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Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. by Matheswaran Kandasamy, Poon C Ying, Adrian W S Ho, Hermi R Sumatoh, Andreas Schlitzer, Timothy R Hughes, David M Kemeny, B Paul Morgan, Florent Ginhoux, Baalasubramanian Sivasankar

“…We further show that direct signaling by C3a and C5a through C3aR and C5aR respectively expressed on lung DCs is required for their efficient trafficking. …”
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Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction by T. Jadczyk, K. Baranski, M. Syzdol, E. Nabialek, W. Wanha, R. Kurzelowski, M. Z. Ratajczak, M. Kucia, B. Dolegowska, M. Niewczas, J. Zejda, W. Wojakowski

“…Acute myocardial infarction (AMI) and coronary artery bypass graft (CABG) surgery are associated with a pathogen-free inflammatory response (sterile inflammation). Complement cascade (CC) and bioactive sphingolipids (BS) are postulated to be involved in this process. …”
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Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study by Nicole Pinzon-Hoyos, Yibo Li, Monnie McGee, Nicholas P. Poolos, Nicola Marchi, Amy L. Brewster

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A novel and rapid method to purify the human complement opsonin C3b from human plasma by Jannik Sichau, Christoph Q. Schmidt

“…All complement initiation pathways converge when convertases activate C3, converting it into the anaphylatoxin C3a and the opsonin C3b, which can attach to surfaces via its freshly exposed thioester moiety. …”
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Acute exposure of perchlorate on zebrafish larvae: Neurotoxicity during development by Xiaoran Xue, Zaiqiu Zhang, Yang Yang, Lin Hu, Mingyi Zhao, Qingnan He

“…Transcriptomic analysis revealed that c3a.1, c5, fga, fgb, and fgg were upregulated in the complement and coagulation cascades, and the mRNA levels of c3a.1, dusp1, slc2a6, purba, and klf9 were found upregulated in PCR. …”
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Complement System as a Target for Therapies to Control Liver Regeneration/Damage in Acute Liver Failure Induced by Viral Hepatitis by Juliana Gil Melgaço, Carlos Eduardo Veloso, Lúcio Filgueiras Pacheco-Moreira, Claudia Lamarca Vitral, Marcelo Alves Pinto

“…Our findings displayed low levels of C3a in plasma samples with high frequency of C3a, C5a, and C5b/9 deposition in liver parenchyma. …”
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Oxidative Stress and Complement Activation in Aqueous Cells and Vitreous from Patient with Vitreoretinal Diseases: Comparison Between Diabetic ERM and PDR by Lucia Dinice, Pamela Cosimi, Graziana Esposito, Fabio Scarinci, Andrea Cacciamani, Concetta Cafiero, Luca Placentino, Guido Ripandelli, Alessandra Micera

“…In vitreous, C3a, C5b9, and MDA levels were significantly increased in dERM compared with PDR and no-dERM. …”
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Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS‐mutant Cancers by Yafang Wang, Lansong Xu, Lijun Ling, Mingyue Yao, Shangxuan Shi, Chengcheng Yu, Yingnian Li, Jie Shen, Hualiang Jiang, Chengying Xie

“…Mechanistically, CDK9 inhibition leads to compensatory activation of ERK‐MYC signaling, accompanied by the recovery of proto‐oncogenes, upregulation of immediate early genes (IEGs), stimulation of the complement C1r‐C3‐C3a cascade, and induction of tumor immunosuppression. …”
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Impact of complement C3 levels on the development of healthcare-associated infections in intensive care patients: a retrospective case-control study by Chenjuan Wang, Binhao Chen, Zhekai Ying, Mengyuan Shen, Yiling Luo, Tianchen Lin, Dandan Feng, Dongdong Yang, Zhongheng Zhang, Jiannong Wu

“…Patients were then divided into high C3 and low C3 groups based on a cut-off value of 0.455 for C3. A time-to-event plot showed that the median time to HAIs occurrence was nine days in the high C3 group and six days in the low C3 group (p = .048).Conclusions Elevated complement C3 levels may associat with a reduced incidence of HAIs in ICU patients.…”
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Normothermic Machine Perfusion Reconstitutes Porcine Kidney Tissue Metabolism But Induces an Inflammatory Response, Which Is Reduced by Complement C5 Inhibition by Eline de Boer, Eline de Boer, Marina Sokolova, Marina Sokolova, Neeltina M. Jager, Camilla Schjalm, Camilla Schjalm, Marc G. Weiss, Olav M. Liavåg, Hanno Maassen, Hanno Maassen, Harry van Goor, Ebbe Billmann Thorgersen, Ebbe Billmann Thorgersen, Kristin Pettersen, Dorte Christiansen, Judith Krey Ludviksen, Bente Jespersen, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Henri G. D. Leuvenink, Henri G. D. Leuvenink, Søren E. Pischke, Søren E. Pischke, Søren E. Pischke

“…This study aimed to assess the effect of complement inhibition on NMP induced inflammatory responses. …”
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Applying the Cognitive Walkthrough for Implementation Strategies methodology to inform the redesign of a selection-quality implementation toolkit for use in schools by Kelsey S. Dickson, Olivia G. Michael, Amy Drahota, Aksheya Sridhar, Jessica E. Tschida, Jill Locke

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Sequential Increase in Complement Factor I, iC3b, and Cells Expressing CD11b or CD14 in Cutaneous Vasculitis by Dina Rahkola, Tiina Lipitsä, Hanna Siiskonen, Anita Naukkarinen, Ilkka T. Harvima

“…Mast cells contribute to the pathogenesis of cutaneous vasculitis through complement C3 that is cleaved to C3b and then to iC3b by complement factor I. …”
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THE KPI IMPLEMENTATION AND THE RESULTS OF ITS USE IN RUSSIA by Ilya I. Rodin

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Using Implementation Science to Evaluate the Implementation of Patient-Reported Outcome Measures (PROMs) in a Clinical Heart Failure Care Setting by Sarah V.C. Lawrason, MSc, PhD, Heather Ross, MSc, MD, Michael McDonald, MD, Juan Duero Posada, MD, Samantha Engbers, BAH, Anne Simard, MHSc

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Integration and evaluation of implementation strategies to improve guideline-concordant bladder cancer surveillance: a prospective observational study by Lisa Zubkoff, A. Aziz Ould Ismail, Laura Jensen, David A. Haggstrom, Soham Kale, Muta M. Issa, Jeffrey J. Tosoian, Mohummad Minhaj Siddiqui, Kennedi Bloomquist, Elisabeth R. Kimball, Susan Zickmund, Florian R. Schroeck

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An anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–l... by Xinxing Li, Wenxin Ding, Yan Lu, Haiyan Zhu, Weilian Bao, Yang Liu, Jiaren Lyu, Lishuang Zhou, Hong Li, Jiyang Li, Daofeng Chen

“…Mechanistically, HCPM inhibited the overactivation of the intestinal complement (C3a and C5a) and suppressed the activation of the NLR family pyrin domain-containing 3 (NLRP3) pathway, which contributes to the regulation of the Treg/Th17 cell balance in the gut–lung axis. …”
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