C-reactive protein: the nexus between inflammation and protein misfolding diseases by Abhishek Roy, Abhishek Roy, Johannes Zeller, Johannes Zeller, Tracy L. Nero, Tracy L. Nero, Tracy L. Nero, Johanna Klepetko, Steffen U. Eisenhardt, Michael W. Parker, Michael W. Parker, Michael W. Parker, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter

“…Upon interaction with activated cell membranes, pCRP undergoes a transitional conformation change into activated pCRP (pCRP*) and subsequently fully dissociates into its monomeric subunits (mCRP). pCRP* and mCRP interact with C1q and thereby activate the classical complement system pathway and both exert pro-inflammatory effects on platelets and endothelial cells. …”
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De Novo Donor-Specific HLA Antibodies Developing Early or Late after Transplant Are Associated with the Same Risk of Graft Damage and Loss in Nonsensitized Kidney Recipients by Michela Cioni, Arcangelo Nocera, Annalisa Innocente, Augusto Tagliamacco, Antonella Trivelli, Sabrina Basso, Giuseppe Quartuccio, Iris Fontana, Alberto Magnasco, Francesca Drago, Antonella Gurrado, Ilaria Guido, Francesca Compagno, Giacomo Garibotto, Catherine Klersy, Enrico Verrina, Gian Marco Ghiggeri, Massimo Cardillo, Patrizia Comoli, Fabrizio Ginevri

“…The two groups were comparable when considering patient- and transplant-related factors, as well as DSA biological properties, including C1q and C3d complement-binding ability. Only recipient age at transplant significantly differed in the two cohorts, with younger patients showing earlier dnDSA development. …”
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Urticarial hypocomplementemic vasculitis syndrome and systemic lupus erythematosus: a case report and review of the literature by Yasmina Ouerdani, Tayssir Ben Achour, Tayssir Ben Achour, Ahlem Ben Hmid, Ahlem Ben Hmid, Ahlem Ben Hmid, Fatma Said, Fatma Said, Imen Ayadi, Imen Ayadi, Alia Zehani Kassar, Alia Zehani Kassar, Maysam Jridi, Maysam Jridi, Imed Ben Ghorbel, Imed Ben Ghorbel, Ines Naceur, Ines Naceur, Samar Samoud, Samar Samoud, Yousr Galai, Lilia Laadhar, Lilia Laadhar, Slim Haouet, Slim Haouet, Maryam Kallel Sellami, Maryam Kallel Sellami, Monia Smiti, Monia Smiti, Imen Zamali, Imen Zamali, Imen Zamali, Mélika Ben Ahmed, Mélika Ben Ahmed, Mélika Ben Ahmed

“…The diagnosis of SLE was established according to the 2019 European League Against Rheumatism (EULAR) criteria, based on the combination of inflammatory polyarthralgia, lymphopenia, a high titer of anti-nuclear antibodies, specific anti-Sm and anti-DNA antibodies, and consumption of C3 and C4 complement fractions. The diagnosis of HUV was made based on the presence of two major criteria: chronic urticaria and hypocomplementemia, along with four minor criteria: leukocytoclastic vasculitis, recurrent abdominal pain, episcleritis, and the presence of anti- C1q antibodies.ConclusionHUV and SLE share key clinical, immunological, and pathophysiological features, suggesting that they may lie along the same spectrum of autoimmune diseases. …”
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