Astrocyte-derived complement C3 facilitated microglial phagocytosis of synapses in Staphylococcus aureus-associated neurocognitive deficits. by Haifang Zhang, Qiyuan Jin, Jijie Li, Jiali Wang, Mengqi Li, Qiao Yin, Qi Li, Yuwan Qi, Lingling Feng, Liang Shen, Yuan Qin, Qifei Cong

“…Our findings indicate that the complement C1q and C3 are upregulated, and astroglial release of C3 activates microglia to phagocytose synapses. …”
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Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study by Nicole Pinzon-Hoyos, Yibo Li, Monnie McGee, Nicholas P. Poolos, Nicola Marchi, Amy L. Brewster

“…We identified DRE-associated complement decreases, including reduced levels of C1q, Factor H, C4, C4b, C3, and C3b/iC3b, as well as elevated bFGF. …”
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Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment by Guo T, Zhao Y, Liang S, Wang J, Liu H, Zhou Y, Xu H, Chen Z

“…The concentrations of 13 complement proteins and vascular endothelial growth factor A (VEGF-A) were measured using Luminex® × MAP® technology.Results: During ranibizumab treatment, a reduction in the levels of C1q (p < 0.001), C2 (p = 0.030), C4 (p = 0.001), C4b (p = 0.026), C3b/iC3b (p < 0.001), C5 (p = 0.007), C5a (p = 0.005), CFD (p = 0.022), CFH (p < 0.001), and CFI (p < 0.001) in AH was observed. …”
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Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa by Jillian Eisenhauer, Jillian Eisenhauer, Spencer Dublin, Jihae Choi, Abigail R. Trachtman, Jacqueline D. Chu, David Custodio-Zegarra, Suman Bharti, Bhavya Bhardwaj, Shuangyi Bai, William T. Witt, Maria de la Paz Gutierrez, Sarah J. Miller, Kaitlyn Flowers, Trevor R. F. Smith, Bronwyn M. Gunn, Mariette Barbier, Elizabeth M. Parzych, David B. Weiner, Ami Patel

“…Here, we show that modification of DMAb-V2L2-MD with an Fc-point mutation designed to enhance complement engagement demonstrates improved binding to C1q, C3 deposition, and improved opsonophagocytic killing. …”
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Astragalin-functionalized ultrasmall nanoparticles modulate the complement pathway to inhibit microglial synaptic phagocytosis for reducing anesthetic neurotoxicity by Gang Wang, Yaobao Han, Ke Peng, Zhilin Jiang, Tingting Wang, Qing Zheng, Wenting Li, Hanbing Xu, Fuhai Ji, Zhen Li

“…Furthermore, CSPA NPs decrease complement C1q and C3 levels, inhibiting microglial synaptic engulfment and ameliorating cognition dysfunction in sevoflurane-treated mice. …”
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Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies by Yang Yang, Ying Zhang, Yuan Li, Xinjin Zhou, Kazuho Honda, Dedong Kang, Muxi Wang, Jing-Hua Yang, Zongping Xia, Yuan Wei, Lu Liu, Ruimin Hu, Takashi Takaki, Guolan Xing

“…The glomerular abundances of three proteins related to classical pathway (CP) (C1q, C1r, C1s), five proteins related to alternative pathway (AP) (CFB, CFH, CFHR1, CFHR3, CFHR5), one common protein related to CP and lectin pathway (LP) (C4), and six proteins related to terminal complement pathway (C3, C5, C6, C7, C8, C9) were significantly increased in DKD. …”
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<i>Echinococcus multilocularis</i> Calreticulin Inhibits Lectin Pathway of Complement Activation by Directly Binding to Mannose-Binding Lectin by Yuxiao Shao, Meng Xia, Yinghui Song, Yan Yan, Xiaofang Dong, Haoran Zong, Bin Zhan, Yanhai Wang, Limei Zhao

“…Combining with its role in inhibiting C1q-initiated classical complement activation in our previous study, the inhibition of MBL-mannose-initiated lectin pathway identified in this study suggests <i>Em</i>CRT plays an important role in the immune evasion of <i>E. multilocularis</i> alveolar larvae against host complement attack as a survival strategy within human tissue. …”
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Crosstalk between miRNAs, high mobility group box-1 and complement system in epilepsy: relevance of response to valproic acid by Dalia Kamal Mostafa, Dina Elsayed Gaber, Passanite S. Hassaan, Fatma I. Dwedar, Abeer E. Dief, Mona Hassan Fathelbab

“…The serum level of the complement system C1q and C3 components was significantly elevated in epileptic patients. …”
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Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria. by Patience B Tetteh-Quarcoo, Christoph Q Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn D T Mertens, Arthur Rowe, John P Atkinson, Alan F Cowman, J Alexandra Rowe, Paul N Barlow

“…Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected erythrocytes. …”
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The relationship between serum CTRP-5, C3a/desArg, and complement-C3 levels and hypothyroidism in women with polycystic ovary syndrome by Fatima Abdul-ameer, Itlal Jummha AbudlRasool AlAsadi, Asieh Hosseini, Elham Bahreini

“…There is a notable similarity in energy metabolism among PCOS, C1q/tumor necrosis factor (TNF)-related proteins (CTRP-5)deficiency, C3a/desArg (also known as acylation-stimulating protein (ASP)) deficiency, and hypothyroidism. …”
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The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia. by Omar Sharif, Riem Gawish, Joanna M Warszawska, Rui Martins, Karin Lakovits, Anastasiya Hladik, Bianca Doninger, Julia Brunner, Ana Korosec, Roland E Schwarzenbacher, Tiina Berg, Robert Kralovics, Jacques Colinge, Ildiko Mesteri, Susan Gilfillan, Andrea Salmaggi, Admar Verschoor, Marco Colonna, Sylvia Knapp

“…Mechanistically, we detected that in the absence of TREM-2, pulmonary macrophages selectively produced elevated complement component 1q (C1q) levels. We found that these increased C1q levels depended on peroxisome proliferator-activated receptor-δ (PPAR-δ) activity and were responsible for the enhanced phagocytosis of bacteria. …”
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Genetic markers involved in neuroinflammation in Down syndrome: a systematic review by Marina Nascimento Silva, Mariana Dias Lula, Lucas Reis Felício, Bárbara Santos, Lívia Silva Nassif, Marcus Carvalho Borin, Juliana Alvares-Teodoro, Francisco de Assis Acurcio, Augusto Afonso Guerra Júnior

“…Additionally, elevated levels of pro-inflammatory cytokines, such as IL–1, IL–6, IL–10, IFNγ, and TNF-α, and complement proteins like C1q, C3, and C9 suggest an exacerbated activation of the immune response. …”
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Five autoantibodies identified from immune complexes as breast cancer biomarkers by Ningwei Zheng, Yueqi Li, Zhengke Peng, Yaolin Tang, Zhiqiang Liang, Hong Wang, Hong Dai, Gongjun Tan

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Improvement in the definition of anti-HLA antibody profile in highly sensitized patients. by Juan Irure, Esther Asensio, Emilio Rodrigo, Íñigo Romón, Javier Gómez, Manuel Arias, Marcos López-Hoyos, David San Segundo

“…Here we propose different levels of risk based on the results of anti-HLA antibody testing in neat serum (N) and after sera dilution (DIL) and C1q test in 18 highly sensitized patients. This group was heterogeneous in terms of anti-HLA antibody titers and their ability to fix complement. …”
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Systematic analysis of Fc mutations designed to enhance binding to Fc-gamma receptors by Geoff Hale, Alastair Douglas Davy, Ian Wilkinson

“…A critical attribute of therapeutic antibodies is their ability to engage with humoral or cellular effector mechanisms, and this depends on the ability of the Fc region to bind to complement (C1q) or Fc receptors. Investigators have sought to optimize these effects by engineering the Fc region to bind to a greater or lesser extent to individual receptors. …”
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Measuring plasma C4D to monitor immune complexes in lupus nephritis by Tineke Kraaij, Sara C. Nilsson, Cees van Kooten, Marcin Okrój, Anna M Blom, YK Onno Teng

“…Additionally, changes in C4d:C4 over time correlated strongly with changes in proteinuria (R=0.59, p&lt;0.001) as well as anti-dsDNA (R=0.46, p=0.003) and anti-C1q (R=0.47, p=0.002).Conclusion In patients with severe SLE, plasma C4d levels in relation to C4 levels is useful for longitudinal monitoring after RTX+BLM treatment to reflect amelioration of classical complement activation by ICx as well as proteinuria.…”
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The correlation of neutrophil to lymphocyte ratio with proportional crescent purpura nephritis by YU Ya, YANG Ding-ping, Yang Hong-xia, LI Xiao-li

“…Furthermore, the differences of hs-CRP between group C0 and group C1/C2(P<0.05), IgA between group C0 and group C1(P<0.05), complement C1 q between group C1 and group C2(P<0.05), complement C3 between group C1 and group C0/C2(P<0.05), BUN and Alb levels between group C2 and group C0/C1(P<0.05) were all statistically significant. …”
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Age-Related Macular Degeneration in the Aspect of Chronic Low-Grade Inflammation (Pathophysiological ParaInflammation) by Małgorzata Nita, Andrzej Grzybowski, Francisco J. Ascaso, Valentín Huerva

“…The complement system, mainly alternative pathway, mediates chronic autologous pathophysiological parainflammation in dry and exudative AMD, especially in the Y402H gene polymorphism, which causes hypofunction/lack of the protective complement factor H (CFH) and facilitates chronic inflammation mediated by C-reactive protein (CRP). …”
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Clinicopathological Characteristics and Outcomes of Chinese Patients with Scanty Immune Deposits Lupus Nephritis: A Large Cohort Study from a Single Center by Qiuyu Li, Di Song, Fengmei Wang, Ying Tan, Feng Yu, Minghui Zhao

“…As for comparisons of plasma complement components, there were significantly higher levels of C1q (P=0.005) and Bb (P=0.02) and lower level of factor H (P=0.003) in scanty immune deposits group. …”
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Low-density lipoprotein apheresis shows a rapid response to proteinuria due to C3 glomerulonephritis: a case report and literature review by Hideki Matsumura, Yuko Fujii, Tomoko Tanaka, Maki Kagitani, Akira Ashida

“…Genetic testing identified a rare complement B factor mutation linked to complement pathway dysregulation. …”
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