Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands by Jessica A. Greven, Joshua R. Wydra, Rory A. Greer, Cynthia Zhi, David A. Price, Jordyn D. Svoboda, Christopher L. M. Camitta, Mya Washington, Daisy W. Leung, Yuhua Song, Jen Alexander-Brett, Tom J. Brett

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Association of Plasma C1q/TNF-Related Protein 3 (CTRP3) in Patients with Atrial Fibrillation by Liwen Chen, Shuwang Liu, Wei Xu, Yuan Zhang, Jin Bai, Lei Li, Ming Cui, Lijie Sun

“…Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia characterized by atrial remodeling. Complement C1q tumor necrosis factor-related protein 3 (CTRP3) is one of the adipokines associated with obesity, diabetes, and coronary heart disease. …”
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Significance of autoantibodies in diagnostics of systemic vasculitis by Katarzyna Fischer, Marek Brzosko

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Idebenone Mitigates Traumatic-Brain-Injury-Triggered Gene Expression Changes to Ephrin-A and Dopamine Signaling Pathways While Increasing Microglial Genes by Hyehyun Hwang, Chinmoy Sarkar, Boris Piskoun, Naibo Zhang, Apurva Borcar, Courtney L. Robertson, Marta M. Lipinski, Nagendra Yadava, Molly J. Goodfellow, Brian M. Polster

“…Gene co-expression analysis correlated levels of microglial complement component 1q (<i>C1q</i>) and the neurotrophin receptor gene <i>Ntrk1</i> to large (>3-fold) TBI-induced decreases in dopamine receptor genes <i>Drd1</i> and <i>Drd2</i> that were mitigated by idebenone treatment. …”
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Clinical and immunological biomarkers can identify proliferative changes and predict renal flares in lupus nephritis by Marta Calatroni, Emanuele Conte, Matteo Stella, Federica De Liso, Francesco Reggiani, Gabriella Moroni

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Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes? by James C. Cicciarelli, Nathan A. Lemp, Youngil Chang, Michael Koss, Katrin Hacke, Noriyuki Kasahara, Kevin M. Burns, David I. Min, Robert Naraghi, Tariq Shah

“…Among the patients with C4d+ biopsies, 100% had IgG DSA, 70% had C1q+ DSA, and 83% had complement fixing IgG subclass antibodies. …”
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Predictive Potential of CRTP5 and SII for Coronary Artery Severity and Myocardial Fibrosis in Patients with NSTE-ACS: An Exploratory Biomarker Study by Ji J, Qiao M, Ding Y, Wei X, Wan D, Wu L, Liu H

Subjects: “…Complement C1q tumor necrosis factor-related protein 5…”
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Rheumatoid Factor, Complement, and Mixed Cryoglobulinemia by Peter D. Gorevic

“…Low serum level of complement component 4 (C4) that occurs in mixed cryoglobulinemia (MC) may be due to in vivo or ex vivo activation of complement by the classical pathway. …”
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Complement levels and their diagnostic utility in neonatal sepsis by Fuqiang Diao, Feng Zhong, Lingling Tang, Chunming Gu, Junfei Guo, Lihong Wu, Weixiang Wu, Mingyong Luo

“…Cases included neonates with culture-positive or clinically diagnosed sepsis, while controls consisted of neonates hospitalized for non-septic conditions, confirmed by negative blood cultures. Ten complement components (C1q, C3, C3c, C3b, C4, C5, C5a, H, B, mannose-binding lectin [MBL]) were quantified using residual specimens from routine clinical tests. …”
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The role of complement C3 deposition in ANCA-associated glomerulonephritis: a registry-based study of clinical, histopathological, and prognostic insights by Sami Uzun, Ebru Gok Oguz, Abdülmecit Yıldız, Ulver Derici, Emre Cankaya, Gulizar Sahin, Erhan Tatar, Garip Şahin, Mevlüt Tamer Dinçer, Necmi Eren, Kenan Turgutalp, Taner Baştürk, Melike Betül Öğütmen, Mehmet Tanrısev, Sim Kutlay, Murvet Yilmaz, Meltem Gürsu, Zülfükar Yılmaz, Zeki Toprak, Onur Tunca, Şebnem Karakan, Ece Ük, Belda Dursun, Mahmud İslam, Dilek Torun, Cuma Bulent Gul, Bulent Kaya, Bülent Altun, Abdulkadir Çelik, İdris Şahin, Serap Yadigar, Dilek Gibyeli Genek, Mehmet Deniz Ayli, Saide Elif Güllülü Boz, Omer Faruk Akcay, Meryem Keleş, Savaş Öztürk

“…Recent evidence indicates that complement activation, marked by C3 deposition in glomeruli, may contribute to more severe renal injury and influence renal outcomes. …”
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Complement activation in wasp venom-induced acute kidney injury by Rui Cheng, Liang Xu, Jianhua Gong, Fanglin Yu, Ying Lv, Hai Yuan, Fengqi Hu

“…The expression levels of renal complement 3 (C3), complement 5 (C5), complement 1q (C1q), factor B (FB), mannose-binding lectin (MBL), and C5b-9 in AKI group were upregulated compared with the control group. …”
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Nanobody‐mediated complement activation to kill HIV‐infected cells by Maria Lange Pedersen, Dennis Vestergaard Pedersen, Mikael Becher Lykkegaard Winkler, Heidi Gytz Olesen, Ole Schmeltz Søgaard, Lars Østergaard, Nick Stub Laursen, Anna Halling Folkmar Rahimic, Martin Tolstrup

“…This bispecific complement engager (BiCE) is comprised of a nanobody recruiting the complement‐initiating protein C1q, and single‐chain variable fragments of broadly neutralizing antibodies (bNAbs) targeting the HIV‐1 envelope (Env) protein. …”
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Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis by Lingliang Zhang, Lingling Huang, Yuhang Zhou, Jian Meng, Liang Zhang, Yunqiang Zhou, Naizhen Zheng, Tiantian Guo, Shanshan Zhao, Zijie Wang, Yuanhui Huo, Yingjun Zhao, Xiao-fen Chen, Honghua Zheng, David M. Holtzman, Yun-wu Zhang

“…In addition, we find that CD2AP expression is positively correlated with the expression of the complement C1q that is important for synapse phagocytosis and the formation of DAM in response to Aβ deposition. …”
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Complement pathway: Risk molecular pattern of cardiovascular diseases in patients with diabetic nephropathy by Liu JunFei, Qian XiaoPing, Wang TaoXia, Liu XiaoLi, Liu WeiGang, Wang LiJie, Zhang HuiFang, Han Li, Li GuiYing, Yu XiaoJuan

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Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury by Sofie Vandendriessche, Matheus Silvério Mattos, Emilia Laura Bialek, Sara Schuermans, Paul Proost, Pedro Elias Marques

“…Using human neutrophils, we showed that absence of C3 or C1q caused a reduction in the volume of necrotic debris that is phagocytosed, indicating that complement promotes effective debris uptake in mice and humans. …”
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Profile of antiphospholipid antibodies and complement system in COVID-19 patients of different severity by N. V. Dolgushina, I. V. Menzhinskaya, O. S. Beznoshchenko, S. M. Mullabayeva, E. A. Gorodnova, L. V. Krechetova

“…IgM and IgG antibodies to cardiolipin (CL), phosphatidylserine (PS), β2-glycoprotein-I (β2-GP-I), prothrombin (PT), annexin V (An V), as well as C1q complement component, content of its C3 and C4 components and total complement activity were determined in blood serum using ELISA approach. 141 patients with COVID-19 were included in the study. …”
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A bioinformatics-driven approach to identify biomarkers and elucidate the pathogenesis of type 2 diabetes concurrent with pulmonary tuberculosis by Yan Liu, Yonglan Pu, Jie Wang, Zhiyong Li, Songliang Liu, Shenjie Tang

“…Compared to HCs and T2DM-only patients, PTB + 2DM patients showed upregulated expression of complement component C1q. WGCNA identified five crucial genes associated with PTB + T2DM: C1QA, CD248, LINC00278, MMP8, and MMP9. …”
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PepO and CppA modulate Streptococcus sanguinis susceptibility to complement immunity and virulence by Lívia A. Alves, Hassan Naveed, Eduardo M. Franco, Maíra Terra Garcia, Victor A. Freitas, Juliana C. Junqueira, Débora C. Bastos, Thaís L. S. Araujo, Tsute Chen, Renata O. Mattos-Graner

“…These mutants differ, however, in their profiles of binding to serum amyloid P component (SAP) and C1q, whereas both showed reduced interaction with C4b-binding protein (C4BP) and/or factor H (FH) regulators as compared to SK36. …”
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Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease by Celia Luchena, Jone Zuazo-Ibarra, Elena Alberdi, Carlos Matute, Estibaliz Capetillo-Zarate

“…This review is aimed at comprehensively reporting the source and/or cellular localization in the CNS—in microglia, astrocytes, or neurons—of the triggering components (C1q, C3) of the classical complement pathway involved in synapse pruning in development, adulthood, and AD.…”
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Gut microbial dysbiosis activates the classical complement pathway in a short-term morphine treatment model by Nicolas Vitari, Richa Jalodia, Junyi Tao, Udhghatri Kolli, Salma Singh, Lily V. Rodriguez, Umakant Sharma, Sabita Roy

“…Within 24 h, morphine treatment upregulates the expression of classical complement pathway genes in intestinal tissue, with a concurrent increase in the complement proteins C1q and C3 in the ileal luminal content. …”
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