Tumor-intrinsic TTLL12 drives resistance to cancer immunotherapy via modulating myeloid-derived suppressor cells by Chong Chen, Xin-xin Huang, Ping Lan, Dong-Wen Chen, Yi-Kan Cheng, Pei-Si Li, Xiao-Jian Wu, Jia-Hui Long, Zhizhong Xiong, Shu-Biao Ye

“…The gain-of-function or loss-of-function approaches were then implemented in vitro and in vivo, followed by flow cytometry to quantify immune cell population frequency. …”
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Implications of No Tail Docking on Performance, Health, and Behavior of Pigs Raised Under Commercial Conditions in Brazil by Juliana Cristina Rego Ribas, Joseph Kaled Grajales-Cedeño, Isadora Gianeis, Vivian S. Sobral, Mateus José Rodrigues Paranhos da Costa

“…Productivity performance was not affected (<i>p</i> > 0.05), and new cases of tail biting ceased after the contingency plan was implemented. The number of animals that died or were removed did not differ between the treatments (<i>p</i> > 0.05). …”
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Adolescent Youth Survey on HIV Prevention and Sexual Health Education in Alabama: Protocol for a Web-Based Survey With Fraud Protection Study by Henna Budhwani, Ibrahim Yigit, Josh Bruce, Christyenne Lily Bond, Andrea Johnson

“…A 7-step fraud and bot detection protocol was implemented and applied to web-based recruitment to reduce the likelihood of collecting false information. …”
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One size doesn’t fit all: regional dynamics in pediatric emergency visits during the SARS-CoV-2 pandemic by Michelle Seiler, Gregory Biland, Oliver Gruebner, Oliver Gruebner, Sergio Manzano, Gianluca Gualco, Marc Sidler, Ursula Laasner, Julia Dratva, Julia Dratva, Michael von Rhein

“…Background and aimsThe Swiss government implemented lockdown measures during the COVID-19 pandemic to contain outbreaks and prevent healthcare system overload. …”
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Ageing well in the urban environment: meeting the health and social needs of older Adults - study protocol for a prospective, longitudinal mixed-methods study by Marie Bolster, Abhijit Visaria, David Matchar, Denis Gerstorf, Tillman Schmitz, Benjamin Labohm, Raphael Kohl, Dagmar Haase, Paul Gellert, Angelique Chan, Wolfram J. Herrmann

“…Minor adaptations of the instruments and methods were implemented to best suit local context, administrative regulations, and feasibility at the study site. …”
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Sistem Pakar Penentuan Penggunaan Bahan Tambahan Pangan untuk Produk Pangan by Melva Linda Aritonang, Kudang Boro Seminar, Nugraha Edhi Suyatma, Irman Hermadi

“…The last result of this research is the implementation of the system in the form of a website by providing a solution in the form of food additives and a maximum limit value in its use.  …”
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Improvement of Technologies for Isolation and Purification of Biologically Active Substances from Plant Raw Materials by G. N. Turmanidze, V. V. Sorokin, K. S. Stepanov, M. A. Ignatenko

“…During the modernization of equipment for the implementation of new technologies, it is possible to improve its configuration, which makes it possible to significantly increase the yield of active substances at minimal cost. …”
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Virtual Primary Care for People With Opioid Use Disorder: Scoping Review of Current Strategies, Benefits, and Challenges by Shawna Narayan, Ellie Gooderham, Sarah Spencer, Rita K McCracken, Lindsay Hedden

“…We appraised the quality of the studies using the Quality Assessment With Diverse Studies tool and categorized the findings using the Consolidated Framework for Implementation Research. ResultsOur search identified 1474 studies. …”
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Electronic Sensor-Based Automated Irrigation System for Rice Cultivated Under Alternate Wetting and Drying Technique by Mukesh Kumar, Ramesh Kumar Sahni, Abhishek M. Waghaye, Manoj Kumar, Ravindra D. Randhe

“…The alternate wetting and drying (AWD) technique is one of these water-saving techniques; however, it requires continuous monitoring of water levels in the field. The implementation of real-time, electronic sensor-based precision irrigation technology may address the problems associated with conventional irrigation systems and AWD leading to high water use efficiency. …”
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Feasibility and Cost-Benefit Analysis of Methanol as a Sustainable Alternative Fuel for Ships by Pei-Chi Wu, Cherng-Yuan Lin

“…Therefore, this study adopts a cost-benefit analysis method to evaluate the feasibility and implementation benefits of two promising strategies: methanol dual fuel and very low-sulfur fuel oil (VLSFO). …”
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The Impact of Smoke Curtains on the Operation of ESFR Sprinklers in Terms of NFPA 204 and NFPA 13 Standards by Kamila Sikorska-Podyma, Aleksandra Byczyk, Jacek Podyma, Paulina Stanek, Przemysław Kubica

“…The use of smoke curtains in storage buildings equipped with ESFR sprinklers should only be implemented in strictly defined cases. In the current legal system, a designer with the authorization to perform an independent technical function in construction and a fire protection expert are fully responsible for the execution of the project in accordance with the regulations, principles of technical knowledge and fire protection requirements. …”
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Leveraging artificial intelligence for photo identification to aid CITES enforcement in combating illegal trade of the endangered humphead wrasse (Cheilinus undulatus) by C. Y. Hau, W. K. Ngan, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson

“…A Licence to Possess system for CITES is implemented in the city to regulate the quota of live wild-sourced CITES specimens, including humphead wrasse, held at each registered trading premise and ensure traceability through documentation. …”
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Perceptions and Experiences of Self-Management in Patients with Prediabetes: A Qualitative Study in China by Jiang J, Feng Q, Yan L, Guo Y, Yang Q

“…Key recommendations include: (1) Healthcare providers’ perceptions and attitudes toward prediabetes significantly influence patient engagement, necessitating standardized diagnostic and treatment protocols that emphasize disease progression risks during initial diagnosis to enhance clinical awareness; (2) Implementation of motivational interviewing (MI) techniques could effectively strengthen patients’ intrinsic motivation for behavioral modification; (3) Multidimensional support systems should be established through AI-powered medical question-answering systems, standardized nutritional labeling regulations, family-involved health education programs, and peer-led “health coach” initiatives. …”
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SELF-EDUCATION AS A PEDAGOGICAL PROBLEM by Oleksandr L. Shums’kyi, Ol’ha O. Shums’ka

“…It has been proved that the student’s self-educational activity, in contrast to independent activity, goes beyond external goal-setting and control and is implemented in a completely autonomous mode both during training at university and after graduation. …”
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Dysregulated ac4C modification of mRNA in a mouse model of early-stage Alzheimer’s disease by Hao-Nan Ji, Hai-Qian Zhou, Jing-Bo Qie, Wen-Mei Lu, Hai-Tao Gao, Dan-Hong Wu

“…Abstract Background The identification and intervention of Alzheimer’s Disease (AD) in its early-stage allows for the timely implementation of lifestyle modifications and therapeutic strategies. …”
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MicroRNA‐378a‐3p contributes to ovarian cancer progression through downregulating PDIA4 by Yao Chanjiao, Chen Chunyan, Qiu Xiaoxin, Han Youjian

“…Luciferase activity and RIPA assays were implemented to validate the interaction between miR‐378a‐3p and PDIA4. …”
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Current status and prospect of diagnosis and treatment of bone metastasis of thyroid cancer by ZHAO Yihan, LI Ruochen, LIN Yansong

“…Currently, existing clinical guidelines at home and abroad have not yet provided comprehensive management recommendations and precise diagnostic and treatment strategies for bone metastasis in thyroid cancer, making it imperative to promote the implementation of systematic and personalized diagnostic and treatment plans. …”
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THE VALUE OF COMPETENCE-BASED APPROACH IN THE PREPARATION OF DENTAL HYGIENISTS by V.M. Kosenko

“…Prospects for further research The implementation of competency-based approach to life requires close cooperation between educators, students and potential employers. …”
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New mutation of the TP53 gene associated with the hereditary breast cancer in a young Tuvinian woman by P. A. Gervas, A. Yu. Molokov, A. A. Zarubin, A. A. Ponomareva, N. N. Babyshkina, V. A. Belyavskaya, L. F. Pisareva, E. L. Choynzonov, N. V. Cherdyntseva

“…We reclassified the mutation of the unknown significance using the activedrivedb database that assessed the effect of mutations on sites of post-translational modifications, and the proteinpaint tool that complemented the existing cancer genome portals and provided a comprehensive and intuitive view of cancer genomic data. …”
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UNC-10/SYD-2 links kinesin-3 to RAB-3-containing vesicles in the absence of the motor's PH domain by Odvogmed Bayansan, Prerana Bhan, Chien-Yu Chang, Syed Nooruzuha Barmaver, Che-Piao Shen, Oliver Ingvar Wagner

“…However, co-immunoprecipitation and bimolecular fluorescence complementation (BiFC) assays reveal functional interactions between UNC-104, SYD-2, UNC-10 and RAB-3. …”
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