Review of Post-registration Changes in the Life Cycle of Сholera Bivalent Chemical Vaccine (Review) by I. V. Shulgina, O. A. Lobovikova, O. A. Voloh, O. V. Gromova, A. K. Nikiforov, A. V. Komissarov, V. A. Demchenko, A. S. Fes’kova, S. S. Galetova, N. P. Mironova, V. I. Pavlova

“…At the same time harmonization of documents of the registration dossier with novelties of the Russian legislation is a necessary condition for implementation of production activity within the legal field.…”
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Ecological reef restoration: consumptive and nonconsumptive interactions among common North Sea predators and European oysters by Julius A. Ellrich, Clemens Kozian-Fleck, Markus Brand, Bérenger Colsoul, Bérenger Colsoul, Bernadette Pogoda, Bernadette Pogoda

“…To halt and reverse the associated biodiversity loss, oyster reef restoration was implemented into marine conservation measures and several reef restoration projects started across Europe. …”
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Model-based multi-year P flow analyses and strategies for sustainable food chain management in Changzhou city at China's Taihu Basin by Zheng Guo, Zheng Guo, Yunwei Xu, Sophia Shuang Chen, Sophia Shuang Chen, Giri Raj Kattel, Giri Raj Kattel, Giri Raj Kattel

“…Leveraging the self-management and replicability of cities, this framework can be easily implemented in other regions and has the potential to be scaled up nationally, aiming to mitigate P loss and enhance P utilization efficiency.…”
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Process Analytical Strategies for Size Monitoring: Offline, At-Line, Online, and Inline Methods in a Top-Down Nano-Manufacturing Line by Christina Glader, Ramona Jeitler, Yan Wang, Remy van Tuijn, Albert Grau-Carbonell, Carolin Tetyczka, Steve Mesite, Philippe Caisse, Johannes Khinast, Eva Roblegg

“…To ensure reliable implementation, key factors such as sample dilution, viscosity, focus position, measurement angle and temperature effects were systematically assessed for offline and at-line DLS using the Litesizer 500, as well as for offline, inline, and online SR-DLS using the NFS. …”
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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

“…The CONSORT-DEFINE statement introduced 21 new items and modified 19 existing CONSORT items.This CONSORT-DEFINE Explanation and Elaboration (E&E) document provides important information to enhance understanding and facilitate the implementation of the CONSORT-DEFINE checklist. For each new or modified checklist item, we provide a detailed description and its rationale with supporting evidence, and present examples from EPDF trial reports published in peer-reviewed scientific journals. …”
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Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondria... by Junyan Wang, Haowen Zhuang, Chun Li, Ruiqi Cai, Hongshuo Shi, Boxian Pang, Zhijiang Guo, Sang-Bing Ong, Yifeng Nie, Yingzhen Du, Hao Zhou, Xing Chang

“…The mechanism of LIG was validated by molecular biology and integrated pharmacology with the implementation of the LIG nano-drug loading method. Results LIG nano-delivery enhanced DOX-induced cardiac dysfunction and mitochondrial impairment by modulating the PHB2Ser91/Ser176 phosphorylation axis through PIEZO1-TMBIM6, and significantly suppressed cardiomyocyte pyroptosis resulting from mitochondrial homeostasis dysregulation. …”
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Effect of HPV integration on prognosis of young women with CIN2 in China: protocol for a multicentre prospective cohort study by Yan Zhang, Huachun Zou, Wei Zhang, Xiaoyuan Huang, Yuan Ren, Ting Hu, Wenyu Lin, Pengming Sun, Kelvin Stefan Osafo, Binhua Dong, Yuhang Zhang, Xiaowen Pu, Xunyuan Tuo, Qiongying Lyu, Wenrong Huang, Huifeng Xue, Shuxia Xu, Jue Su

“…This study examines HPV integration status as a prognostic biomarker in women aged 18–45 diagnosed with CIN2, with the objective of developing a predictive tool for personalised therapeutic strategies and minimising overtreatment in this high-regression population.Method and analysis This multicentre cohort study will be implemented across 20 tertiary Grade A hospitals in China, encompassing eastern, western, central and northern regions. …”
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Comparative analysis of lithium-iron-phosphate and sodium-ion energy storage devices by Huthaifa A. Al_Issa, Mohamed Qawaqzeh, Lina Hani Hussienat, Ruslan Oksenych, Oleksandr Miroshnyk, Oleksandr Moroz, Iryna Trunova, Volodymyr Paziy, Serhii Halko, Taras Shchur

“…Also, their economic feasibility and prospects for implementation in commercial and domestic applications will be assessed. …”
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Wearable Arduino-Based Electronic Interactive Tattoo: A New Type of High-Tech Humanized Emotional Expression for Electronic Skin by Chuanwen Luo, Yan Zhang, Juan Zhang, Linyuan Hui, Ruisi Qi, Yuxiang Han, Xiang Sun, Yifan Li, Yufei Wei, Yiwen Zhang, Haoying Sun, Ning Li, Bo Zhang

“…The study demonstrates that the proposed design philosophy and implementation strategy can be generalized to the interactive design of other wearable devices, thereby providing novel insights and methodologies for human–computer interaction, electronic devices, and sensor applications.…”
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Population Structure Dynamics of Elasmobranchs Susceptible to Shrimp Trawling Along the Southern Gulf of Mexico by Heber Zea-de la Cruz, César Meiners-Mandujano, Javier Tovar-Ávila, Lourdes Jiménez-Badillo, Jorge Luis Oviedo-Pérez

“…The impacts of bycatch on the most susceptible elasmobranchs may be mitigated through improvements in trawl fishing technology and the implementation of additional temporal bans in specific trawling areas, enhancing species-specific conservation efforts.…”
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Classification of management tools in small business organizations for developing a sales funnel by E. R. Tolstova, L. V. Silakova

“…A comparison of various services that help in the development and implementation of a marketing strategy is carried out. …”
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Antimicrobial resistance in Nigeria’s healthcare system: a comprehensive narrative review and policy implications by James Esther, Ogbonna Brian Onyebuchi, Onwuchuluba Ebele Eugenia, Ogbonna Chigozie Ann, Nwaodu Mercy Adamma, Ibeneme Georgian Chiaka, Folaranmi Omowumi, Nduka Sunday Odunke, Folaranmi Nkeiruka, Umeh Ifeoma Blessing

“…Despite launching a National Action Plan in 2017, only 45% of the activities were implemented by 2021 due to funding constraints and competing health priorities. …”
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Current scenario and potential of waste cooking oil as a feedstock for biodiesel production in Indonesia: Life cycle sustainability assessment (LCSA) review by Arif Rahman, M.A.M. Oktaufik, Triyono Widi Sasongko, Iwan Guntoro, Dadi Soedjati, Najmi Abbas, Abdul Rahman, Fathiah Ulfah, Ari Widiarto, Siswanto, Dharmawan, Sudarwaji Edi Yuwono Trihadi, Kusrestuwardani, Anggara Lomak Prihatin, Adim Hadi, Surat Indrijarso, Priyambodo Rahardjo, Arief Barkah, Irhan Febijanto, Nugroho Adi Sasongko

“…To produce high-quality biodiesel, the government must support all of these stages, establish regulations and governance for WCO supply and the WCO processing industry, and provide implementable R&D, adequate funding, and a campaign to raise awareness of the importance of reprocessing WCO into potentially profitable biodiesel in a circular economy.…”
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Online community users’ perceptions of particulate matter in South Korea through topic modeling and semantic network analysis by Hansol Choi, Yong Pyo Kim, Yungwook Kim, Ji Yi Lee, Hyemi Lee

“…For instance, although the public tends to attribute PM primarily to external factors such as pollution from China, government policies appear to emphasize internal sources, such as regulating vehicle emissions. The discrepancy was found to make the public feel dissatisfied with policy implementation. …”
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Three Decades of Land Cover Dynamics in a Boreal Coastal Basin: A Multisensor Spectral Index and Machine Learning Approach Using Landsat Data and GB-SAR Data by Jinsong Zhang, Bochi Zou, Yifei Yuan, Asad Khan, Muhammad Bilawal Junaid, Qaiser Abbas, Rana Muhammad Zulqarnain, Nazih Y. Rebouh, Olga D. Kucher, Hassan Alzahrani

“…To ensure methodological consistency and computational efficiency, a cloud-based processing workflow was implemented using the Google Earth Engine platform. …”
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Exogenous melatonin enhances Lr10-mediated resistance to Puccinia triticina by upregulating TaRAR1 and potentiating salicylic acid pathway and antioxidant defense system by Johannes Mapuranga, Lulu Song, Ruolin Li, Hao Li, Jiaying Chang, Jiaojie Zhao, Yingdan Zhang, Na Zhang, Wenxiang Yang

“…Wheat leaf rust, caused by the biotrophic fungal pathogen Puccinia triticina (Pt), continuously threatens global wheat production, causing considerable yield losses necessitating the implementation of effective management approaches. While conventional breeding and chemical control strategies have been used, priming agents and genetic regulators offer sustainable strategies for wheat leaf rust management. …”
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Identification of CCNB1 as a biomarker for cellular senescence in hepatocellular carcinoma: a bioinformatics and experimental validation study by Zhilan Zhang, Jie Zhou, Ruiru Huang, Xingxing Zhuang, Shoudong Ni

“…Ultimately, the conclusions from bioinformatics analysis were confirmed via in vitro experiments, complemented by molecular docking simulations of gene-drug interactions. …”
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Small Molecule DFPM Derivative-Activated Plant Resistance Protein Signaling in Roots Is Unaffected by EDS1 Subcellular Targeting Signal and Chemical Genetic Isolation of victr R-Pr... by Hans-Henning Kunz, Jiyoung Park, Emily Mevers, Ana V García, Samantha Highhouse, William H Gerwick, Jane E Parker, Julian I Schroeder

“…The essential nucleo-cytoplasmic regulator of TIR-NB-LRR-mediated effector-triggered immunity, EDS1, was reported to have both nuclear and cytoplasmic actions in pathogen resistance. …”
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SiCST1, a novel plant-specific protein of foxtail millet, confers cold stress tolerance in plants by Fan Yang, Jiaqi Qiao, Xiao Zhang, Zhuoya Zhang, Dongao Huo, Dongao Huo

“…This impaired cold stress tolerance was rescued by complementation with SiCST1, indicating the vital role of SiCST1 in cold stress tolerance. …”
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Fluorescence spectral characteristics of DOM and its effects on the bacterial community structure in Bosten Lake, China by Jiali Wang, Chen Li, Wei Wu, Lei Ren, Yuhe Dong

“…However, the influence of the dissolved organic matter (DOM) source composition on the bacterial community structure and diversity across various functional zones, as well as the role of the bacterial community structure in regulating DOM composition, remains unclear. In this study, we combined excitation-emission matrix (EEM) fluorescence spectroscopy with the parallel factor analysis (PARAFAC) method to investigate the characteristics and source distribution of the DOM fluorescence components in the water of Bosten Lake. …”
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