Phase IV adaptive randomised clinical trials evaluating efficacy and cost-efficacy of pre-emptive pharmacogenetic genotyping strategies in the Spanish National Health System: iPHAR... by Xandra García-González, Alberto M Borobia, Antonio J Carcas, Miriam Estébanez, Montserrat Carmona, Irene García García, Francisco Abad-Santos, Luis A López-Fernández, Esther Cubo, Iñaki Imaz-Iglesia, Alicia Marín-Candón, Miriam Saiz-Rodríguez, Irene Taladriz-Sender, Pedro Arias, Rocío Rosas-Alonso, Enrique Seco-Meseguer, Stefan Stewart, Elena Diago-Sempere, María del Mar García Saiz, Emilio J Laserna-Mendieta, Ana M Peiró, Magí Farré, Consuelo Rodriguez-Jimenez, Judith Sanabria-Cabrera, Lucia Pedrosa, Ignacio Bernardino, Javier Guiijarro-Eguinoa, Arturo Gómez López De Las Huertas, Susana Martín-López, Olga Hladun Alvaro, Vicente Arrate, Ana Fries, Daniel Rodriguez Díaz, Fernando Marqués García, Núria Alonso Pedrol, Modesto M Maestre Muñiz, Leticia Rodríguez Alcolado, Carlos Ortiz-Bautista, Angela Remesal-Doblado, María Isabel Lucena, Zaida Salmón González, Inmaculada Coca-Prieto

“…However, the adoption of pre-emptive pharmacogenetic testing for commonly prescribed drugs, such as statins, outside of tertiary hospitals is limited due to a lack of pharmacoeconomic evidence to support widespread implementation by healthcare policy-makers. The Spanish Consortium for the Implementation of Pharmacogenetics (iPHARMGx Consortium) addresses this by developing a clinical trial master protocol that will govern multiple nested adaptive clinical trials that compare genotype-guided treatments to standard care in specific drug–gene–population triads, asses their cost-efficacy and identify novel biomarkers through advanced sequencing techniques. …”
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Pemeriksaan Setempat Oleh Hakim Dalam Perkara Pidana by Andi Desmon, Rina Rahma Ornella Angelia, Rahmi Erwin

“…The discretionary authority possessed by judges in carrying out local examinations in criminal cases is facultative, meaning that it is not a priori binding and is only complementary, the implementation of which depends on the judge's judgment. …”
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Perlindungan Data Pribadi Konsumen Oleh Penyelenggara Sistem Elektronik Dalam Transaksi Digital by Rista Maharani, Andria Luhur Prakoso

“…Compliance of electronic service providers is reflected in the privacy policies and usage regulations implemented by each platform. Additionally, non-compliance with these obligations results in administrative sanctions. …”
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StomaYOLO: A Lightweight Maize Phenotypic Stomatal Cell Detector Based on Multi-Task Training by Ziqi Yang, Yiran Liao, Ziao Chen, Zhenzhen Lin, Wenyuan Huang, Yanxi Liu, Yuling Liu, Yamin Fan, Jie Xu, Lijia Xu, Jiong Mu

“….), a vital global food crop, relies on its stomatal structure for regulating photosynthesis and responding to drought. …”
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Toward European harmonization of national myasthenia gravis registries: modified Delphi procedure-based expert consensus on collectable data by Abderhmane Slioui, Giulia Tammam, Fiammetta Vanoli, Adela Della Marina, Stanislav Vohanka, Nils Erik Gilhus, Isabella Moroni, Maria Isabel Leite, Fredrik Piehl, Carlo Antozzi, Jonathan Pini, Frauke Stascheit, Shahram Attarian, Ernestina Santos, Jan Verschuuren, Lou Canonge, Jeremy Garcia, Caroline Perriard, Elena Cortés-Vicente, Renato Mantegazza, Andreas Meisel, Sabrina Sacconi

“…To avoid duplication and ensure harmonization in data collection, a modified Delphi procedure was implemented to identify essential data elements for inclusion in national registries. …”
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Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium by Oliver Labrenz, Oliver Labrenz, Lucie Waedel, Lucie Waedel, Michael Kölch, Michael Kölch, Susanne Lezius, Christina Wacker, Antonia Fröhlich, Antonia Fröhlich, Kerstin Paschke, Rainer Thomasius, Olaf Reis, Olaf Reis

“…The objective is to reduce DMUD-related symptoms and improve media use behaviour through the implementation of an app-based training programme.MethodsThe efficacy of Res@t digital, initially conceived as an adjunct to child and adolescent psychiatric treatment, is to be evaluated for n= 32 children and adolescents with a media use disorder or at risk of developing this disorder, and their families enrolled in child and youth welfare services. …”
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Impact of improper municipal solid waste management on fostering One Health approach in Ethiopia — challenges and opportunities: a systematic review by Tsegay Kahsay Gebrekidan, Niguse Gebru Weldemariam, Hagos Degefa Hidru, Gebremariam Gebrezgabher Gebremedhin, Abraha Kahsay Weldemariam

“…Despite efforts to advance the One Health approach in Ethiopia through the formation of the National One Health Steering Committee and technical working groups, implementation is hindered by challenges such as poor sectoral integration, insufficient advocacy, financial constraints, and limited research. …”
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The Influence of the Cu-Al₂O₃ Ratio of the Receiving Tube in a 50 MW Hybrid Solar Plant by Guillermo Benítez-Olivares, Alejandro Torres-Aldaco, Raúl Lugo-Leyte, José Javier Valencia-López, Luis Alberto Romero-Vázquez, Helen D. Lugo-Méndez

“…These phenomena can reduce the mechanical strength of the receiver tube and lead to sudden pressure increases, deformation, or rupture, which hinder the implementation of DSG in solar thermal plants. To address these challenges, the behavior of a receiver tube composed of copper on the inside and an Al₂O₃ envelope is studied. …”
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Lactobacillus Supplementation Modulates Rumen Microbiota and Metabolism in Yaks Under Fattening Feeding Conditions: A Comprehensive Multi-Omics Analysis by Jianlei Jia, Pengjia Bao, Ning Li, Siyuan Kong, Min Chu, Qian Chen, Ping Yan

“…In this study, 80 male Pamir yaks were selected, and a 170-day data collection phase was implemented. Correlation phenotypic data and multi-omics analyses (rumen microbial sequencing and rumen epithelial metabolomics) were conducted to investigate the regulatory effects of Lactobacillus supplementation on rumen microbiota and metabolic processes in a concentrate-based rearing yak model. …”
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Thermofluids analysis of four novel anchor-shaped turbulator and eco-friendly nanofluid (GAGNPs /H2O) in a parabolic trough solar collector: A CFD modeling approach by M. Gholinia, A.H. Ghobadi, E. Shahcheraghi, M. Armin

“…In this paper, four new turbulator models are implemented inside the absorber tube of the Parabolic Trough Solar Collector (PTSC) in a linear arrangement (anchored shape) to regulate and standardize its surface temperature. …”
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Evaluation of ecological environment quality in China's mining areas by remote sensing: A review by LI Feiyue, LI Jun, XIAO Wu, ZHANG Chengye, WANG Shanshan, YANG Junquan, ZHANG Xiaoping, CHENG Yang

“…We found that existing studies have made progress in indicator acquisition, establishment and improvement of evaluation models, yet are still limited in 1) the acquisition capacity and accuracy of remote sensing indicators, including difficulties in acquiring information about the subsurface environment in mining areas, insufficient temporal and spatial resolution of observations, and low accuracy of models for monitoring remote sensing parameters, 2) the generalization ability of existing evaluation models by remote sensing, including low applicability of indicators in different mining areas, excessively complex model implementation and difficulties in automation. Potential research opportunities include expanding accessible indicators by remote sensing, constructing a framework for integrated data collection on the surface and underground, improving the data quality of remote sensing indicators, constructing a new indicator system for evaluation using remote sensing, and developing cloud computing algorithms.…”
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Enhancing doxorubicin sensitivity in osteosarcoma via iRGD-modified biomimetic nanoparticles targeting MCAM m6A modification by Dongjian Song, Qiuliang Liu, Da Zhang, Zechen Yan, Meng Su, Qian Zhang, Hui Zhang, Longyan Shi, Yingzhong Fan, Heying Yang

“…Functional assays were implemented to examine their impact on cell biological functions in vitro. …”
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Research on the Impact of Energy-Use Right Trading System Driving Green Technology Innovation in Energy-Intensive Enterprises by Zihao Fu, Haixia Cao, Yan Li, Gang Wang

“…This paper provides theoretical support for the implementation of the energy-use right trading system, as well as empirical evidence and policy implications for its green innovation effects.…”
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First-principles study on the effect of Ce on segregation behavior of bcc-Fe grain boundaries in low-carbon low-alloy steel by Zongzheng Xie, Chenghao Song, Weiyi Shen, Haoliang Wang, Zhenzhong Sun, Hao Yu, Jun Cheng

“…The first-principles calculations were implemented to systematically study the segregation energy, GB energy (γGB), strengthening energy (Es) and differential charge density of Ce at symmetrically tilted grain boundaries (STGBs) (Σ3/Σ5/Σ7/Σ9/Σ11) in bcc-Fe. …”
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Development of peptone-based serum-free media to support Vero CCL-81 cell proliferation and optimize SARS-CoV2 viral production by Suryo Kuncorojakti, Diena Delaiah, Ahmad Aswin, Yulianna Puspitasari, Yeni Damayanti, Helen Susilowati, Diyantoro, Iwan Sahrial Hamid, Mohammad Anam Al Arif, Suwarno, Watchareewan Rodprasert

“…The United States Food and Drug Administration (FDA) and the European Medicines Agency have implemented stricter regulations on the use of animal-derived components in commercial protein manufacturing to ensure patient safety. …”
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Regenerative medicine in Obstetrics & Gynecology: Current status under the Act on the Safety of Regenerative Medicine in Japan by Satoshi Hosoya, Sena Awano-Kim, Ryo Yokomizo, Yuichiro Ukon, Kazuki Morita, Yuta Kasahara, Hiroshi Kishi, Aikou Okamoto

“…Introduction: While the provision of unapproved regenerative medicine has been problematic worldwide, few studies have examined the implementation status of regenerative medicine (RM) in the specific field. …”
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GRADE guidance 40: The GRADE evidence-to-decision framework for environmental and occupational health by Emily Senerth, Paul Whaley, Elie Akl, Brandy Beverly, Pablo Alonso-Coello, Andrew Rooney, Holger J. Schünemann, Kristina A. Thayer, Katya Tsaioun, Rebecca L. Morgan

“…The new EtD framework is also accompanied by a user guide intended to support its implementation in the EOH context. Conclusion: Policymakers, regulators, and other stakeholders may use this GRADE EtD framework to approach decision-making about environmental and occupational exposures and interventions.…”
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A TD3-Based Reinforcement Learning Algorithm With Curriculum Learning for Adaptive Yaw Control in All-Wheel-Drive Electric Vehicles by Reza Jafari, Pouria Sarhadi, Amin Paykani, Shady S. Refaat, Pedram Asef

“…A detailed reward function and well-structured actor-critic networks are devised, and the proposed algorithm is compared with a conventional model-based linear quadratic regulator (LQR) approach. A nonlinear model with 7 degrees of freedom is used to model the dynamic behavior of the vehicle in MATLAB/Simulink, and the results are further verified through the implementation of IPG CarMaker under realistic driving scenarios. …”
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Interleukin-20 Acts as a Promotor of Osteoclastogenesis and Orthodontic Tooth Movement by Yuanbo Liu, Yilong Ai, Xuan Sun, Bowen Meng, Xi Chen, Dongle Wu, Lei Gan, Benyi Yang, Chaoran Fu, Yilin Wu, Yang Cao

“…Orthodontics is a clinical discipline that involves the investigation and implementation of moving teeth through the bone. The application of mechanical force to the teeth causes an imbalance between osteogenesis and osteogenesis in alveolar bone, leading to tooth movement. …”
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A cysteine-rich transmembrane module peptide GhCYSTM9 is involved in cold stress response by Xiao Cai, Cunjing Liu, Liyuan Tang, Sujun Zhang, Xinghe Li, Haitao Wang, Jianhong Zhang

“…Yeast two-hybrid and bimolecular fluorescence complementation assays confirmed that GhCYSTM9 interacted with the light-harvesting chlorophyll a/b-binding protein GhLHBC2A1. …”
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