Construction and validation of renal cell carcinoma tumor cell differentiation-related prognostic classification (RCC-TCDC): an integrated bioinformatic analysis and clinical study by Yifan Liu, Keqin Dong, Yuntao Yao, Bingnan Lu, Lei Wang, Guo Ji, Haoyu Zhang, Zihui Zhao, Xinyue Yang, Runzhi Huang, Wang Zhou, Xiuwu Pan, Xingang Cui

“…Subsequently, we conducted consensus clustering to construct the RCC tumor cell differentiation-related prognostic classification (RCC-TCDC) and implemented prognostic and multi-omics analyses. Moreover, we utilized Lasso regression to help develop a multivariable prognostic model. …”
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Diagnostic, Therapeutic, and Prognostic Applications of Artificial Intelligence (AI) in the Clinical Management of Brain Metastases (BMs) by Kyriacos Evangelou, Panagiotis Zemperligkos, Anastasios Politis, Evgenia Lani, Enrique Gutierrez-Valencia, Ioannis Kotsantis, Georgios Velonakis, Efstathios Boviatsis, Lampis C. Stavrinou, Aristotelis Kalyvas

“…Despite these advancements and the promising landscape, multiple challenges—including data availability and variability, decision-making interpretability, and ethical, legal, and regulatory concerns—limit the broader implementation of AI into the everyday clinical management of BMs. …”
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Curing using the minimal – Strategies for treatment reduction in childhood acute lymphoblastic leukemia by Bernice LZ Oh, Stephen P. Hunger, Allen EJ Yeoh, Shawn HR Lee

“…Future directions include potential implementation of immunotherapy upfront to low-risk ALL, which may allow for even further reducing toxic chemotherapy or treatment duration. …”
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Sources and Health Risks of PM2.5-bound PAHs in a Small City along with the “Clean Heating” Policy by Zhiyong Li, Ziyuan Yue, Jixiang Liu, Zhen Zhai, Jianwei Meng, Lei Wang, Jihong Wei, Dingyuan Yang, Ailian Hu, Wenjia Zhu, Ning Ding, Xiaoxia Lu, Chunhao Lin

“…The far lower PAHs in this study than those of small cities before CH implementation indicated the CH effectiveness. Higher diagnostic ratios (DRs) of FA/(FA + PY), BaA/(BaA + CHR), and IP/(IP + BgP) in the HS were in agreement with the increased coal/biomass usage. …”
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Measurement-Based Prediction of mmWave Channel Parameters Using Deep Learning and Point Cloud by Hang Mi, Bo Ai, Ruisi He, Anuraag Bodi, Raied Caromi, Jian Wang, Jelena Senic, Camillo Gentile, Yang Miao

“…Last, the deployment and implementation method of the proposed model is recommended to the readers.…”
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Evaluating the Effectiveness of Artificial Intelligence in Prostate Cancer Detection using Biparametric Magnetic Resonance Imaging: A Comparative Study by Rossy Vlăduţ TEICĂ, Ioana Andreea GHEONEA

“…Further software refinements could enhance PI-RADS scoring, but contrast enhancement remains an important factor in certain diagnostic scenarios. …”
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The association risk of male subfertility and testicular cancer: a systematic review. by Xiaoning Peng, Xiaomin Zeng, Sihua Peng, Defeng Deng, Jian Zhang

“…<h4>Principal findings</h4>We searched the Medline database for records from January 1966 to March 2008 complemented with manual searches of the literature and then identified studies that met our inclusion criteria. …”
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Brazilian clays for environmental solutions applied to radioactive waste management by Gabriel Gonzalo Machado, Victoria Krupskaya, Sergey V Zakusin, Julio HARADA, Rodrigo Papai de Souza, Leandro Goulart Araujo, Denise Crocce Espinosa, Edy L.T. Montalvan, Henrique Kahn, Roberto Vicente, Sabine Guilhen

“…Samples coming from the Brazilian states of Paraná, Bahia, Paraíba, and Maranhão were treated and analyzed by means of X-Ray diffraction as main technique, and complemented by FTIR, LALLS, XRF, and SEM-EDS, in order to establish the mineralogical composition, particle size distribution, and chemical composition. …”
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Evidence of a role for the F1 capsule of Yersinia pestis in enhancing transmission from mammals to fleas in a mouse model of bubonic plague by Christopher F. Bosio, Clayton O. Jarrett, B. Joseph Hinnebusch

“…Although the F1 capsule is not an essential virulence factor in many mammals, Y. pestis isolates lacking the caf operon are very rare in nature, indicating an essential biological role. …”
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TIPE regulates glucometabolic reprogramming by modulating LDHA expression in triple-negative breast cancer by HU Wei, REN Xiaomeng, WANG Yang, ZHAO Peiqing, CAO Kai

“…Extracellular acidification rate (ECAR) was measured using the Seahorse XF Analyzer, complemented by lactate production assays to evaluate glycolytic capacity. …”
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Mandibular implant stability in oral cancer patients: a systematic review by Brasme David, Cloitre Alexandra, Lesclous Philippe, Chaux Anne-Gaelle

“…The objective of this systematic review was to assess the changes in the implant stability for dental implants over time in oral cancer patients and to determine whether the measurement of the Implant Stability Quotient at the time of implant placement could be a predictive factor of implant failure. Materials and methods: An electronic search of PubMed, ScienceDirect, and Google Scholar databases was performed prior to August 2023 and complemented by a manual search. …”
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Synergistic Mechanisms Between Elderly Oriented Community Activity Space Morphology and Microclimate Performance: An Integrated Learning and Multi-Objective Optimization Approach by Fang Wen, Lu Zhang, Ling Jiang, Rui Tang, Bo Zhang

“…The results of the two methods complemented and reinforced each other. Based on a comparison of these two approaches, morphological indicators showing significant differences were selected for attribution and sensitivity analyses, clarifying the mechanisms by which spatial morphological parameters influence environmental performance and identifying their critical thresholds. …”
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“Can computed tomographic angiography” solve the puzzle of complexities in the pediatric complex congenital heart disease’s by Javaid Iqbal, Sheikh Riaz Rasool, Tariq Ahmad Gojwari, Naseer Ahmad Choh, Moonisah Rafiq

“…However, radiation dose remains a limiting factor, this can be overcome to some extent by employing low radiation dose protocols.…”
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Unraveling the central role of root morphology and anatomy in lodging of tef (Eragrostis tef) by Shiran Ben‐Zeev, Noa Kirby, Sabrina Diehn, Ilana Shtein, Rivka Elbaum, Yehoshua Saranga

“…Lodging, the greatest factor limiting tef productivity and its wide adoption, was targeted in this study. …”
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Comparative genomics analysis of the MYB gene family in barley: preliminary insights into evolution and biological function in Blue Qingke by Hongyan Li, Youhua Yao, Xin Li, Yongmei Cui, Likun An, Baojun Ding, Xiaohua Yao, Kunlun Wu

“…Background The Myeloblastosis related (MYB) family is one of the most widely distributed transcription factor families in plants and plays a significant role in plant growth and development, hormone signal transduction, and stress response. …”
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A novel Klebsiella pneumoniae diguanylate cyclase contributes to intestinal cell adhesion, biofilm formation, iron utilization, and in vivo virulence by gastrointestinal infection by Chun-Ru Hsu, Ya-Ling Huang, Pang-Hung Hsu, Chen-Hsiu Huang, Yu-Chieh Huang, Ming-Ti Kao, You-Wei Ye

“…Clinical studies suggest intestinal colonization by K. pneumoniae as a risk factor for subsequent infections, but the underlying mechanisms remain unclear. …”
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Serum FGF21 as a predictor of response to atezolizumab and bevacizumab in HCC by Risako Kohya, Goki Suda, Masatsugu Ohara, Shunichi Hosoda, Takuya Sho, Makoto Chuma, Atsumasa Komori, Yuki Kugiyama, Yutaka Yasui, Kaoru Tsuchiya, Masayuki Kurosaki, Joji Tani, Shun Kaneko, Mina Nakagawa, Yasuhiro Asahina, Shinya Maekawa, Nobuyuki Enomoto, Yoshiya Yamamoto, Masaru Baba, Ren Yamada, Takashi Sasaki, Tomoka Yoda, Sonoe Yoshida, Qingjie Fu, Zijian Yang, Osamu Maehara, Shunsuke Ohnishi, Yoshimasa Tokuchi, Takashi Kitagataya, Naoki Kawagishi, Masato Nakai, Mitsuteru Natsuizaka, Koji Ogawa, Naoya Sakamoto

“…Background &amp; Aims: Fibroblast growth factor 21 (FGF21) is a crucial regulator of cell metabolism. …”
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Genetic evidence for the causal effect of clonal hematopoiesis on pulmonary arterial hypertension by Jia-Yong Qiu, Shen-Shen Huang, Chao Liu, Dong Ding, Yan-Hong Xu, Yi-Min Mao, Ya-Dong Yuan

“…The inverse-variance weighted (IVW) method was employed as the primary analysis, complemented by sensitivity analyses to assess the robustness of our findings. …”
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Dissecting immune-mediated pathways in rheumatoid arthritis: A multivariate mediation analysis of antibodies and circulating proteins by Jingmin Niu, Pingxin Zhang, Wei Liu, Song Sun, Yingkai Zhang, Jinghao Sang, Jialin Yang, Qin Zhang, Limin Chai

“…Statistical methods including IVW, weighted median, and mode-based approaches were employed, complemented by sensitivity analyses to ensure the robustness of the findings; The study identified significant causal relationships between six antibody immune responses and RA, with three specific responses—Epstein-Barr virus EBNA-1, Epstein-Barr virus ZEBRA, and Anti-polyomavirus 2 IgG seropositivity—showing strong associations. …”
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Expression of scavenger receptors CD163, CD204, and CD206 on macrophages in patients with pulmonary tuberculosis by E. G. Churina, A. V. Popova, O. I. Urazova, M. R. Patysheva, Ju. V. Kolobovnikova, S. P. Chumakova

“…The analysis of the expression of scavenger receptors CD163, CD204, and CD206 on macrophages allowed to conclude that, in pulmonary TB, especially in patients with drug resistant M. tuberculosis and infiltrative TB, regulatory mechanisms that suppress the activation of innate immunity are implemented together with polarization of macrophage differentiation towards the M2 phenotype. …”
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