Thrombotic microangiopathy in IgA nephropathy: pathophysiology, histopathology, and treatment perspectives by Ali Rastegar-Kashkouli, Mohsen Jafari, Seyedeh Ghazal Shahrokh, Amir Mohammad Taravati, Pourya Yousefi, Mohammadreza Jafari

“…Endothelial injury is a key factor in TMA development in IgAN, triggered by immune complex deposition, complement activation, and potentially hypertension. …”
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N-terminomics profiling of host proteins targeted by excretory-secretory proteases of the nematode Angiostrongylus vasorum identifies points of interaction with canine coagulation... by Nina Germitsch, Tobias Kockmann, Manuela Schnyder, Lucienne Tritten

“…A total of eight dog proteins were significantly cleaved at higher levels upon exposure to A. vasorum ESP: of these, three were coagulation factors (factor II, V and IX) and three were complement proteins (complement C3, C4-A and C5). …”
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Shedding of membrane complement inhibitors CD59 and CD46 into the circulation is associated with poor prognosis in acute coronary syndrome patients: a cohort study by Baojun Zhong, Ben King, Homa Waziri, Troels Yndigegn, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Isabel Goncalves, Anna M. Blom, Alexandru Schiopu

“…Abstract Introduction The role of the complement inhibitory proteins CD46 and CD59 in the immune response to an acute coronary syndrome (ACS) is unknown. …”
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Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery by Massimo Nunes, Mare Vlok, Amy Proal, Douglas B. Kell, Etheresia Pretorius

“…Complement machinery was also significantly downregulated, including C9 which forms part of the membrane attack complex. …”
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A TRANSFORMATION OF PROPERTY RELATIONSHIPS AND ITS PROSPECTIVE IN GEORGIA by S. Pavliashvili, D. Gubeladze

“…The internal and external factors which prevented privatization from being implemented successfully in Georgia are described.…”
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Designing for Engagement in Primary Health Education Through Digital Game-Based Learning: Cross-National Behavioral Evidence from the iLearn4Health Platform by Evgenia Gkintoni, Emmanuella Magriplis, Fedra Vantaraki, Charitini-Maria Skoulidi, Panagiotis Anastassopoulos, Alexandra Cornea, Begoña Inchaurraga, Jaione Santurtun, Ainhoa de la Cruz Mancha, George Giorgakis, Kleri Kouppas, Stella Timotheou, Maria Jose Moreno Juan, Miren Muñagorri, Marta Harasiuk, Alfredo Garmendia Lopez, Efi Skoulidi, Apostolos Vantarakis

“…Multiple regression analysis identified initial design experience as the strongest predictor of continued engagement (β = 0.479, <i>p</i> < 0.001), followed by country-specific implementation factors (Romania vs. Cyprus, β = 0.183, <i>p</i> = 0.001) and evaluator age (β = 0.108, <i>p</i> = 0.049). …”
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Complement Fixation Test for Specific Antibody Detection against Bovine Brucellosis in Selected Peasant Association of Guto Gida District, East Wollega Zone, Oromia, Ethiopia by Gudeta Ararsa, Eyob Hirpa, Morka Amante

“…Serum was tested by complement fixation test (CFT) for Brucella antibody detection. …”
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Seroprevalence and risk factors associated with anaplasma phagocytophilum infection in horses in egypt by Mohamed MARZOK, Hattan S. GATTAN, Ibrahim ALBOKHADAIM, Mohammed H. ALRUHAILI, Mohamed SALEM, Abdelfattah SELIM

Subjects: “…regular monitoring and genetic identification of pathogens are critical for implementing an effective control program and reducing public health risks.…”
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How to design effective educational videos for teaching evidence-based medicine to undergraduate learners – systematic review with complementing qualitative research to develop a p... by Lukas Niekrenz, Cord Spreckelsen

“…In particular, studies on the requirements and design goals of educational videos need to be complemented by qualitative research using grounded theory methodology.Methods Due to the paucity of randomized controlled trials in this area, there is an urgent need to generate recommendations based on a broader fundament than a literature search alone. …”
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Elevated Plasma Complement C1Q Measured Subacutely after Traumatic Brain Injury Is Associated with Poor Functional Outcome Independent of Initial Injury Severity by Tracy Butler, Kewei Chen, Abigail Patchell, Xiangling Mao, Dikoma Shungu, Diany Paola Calderon, Jeanne T. Paz, Sudhin A. Shah

“…This study investigates the role of complement factor 1q (C1Q) in TBI recovery. Motivated by our rodent studies showing that thalamic inflammation post-TBI is dependent on C1Q and that blocking C1Q during the subacute period can prevent thalamic inflammation and improve aspects of TBI outcome, particularly sleep, we measured plasma C1Q levels 3–6 months post-injury in 27 patients with TBI ranging from complicated mild to severe, as well as 30 controls. …”
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X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and cervical cancer risk: a huge systematic review and meta-analysis. by Ya Li, Fei Liu, Shi-Qiao Tan, Yan Wang, Shang-Wei Li

“…<h4>Background</h4>Previous studies investigating the association between X-ray repair cross-complementation group 1(XRCC1) polymorphisms and cervical cancer (CC) risk has provided inconsistent results. …”
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Response gene to complement 32 promotes tumorigenesis by mediating DNA damage repair and inhibits CD8+ T cells infiltration in diffuse large B-cell lymphoma by Xiyuan Zhang, Xiyuan Zhang, Tiange Lu, Chunlei Shi, Mengfei Ding, Ling Wang, Xinting Hu, Xin Wang, Xin Wang

“…BackgroundResponse gene to complement 32 (RGC32), a complement activation-inducible factor broadly expressed in normal human tissues, has been implicated in tumorigenesis through its dysregulated expression in various malignancies and its involvement in critical oncogenic processes. …”
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Designing and Implementing Content-Based Courses in English with a Non-Language Faculty at a Public Colombian University Diseño e implementación de cursos basados en contenido en i... by Leidy Natalia Salazar Valencia, Claudia Patricia Díaz Mosquera, Fabio Alberto Arismendi Gómez

“…This article reports the findings of an investigation into the experience of a group of eight professors from undergraduate programs in hard sciences who participated in a multi-site study to implement content-based (CB) courses in English. The professors, who had a high level of proficiency in English, worked in collaboration with language faculty. …”
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Novel Treatment Paradigms: Primary IgA Nephropathy by Haresh Selvaskandan, Jonathan Barratt, Chee Kay Cheung

“…Advancing insights into the pathophysiology of IgAN, including the roles of the mucosal immune system, B-cells, the complement system, and the endothelin system have driven development of therapies that target these factors. …”
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Therapeutic targeting of alternative pathway and C5 but not C5a protects from disease development in a preclinical model of autoimmune blistering dermatosis by Björn Laffer, Mareike Ohms, Samyr Kenno, Ping Tsui, Elvira Ehlers-Jeske, Wenru Song, Wen-Chao Song, Jörg Köhl

“…IntroductionEpidermolysis Bullosa Acquisita (EBA) is an autoimmune blistering dermatosis characterized by autoantibodies (AAbs) against type VII collagen (COL7) located at the dermal epidermal junction (DEJ). Local complement activation drives C5a generation associated with neutrophil recruitment and activation resulting in skin lesions and inflammation. …”
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Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT by Melanie J Davies, Shona Agarwal, Danielle H Bodicoat, Alan Brennan, Simon Dixon, Helen Eborall, Agnieszka Glab, Laura J Gray, Michelle Hadjiconstantinou, Lisa Huddlestone, Nicky Hudson, Anju Keetharuth, Kamlesh Khunti, Caroline Kristunas, Graham Martin, Alison Northern, Mike Patterson, Daniel Pollard, Rebecca Pritchard, Sally Schreder, Jane Speight, Bernie Stribling, Jackie Sturt, Jess Turner, Christina Weis

“…A delayed start to the feasibility study prevented all learnings being taken into the wait-list trial, particularly around implementing the intervention at provider, not practice level. …”
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THE MAIN PROBLEMS IN ARCHITECTURAL MANAGEMENT OF SETTLEMENTS TERRITORIES by O. Drogitskaya

“…The main architectural principles and requirements necessary for settlement functional and planning structure in its dynamic development accounting the changes in allocation the labour relationships, manufactures, housing development, transport system.The rural designing peculiarities are considered in details, the main functions of these settlements and its role of organizing the settlements territories are exposed.The necessity of working out the forecasting documents on perspective urban and rural development is substantiated regarding the architectural programmes defining the main directions of settlements development, the terms and objectives of architectural decisions’ implementation. The designing, planning and architectural decisions’ implementation tasks for the present moment and forecasting period are identified.The article states the issues of organizing the road network in urban and rural settlements planning structure dynamic development. …”
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IgM, IgA, IgG, and complement components as pre-operative markers for the development of multiple organ dysfunction syndrome in patients with infective endocarditis in early postop... by A. V. Ponasenko, M. V. Khutornaya, A. V. Tsepokina, Yu. A. Kudryavtseva

“…Serum IgM, IgG, and complements factors C3d and C5a may be used as prognostic markers of multiple organ dysfunction syndrome in the early postoperative period.…”
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Case Report: Iptacopan in a paroxysmal nocturnal hemoglobinuria patient with severe renal insufficiency by Ting Wu, Xiaoqin Wang

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder characterized by complement-mediated hemolysis, thrombosis, and bone marrow failure. …”
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Valoración de la imagen y la composición corporal tras la implementación de un programa de actividad física en alumnado de Educación Primaria (Assessment of body image and composit... by Jose Alberto Martín Sánchez, Rafael Francisco Caracuel Cáliz, Diego Collado Fernández, Beatriz Torres Campos, María del Mar Cepero González

“…Adolescence is a key stage in this matter and there are several factors that negatively influence it. The objectives of this research are to study and assess body image and physical condition to analyze the relationship between them, especially body composition, during the implementation of a physical exercise intervention programme in the school environment, in a sample of forty-one students in the sixth year of Primary Education throughout a school year, through a quasi-experimental longitudinal study. …”
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