Challenges in adopting health technology assessment for evidence-based policy in Iran: a qualitative study by Meysam Behzadifar, Saeed Shahabi, Ahad Bakhtiari, Samad Azari, Mohammad Yarahmadi, Mariano Martini, Masoud Behzadifar

“…The findings also offer valuable lessons for other low- and middle-income countries facing similar challenges, contributing to the global discourse on HTA implementation in resource-constrained settings.…”
Get full text

Correlation between serum complement C3 levels and cognitive dysfunction in patients with end-stage renal disease by Wu Si-yang, Zhang Jin, Wang Ying, Zhang Pei, Qi Xiang-ming, Wu Yong-gui

“…ObjectiveTo explore the correlation between complement level of C3， other risk factors and cognitive dysfunction in patients with end-stage renal disease （ESRD）.MethodsFrom July 2019 to July 2021， medical records and laboratory examinations were collected from 92 ESRD patients. …”
Get full text

THE APPLICATION OF MODERN TOOLS OF PREINVESTMENT ANALYSIS by D. D. Kuznetsova, T. M. Rogulenko

“…In addition to financial quantitative indicators, it is important for a potential investor to assess other types of risks, that he may face during the implementation of the investment project. The article deals with the tools of pre-investment analysis, applied by oil refining companies in the analysis of future financial flows from implemented investment projects.…”
Get full text

Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. by Matheswaran Kandasamy, Poon C Ying, Adrian W S Ho, Hermi R Sumatoh, Andreas Schlitzer, Timothy R Hughes, David M Kemeny, B Paul Morgan, Florent Ginhoux, Baalasubramanian Sivasankar

“…However, little is known about the factors that regulate lung DC migration to the dLN. …”
Get full text

A core UPS molecular complement implicates unique endocytic compartments at the parasite–host interface in Giardia lamblia by Erina A. Balmer, Corina D. Wirdnam, Carmen Faso

Get full text

Suicide prevention starts before the crisis: intervention guidelines for university students by Hareli Fernanda Garcia Cecchin, Sheila Giardini Murta

“…Despite the availability of various interventions, these efforts often fail to address the contextual and systemic factors that influence their success. Objective Investigate the elements that can support implementing actions to prevent suicide among university students. …”
Get full text

Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment by Guo T, Zhao Y, Liang S, Wang J, Liu H, Zhou Y, Xu H, Chen Z

“…The concentrations of 13 complement proteins and vascular endothelial growth factor A (VEGF-A) were measured using Luminex® × MAP® technology.Results: During ranibizumab treatment, a reduction in the levels of C1q (p < 0.001), C2 (p = 0.030), C4 (p = 0.001), C4b (p = 0.026), C3b/iC3b (p < 0.001), C5 (p = 0.007), C5a (p = 0.005), CFD (p = 0.022), CFH (p < 0.001), and CFI (p < 0.001) in AH was observed. …”
Get full text

The role of mediators in the formation of leading pathological processes in psoriatic arthritis by D. A. Pogonchenkova, L. V. Chetvernya, O. A. Vasilyeva, T. E. Kononova, V. S. Poletika, V. K. Abramov, S. P. Chumakova, L. V. Eliseeva, O. I. Urazova

Subjects: Get full text

Facilitators and barriers to online medical consultation in Iran: a qualitative study exploring the perspectives of healthcare policymakers and administrators using the CFIR framew... by Azadeh Ghasempour, Marzieh Nojomi, Salime Goharinezhad, Neda SoleimanvandiAzar, Zahra Rampisheh

“…Data were analysed using inductive thematic coding, mapped onto CFIR domains, to systematically identify multilevel factors influencing OMC implementation. Results Key facilitators included perceived advantages of access and efficiency, Adaptability across healthcare functions, Recipient-Centred Transparency and Accountability, urban digital readiness, and increased acceptance during the COVID-19 pandemic. …”
Get full text

FEATURES OF THE APPLICATION OF INNOVATIVE TOOLS IN THE MANAGEMENT OF ENTERPRISES IN THE AGRICULTURAL SECTOR OF THE ECONOMY by Oleksandr Kondrat

Get full text

Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction by T. Jadczyk, K. Baranski, M. Syzdol, E. Nabialek, W. Wanha, R. Kurzelowski, M. Z. Ratajczak, M. Kucia, B. Dolegowska, M. Niewczas, J. Zejda, W. Wojakowski

“…Acute myocardial infarction (AMI) and coronary artery bypass graft (CABG) surgery are associated with a pathogen-free inflammatory response (sterile inflammation). Complement cascade (CC) and bioactive sphingolipids (BS) are postulated to be involved in this process. …”
Get full text

Impact of a multi-component implementation strategy to increase outdoor free play opportunities in early childhood education and care (ECEC) services: the get outside get active (G... by Sze Lin Yoong, Nicole Pearson, Luke Giles, Hannah Lamont, Luke Wolfenden, Jannah Jones, Christophe Lecathelinais, Patti-Jean Naylor, Anthony Okely, Nicole Nathan, Kathryn Reilly, Rebecca Lorch, John Wiggers, Jacklyn Jackson, Melanie Lum, Karen Gillham, Alice Grady

“…Future research should focus on ensuring the long-term impact of implementation strategies and understanding the factors driving changes in control group behaviour. …”
Get full text

“When he is around, I’ll take the PrEP, but when he is not, I will not take PrEP”: key influences on PrEP use decisions among women attending family planning clinics in Kenya by Vallery Ogello, Kristin Beima-Sofie, Sandra Urusaro, Mercy Awuor, Annabell Dollah, Winnie Atieno, Cynthia Wandera, Daniel Matemo, Jennifer F. Morton, Kenneth Ngure, Kenneth Ngure, John Kinuthia, John Kinuthia, Kenneth K. Mugwanya, Kenneth K. Mugwanya

Get full text

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina by Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz‐Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann, Harald Neumann

“…First, polySia avDP20 prevented tumor necrosis factor‐α, vascular endothelial growth factor A, and superoxide production by SIGLEC11‐positive phagocytes. …”
Get full text

Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study by Nicole Pinzon-Hoyos, Yibo Li, Monnie McGee, Nicholas P. Poolos, Nicola Marchi, Amy L. Brewster

“…We identified DRE-associated complement decreases, including reduced levels of C1q, Factor H, C4, C4b, C3, and C3b/iC3b, as well as elevated bFGF. …”
Get full text

Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart by Inge Van de Walle, Laura Bracke, Heidi Gytz Olesen, Tonke van Bragt, Stéphanie Cadour, Phillip De Decker, Giorgia Ciurlia, Erwin Pannecoucke, Emma K. Persson, Olivier Van de Steen, Xinghong Leng, Gregers Rom Andersen, Domenica Gandini, C. Erik Hack

“…Empasiprubart is a humanized recycling monoclonal antibody that inhibits both pathways by binding to the CCP2 domain of complement factor 2 (C2), an interaction that is dependent on both Ca2+ and pH. …”
Get full text

Impact of preoperative complement-dependent cytotoxicity crossmatch on postoperative outcomes in kidney transplant recipients: A retrospective analysis by Chonghe Xu, Siqi Xie, Meiyi Lu, Wei Xu, Mei Zhu

“…However, delayed graft function rate was highest in the complement-dependent cytotoxicity of 5%–10% group. The source of donor kidneys was the most important factor influencing delayed graft function, and a larger cohort with a longer follow-up period may be needed to verify the tendency.…”
Get full text

Complement Activation is More Pronounced in the Kidneys of Critically Ill Patients With COVID-19 Than in Those With Bacterial Sepsis by Firas F. Alkaff, Grietje G. Talen, Marius C. van den Heuvel, Meint Volbeda, Matijs van Meurs, Jill Moser, Mohamed R. Daha, Jacob van den Born, Stefan P. Berger

“…Immunohistochemical staining was performed for complement factor properdin and complement activation products C4d, C3d, and C5b-9. …”
Get full text

Novel and established biomarkers to complement risk scores in patients with acute decompensated heart failure – a pilot study by Valentin Hähnel, Victoria Meretz, Christian Butter, Vera Paar, Christoph Edlinger, Michael Lichtenauer, Ronald Biemann, Berend Isermann, Meike Hoffmeister, Michael Haase, Anja Haase-Fielitz, Marwin Bannehr

Get full text

Information support for geomechanical calculations of stability of the undermined rock mass with a complex tectonic structure by Baryakh Aleksandr, Dyakonov Maksim, Lobanov Sergej, Nikiforova Anastasiya Igorevna, Sanfirov Igor' Aleksandrovich

“…The formation of plasticity zones in physical terms was identified with the formation of fracturing areas in the water protection layer, which determine the danger of violating its continuity. Numerical implementation of the geomechanical model using the finite element method made it possible to substantiate the optimal parameters of the chamber development system, ensuring the safety of the water protection layer, including fault zones.…”
Get full text