Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement. by Brian Stevenson, Henry A Choy, Marija Pinne, Matthew L Rotondi, M Clarke Miller, Edward Demoll, Peter Kraiczy, Anne E Cooley, Trevor P Creamer, Marc A Suchard, Catherine A Brissette, Ashutosh Verma, David A Haake

“…The LenA outer surface protein (formerly called LfhA and Lsa24) was previously shown to bind the host ECM component laminin and the complement regulators factor H and factor H-related protein-1. …”
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Genotypic and phenotypic diversity of Lactobacillus rhamnosus clinical isolates, their comparison with strain GG and their recognition by complement system. by Eija Nissilä, François P Douillard, Jarmo Ritari, Lars Paulin, Hanna M Järvinen, Pia Rasinkangas, Karita Haapasalo, Seppo Meri, Hanna Jarva, Willem M de Vos

“…Binding of complement regulators factor H and C4bp was also determined using radioligand assays. …”
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Classical Complement (CH 50 ) activity among children with some bacterial and parasitic infections in Sokoto, Nigeria by Kalgo, M.U.* , Muhammad, T.B. , Yeldu, M.H. , Garba, B.I. , Hamid, K.M. , Isiyaku, A. , Raji, H.Y. , Bello, M. , Bunza, N.M. Garba, M.R.

“…Similarly, age, gender, and residence of the participants appeared not to be a factor affecting classical complement activity of children with microbial infections. …”
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Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle by Jonas Brorson, Lin Lin, Jakob Wang, Amanda Bæk, Tine Borum Billeskov, Frederik Forsberg Thybo, Jesper Just, János Haskó, Christen Ravn, Rehne L. Hansen, Mats Bue, Jens Otto Lunde Jørgensen, Yonglun Luo, Niels Jessen, Jean Farup

“…Spatial correlation analysis unveils FAPs and monocytes/macrophages co-localization and intercellular communication, mediated by complement factor C3. Immunostaining confirms C3 expression in FAPs and FAP secretion of C3, suggesting a role in phagocytosis of necrotic muscle cells. …”
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The role of complement C1q in atrial fibrillation: a marker for disease progression and surgical outcomes by Yuefeng Ju, MaoJing Wang, Yang Ji, Zhihui Wang, Wenzhuo Wang, Feiyue Liu, Qing Zhao

“…Background and objectiveThe complement system plays a crucial role in the pathogenesis and progression of cardiovascular diseases. …”
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Successful targeting of the alternative complement cascade with iptacopan for the treatment of IgA nephropathy: a case report by Leonore Ingold, Michael Dickenmann, Thomas Menter, Helmut Hopfer, Patricia Hirt-Minkowski

“…Iptacopan is an oral inhibitor of complement factor B that effectively blocks the alternative complement pathway. …”
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KLF4 overexpression protects against complement-mediated endothelial injury in transplant-associated thrombotic microangiopathy by Shuhui Jiang, Jiaqian Qi, Tingting Pan, Zhenzhen Yao, Siyi Lu, Yifei Han, Depei Wu, Yue Han

“…Therefore, plasma samples from 20 TA-TMA patients and 1:1 matched control patients (matched by age, sex, underlying diagnosis, HLA compatibility, graft source, and donor–recipient ABO blood type) were measured for krüppel-like factor 4 (KLF4), complement proteins and endothelial injury markers. …”
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The SIMCA Study Protocol: Factors influencing the implementation of the Midwifery Continuity of Carer (MCoC) model of care in NHS maternity care in England: A mixed methods cross case analysis involving clinicians, women and policy makers [version 1; peer review: 2 approved, 1 approved with reservations] by Heather Strange, Aimee Middlemiss, Lena Choudary-Salter, Kate Davies, Tina Prendeville, Susan Barry, Rebecca Milton, Julia Sanders, Aled Jones, Sara Kenyon, Susan Channon

“…This study proposes to evaluate the implementation and delivery of MCoC across England, aiming to better understand the factors that result in different rates of progress with MCoC implementation. …”
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Policy Implementation of Marine Protected Areas Program in Indonesia: a Case Study of The Marine Recreational Park of Gili Meno, Gili Ayer, and Gili Trawangan, West Nusa Tenggara,... by A. Boby Yefry Adi Rianto, Bambang Supriyono, M.R. Khairul Muluk

“…The result of the study shows that implementation of MPAs policy in TWP Gili Matra has not well implemented yet because of some constraining factors explained by the Najam’s framework. …”
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Attitudes toward scale-up of an Intensive Combination Approach to Rollback the Epidemic in Nigerian adolescents (iCARE) intervention for youth in Nigeria: results of a mixed method... by Arthi Kozhumam, Revika Singh, Oche Agbaji, Adedotun Adetunji, Bopo Taiwo, Olayinka Omigbodun, Kehinde Kuti, Agatha David, Sulaimon Akanmu, Folashade Adekambi, Akinsegun Akinbami, Bibilola Oladeji, Babafemi Taiwo, Lisa M. Kuhns, Ogochukwu Okonkwor, Baiba Berzins, Amy K. Johnson, Titilope Badru, Patrick Janulis, Olubusuyi M. Adewumi, Marbella Cervantes, Olutosin Awolude, Robert Garofalo, Aima A. Ahonkhai, Lisa R. Hirschhorn

“…Intervention-specific barriers included legal limitations for MSM and few YMSM friendly clinics (testing), limited client financial resources and cell-phone access (treatment). Conclusions Implementers of the initial scale-up of both components of the iCARE Nigeria intervention reported high readiness and adoption, supported by implementation strategies and facilitating factors including intervention design. …”
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Implementation of two transdiagnostic interventions based on emotional regulation for professionals who treat alcohol addiction in the Spanish mental health system: A multicenter m... by María V Navarro-Haro, Alba Abanades-Morillo, Óscar Péris-Baquero, Verónica Martínez-Borba, Elena Crespo-Delgado, Abel Baquero-Escribano, Laura Masferrer-Boix, Jorge Osma

“…Findings of this study will inform of factors influencing the successful implementation of DBT and UP in community-based addiction services.…”
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A survey on the implementation of health education among nurses in the stomatology clinic in Guangdong Province (广东省口腔门诊护士健康教育实施现状的调查研究) by SHEN Fang (沈芳), YE Ziwen (叶子文), FENG Xiaowen (冯晓文), SU Wanying (苏婉莹), XIAO Wei (肖炜)

“…Objective To investigate the status quo of health education implemented by nurses in stomatology clinics in Guangdong Province, analyze the factors affecting the implementation of oral health education, so as to provide reference for the implementation of health education for patients in stomatology clinics in the future. …”
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Development, implementation and evaluation of a smartphone application aimed to reduce sedentary time and increase physical activity among Indian sedentary office workers – finding... by Baskaran Chandrasekaran, Ashokan Arumugam, Arto J. Pesola, Poornima Panduranga Kundapur, Chythra R. Rao

“…This study aimed to explore the development, implementation and acceptability of a SmPh application among Indian desk-based office workers. …”
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Scaling up hepatitis C testing and linkage-to-care among people who use drugs: lessons learned from a pilot project implemented at a supervised consumption site by Alannah Hannigan, Nandini Krishnan, Kirti Singh, Shannon Bytelaar, Deb Schmitz, Sofia Bartlett, David Hall, Rolando Barrios, Julio S. G. Montaner, Marianne Harris, Mark W. Hull, Kate A. Salters

“…The Hep C Connect pilot project was implemented to characterize HCV testing outcomes and linkage-to-care rates within a low-barrier supervised consumption site (SCS) in Vancouver, BC. …”
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The development and implementation of an innovative community-based intervention to strengthen community capacity for HIV prevention and care among Canadians of African Caribbean a... by Josephine Etowa, Notisha Massaquoi, Francisca Omorodion, Danielle Brown-Shreves, Ilene Hyman, Akalewold Gebremeskel, Hugues Loemba, Bishwajit Ghose, Egbe Etowa, Jennifer Rayner, Charles Dabone, Lounanjio Brown O’Sullivan, Azeeza Sule, Joseph Kiirya, Sanni Yaya, Wangari Tharao, Haoua Inoua, Angela Kaida, Apondi Odhiambo, Clinton Beckford

“…African, Caribbean, and Black (ACB) women are overrepresented among new HIV diagnoses due to social and structural factors. This study seeks to create, implement, and evaluate a community-based peer-led intervention to improve access to HIV prevention and care for ACB women in Canada. …”
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Implementation of a Scalable Online Weight Management Programme in Clinical Settings: Protocol for the PROPS 2.0 Programme (Partnerships for Reducing Overweight and Obesity with Pa... by David Westfall Bates, Jason P Block, Lipika Samal, Ronen Rozenblum, Caroline M Apovian, Benjamin M Scirica, Heather J Baer, John E Orav, JoAnn Cho, Sarah H Noonan, Richard Fay, Ashley C McCarthy, Alexander J Blood, Naomi Fisher, Jorge Plutzky, Michela Tucci, Marian McPartlin, Willam J Gordon, Katherine D McManus, Cheryl Morrison-Deutsch

“…PROPS 2.0 (Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0) aims to adapt and implement the combined intervention from the PROPS Study at scale, in a diverse cross-section of patients and providers.Methods and analysis We are implementing PROPS 2.0 across a variety of clinics at Brigham and Women’s Hospital, targeting enrolment of 5000 patients. …”
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Analysis of Effective Drivers on the Implementation of Rural Development Plan and Progress of Rural System Using DPSIR Model; A Case Study: Rural System of Central and Dotapeh Dist... by Seyyed amirhosein Garakani, Jafar Mahdioun, Majid Hazrati

“…The research findings indicate that the "driving force" factor, with a score of 0.637, had a greater impact on the implementation of the rural development plan and progress of the rural systems in the central and Dotapeh districts of Khodabandeh County than other components. …”
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Atypical hemolytic uremic syndrome: pathophysiology, clinical presentation, and treatment strategies by Ji Yeon Song

“…The condition is primarily attributed to dysregulation of the alternative complement pathway, with up to 60% of patients exhibiting genetic mutations in complement regulatory proteins such as complement factor H, complement factor I, membrane cofactor protein, and thrombomodulin. …”
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Severe hemolysis flare of refractory autoimmune hemolytic anemia with positive complement component C3d responsive to Iptacopan with cyclophosphamide and prednisone: a case report by Yawen Zhang, Yuemin Gong, Guangsheng He

“…Refractory AIHA shows poor responsiveness to multiple treatment regimens, and there is still a lack of effective treatment regimens for serious hemolytic episodes.Methods: Three refractory AIHA cases with a positive complement component C3d and hemolytic flare were treated with the oral factor B inhibitor ptacopan in conjunction with cyclophosphamide and prednisone.Results: After treatment with iptacopan plus cyclophosphamide and prednisone, all three patients showed a rapid increase in Hb levels, a decrease in reticulocyte proportion, and a significant reduction in hemolysis manifestations (Lower LDH level and unconjugated bilirubin).Conclusion: Three refractory cases of AIHA showed good therapeutic efficacy after treatment with iptacopan combined with cyclophosphamide and prednisone. …”
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The mediating effect of the budget process on the performance of small- and medium-sized enterprises in Ho Chi Minh City, Vietnam by Vuong Khanh Tuan, Premkumar Rajagopal

“…We analyzed factors like business planning, organizational commitment, strategy implementation, and managerial control, adopting the budget process as the mediating factor, as it was determined to positively affect SME performance. …”
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