Evidence for Coordinated Control of PM_2.5 and O₃: Long-Term Observational Study in a Typical City of Central Plains Urban Agglomeration by Chenhui Jia, Guangxuan Yan, Xinyi Yu, Xue Li, Jing Xue, Yanan Wang, Zhiguo Cao

“…Fine particulate matter (PM_2.5) and Ozone (O₃) pollution have emerged as the primary environmental challenges in China in recent years. Following the implementation of the Air Pollution Prevention and Control Action Plan, a substantial decline in PM_2.5 concentrations was observed, while O₃ concentrations exhibited an increasing trend across the country. …”
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Predicting the risk of postoperative gastrointestinal bleeding in patients with Type A aortic dissection based on an interpretable machine learning model by Lin Li, Xing Yang, Wei Guo, Wenxian Wu, Meixia Guo, Huanhuan Li, Xueyan Wang, Siyu Che

“…SHAP analysis identified the three most influential clinical features on the RF model’s output: duration of mechanical ventilation (MV), Time to aortic occlusion, and red blood cell (RBC) transfusion.ConclusionThe machine learning-based predictive model effectively assesses postoperative GIB risk in TAAD patients, aiding healthcare providers in early identification of risk factors and implementation of targeted preventive strategies.…”
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Amplifying children’s leadership roles and voice in decision-making through co-production in outside of school hours care: qualitative findings from the connect promote and protect... by Alyssa C. Milton, Alyssa C. Milton, Alyssa C. Milton, Kristin Ballesteros, Helen Hernandez, Yenni Hwang, Nick Glozier, Nick Glozier, Tom McClean, Haley M. LaMonica, Haley M. LaMonica, Karen Thorpe, Karen Thorpe, Ian B. Hickie, Ian B. Hickie

“…Process related sub-themes included the following: co-production (ko-production) as a key driver; high-quality programming practice in a demanding environment; structure balanced with flexibility; the importance of being agile and having a willingness to adjust; and implementation factors supporting child voice. The impact related sub-themes included the following: empowerment of children through meaningful engagement; we all have a role in the team (a space for growing leadership skills); a spark through engagement and enjoyment; and being and belonging (the impact on children’s social and emotional wellbeing).ConclusionThis is the first known qualitative study to examine the use and impact of co-production processes in OSHC—where children not only co-design but also co-plan, co-deliver, and co-evaluate the activity programming alongside OSHC educators and their communities. …”
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Social Media Suicide Watch by Katherine Prothro

“…The public was compelled to weigh in on this issue in 2014 when Samaritans implemented an app that scanned Twitter users’ posts for signs of suicidal ideation and alerted fellow users. …”
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A Framework for Cervical Cancer Elimination in Low-and-Middle-Income Countries: A Scoping Review and Roadmap for Interventions and Research Priorities by Michelle B. Shin, Gui Liu, Nelly Mugo, Nelly Mugo, Patricia J. Garcia, Patricia J. Garcia, Darcy W. Rao, Darcy W. Rao, Cara J. Broshkevitch, Linda O. Eckert, Linda O. Eckert, Leeya F. Pinder, Leeya F. Pinder, Judith N. Wasserheit, Judith N. Wasserheit, Judith N. Wasserheit, Ruanne V. Barnabas, Ruanne V. Barnabas, Ruanne V. Barnabas, Ruanne V. Barnabas

“…The scoping review highlights existing and innovative strategies, unmet needs, and collaborations required to achieve elimination across implementation contexts.…”
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Machine learning predicting acute pain and opioid dose in radiation treated oropharyngeal cancer patients by Vivian Salama, Vivian Salama, Laia Humbert-Vidan, Brandon Godinich, Brandon Godinich, Kareem A. Wahid, Kareem A. Wahid, Dina M. ElHabashy, Mohamed A. Naser, Renjie He, Abdallah S. R. Mohamed, Ariana J. Sahli, Katherine A. Hutcheson, Gary Brandon Gunn, David I. Rosenthal, Clifton D. Fuller, Amy C. Moreno

“…Baseline pain score and vital signs are crucial predictors. Their implementation in clinical practice could facilitate early risk stratification and personalized pain management.…”
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Effect of HPV integration on prognosis of young women with CIN2 in China: protocol for a multicentre prospective cohort study by Yan Zhang, Huachun Zou, Wei Zhang, Xiaoyuan Huang, Yuan Ren, Ting Hu, Wenyu Lin, Pengming Sun, Kelvin Stefan Osafo, Binhua Dong, Yuhang Zhang, Xiaowen Pu, Xunyuan Tuo, Qiongying Lyu, Wenrong Huang, Huifeng Xue, Shuxia Xu, Jue Su

“…This study examines HPV integration status as a prognostic biomarker in women aged 18–45 diagnosed with CIN2, with the objective of developing a predictive tool for personalised therapeutic strategies and minimising overtreatment in this high-regression population.Method and analysis This multicentre cohort study will be implemented across 20 tertiary Grade A hospitals in China, encompassing eastern, western, central and northern regions. …”
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Understanding and maximising the community impact of seasonal malaria chemoprevention in Burkina Faso (INDIE-SMC): study protocol for a cluster randomised evaluation trial by John Bradley, Alphonse Ouedraogo, Issiaka Soulama, Chris Drakeley, Teun Bousema, Alfred B Tiono, Denise Hien, Sodiomon Bienvenu Sirima, Issa N Ouedraogo, Jean Baptist Yaro, Aïssata Barry, Seyi Soremekun, Marta Moreno, Jean Sawadogo, Markus Gmeiner, Samuel S Sermé, Isabel Byrne, Jordache Ramjith, Lynn Grignard, Simon Koele, Rob ter Heine, Amidou Z Ouedraogo, Edith Sanogo

“…We aim to assess the impact of SMC on clinical incidence and parasite prevalence and quantify the human infectious reservoir for malaria in this population.Methods and analysis We will perform a cluster randomised trial in Saponé Health District, Burkina Faso, with three study arms comprising 62 clusters of three compounds: arm 1 (control): SMC in under 5-year-old children, implemented by the MoH without directly observed treatment (DOT) for the full course of SMC; arm 2 (intervention): SMC in under 5-year-old children, with DOT for the full course of SMC; arm 3 (intervention): SMC in under 10-year-old children, with DOT for the full course of SMC. …”
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Decoding stress specific transcriptional regulation by causality aware Graph-Transformer deep learning by Umesh Bhati, Akanksha Sharma, Sagar Gupta, Anchit Kumar, Upendra Kumar Pradhan, Ravi Shankar

“…Cells respond to environmental stimuli through transcriptional reprogramming orchestrated by transcription factors (TFs) which interpret cis-regulatory DNA sequences to determine the timing and locations of gene expression. …”
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Addressing the challenges and constraints of social protection policies for Peruvian women domestic workers: the ANITA project study protocol by Maria Lazo-Porras, Maria Kathia Cardenas, Nathaly Aya Pastrana, Christopher Meaney, Andrew David Pinto, Archna Gupta, María Sofía Cuba-Fuentes, Silvana Perez-Leon, Janeth Tenorio-Mucha, Sebastián García, Jill Portocarrero, Karina Romero Rivero, David Vera Tudela, Ayu Pinky Hapsari, Viviana Cruzado

“…We use a sequential mixed-methods design organised in four phases: (1) secondary data analysis (n=4216): using two Peruvian national surveys to characterise working conditions, health status and access to healthcare; (2) face-to-face survey (n=448): with DWs in three cities, using respondent-driven sampling to further characterise working and health conditions and to identify factors that influence knowledge of and access to social protection policies; (3) qualitative interviews (n=30–46): with DWs, leaders of DW organisations, employers and policymakers to gather different perspectives on the facilitators and barriers to access to social protection policies; and (4) deliberative dialogues (n=14–26): with DW, leaders of DW organisations, employers, policymakers and academics to identify key barriers to the implementation of social protection policies and to develop recommendations for overcoming these barriers.Ethics and dissemination Phase 1 and Phase 2 received ethical clearance from Universidad Peruana Cayetano Heredia in Peru and Unity Health Toronto in Canada. …”
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Adherence to a Vaccination Schedule in a Simulated HIV Vaccine Efficacy Trial Among Adults in Fishing Communities Around Lake Victoria, Uganda by Sharon Barbara Nabasumba Kalenge, Andrew Abaasa, Teddy Nakaweesi, Victoria Menya Biribawa, Annet Nanvubya, Ali Ssetaala, Juliet Mpendo, Brenda Okech, Matt A. Price, Bernard S. Bagaya, Noah Kiwanuka

“…To inform trial design and implementation, we evaluated adherence to vaccination schedules and study retention in a simulated HIV vaccine efficacy trial (SiVET) among adults from two fishing communities in Uganda. …”
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Educational utility of observational workplace-based assessment modalities in Australian vocational general practice training: a cross-sectional study by Alison Fielding, Benjamin Mundy, Amanda Tapley, Sarah Gani, Rula Ali, Michael Bentley, Rachael Boland, Lina Zbaidi, Elizabeth Holliday, Jean Ball, Mieke van Driel, Linda Klein, Parker Magin

“…Traditionally, ECTVs are conducted face-to-face, but the COVID-19 pandemic saw the development and implementation of remote ECTV modalities. It remains unknown if perceived educational utility of remote ECTVs differs from traditional face-to-face ECTVs. …”
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Interpretable prediction of hospital mortality in bleeding critically ill patients based on machine learning and SHAP by Bingkui Ren, Yuping Zhang, Siying Chen, Jinglong Dai, Junci Chong, Yifei Zhong, Mengkai Deng, Shaobo Jiang, Zhigang Chang

“…Nevertheless, the implementation of effective predictive models in clinical practice remains limited, primarily due to the lack of robust and interpretable tools. …”
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Hematological reference intervals for adult population of Debre Berhan town, North East Ethiopia by Amanuel Kelem, Getabalew Engidaye, Bedasa Addisu, Befikad Mandefro, Bisrat Birke Teketelew, Dereje Mengesha Berta, Zewudu Mulatie, Yemataw Gelaw, Tiruneh Adane, Aster Tsegaye

“…The reference intervals reported in this study strongly advocate for the implementation of population-specific reference intervals, ensuring accurate diagnoses and enhanced patient safety. …”
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<i>Aeromonas caviae</i> subsp. <i>aquatica</i> subsp. nov., a New Multidrug-Resistant Subspecies Isolated from a Drinking Water Storage Tank by Victor Hugo Moreira, Lidiane Coelho Berbert, Ayodele Timilehin Adesoji, Kayo Bianco, Janaina Japiassu Vasconcelos Cavalcante, Flávia Lúcia Piffano Costa Pellegrino, Rodolpho Mattos Albano, Maysa Mandetta Clementino, Alexander Machado Cardoso

“…This study highlights the genomic plasticity and pathogenic potential of <i>Aeromonas</i> within household drinking water systems, calling for the revision of water treatment protocols to address biofilm-mediated resistance and the implementation of routine genomic surveillance to mitigate public health risks.…”
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Lessons learnt in the response to COVID-19 in Mozambique: enabling readiness for the next pandemic by Mariana E. Posse, Grace Njeri Muriithi, Daniel Malik Achala, Elizabeth Naa Adukwei Adote, Chinyere Ojiugo Mbachu, Senait Alemayehu Beshah, Senait Alemayehu Beshah, Chijioke Osinachi Nwosu, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba, John Ele-Ojo Ataguba

“…The risk of another pandemic occurring is ever-present requiring countries to document factors that influenced the response to COVID-19 to guide the response to future pandemics. …”
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Oral Management Improves Patient Outcomes in Hematopoietic Stem Cell Transplantation by Mutsuko Moriwaki, Mikayo Toba, Makiko Takizawa, Hiroaki Shimizu, Haruna Tanaka, Chihiro Takahashi, Shinobu Imai, Masayuki Kakehashi, Kiyohide Fushimi

“…The certification standard for unrelated HSCT, categorized into four classes (no certification and certification levels 1-3), was associated with an 8.41 point increase in hospital oral management implementation per class. Conclusion: Ensuring an appropriate oral environment for allogeneic HSCT patients helps preventing infection, extending life expectancy, and alleviating pain. …”
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Survival time and its predictors among preterms in the neonatal period post-discharge in Busoga region-Uganda June – July 2017 by Charles Opio, Richard Malumba, Joseph Kagaayi, Olufemi Ajumobi, Carol Kamya, Aggrey Mukose, Yeka Adoke, Fiston Muneza, Angela Kisaakye, Christine Nalwadda, Peter Waiswa

“…We recommend follow-up care for preterm infants following hospital discharge, implementation of prevention of mother to child transmission of HIV and exclusive breastfeeding of preterm babies.…”
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Preliminary effectiveness of social prescription and virtual patient information in increasing tertiary prevention among cancer patients (ESPRIT): protocol for a single-centre, ran... by Karen Steindorf, Michael Koller, Michael Leitzmann, Wolfgang Herr, Daniel Heudobler, Lisa Boyer, Anne Herrmann, Tobias Pukrop, Christine Bernardi, Sabine Einhell

“…Cost-effectiveness and the time spent in the consultation, as well as potential implementation barriers and facilitators, will also be explored as part of a mixed-methods hybrid design. …”
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Mixed-Methods Investigation of Rural Emergency Medical Services ST-Elevation Myocardial Infarction Time to Percutaneous Coronary Intervention: High- vs Low-Performing Agencies by Michael Supples, McKenna E. Gallagher, Nicklaus P. Ashburn, Anna C. Snavely, Ashley E. Strahley, Chadwick D. Miller, Simon A. Mahler, Jason P. Stopyra

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