A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion. by Quynh Huong Nguyen, Chun Heng Royce Lai, Michael J Norris, Dixon Ng, Megha Shah, Christine Chieh-Lin Lai, David E Isenman, Trevor F Moraes

“…Here, we report that PmSLP binds host complement factor I (FI) and facilitates cleavage of complement components C3b and C4b independently of any cofactors (e.g., FH, C4BP), thereby allowing the pathogen to evade host defence. …”
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In trans complementation of lethal factor reveal roles in colonization and dissemination in a murine mouse model. by David E Lowe, Jason Ya, Ian J Glomski

“…Lethal factor (LF) is a component of the B. anthracis exotoxin and critical for pathogenesis. …”
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Urinary Complement Factor Ba: A New Tool for Early Detection of Acute Kidney Injury by Daan P.C. van Doorn, Augusto Cesar Soares dos Santos Junior, Sjoerd A.M.E.G. Timmermans

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Complement-Inhibiting Therapy of Atypical Haemolytic Uremic Syndrome in a Patient With Factor H Mutation by Irina N. Lupan, Alexander Yu. Pischalnikov, Hadizha M. Emirova, Ekaterina S. Stolyarevich, Alexander M. Volyansky, Larisa V. Glukhova

“…Atypical haemolytic uremic syndrome (aHUS) is an extremely rare pathology with the development of complement-mediated thrombotic microangiopathy (TMA). …”
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Facilitators and barriers to the implementation of DIP payment methodology reform in a public hospital in Guangzhou: a qualitative study based on the implementation of the meta-fra... by Jinghui Chang, Siyi Chen, Anqi Li, Xixi Yang, Hualian Luo, Maidina Yilamu, Bingqian Fu, Nuoyan Xu, Jing Liu, Huishu Tian

“…The analysis of the positive and negative factors affecting the implementation of the reform and the proposed measures to optimize internal hospital management are expected to provide practical evidence for the implementation of DIP payment reform in other public hospitals.MethodsThis study develops an interview guide based on the Consolidated Framework for Implementation Research (CFIR) and conducts one-on-one semi-structured interviews offline with personnel from a Grade A tertiary public hospital in Guangzhou. …”
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Health professionals’ readiness for and factors influencing electronic medical record systems implementation in Southern Oromia, Ethiopia, 2024: a cross-sectional study by Miesa Gelchu, Geleta Chala, Gemechis Tuke, Gelgelo Wodessa, Angefa Ayele, Terefu Yambo, Anteneh Fikrie

“…There is a dearth of information regarding the readiness of health professionals to implement Electronic Medical Records system and the factors influencing this readiness, particularly in the study setting.ObjectiveThe study aimed to evaluate the readiness of healthcare professionals in Southern Oromia for the implementation of the electronic medical record system.MethodsA facility-based cross-sectional study was conducted using self-administered questionnaires among 384 health professionals from May 1–30, 2024, at public hospitals in the Borena and West Guji zones in southern Ethiopia. …”
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Factors associated with sexual behaviours among adolescents in a rural Tanzania: evidence from the African Research, Implementation Science, and Education (ARISE) Network by Elihuruma Eliufoo Stephano, Mussa Hassan Bago, Tian Yusheng, Jacktan Josephat Ruhighira, Mtoro J. Mtoro, Azan Abubakar Nyundo, Li Yamin

“…Methods This study utilises data from the African Research, Implementation Science, and Education (ARISE) Network’s Adolescent Health Study, a cross-sectional study in six countries in sub-Saharan Africa involving rural adolescents aged 10–19 years. …”
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Factors influencing the implementation of a guideline for re-engagement in HIV care in primary care settings in Johannesburg, South Africa: A qualitative study. by Ndinda Makina-Zimalirana, Lynne Susan Wilkinson, Anna Grimsrud, Natasha Davies, Chipo Mutyambizi, Anele Jiyane, Fezile Buthelezi, Kate Rees

“…The Consolidated Framework for Implementation Research (CFIR) was used to analyse factors influencing implementation. …”
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Factors Contributing to Successful Information System Implementation and Employee Well-Being in Health Care and Social Welfare Professionals: Comparative Cross-Sectional Study by Janna Nadav, Anu-Marja Kaihlanen, Sari Kujala, Ilmo Keskimäki, Johanna Viitanen, Samuel Salovaara, Petra Saukkonen, Jukka Vänskä, Tuulikki Vehko, Tarja Heponiemi

“…ObjectiveThis study aimed to examine whether professional groups and the factors that contribute to successful implementation (participation in information systems development and satisfaction with software providers’ development work) are associated with the well-being of health care and social welfare professionals. …”
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Exploring meso- and macro-level contextual factors associated with inequalities in program adoption during statewide scale-up of TransformUs Primary, a whole-school physical activi... by Elly Ganakas, Jo Salmon, Jiani Ma, Karen E. Lamb, Lisa Barnett, Adrian Bauman, Amanda Telford, Nicola D. Ridgers, Anna Timperio, Harriet Koorts

“…Abstract Background Contextual influences on program implementation exist across micro (individual), meso (organization), and macro (government/environment) system levels, yet macro factors are less frequently explored in implementation research. …”
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Understanding context: leveraging the pragmatic robust implementation sustainability model to inform the implementation of a community-based southeastern preconception counseling i... by N. D. Hernandez-Green, K. Berry, M. D. Haiman, A. McDonald, O. T. O. Farinu, E. Harris, A. Suarez, L. Rollins, C. Franklin, T. Williams, L. S. Clarke, M. P. Fort, A. G. Huebschmann

“…This article examines contextual factors influencing the implementation of a community-based and culturally tailored PC intervention, ensuring equitable access amongst underserved populations. …”
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Advancements in complement inhibition for PNH and primary complement–mediated thrombotic microangiopathy by Thalia Padilla Kelley, Hannah King, Aditya Malhotra, Thomas G. DeLoughery, Kylee Martens, Joseph J. Shatzel

“…Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) and primary complement–mediated thrombotic microangiopathy, also known as atypical hemolytic uremic syndrome (aHUS), are hematologic disorders characterized by dysregulation of the complement system leading to hemolysis and other systemic and potentially lethal complications. …”
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Urine complement analysis implies complement activation is involved in membranous nephropathy by Yingxue Xu, Yingxue Xu, Yi Li, Yong Zhang, Guisen Li, Guisen Li

“…BackgroundThe onset and progression of membranous nephropathy (MN) have been associated with complement activation, yet the overall characteristics of this activation in the kidneys remain unclear. …”
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Advancing Regional and Remote Health Care With Virtual Hospital Implementation: Rapid Review by Artika Archana Kumari, Tafheem Ahmad Wani, Michael Liem, James Boyd, Urooj Raza Khan

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Driving and Restraining Forces in the Implementation of Information Systems in the Public Sector: Scoping Review by Arja Lemmettylä, Ulla-Mari Kinnunen

“…ResultsThe findings highlight that IS implementation is influenced by 6 domains: organizational practices and challenges, technological factors and barriers, management practices and issues, change project factors and challenges, end user factors and concerns, as well as institutional factors and barriers. …”
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Design and Implementation of 24-GHz and 48-GHz VCOs Using Noise Filtering Technique in 90-nm CMOS by Chen-Chih Ku, Sen Wang

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Exploring factors influencing the consistent adoption of a post-stroke upper extremity outcome measure using Normalisation Process Theory by Silvana X. Choo, Joshua Yong, Shaikh Abdullah Bin Mohamed Rafi, Chen Ju Lo, Jun Bin Tong, Elaine Lum, Julian Thumboo

“…However, integrating such outcome measures into routine clinical practice remains challenging, highlighting the need to understand factors affecting their implementation in evolving healthcare models. …”
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Factors influencing the utilization of Traditional Chinese Medicine in cancer treatment: a qualitative meta-synthesis of patient and healthcare professional perspectives by Runbing Xu, Yanan Sun, Yifei Liu, Jiajun Pan, Yingying Han, Xinyu Zhang, Hequn Zhao, Mengfei Li, Yu Wu, Changhe Yu, Miao Jiang, Miao Jiang

“…In response to these barriers, we recommend improving structured referral pathways, developing a structured communication manual, and other targeted interventions to enhance the integration of TCM in cancer care.ConclusionThis study identifies 48 factors that influence the implementation of TCM and tentatively proposes a series of intervention strategies. …”
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Implementing screening for social determinants of health using the Core 5 screening tool by Alison Bradywood

“…The aim of this project was to implement the Core 5 social risk screening tool and evaluate its efficacy and usability in identifying social risk factors in a presurgical spine population. …”
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Strategies for implementing Sustainability in Quality Improvement (SusQI) education: educator perspectives by Kathleen Leedham-Green, Ayoma Ratnappuli, Frances Mortimer, Alice Clack, Victoria Stanford, Siobhan Parslow-Williams

“…The most successful implementations demonstrated synergistic benefits for both learners and institutions, engendering self-sustaining communities of practice.Strong institutional commitment, distributed expertise and opportunities for supported project work emerge as key success factors. …”
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