Vaccine-induced responses to R21/Matrix-M – an analysis of samples from a phase 1b age de-escalation, dose-escalation trial by Caroline Bundi, Caroline Bundi, Duncan Bellamy, Elizabeth Kibwana, Lydia Nyamako, Rodney Ogwang, Kelvias Keter, Domtila Kimani, Ahmed M. Salman, Samuel Provstgaard-Morys, Lisa Stockdale, Adrian V. S. Hill, Philip Bejon, Philip Bejon, Ally Olotu, Mainga Hamaluba, Mainga Hamaluba, Katie J. Ewer, Melissa C. Kapulu, Melissa C. Kapulu

“…We measured antibodies (quantity) by MSD and ELISA; and function (quality) by complement (C1q) fixation assay, inhibition of sporozoite invasion (ISI) assay, and avidity assay. …”
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Neuroprotective role of sialic-acid-binding immunoglobulin-like lectin-11 in humanized transgenic mice by Tawfik Abou Assale, Negin Afrang, Jannis Wissfeld, German Cuevas-Rios, Christine Klaus, Bettina Linnartz-Gerlach, Harald Neumann

“…Brains of 24-month-old Siglec-11 tg mice also exhibited lower gene transcription of complement components 3, 4, and integrin alpha M (C3, C4, and Itgam), along with the complement C1q subcomponents a-c (C1qa, C1qb, and C1qc). …”
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Impact of Gestational and Lactational Live Yeast Supplementation to Sows on Litter Performance, Colostrum and Milk Proteome Profiles by Yuechi Fu, Venkatesh P. Thirumalaikumar, Theresa M. Casey, Timothy A. Johnson, Jun Xie, Olayiwola Adeola, Kolapo M. Ajuwon

“…Results showed that there was a higher abundance of immune‐associated proteins such as Ig‐like domain‐containing protein and complement proteins (Complement C8 alpha chain and C1q domain‐containing proteins) in the colostrum and IgG heavy chain in Day 10 milk of LY sows than control sows (p < 0.05), whereas the abundance of prostaglandin D synthase was greater in D10 milk of control sows than LY sows (p < 0.05). …”
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Effects of renal replacement therapy combined with immune adsorption on inflammatory factors and immune function in patients with lupus nephritis by GAO Yang, RUAN Xiu-fang, AN Ling-chun

“…Objective To investigate the effect of renal replacement therapy combined with immune adsorption on inflammatory factors and immune function in patients with lupus nephritis.Methods Ninety-four patients with lupus nephritis were selected and randomly divided into the observation group and the control group(n=47 each group).The patients in two groups were treated with conventional hormone and immunosuppressant.The patients in the control group were treated with PH-350,and those in the observation group were treated with renal replacement therapy combined with immune adsorption for 4 courses(one week of one course).The inflammatory factors(TNF-alpha,IL-6,IL-8),immune function(IgG,IgA,IgM,C3,C4),systemic lupus erythematosus activity index(SLEDAI)and antibody levels(anti C1 q antibody,anti nucleosome antibody and anti ds-DNA antibody)were compared between the two groups before and after treatment.Results Before treatment,there was no significant difference in the serum levels of TNF-alpha,IL-6 and IL-8 between the two groups(P>0.05).After treatment,TNF-alpha,IL-6 and IL-8 levels in two groups were decreased significantly as compared with those before treatment,and the levels of TNF-alpha,IL-6 and IL-8 in the observation group were significantly lower than those in the control group(P<0.05).Before treatment,the levels of IgG,IgA,IgM,C3 and C4 in the two groups were not statistically significant(P>0.05).After treatment,the IgG,IgA and IgM levels in two groups were significantly reduced,but C3,C4 complement levels were increased significantly.The levels of IgG,IgA and IgM in the observation group were significantly lower than those in the control group,but the levels of C3 and C4 were significantly higher than those in the control group(P<0.05).Before treatment,there was no significant difference between the two groups in SLEDAI score and anti C1 q antibody,anti nucleosome antibody and anti ds-DNA antibody(P>0.05).After treatment,SLEDAI scores and the levels of anti ds-DNA antibody and anti C1 q antibody,anti nucleosome antibody in the two groups were significantly decreased,and those in the observation group were significantly lower those in the control group(P<0.05).Conclusions Renal replacement therapy combined with immune adsorption can help reduce inflammation,improve immune function and reduce systemic lupus activity index and antibody level.…”
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Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation. by Dylan Carter-Cusack, Stephen Huang, Sahar Keshvari, Omkar Patkar, Anuj Sehgal, Rachel Allavena, Robert A J Byrne, B Paul Morgan, Stephen J Bush, Kim M Summers, Katharine M Irvine, David A Hume

“…Network analysis revealed a common signature of CSF1R-dependent resident tissue macrophages that includes the components of complement C1Q (C1qa/b/c genes). Circulating C1Q was almost undetectable in Csf1rko rats and rapidly restored to normal levels following BMT. …”
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Clinical and pathological features of idiopathic membranous nephropathy patients combined with hyperuricemia by ZHAO Li, JIN Juan, GONG Jian-guang, LI Yi-qiao, HE Qiang

“…Immunopathologic features of patients in both two groups were dominated by immunoglobulin Ig G and complement C3 deposition,accompanied by some immunoglobulin Ig M deposition and a small amount of complement C1 q deposition,with the difference between the two groups being not statistically significant( P > 0. 05). …”
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Analysis of zebrafish homologs within the human genome provides valuable insights into exploring pan-cancer alternative splicing events as prognostic markers and therapeutic target... by Yanjun Liang, Xiao Zhu

“…A risk-scoring model distinguished high and low-risk groups, revealing differences in survival, tumor microenvironment, and immune cell infiltration. Notably, Complement C1q C Chain (C1QC), DENND5A, HP, IRF5, and LRP1 were associated with poor prognosis and immune infiltration. …”
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Mycoplasma pneumoniae Infection Associated C3 Glomerulopathy Presenting as Severe Crescentic Glomerulonephritis by Lalani De Silva, Dinesha Jayasinghe, Priyani Amarathunga

“…C3 glomerulopathy (C3GP) is a group of diseases caused by a deregulated complement system, which encompasses both dense deposit disease and C3 glomerulonephritis. …”
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A Novel Perspective on Tubular C4d Positivity in BK Polyomavirus Nephropathy by Tong Wu, Fangzhou Guo, Shicong Yang, Zeying Jiang, Xianghong He, Qihua Wang, Zhixin Huang, Jue Wang, Zhenyu Xu, Meiyi Song, Xiaotao Hou, Gang Huang, Wenfang Chen

“…Immunofluorescence (IF) for Ig and complement components and electron microscopy were performed to assess complement activation. …”
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Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model by Maria Tsalenchuk, Kyle Farmer, Sandra Castro, Abigail Scheirer, Yuqian Ye, J. Timothy Greenamyre, Emily M. Rocha, Sarah J. Marzi

“…We identified a strong, rotenone-induced immune response in the substantia nigra, including increased activity in the C1q complement pathway, suggesting immune involvement driven by regulatory mechanisms. …”
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SYSTEMIC VASCULITIS: NOVELTY IN CLASSIFICATION, DIAGNOSIS, AND TREATMENT by N. A. Shostak, A. A. Klimenko

“…Screening for SV determines the levels of anti-neutrophil cytoplasmic antibodies (ANCA), cryoglobulins, anti-glomerular basement membrane antibodies, and anti-complement C1q antibodies. However, biopsy with its specimen being pathomorphologically characterized, as well as current noninvasive or minimally invasive diagnostic techniques remain relevant because of a large number of seronegative variants of vasculitis. …”
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BLOOD PLATELETS AS ACTIVATORS AND REGULATORS OF INFLAMMATORY AND IMMUNE REACTIONS. PART 2. THROMBOCYTES AS PARTICIPANTS OF IMMUNE REACTIONS by N. B. Serebryanaya, S. N. Shanin, E. E. Fomicheva, P. P. Yakutseni

“…Platelets possess receptors for activated complement components and its fragments (CR2, CR3, CR4, C1q, C1 inhibitor and factors D and H). …”
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Acquired Angioedema as the First Sign of Lymphoproliferative Disorder: Case Report and Review of Literature by Juan Carlos Cardenas Rosales, Ahmad Ridwan, Carlos Ruiz-Orasma, Santiago F. Galeano-Lovera, Fernando Gil Lopez, Jhonny Perusina, Jacqueline D. Squire, Liuyan Jiang, Muhamad Alhaj Moustafa, Dana M. Harris, Salma Iftikhar, Bala Munipalli

“…Laboratory testing showed decreased C1q and C4 complement levels, and C1 esterase inhibitor levels, indicative of AAE-C1INH. …”
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Clinicopathological Features of Lupus Nephritis Patients in North-East India; A Single Center Retrospective Observational Study by Shahzad Alam, Manzoor Parry, Manjuri Sharma, Hamad Jeelani, Mastakim Mazumder

“…Immunoglobulin (Ig) G was the most abundant immunoglobulin (positive in 98.47%) and the least positive was IgA (positive in 41.18%). Complement (C) 3 and C1q were positive in all. Full house deposition was found in 59.3% of the biopsies. …”
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Correlation of Platelet to Lymphocyte Ratio and C-Reactive Protein to Albumin Ratio with MEX-SLEDAI Scores in Patients with Systemic Lupus Erythematosus by Rachel Amelia, Fajar Wasilah, Nida Suraya Suraya

“…Markers of SLE  disease activity such as anti-dsDNA antibodies, complement, and anti C1q  have limitations in terms of sensitivity and specificity.  …”
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Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice. by Catarina E Hioe, Guangming Li, Xiaomei Liu, Ourania Tsahouridis, Xiuting He, Masaya Funaki, Jéromine Klingler, Alex F Tang, Roya Feyznezhad, Daniel W Heindel, Xiao-Hong Wang, David A Spencer, Guangnan Hu, Namita Satija, Jérémie Prévost, Andrés Finzi, Ann J Hessell, Shixia Wang, Shan Lu, Benjamin K Chen, Susan Zolla-Pazner, Chitra Upadhyay, Raymond Alvarez, Lishan Su

“…While these mAbs had no or weak neutralizing activity and elicited undetectable levels of antibody-dependent cellular cytotoxicity (ADCC), V3 mAb 2219 displayed a greater capacity to bind virus- and cell-associated HIV-1 envelope and to mediate antibody-dependent cellular phagocytosis (ADCP) and C1q complement binding as compared to V1V2 mAb 2158. …”
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Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma by Rong Su, Yong Du, Pan Tian, Weifang Ma, Yongfeng Hui, Shaoqi Yang

“…The data integration of scRNA-seq and bulk RNA-seq showed the decreased TIDE score in the high-risk patients and the elevated levels of Macro-secreted phosphoprotein 1 (SPP1), MDSC-meiotic nuclear divisions 1 (MND1), γδ T cells, and Macro-complement C1q C chain (C1QC) predicted adverse prognosis. …”
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Unveiling host-genetic drivers of caecal microbial communities in chickens through genome-wide association studies by Ankit Hinsu, Xiaoxia Dai, Christos Dadousis, Christos Dadousis, Melanie Hay, Bruno Fosso, Matteo Crotta, Ramesh Pandit, Javier Guitian, Fiona Tomley, Prakash Koringa, Chaitanya Joshi, Chaitanya Joshi, Damer Blake, Androniki Psifidi

“…Of note, we found markers nearby the genes coding for classical complement activation component C1q, ephrin receptors, and other immunity and inflammatory responses as well as genes coding for products associated with vitamin and co-factor metabolism. …”
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Clinico-morphological comparison of the mesangiocapillary glomerulonephritis type I and diffuse lupus glomerulonephritis by О. V. Khmara, О. О. Dyadyk, N. F. Yarovaya, Yu. E. Lyakh, V. G. Gurianov

“…Materials and methods. 39 cases with DLGN and 43 cases with MCGN type I were analyzed with routine histological methods and immunohistochemical stains with polyclonal antibodies to IgA, IgG, IgM and complement C3, С1q fractions. In order to establish the link between the clinical morphological data the correlation analysis was used (Spearmen coefficient). …”
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A novel multiple marker microarray analyzer and methodology to predict major obstetric syndromes using surface markers of circulating extracellular vesicles from maternal plasma by Malene Møller Jørgensen, Rikke Bæk, Jenni K. Sloth, Rami Sammour, Adi Sharabi‐Nov, Manu Vatish, Hamutal Meiri, Marei Sammar

“…Preeclampsia prediction over preterm delivery had an AUC of 0.91 (0.79–0.99) with 80% sensitivity and 90% specificity with markers for complement activation (C1q) and autoimmunity markers. …”
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