C1q reprograms innate immune memory by Inge Jonkman, Maaike M. E. Jacobs, Yutaka Negishi, Yutaka Negishi, Julia I. P. van Heck, Vasiliki Matzaraki, Joost H. A. Martens, Marijke Baltissen, Michiel Vermeulen, Zahi A. Fayad, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Willem J. M. Mulder, Willem J. M. Mulder, Willem J. M. Mulder, Willem J. M. Mulder, Luuk B. Hilbrands, Leo A. B. Joosten, Leo A. B. Joosten, Mihai G. Netea, Mihai G. Netea, Musa M. Mhlanga, Musa M. Mhlanga, Nils Rother, Raphaël Duivenvoorden, Raphaël Duivenvoorden, Raphaël Duivenvoorden

Subjects: “…C1q…”
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Prognostic implications of complement C1q-like 4 expression in breast cancer by Qing Zhang, Zhijun Xing, Lu Bai, Xiao Li, Fan Xu

“…Abstract Higher expression of Complement C1q-like protein 4 (C1ql4) in breast cancer may be associated with increased tumor malignancy. …”
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Complement component C1q initiates extrinsic coagulation via the receptor for the globular head of C1q in adventitial fibroblasts and vascular smooth muscle cells by Christopher T. Freda, Wei Yin, Berhane Ghebrehiwet, David A. Rubenstein

Subjects: “…complement…”
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The role of complement C1q in atrial fibrillation: a marker for disease progression and surgical outcomes by Yuefeng Ju, MaoJing Wang, Yang Ji, Zhihui Wang, Wenzhuo Wang, Feiyue Liu, Qing Zhao

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C1q deficiency with severe skin manifestations: A case report from Pakistan by Kashmala Hussain, Shamila Ladak, Fizza Akbar, Salman Kirmani, Sadaf Altaf

Subjects: “…C1q…”
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Complement C1q is associated with neuroinflammation and mediates the association between amyloid-β and tau pathology in Alzheimer’s disease by Fan Guo, Ze-Hu Sheng, Yan Fu, Zhi-Bo Wang, Rong-Ji Xue, Lan Tan, Meng-Shan Tan, Zuo-Teng Wang

“…Abstract Complement C1q initiates the classical complement pathway and becomes activated in Alzheimer’s disease (AD), contributing to the association between amyloid-β (Aβ) and tau pathologies. …”
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Complement in anti-glomerular basement membrane glomerulonephritis by Pei Zhang, Kai-li Shi, Chun-lin Gao, Feng Xu, Li-li Jia, Ji-chao Sun

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Hereditary C1q deficiency: a new family with C1qA deficiency by Cağman Sun-Tan, Tuba Turul Ozgür, Gamze Kilinç, Rezan Topaloğlu, Ozay Gököz, Sibel Ersoy-Evans, Ozden Sanal

“… Hereditary deficiency of complement component C1q is a rare genetic disorder with susceptibility to recurrent infections with polysaccharide-containing encapsulated microorganisms and a high prevalence of autoimmune diseases, most often systemic lupus erythematosus (SLE). …”
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KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q by Jinglin Ji, Catherine Choi, Christopher E. Bope, Jacob S. Dengler, Stephen J. Moss, Joshua L. Smalley

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Obesity enhances ovarian cancer chemotherapy efficacy through C1q-mediated tumor targeting and immune activation by Shiyi Xu, Nana Bie, Xinzhuang Su, Xiaojuan Zhang, Shiyu Li, Haojie Liu, Tuying Yong, Qing Chen, Xiangliang Yang, Lu Gan

“…Mechanistically, the protein corona, particularly enriched with complement component 1q (C1q) in the plasma of obese mice, significantly enhances the internalization of PLD by ovarian cancer cells and elicits strong immunogenic cell death (ICD) effects. …”
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Dysregulated C1q and CD47 in the aging monkey brain: association with myelin damage, microglia reactivity, and cognitive decline by Sarah A. DeVries, Christina Dimovasili, Maria Medalla, Maria Medalla, Tara L. Moore, Tara L. Moore, Douglas L. Rosene, Douglas L. Rosene

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Prediction of activity of low-molecular inhibitors of the classic complement pathway using computational screening approach by D. M. Karlinsky, A. P. Kaplun, M. E. Popov

“…Using the molecular docking we estimated the free energy of binding of low-molecular ligands with the first component of complement protein C1q. The theoretically predicted values of IC50 allow selecting ligands with the highest inhibitory potential for further in vitro experiments…”
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Complement Evasion Protects FCoV from Virus Clearance Within Prototypic FIP Lesions by Anne Hönl, Sandra Felten, Katharina Erber, Michèle Bergmann, Sven Reese, Regina Hofmann-Lehmann, Marina L. Meli, Andrea M. Spiri, Katrin Hartmann, Kaspar Matiasek

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Elevated Plasma Complement C1Q Measured Subacutely after Traumatic Brain Injury Is Associated with Poor Functional Outcome Independent of Initial Injury Severity by Tracy Butler, Kewei Chen, Abigail Patchell, Xiangling Mao, Dikoma Shungu, Diany Paola Calderon, Jeanne T. Paz, Sudhin A. Shah

“…This study investigates the role of complement factor 1q (C1Q) in TBI recovery. Motivated by our rodent studies showing that thalamic inflammation post-TBI is dependent on C1Q and that blocking C1Q during the subacute period can prevent thalamic inflammation and improve aspects of TBI outcome, particularly sleep, we measured plasma C1Q levels 3–6 months post-injury in 27 patients with TBI ranging from complicated mild to severe, as well as 30 controls. …”
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A distinct variant of the SzM protein of Streptococcus equi subsp. zooepidemicus recruits C1q independent of IgG binding and inhibits activation of the classical complement pathway by René Bergmann, Wieland Schroedl, Uwe Müller, Christoph Georg Baums

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Value of prothrombotic state molecules and the serum level of complement C1q tumor necrosis factor-related protein 1 in predicting the prognosis of patients after percutaneous coronary intervention by WEN Bo

Subjects: “…coronary disease|percutaneous coronary intervention|thrombophilia|complement c1q|prognosis…”
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C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch by José M. Arreola-Guerra, Natalia Castelán, Adrián de Santiago, Adriana Arvizu, Norma Gonzalez-Tableros, Mayra López, Isaac Salcedo, Mario Vilatobá, Julio Granados, Luis E. Morales-Buenrostro, Josefina Alberú

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Evolving understanding of Guillain-Barré syndrome pathophysiology and the central role of the classical complement pathway in axonal injury by Kenneth C. Gorson

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Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia by Megumi Andoh, Natsuki Shinoda, Yusuke Taira, Tasuku Araki, Yuka Kasahara, Haruki Takeuchi, Masayuki Miura, Yuji Ikegaya, Ryuta Koyama

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Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain by Noosha Yousefpour, Shannon N. Tansley, Samantha Locke, Behrang Sharif, Marc Parisien, Farin B. Bourojeni, Haley Deamond, Vidhu Mathur, Nia Rahman-Khan Arana, Jean Sebastien Austin, Valerie Bourassa, Chengyang Wang, Valérie C. Cabana, Calvin Wong, Kevin C. Lister, Rose Rodrigues, Manon St-Louis, Marie-Eve Paquet, Michael C. Carroll, Yaisa Andrews-Zwilling, Philippe Seguela, Artur Kania, Ted Yednock, Jeffrey S. Mogil, Yves De Koninck, Luda Diatchenko, Arkady Khoutorsky, Alfredo Ribeiro-da-Silva

“…Furthermore, pharmacological inhibition of the complement protein C1q prevents dorsal horn inhibitory synapse loss and attenuates neuropathic pain. …”
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