Suppression of MT5-MMP Reveals Early Modulation of Alzheimer’s Pathogenic Events in Primary Neuronal Cultures of 5xFAD Mice by Dominika Pilat, Jean-Michel Paumier, Laurence Louis, Christine Manrique, Laura García-González, Delphine Stephan, Anne Bernard, Raphaëlle Pardossi-Piquard, Frédéric Checler, Michel Khrestchatisky, Eric Di Pasquale, Kévin Baranger, Santiago Rivera

“…MT5-MMP deficiency decreased endogenous and overexpressed C83 and C99 levels but did not affect Aβ levels. C99 appears to be cleared by several pathways, including γ-secretase, the autophagolysosomal system, and also α-secretase, via its conversion to C83. …”
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Lower respiratory rate during sleep in children with Angelman syndrome compared to age-matched controls by Leo Gschwind, Sebastian Camillo Holst, David Nobbs, Florian Lipsmeier, Katalin Buzasi, Ponghatai Boonsimma, Alexander Rotenberg, Vitaliy Kolodyazhniy, Jörg Felix Hipp

“…Abstract Background Angelman syndrome (AS) is a rare genetic neurodevelopmental disorder caused by the absence of a functional UBE3A gene, leading to developmental, behavioral, and medical challenges. …”
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The Conversion Polymorphism of Perovskite Phases in the BiCrO₃–BiFeO₃ System by Alexei A. Belik

“…This can be illustrated by a lot of discoveries of different new functionalities in bulk and thin films of BiFeO₃ and its derivatives. …”
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Mortality from external causes in late adolescence and early adulthood by gestational age and sex: a population-based cohort study in four Nordic countries by Josephine Funck Bilsteen, Signe Opdahl, Anna Pulakka, Per Ivar Finseth, Weiyao Yin, Kristine Pape, Jorun Schei, Johanna Metsälä, Anne-Marie Nybo Andersen, Sven Sandin, Eero Kajantie, Kari Risnes

“…Individuals born preterm are at increased risk of mental disorders, and impaired cognitive and executive functions, potentially increasing their vulnerability to death from external causes. …”
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Narrow-Margin Treatment with Modified Mohs Microsurgery for Extramammary Paget’s Disease: A Retrospective Clinical Analysis by Yang J, Yan J, Luo H, Li L, Jiang L, Chen X, Wu L, Chai J, Xue H, Gan L, Liu Y, Chen J, Fei W, Bai Y, Zhu Q, Chen Z, Guo L, Chen Y

“…Approximate 95% of tumors with 1 cm of non-scrotal skin extension or 1.5 cm of scrotal skin extension could be completely cleared. Univariable analysis revealed that hypopigmented patches (HR=14.0, 95% CI=1.269,154.395, p = 0.031) correlated with tumors recurrence.Conclusion: Narrow-margin mMMS is the ideal therapy combine a disease control rate with more satisfying functional results. …”
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Cloning, expression of carboxylesterase BioH and improvement of its hydrolysis activity by directed evolution by XU Hongna, YU Hongwei

“…It shows great significance to get the protein and optimize its functions.In this study, BioH gene from E. coli K12 was cloned into pET30a (+) using double digestion method by Bam HI and Hind Ⅲ and was overexpressed in E. coli BL21 (DE3) induced by isopropyl-β-D-thiogalactoside (IPTG). …”
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Bibliometric analysis of laryngeal cancer treatment literature (2003–2023) by Yan Zhao, Jiancheng Xue

“…Overall, the two tools differ in terms of functionality, data sources, visualization effects, and operational complexity, offering researchers complementary options for bibliometric analysis based on their specific needs.) …”
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Penerapan Metode K-Means Clustering dan Simple Moving Average untuk Memprediksi Jenis Penyakit di Provinsi Jawa Timur by Shynta Ayu Dwi Darmawan, Karmilasari

“…From this data, it is not clear which areas need priority handling. There are difficulties in identifying priority areas in disease management. …”
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Characterizing Patient-Reported Fatigue Using Electronic Diaries in Neurodegenerative and Immune-Mediated Inflammatory Diseases: Observational Study by Adrien Bennetot, Rana Zia Ur Rehman, Robbin Romijnders, Zhi Li, Victoria Macrae, Kristen Davies, Wan-Fai Ng, Walter Maetzler, Jennifer Kudelka, Hanna Hildesheim, Kirsten Emmert, Emma Paulides, C Janneke van der Woude, Ralf Reilmann, Svenja Aufenberg, Meenakshi Chatterjee, Nikolay V Manyakov, Clémence Pinaud, Stefan Avey

“…ObjectiveThis study aimed to evaluate the feasibility and acceptability of using a high-frequency eDiary to capture intraday variability in fatigue and to compare eDiary data with scores obtained from the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), a validated weekly recall PRO. …”
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Biofortification: Future Challenges for a Newly Emerging Technology to Improve Nutrition Security Sustainably by Howarth Bouis, Jennifer Foley, Keith Lividini, Jaya Jumrani, Russell Reinke, Dominique Van Der Straeten, Ronan Zagado, Erick Boy, Lynn R Brown, Bho Mudyahoto, Richard Alioma, Munawar Hussain, Wolfgang H Pfeiffer

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Issues of Interpretation and Application of the Notion of “International Legal Legitimation” by A. M. Korzhenyak

“…In the process of adapting to the changing realities of geopolitics and international law, collective legitimation has become one of the main political functions of the UN as a means of politically significant approval (or disapproval) of the behaviour and positions of states as consistent with international law and at the same time meeting the needs of the present, a means of recognising them as legitimate (or illegitimate). …”
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Evaluating the Effectiveness of a Roblox Video Game (Super U Story) in Improving Body Image Among Children and Adolescents in the United States: Randomized Controlled Trial by Nicole Paraskeva, Sharon Haywood, Jason Anquandah, Paul White, Mahira Budhraja, Phillippa C Diedrichs, Heidi Williamson

“…State mood, state body functionality, internalization of appearance ideals, and social media literacy showed no effects. …”
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Gene Editing Anxiety by Angelo Osofsky

“…For instance, gene-editing technologies like CRISPR-Cas9 can make unintended cuts in the genome, possibly preventing important genes from functioning properly. Additionally, cells may divide before gene-editing has completed, or the editing technology may inadvertently modify only one copy of the target alleles. …”
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Advancing Understanding of Anorectal Malformations Through Microfocus Computed Tomography Imaging of Resected Material by Daniël Docter, Bernadette S. de Bakker, Jaco Hagoort, Joris J.T.H. Roelofs, Sjoerd de Beer, Ernst van Heurn, Joep Derikx, Marc A. Benninga, Justin de Jong, Ramon R. Gorter

“…Although clinical functionality should be studied in the future, our results indicate that the fistula has a normal anal canal morphology and should be spared during ARM reconstruction if possible.…”
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Future Low-Cost Urban Air Quality Monitoring Networks: Insights from the EU’s AirHeritage Project by Saverio De Vito, Antonio Del Giudice, Gerardo D’Elia, Elena Esposito, Grazia Fattoruso, Sergio Ferlito, Fabrizio Formisano, Giuseppe Loffredo, Ettore Massera, Paolo D’Auria, Girolamo Di Francia

“…Its implementation allowed us to explore the benefits and limitations of citizen science approaches, the logistic and functional impacts of IoT infrastructures and calibration methodologies, and the integration of AI and geostatistical sensor fusion algorithms for mobile and opportunistic air quality measurements and reporting. …”
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How do strategic attributes of electronic commerce impel the perceived value and electronic loyalty of online food delivery applications (OFDAs) by Muhammad Asif Zaheer, Tanveer Muhammad Anwar, Zoia Khan, Muhammad Ali Raza, Hira Hafeez

“…Similarly, the study enabled the author to learn more about how people would use the information system after successfully applying the UTAUT. …”
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Multi-relation-pattern knowledge graph embeddings for link prediction in hyperbolic space by Longxin Lin, Huaibin Qin, Quan Qi, Rui Gu, Pengxiang Zuo, Yongqiang Cheng

“…The aim of Knowledge Graph Embedding (KGE) is to acquire low-dimensional representations of entities and relationships for the purpose of predicting new valid triples, thereby enhancing the functionality of intelligent networks that rely on accurate data representation. …”
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The 'missing babies' cases: Constitutional court vs. European court of human rights? by Draškić Marija

“…Therefore, the first and most important consequence of the Constitutional Court decision reviewed in this article is to learn that all so-called 'missing babies' cases - both before the domestic public authorities as well as before the European Court of Human Rights - are not the same. …”
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Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq by Daniil K. Lukyanov, Daniil K. Lukyanov, Valeriia V. Kriukova, Kristin Ladell, Irina A. Shagina, Irina A. Shagina, Dmitry B. Staroverov, Dmitry B. Staroverov, Bella E. Minasian, Anna S. Fedosova, Pavel Shelyakin, Oleg N. Suchalko, Alexander Y. Komkov, Konstantin A. Blagodatskikh, Kelly L. Miners, Olga V. Britanova, Olga V. Britanova, Olga V. Britanova, Andre Franke, David A. Price, David A. Price, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov

“…IntroductionThe functional programs of CD4+ T helper (Th) cell clones play a central role in shaping immune responses to different challenges. …”
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Full-Blood Inflammatory Ratios Predict Length of Stay but Not Early Death in Romanian Pulmonary Tuberculosis by Ionut-Valentin Stanciu, Ariadna-Petronela Fildan, Barkha Rani Thakur, Adrian Cosmin Ilie, Livia Stanga, Cristian Oancea, Emanuela Tudorache, Felix Bratosin, Ovidiu Rosca, Iulia Bogdan, Anca Chisoi, Ionela Preotesoiu, Viorica Zamfir, Elena Dantes

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