Early posttranscriptional response to tetracycline exposure in a gram-negative soil bacterium reveals unexpected attenuation mechanism of a DUF1127 gene by Jennifer A. F. Kothe, Till Sauerwein, Theresa Dietz, Robina Scheuer, Muhammad Elhossary, Susanne Barth-Weber, Jan Wähling, Konrad U. Förstner, Elena Evguenieva-Hackenberg

“…Besides ten upregulated ribosomal genes, there was no recognizable functional pattern in the observed changes. However, polar differential expression pattern was observed: Mostly, upregulated genes were first and downregulated genes downstream in operons. …”
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Comparative study on the photosynthetic properties of four rare and endangered Dendrobium species by CHEN Ni1,2, PENG Lihui1 , JIANG Haidu1, YANG Zhe1,2, JIANG Qiang3, QIU Shuo1, XIONG Zhongchen1, WEI Xiao1, CHAI Shengfeng1*

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Evaluation of a Guided Chatbot Intervention for Young People in Jordan: Feasibility Randomized Controlled Trial by Anne Marijn de Graaff, Rand Habashneh, Sarah Fanatseh, Dharani Keyan, Aemal Akhtar, Adnan Abualhaija, Muhannad Faroun, Ibrahim Said Aqel, Latefa Dardas, Chiara Servili, Mark van Ommeren, Richard Bryant, Kenneth Carswell

“…The research protocol functioned well in terms of balanced randomization, high retention at postassessment (48/60, 80%), and good psychometric properties of the online questionnaires. …”
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A scRNA-seq reference contrasting living and early post-mortem human retina across diverse donor states by Luning Yang, Yiwen Tao, Qi Pan, Tengda Cai, Yunyan Ye, Jianhui Liu, Yang Zhou, Yongqing Shao, Quanyong Yi, Zen Huat Lu, Lie Chen, Gareth McKay, Richard Rankin, Weihua Meng

“…Additionally, by comparing living and post-mortem samples, our study highlights differences in transcriptional dynamics: living tissue preserved coherent RNA velocity streams, enabling clear dynamic state transitions, while post-mortem tissue exhibited disorganized patterns. …”
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Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy by Xiongbao Wang, Xiongbao Wang, Xiongbao Wang, Liang Fang, Liang Fang, Lixiang Xiao, Guangxin Zhong, Minghao Han, Bingshen Wang, Juchao Ren, Yuanwei Zang, Yuanwei Zang

“…BackgroundLysomembrane-associated protein 1 (LAMP1), known to exhibit differential expression in various tumor types and play a crucial role in the development of tumors. Clear cell Renal Cell Carcinoma (ccRCC) is still the most common pathological type of renal carcinoma with poor prognosis. …”
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Three-Leaf-Clover Thyroid and Minimally Invasive Trans-Cervical Synchronous Thyroidectomy and Ectopic Mediastinal Thyroid Tissue Removal: Does the Age of the Patient Count amid a M... by Claudiu Nistor, Mihai-Lucian Ciobica, Oana-Claudia Sima, Anca-Pati Cucu, Mihai Costachescu, Adrian Ciuche, Lucian-George Eftimie, Dana Terzea, Mara Carsote

“…This innovative surgical procedure offers the advantage of avoiding a sternotomy incision which has clear functional and aesthetic implications, while the video-assisted approach allows optimal visualization of the mediastinal anatomy and safe vascular sealing under visual control, without the risk of a major hemorrhage.…”
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Cognitive impact and brain structural changes in long COVID patients: a cross-sectional MRI study two years post infection in a cohort from Argentina by Sol A. Cataldo, Andrea Micciulli, Laura Margulis, Melina Cibeyra, Sabrina Defeo, Silvina G. Horovitz, Analía Martino, Raul Melano, Milagros Mena, Francisco Parisi, Diego Santoro, Florencia Sarmiento, Martin A. Belzunce

“…Neuroimaging studies have identified structural alterations in brain regions linked to cognitive functions. However, most of these studies have focused on patients within months of their initial infection. …”
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Novel insecticide resistance mutations associated with variable PBO synergy in Anopheles gambiae s.l. from the Democratic Republic of Congo by Bethanie Pelloquin, Fiacre Agossa, Holly Acford-Palmer, Tiffany Clark, Sheila B. Ogoma, Miriam Williams, Narcisse Basosila, Francis Watsenga, Emery Metelo, Richard M. Oxborough, Yibayiri Osee Sanogo, Ferdinand Ntoya, Emma Collins, Sophie Moss, Charles McLoughlin, Monica Campos, Jody Phelan, Mark Rowland, Thomas Walker, Noboru Minakawa, Emile Zola Manzambi, Eric Mukomena, Susana Campino, Louisa A. Messenger

“…Gste2-L119V was significantly associated with resistance to deltamethrin following PBO-pre-exposure, warranting functional validation to determine its putative role in reduced PBO synergy. …”
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Knee-Sparing Resection and Reconstruction Surgery for Bone Sarcoma Using 3D-Surgical Approach: Average of 5-Year Follow-Up by Amit Benady, Noy Yehiel, Ortal Segal, Omri Merose, Amir Sterenheim, Osnat Sher, Ben Efrima, Eran Golden, Yair Gortzak, Solomon Dadia

“…This study aims to evaluate the effectiveness of a precise 3D-based surgical approach for knee-sparing tumor resections, assessing its feasibility and its impact on surgical, oncological, and functional outcomes. <i>Materials and Methods</i>: This single-center retrospective study presents the surgical and oncological outcomes of knee-sparing surgeries following bone sarcoma resections. …”
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Renewable Energy Sources and the New Paradigm in Energy Engineering by Eden Mamut

“…As a consequence, in the new paradigm, the optimization solutions are shifting from compliance with simple objective functions (as minimal cost or minimal impact) towards compliance with complex, dynamic, data driven solutions.…”
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Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials. by Harsha Shanthanna, Ian Gilron, Manikandan Rajarathinam, Rizq AlAmri, Sriganesh Kamath, Lehana Thabane, Philip J Devereaux, Mohit Bhandari

“…Pregabalin (PG) and Gabapentin (GB) are gabapentinoids that have demonstrated benefit in neuropathic pain conditions. Despite no clear rationale, they are increasingly used for nonspecific CLBP. …”
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Evaluation of the efficiency and safety of combined therapy with a symptomatic sustained-release drug and hyaluronic acid versus monotherapy with hyaluronic acid in patients with... by K. A. Berdyugin, I. V. Kadyntsev, O. V. Berdyugina, E. A. Taskina, N. G. Kashevarova

“…At the same time, evaluating the intergroup values revealed clear differences: a more pronounced decrease in all WOMAC indicators in Group 1 patients: pain scores, 2 [1; 3] vs. 4 [2; 5] in Group 2 (p&lt;0.001); stiffness, 1 [0; 2] vs. 2 [1; 4] (p&lt;0.001); functional insufficiency, 8 [3; 12] vs. 15.5 [12; 20] (p&lt;0.001); and total WOMAC scores, 12 [7; 13] vs. 21.5 [15; 28] (p&lt;0.001). …”
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One-dimensional actions of Higman's group by Cristobal Rivas, Michele Triestino

“…(It follows from abstract considerations that the quotient of the space of $\mathbb R$-valued quasimorphisms by the space of bounded functions is of continuum-sized dimension, but that does not imply that any of them are $\mathbb Z$-valued.) …”
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CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA by Hao Ning, Yan Jiang, Binbin Li, Junwu Ren, Cong Wang, Ling Wei, Linfei Li, Ai Ran, Zuozhang Li, Jiao Li, Wei Li, Yongquan Wang, Bin Xiao

“…Abstract Background The reliance of clear cell renal cell carcinoma (ccRCC) on exogenous cholesterol import implies a metabolic susceptibility. …”
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Beyond access: assessing WASH service delivery models in healthcare facilities of North Mecha, Dera, and Farta, Ethiopia by Abireham Misganaw Ayalew

“…Effective WASH service delivery in HCFs involves establishing clear and practical policies and strategies, institutional arrangements and capacity, accountability mechanisms, as well as financing, planning, and monitoring. …”
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Abscisic Acid Can Improve the Salt Tolerance and Yield of Rice by Improving Its Physiological Characteristics by Xi Wang, Guohui Ma, Naijie Feng, Dianfeng Zheng, Hang Zhou, Jiahuang Li, Jiashuang Wu, Bing Xu, Weiling Su, Yixi Huang

“…There was a notable decline in the net photosynthetic rate; moreover, the yield was diminished by 26.90%. Salt-induced stress clearly imposed negative impacts on these aspects of rice’s physiological functions and productivity. …”
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Idade e indicações de osteotomias para avanço frontofacial em pacientes com craniossinostoses sindrômicas Age and indications for osteotomy for frontofacial advancement in patients... by Nivaldo Alonso, Hamilton Matushita, Dov Charles Goldenberg, Endrigo Oliveira Bastos

“…CONCLUSIONS: In cases of severe craniosynostosis with functional problems, monobloc frontofacial advancement is still the best therapeutic option.…”
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Using Human‐Centred Design to Codesign Patient Engagement Tools With a Patient Advisory Council: Successes and Challenges by Madelyn Knaub, Santiago Leon, Surakshya Pokharel, Veronika Kiryanova, Kim Giroux, Prachi Khanna, Anna Rychtera, D'Arcy Duquette, Pamela Mathura, Nancy Verdin, Anshula Ambasta

“…Human Centred Design (HCD), a problem‐solving methodology focused on creating functional solutions for users, offers a promising approach to co‐building patient engagement tools. …”
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INTERNATIONAL LEGAL STANDARDS OF HUMAN RIGHTS: TOWARDS THE OBJECTIVITY OF THE ISSUE OF CODIFICATION WORKS by Mykhailo O. Baimuratov, Boris Ya. Kofman, Natalia V. Yefremova

“….), and secondly, establish mandatory obligations of their member states (international legal obligations of states, obligations of states under international treaties signed by them) in relation to a wide range of rights recognized by their legally recognized international catalog (personal, political, economic, social, cultural, environmental), thirdly, in the process of their implementation in various conditions (peacetime, state of martial law or war, environmental and man-made disasters, other extraordinary conditions of existence and functioning of statehood, etc.). It is noted that in the modern world, since the creation of the UN, the protection and observance of the basic rights and freedoms of a person and a citizen have ceased to be the competence of a specific country, but have become the business of the entire international community, since, first of all, it is the "alpha and omega" of international cooperation of states in its boundaries (the teleological factor of the modern international order – author); secondly, it is precisely within its limits that a powerful international legal array of treaty law documents was created regarding such specialized protection and protection of human and citizen rights / thanks to the increased concern and attention of the international community to these issues at various times, authoritative international organizations, including the UN, adopted about 300 declarations, conventions, charters/ (determining source factor of the modern international order – author); thirdly, for a long time, they have been the most important task of many states of the world community in terms of fulfilling their international legal obligations, taken within the framework of the international treaties signed by them and the implementation of their instructions within the limits of national jurisdiction (a mandatory factor of the modern international order – author); fourthly, there are clear international legal mechanisms of protection, protection and control over the fulfillment by member states of the international community of international legal obligations in the field of human and citizen rights and freedoms (the technologically protected factor of international protection, protection and control of modern international order – author); fifthly, the regulatory and technological phenomenon "international legal standards of the rights and freedoms of man and citizen" was used for the first time, which was transformed into an important, modern, effective phenomenology of modern international law, based on the relevant international and national implementation mechanisms of the international treaty law and provides for the mandatory borrowing of the above standards by the national constitutional legislation of the states – respectively, either signatories, or participants, or parties to relevant contractual international legal acts (transformational and implementation factor of international protection, protection and control of the modern international order – author). …”
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Genetic diversity of Mycobacterium tuberculosis in Peru and exploration of phylogenetic associations with drug resistance. by Patricia Sheen, David Couvin, Louis Grandjean, Mirko Zimic, Maria Dominguez, Giannina Luna, Robert H Gilman, Nalin Rastogi, David A J Moore

“…<h4>Background</h4>There is limited available data on the strain diversity of M tuberculosis in Peru, though there may be interesting lessons to learn from a setting where multidrug resistant TB has emerged as a major problem despite an apparently well-functioning DOTS control programme.…”
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