Integrated genomic and transcriptomic analysis of polydactyly in chickens by Zhiying Huang, Xiaomeng Miao, Diyan Li, Jia Liu, Haolin Chen, Yuan Su, Yuan Su

“…Clustering analyses indicated coordinated regulation of genes involved in ribosome biogenesis, extracellular matrix organization, and muscle development across stages.DiscussionOur integrated analyses pinpoint MAPK pathway genes and lipid-vascular interactions as central to extra-toe formation, with the Days 8–9 embryonic window being pivotal. These findings offer clear targets for functional validation and may guide selective breeding for limb traits in poultry.…”
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Examining the normative results of the Arab Spring on the legal status of religious minorities; Case study of Egypt by mohammad yosefzadeh, mohammad jalali

“…Additionally, the prevailing policies indicated that the Egyptian governments over the years had imposed clear discrimination against these minorities. Therefore, examining the legal norms influenced by the Arab Spring on the legal status of religious minorities in Egypt, which took a more concrete form with the drafting of the 2012 and 2014 constitutions, is an issue worthy of attention.Methods: This paper, adopting a descriptive-analytical approach and utilizing the method of studying library resources, articles, etc., is written to analyze the research topic. …”
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Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells by Qimin Hai, Peter Bazeley, Juying Han, Gregory Brubaker, Jennifer Powers, Claudia M. Diaz-Montero, Jonathan D. Smith

“…Using up to five independent iPSC donors, we performed several assays for macrophage functions and polarization, such as marker protein staining by flow cytometry, lipoprotein uptake, phagocytosis, cytokine release, inflammasome activation, and the effects of M1-like and M2-like polarization. …”
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Rapid method for identification of transgenic fish zygosity by . Alimuddin, G. Yoshizaki, O. Carman

“…The results demonstrated a clear-cut identification of all transgenic fish (n=20) classified as a homozygous or heterozygous.  …”
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Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells by Jerome Tan, Jiahui Chen, Daniel Roxby, Wai Hon Chooi, Tan Dai Nguyen, Shi Yan Ng, Jongyoon Han, Sing Yian Chew

“…On the other hand, cellular biophysical properties have demonstrated a strong correlation to cell state, quality and functionality and can be measured with ingenious label-free technologies in a rapid and non-destructive manner. …”
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Violence against healthcare professionals: perspective of local focal points in the south of Portugal by Maria Otília Zangão, Isaura Serra, Dulce Cruz, Maria da Luz Barros, Anabela Coelho, Maria Antónia Chora, Carolina Santos, Laurência Gemito

“…,departments, services, offices or functional units) on violence against health professionals in the Alentejo region. …”
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Characteristics of Land Use Change and Evaluation of Ecological Sensitivity in Chongqing by XIE Xianjian, GOU Qiantao, WU Han

“…[Objective] Chongqing, as the economic center of the upper reaches of the Yangtze River in China and a barrier to ensure ecological security in the middle and lower reaches of the Yangtze River, is a typical ecological functional and fragile area in China. Studying the spatiotemporal evolution characteristics and ecological sensitivity of its land use is of great significance for the reconstruction of land use and ecological protection in the research area. …”
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Sodium glucose co-transporter 2 inhibitors and cardiovascular event protections: how applicable are clinical trials and observational studies to real-world patients? by Ming-Jui Hung, Edward Chia-Cheng Lai, Shih-Chieh Shao, Yi-Han Lin, Kai-Cheng Chang, Yuk-Ying Chan, Yea-Huei Kao Yang

“…We found channeling uses in different SGLT2i, for example, more patients receiving empagliflozin (15.3%) and canagliflozin (19.6%) had poorer renal functions (eg, estimated glomerular filtration rate <60 mL/min/1.73 m2), compared with dapagliflozin (9.3%).Conclusions The findings provide clear evidence that results from current studies may be less applicable to real-world patients. …”
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Cocreating a Mobile Health App Providing Physical Activity Recommendations for Older People Living With Parkinson Disease or Dementia: User-Centered Pilot Study by Ellen Bentlage, Alberto del Río Ponce, Mona Ahmed, Pilar Gangas, Michael Brach, Jorge Alfonso Kurano, José Manuel Menéndez

“…The research team has identified that digital systems, that provide monitoring functions of the mobile health app and Fitbit wristband are considered advantageous by participants in the cocreation process. …”
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Evaluation of the Back-in-Action test Battery In Uninjured High School American Football Players by Marcel Rohde, Alina Ruhlemann, Andre Busch, Ulrich Grunwald, Marcus Jaeger, Constantin Mayer

“… # Conclusion Only 53% of the healthy athletes would have been cleared for sport using the BIA test criteria, which highlights the challenging passing criteria. …”
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Developing a Digital Tool to Calculate Protein Quality in Plant-Based Meals of Older Adults: User Engagement Design Approach With End Users by Lotte van Dam, Sine Højlund Christensen, Inge Tetens, William Riley III, Mariëlle Timmer, George Suciu Jr, Iuliana Marin, Lisette De Groot, Pol Grootswagers

“…The user-task-environment analysis delivered input among others that dietitians and older adults are good potential users, the tool should be functional as an app as well as a website and the tool should provide preprogrammed meals or recipes. …”
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Micro-climate of nature-based solutions in stockholm royal seaport by Artur Branny, Erik Andersson, Timon McPhearson

“…Despite large differences in vegetation and urban landscape, we did not observe a clear trend in air temperature differences between sites, even for experimental reference sites. …”
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Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis by Lijiao Chen, Shiyuan Luo, Ting Liu, Zhewei Shuai, Yifan Song, Qianzi Yang, Ying Wang, Hongjun Huang, Yan Luo

“…The anti-GDF15 monoclonal antibody ponsegromab was injected intracerebroventricularly before modeling, and cognitive and memory functions of the septic mice were assessed using fear-conditioning and novel object recognition tests. …”
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Young Scientists’ Motivation for the Research Activity in Russian Regional Universities by R. A. Dolzhenko, V. A. Karpilianskii, R. A. Hady, A. S. Didenko

“…The generalisation of results based on the questionnaire and the interviews of young researchers made it possible to specify their motivational features and to identify the structural core. There is a clear discrepancy between the desire of respondents to engage in research and the opportunities provided at the state and regional levels, and in the scientific and educational organisations. …”
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BLACK HUMOUR: ORIGIN DESCRIPTION AND AN ATTEMPT OF IDENTIFICATION by Iryna A. Blynova.

“…The compositional and speech means of organising black humour is based on opposition, antonymy of lexical units, contrast. The functioning of hyperbole, verbal and situational irony, and paradox are frequent at the lexical and semantic level. …”
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LncRNA H19 acts as a ceRNA to promote glioblastoma malignancy by sponging miR-19b-3p and upregulating SERPINE1 by Wonyi Jang, Mijung Im, Goeun Yoon, Jungwook Roh, Wanyeon Kim

“…Experimental validation demonstrated that H19 upregulates SERPINE1 expression, while miR-19b-3p directly binds to both H19 and SERPINE1, suppressing SERPINE1 expression. Functional assays further confirmed that H19 promotes cell survival, migration, and invasion, whereas miR-19b-3p inhibits these processes by downregulating SERPINE1. …”
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Assessing Maritime Search and Rescue Accessibility from South China Sea Islands and Reefs to Shipping Routes by Shi Shaochen, Wu Wenzhou, Zhang Peng, Li Fengyu, Su Fenzhen

“…In this study, a Voronoi diagram was used to spatially configure the South China Sea islands and reefs and indicate their functional areas. Subsequently, multilevel buffer zones were utilized to grade their SAR ranges. …”
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How does soil carbon sequestration affect greenhouse gas emissions from a sheep farming system? Results of an life cycle assessment case study by Pasquale Arca, Enrico Vagnoni, Pierpaolo Duce, Antonello Franca

“…The extensification process shows clear environmental advantage when emission intensity is referred to the area-based functional unit (FU). …”
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WORK EXPERIENCE INTERNSHIP THROUGH THE EYES OF TECHNICAL UNIVERSITY STUDENTS (ON THE MATERIALS OF SOCIOLOGICAL RESEARCH) by Alexandr Yu. Myagkov, Maria V. Grigorieva, Irina V. Zhuravleva, Svetlana L. Zhuravleva

“…The results show that a third of fifth-year students are not satisfied with the work experience internship organization by the university and host company actions, more than a quarter of students are not ready to practical work, 40% feel the clear lack of practical skills in their future profession. …”
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Reform of the Vatican media, a difficult search for a new path by Leszek Gęsiak

“…It became clear that the structural changes in the Vatican would be one of the challenges which would face the next successor of St. …”
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