The interplay among sleep patterns, social habits, and environmental cues: insights from the Spanish population and implications for aligning daily rhythms by María-Ángeles Bonmatí-Carrión, María-Ángeles Bonmatí-Carrión, Jesús Vicente-Martínez, Jesús Vicente-Martínez, Juan Antonio Madrid, Juan Antonio Madrid, Maria Angeles Rol, Maria Angeles Rol

“…A number of indexes were computed to compare bed and work-related habits, together with natural light/dark cycle, along with the Three Times Score. …”
Get full text

Impact of Wind Pressure Coefficients on the Natural Ventilation Effectiveness of Buildings through Simulations by Nayara Rodrigues Marques Sakiyama, Joyce Correna Carlo, Felipe Isamu Harger Sakiyama, Nadir Abdessemed, Jürgen Frick, Harald Garrecht

“…Four <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>C</mi></mrow><mrow><mi>p</mi></mrow></msub></mrow></semantics></math></inline-formula> sources are considered: an analytical model from the BES software (i), surface-averaged <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>C</mi></mrow><mrow><mi>p</mi></mrow></msub></mrow></semantics></math></inline-formula> values for building windows that were calculated with Computational Fluid Dynamics (CFD) simulations using OpenFOAM through a cloud-based platform (ii_a,b,c), and two databases—AIVC (iii) and Tokyo Polytechnic University (TPU) (iv). …”
Get full text

Standardizing Survey Data Collection to Enhance Reproducibility: Development and Comparative Evaluation of the ReproSchema Ecosystem by Yibei Chen, Dorota Jarecka, Sanu Ann Abraham, Remi Gau, Evan Ng, Daniel M Low, Isaac Bevers, Alistair Johnson, Anisha Keshavan, Arno Klein, Jon Clucas, Zaliqa Rosli, Steven M Hodge, Janosch Linkersdörfer, Hauke Bartsch, Samir Das, Damien Fair, David Kennedy, Satrajit S Ghosh

“…ReproSchema is an ecosystem that standardizes survey design and facilitates reproducible data collection through a schema-centric framework, a library of reusable assessments, and computational tools for validation and conversion. Unlike conventional survey platforms that primarily offer graphical user interface–based survey creation, ReproSchema provides a structured, modular approach for defining and managing survey components, enabling interoperability and adaptability across diverse research settings. …”
Get full text

Dry Eye Epidemiology in Patients before Cataract Surgery by S. N. Sakhnov, S. V. Yanchenko, A. V. Malyshev, V. V. Dashina, A. R. Ceeva, L. M. Petrosyan

“…OSDI testing, lipid interferential test, TBUT, Shirmer-1, -2 tests, visual and OCT meniscometry, evaluation of epitheliopaty and microerosion (with vital staining), compression Norn test in Korb modification, visual and OCT LIPCOF assessment, lid viper epitheliopathy evaluation, anterior segment of the eye photoregistration with computer morphometry were performed to assess the ocular surface condition. …”
Get full text

ITGA4 Contributes to 5-Fluorouracil Resistance by Up-Regulating PI3K/AKT Signaling: Evidence from Network Pharmacology, Molecular Docking and Experimental Verification by Yan S, Hu X, Wu Y, Ye W, Zhu Y, He Y, Zhan F, Wu W, Ma Z

“…However, the molecular mechanism of action of 5-FU in GC has not yet been studied using a network pharmacology approach.Methods: The mechanism of action of 5-FU in GC was determined using a network pharmacology technique, and our findings were confirmed by various computational approaches and experimental tests using the GeneCards database, ChEMBL database, STRING database, molecular docking, molecular dynamics simulation, DAVID, GEPIA, Kaplan‒Meier Plotter, CCK-8 assays, colony formation experiments, cell proliferative assay, apoptosis assays, wound-healing assays, Real-time PCR and Western blot tests.Results: A total of 21 shared and 13 potential targets were identified using PPI network analysis. …”
Get full text

MRI based paraspinal muscle mass predicts early cage subsidence after posterior lumbar interbody fusion by Zijian Yang, Jie Liang, Dawei Shi, Can Tuo, Yu Wu, Fan Zhang

“…Although quantitative computed tomography (QCT) offers improved accuracy, it can be compromised by calcified structures. …”
Get full text

Visualization of eschatological semiotics in informational discourses of modern marginal Orthodoxy / Визуализация эсхатологической семиотики в информационных дискурсах современного... by Vladimir Lebedev / Владимир Юрьевич Лебедев, Alexander Prilutskii / Александр Михайлович Прилуцкий

“…The corresponding visual discourse also includes standard elements of computer graphics widely circulated on the internet, such as emoticons, which have simplified and caricatured facial features. …”
Get full text

Associations of greenhouse gases, air pollutants and dynamics of scrub typhus incidence in China: a nationwide time-series study by Haoyue Cao, Jianqiang Han, Weiming Hou, Juxiang Yuan

“…The Quantile-based G Computation (qgcomp) model revealed age-specific differences in susceptibility to environmental factors. …”
Get full text

MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3 by Lou Zhong, Siyuan Sun, Jiahai Shi, Fei Cao, Xiao Han, Zhong Chen

“…The downregulation of miR-125a-5p provided very contrasting results. Computational algorithms predicted that the STAT3 is a target of miR-125a-5p. …”
Get full text

Prostatectomy outcomes for patients with benign prostatic hyperplasia and its associated factors in East and West Gojjam zones comprehensive specialized hospitals, Northwest Ethiop... by Abebe Dilie Afenigus, Berhanu Kassahun, Megbar Dessalegn, Asmamaw Getnet, Mihretie Gedfew, Tiringo Kebede

“…Besides this, logistic regression models were computed to assess the relationship between variables. …”
Get full text

Recommendations for Designing a Digital Health Tool for Blindness Prevention Among High-Risk Diabetic Retinopathy Patients: Qualitative Focus Group Study of Adults With Diabetes by Akua Frimpong, Alvaro Granados, Thomas Chang, Julia Fu, Shannan G Moore, Serina Applebaum, Bolatito Adepoju, Mahima Kaur, Vignesh Hari Krishnan, Amanda Levi, Terika McCall, Kristen Harris Nwanyanwu

“…Over 80% (15/19) had access to smart devices, including smartphones (17/19, 89%), smartwatches (4/19, 21%), computers (14/19, 74%), and tablets (11/19, 58%). Many participants had access to multiple devices (17/19, 89%). …”
Get full text

Acute Symptomatic Epileptic Seizures After Microsurgical Removal of Supratentorial Meningiomas by D. I. Abzalova, A. V. Prirodov, M. V. Sinkin, P. I. Solovyeva, I. I. Goncharova

“…We have identified the following risk factors for the development of acute symptomatic epileptic seizures: an increase in the volume of cerebral edema compared to the preoperative level according to postoperative computed tomography, the development of hemorrhagic transformation of cerebral edema in both groups, and the intersection of one or more veins during surgery (in the placebo group). …”
Get full text

The association between blood count based inflammatory markers and the risk of atrial fibrillation heart failure and cardiovascular mortality by Yi Luo, Liu Yang, XunJie Cheng, YongPing Bai, ZhiLin Xiao

“…The exposures were blood-count-based inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), aggregate index of systemic inflammation (AISI), and systemic inflammatory response index (SIRI), which were computed using leukocyte counts (lymphocytes, monocytes, and neutrophils). …”
Get full text

Abstract 224: Morphological characteristics of carotid webs associated with stroke risk and clot burden by Pedro N. Martins, Mateus D. Monteiro, Mohamed A. Tarek, Fadi Nahab, Jaydevsinh Dolia, Jason Allen, Michael Frankel, Raul Nogueira, Diogo Haussen

“…We aim to evaluate the associations between CaW morphological features evaluated via computed tomography angiography (CTA) with clinical and radiological variables. …”
Get full text

Virtual Patients Using Large Language Models: Scalable, Contextualized Simulation of Clinician-Patient Dialogue With Feedback by David A Cook, Joshua Overgaard, V Shane Pankratz, Guilherme Del Fiol, Chris A Aakre

“… BackgroundVirtual patients (VPs) are computer screen–based simulations of patient-clinician encounters. …”
Get full text

LCFANet: A Novel Lightweight Cross-Level Feature Aggregation Network for Small Agricultural Pest Detection by Shijian Huang, Yunong Tian, Yong Tan, Zize Liang

“…The LCFANet-n model has <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>2.78</mn><mi>M</mi></mrow></semantics></math></inline-formula> parameters and a computational cost of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>6.7</mn></mrow></semantics></math></inline-formula> GFLOPs, enabling lightweight deployment. …”
Get full text

Persistent burden and health inequalities of disease in women of childbearing age attributable to Intimate Partner Violence, 1990–2021 by Yingda Song, Yingda Song, Yingda Song, Juan Wang, Jiaxuan Wang, Yan Ren, Jun Ma

“…To assess both absolute and relative health disparities, the Slope Index of Inequality (SII) and the Concentration Index were computed.ResultsIn 2021, global IPV-related mortality and DALYs among WBCA were 44,661 and 5.35 million, respectively. …”
Get full text

Long-term effect of berberine in preventing recurrence of colorectal adenomas and neoplasms after endoscopic resection: 6-year-follow-up in a randomized, placebo-controlled, multic... by Yongjie Tan, Jingyuan Fang, Tianhui Zou, Ke Yu, Jian-Qiu Sheng, Peng Jin, Ming-Jie Zhang, Xiao-Ping Zou, Xiao-Tan Dou, Si-De Liu, Shao-Hui Huang, Jian-Lin Ren, Xiao-Ning Yang, Zhan-Ju Liu, Xiao-Min Sun, Bang-Mao Wang, Hai-Long Cao, Qin-Yan Gao, Hui-Min Chen, Yun Cui, Ying-Xuan Chen

“…Mantel-Haenszel test was used to compute relative risks (RRs) and 95% confidence intervals (CIs) for the effect of BBR on risk of adenoma recurrence. …”
Get full text

Review and practical excursus on the comparison between traditional statics methods and Classification And Regression Tree (CART) in real-life data: Low protein diet compared to Me... by Vincenzo Calabrese, Daniela Metro, Angela Alibrandi, Domenico Maviglia, Valeria Cernaro, Veronica Maressa, Elisa Longhitano, Guido Gembillo, Domenico Santoro

“…The Classification and Regression Tree (CART) is a supervised learning approach useful used to segment the space of and the predictors/features space into smaller homogeneous regions that are, represented in a decision tree. It computes the selection of features automatically, in contrast to traditional statistic methods. …”
Get full text

Development, characterization, and replication of proteomic aging clocks: Analysis of 2 population-based cohorts. by Shuo Wang, Zexi Rao, Rui Cao, Anne H Blaes, Josef Coresh, Rajat Deo, Ruth Dubin, Corinne E Joshu, Benoit Lehallier, Pamela L Lutsey, James S Pankow, Wendy S Post, Jerome I Rotter, Sanaz Sedaghat, Weihong Tang, Bharat Thyagarajan, Keenan A Walker, Peter Ganz, Elizabeth A Platz, Weihua Guan, Anna Prizment

“…The de novo ARIC PACs were constructed by training them against chronological age using elastic net regression in two-thirds of healthy participants in midlife and late life and validated in the remaining one-third of healthy participants at the corresponding time point. We also computed 3 published PACs. We estimated age acceleration for each PAC as residuals after regressing each PAC on chronological age. …”
Get full text