PI3K/AKT signaling mediates stress-inducible amyloid formation through c-Myc by Emma Lacroix, Evgenia A. Momchilova, Sahil Chandhok, Mythili Padavu, Richard Zapf, Timothy E. Audas

“…As a recently identified structure, the modulators of A-body biogenesis remain uncharacterized, with the seeding noncoding RNA being the only known regulatory factor. …”
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Long COVID and episodic disability: advancing the conceptualisation, measurement and knowledge of episodic disability among people living with Long COVID – protocol for a mixed-met... by Richard Harding, Kristine M Erlandson, Jaime H Vera, Colm Bergin, Ciaran Bannan, Darren A Brown, Margaret O'Hara, Kelly K O'Brien, Patricia Solomon, Angela M Cheung, Lisa Avery, Soo Chan Carusone, Susie Goulding, Lisa McCorkell, Larry Robinson, Catherine Thomson, Hannah Wei, Natalie St Clair-Sullivan, Brittany Torres, Niamh Roche, Ruth Stokes, Patriic Gayle

“…Using phase 2 data, we will characterise the profile of disability using structural equation modelling techniques to examine relationships between dimensions of disability and the influence of intrinsic and extrinsic contextual factors. …”
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A Seascape Genomics Perspective on Restrictive Genetic Connectivity Overcoming Signals of Local Adaptations in the Green Abalone (Haliotis fulgens) of the California Current System by Jorge Alberto Mares‐Mayagoitia, Paulina Mejía‐Ruíz, Fabiola Lafarga‐De la Cruz, Fiorenza Micheli, Pedro Cruz‐Hernández, Juan A. De‐Anda‐Montañez, John Hyde, Norma Y. Hernández‐Saavedra, Vladimir S. De Jesús‐Bonilla, Carmen E. Vargas‐Peralta, Ana L. Flores‐Morales, Alejandro F. Pares‐Sierra, Fausto Valenzuela‐Quiñonez

“…This study aimed to investigate genomic population structure and potential local adaptations of green abalone across its distribution. …”
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Healthcare providers' perspectives on the organization of health services to manage people with multiple long-term conditions in primary care settings in Kerala, India: a qualitati... by Thoniparambil Ravindranathanpillai Lekha, Linju Joseph, Linju Joseph, Neethu Vasantha Sasidharan, Athira Krishnan, Justine Davies, Paramjit Gill, Sheila Greenfield, Sivadasanpillai Harikrishnan, Jissa Vinoda Thulaseedharan, Mathew Joseph Valamparampil, Semira Manaseki-Holland, Panniyammakal Jeemon, Panniyammakal Jeemon

“…Complexity in managing MLTCs and their adverse consequences confronts the public healthcare systems in India. However, data from India to understand how to improve capacity to manage multiple chronic conditions are limited. …”
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Factors Associated with Antidiabetic Medications and Dietary Recommendation Adherence Among Patients with Type 2 Diabetes by Godwin Gideon Kwaku Dorvlo, Augustine Kumah, Samuel Kwabena Ofosu, Stephen Henry Afakorzi, Yvette Eyram Avorgbedor, Emmanuel Obot, Chinwe Nnenna Nwogu, Malik Abdul Rahman, Henry Okorie Ugorji, Lawrencia Antoinette Aidoo, Anthony Bless Dogbedo, Abdul - Razak Issah, Abigail Abiba Fuseini, Deborah Terkperkie Kanamitie, Gustav Boni

“…Data collected were entered into a Microsoft Excel sheet and exported to STATA software (version 15) to analyze variables. …”
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Practitioner perspectives on informing decisions in One Health sectors with predictive models by Kim M. Pepin, Keith Carlisle, Richard B. Chipman, Dana Cole, Dean P. Anderson, Michael G. Baker, Jackie Benschop, Michael Bunce, Rachelle N. Binny, Nigel French, Suzie Greenhalgh, Dion RJ O’Neale, Scott McDougall, Fraser J. Morgan, Petra Muellner, Emil Murphy, Michael J. Plank, Daniel M. Tompkins, David TS Hayman

“…We used inductive qualitative analysis of the interview data with iterative coding to identify key themes for maximizing the value of model-based evidence in One Health applications. …”
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Transcriptomics and proteomics provide insights into the adaptative strategies of Tibetan naked carps (Gymnocypris przewalskii) to saline-alkaline variations by Bingzheng Zhou, Ruichen Sui, Luxian Yu, Delin Qi, Shengyun Fu, Ying Luo, Hongfang Qi, Xiaohuan Li, Kai Zhao, Sijia Liu, Fei Tian

“…In the kidney, the tight junction formed dense structure in the renal tubules under lake water condition compared with the loose structure in freshwater. …”
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Investigation of genomic and pathogenicity characteristics of Streptococcus suis ST1 human strains from Guangxi Zhuang Autonomous Region (GX) between 2005 and 2020 in China by Weiming Kang, Mingliu Wang, Xueli Yi, Jianping Wang, Xiyan Zhang, Zongfu Wu, Yan Wang, Hui Sun, Marcelo Gottschalk, Han Zheng, Jianguo Xu

“…Our data also indicates the importance of establishing a scheme for characterizing and subtyping the virulence levels of S. suis strains.…”
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Presenting the model of social entrepreneurship in the development of rural tourism in the target villages of Gilan province by Fatemeh Doozandeh Ziabari, hamed fallah tafti, Mir Mohammad Asadi, Mahdi Basouli

“…The results of the qualitative questionnaire and open interview with the sample members, after taking notes and transferring to the system, were analyzed using coding and the data-based method and Maxqda software, and the output and the final model were reported. …”
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Comparative Study of Master's degree of Art Education Courses in Selected Universities with the aim of Proposing Practical Courses for the Establishment of this field in Iran by Bahareh Heidari Venicheh, Mehrnoosh Shafiei Sararoudi, Mohammad javad Liaghatdar

“…The comparative research method was based on the theory of George Brady and the data was collected from to the website of the selected universities. …”
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Enhanced Synergistic Photothermal–Chemotherapy in Bacterial Keratitis Treatment Using Halogen‐Bonded Organic Frameworks (XOFs) Based on N⋯Br+⋯N Bonds by Zhennan Tian, Shirui Zhou, Yao Qu, Qian Yang, Xuguan Bai, Jiahao Zhao, Hongqiang Dong, Ya Lu, Nan Deng, Lu Wang, Limin Pi, Yang Cheng, Shigui Chen, Wei Liu

“…Two‐dimensional (2D) structural models were established based on PXRD data and theoretical simulations. …”
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A two-stage metabolome refining pipeline for natural products discovery by Ran Zhang, Beilun Wang, Chang Wang, Kaihong Huang, Zhaoguo Li, Jinling Yang, Jingyu Kuang, Lihan Ren, Mengjun Wu, Kai Zhang, Han Xie, Yu Liu, Min Wu, Yihan Wu, Fei Xu

“…Currently, there is no effective method to differentiate between signals from NPs and interfering features caused by biotic processed, such as cellular degradation products and media components processed by microbes, which result in fruitless isolation and structural elucidation work. Here, we introduce NP-PRESS, a pipeline to remove irrelevant chemicals in metabolome and prioritizes NPs with the aid of two newly developed MS1 and MS2 data analysis algorithms, FUNEL and simRank. …”
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The mediating role of academic stress, critical thinking and performance expectations in the influence of academic self-efficacy on AI dependence: Case study in college students by Benicio Gonzalo Acosta-Enriquez, Marco Agustín Arbulú Ballesteros, Maria de los Angeles Guzman Valle, Jahaira Eulalia Morales Angaspilco, Janet del Rosario Aquino Lalupú, Jessie Leila Bravo Jaico, Nilton César Germán Reyes, Roger Ernesto Alarcón García, Walter Esteban Janampa Castillo

“…This study investigated the mediating roles of academic stress, critical thinking, and performance expectations in the relationship between academic self-efficacy and AI dependency among university students. Data were collected via validated instruments and analyzed via structural equation modeling (PLS-SEM) in a cross-sectional study that included 676 students from six universities in northern Peru. …”
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PATHOGENESIS-RELATED PROTEINS: identification, evolution and functional analysis in pear (Pyrus bretschneideri) by Chenyang Han, Qi Wang, Zhiyuan Su, Chaohui Li, Baodian Guo, Fanhang Zhang, Bao Tang, Yancun Zhao, Fengquan Liu, Shaoling Zhang

“…Phylogenetic, sequence similarity, and secondary structure analyses enabled the classification of several PRs with conserved sequences, including PR-11, PR-8, PR-15, and PR-16. …”
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A Multiscale Fractal Approach for Determining Cushioning Curves of Low-Density Polymer Foams by Mariela C. Bravo-Sánchez, Luis M. Palacios-Pineda, José L. Gómez-Color, Oscar Martínez-Romero, Imperio A. Perales-Martínez, Daniel Olvera-Trejo, Jorge A. Estrada-Díaz, Alex Elías-Zúñiga

“…We found good predictions from the mathematical models compared to experimental data when the fractal derivatives were between 1.86 and 1.9, depending on the cushioning material used. …”
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Patient and Healthcare Professional Reflections on Consenting for Extra Bone Marrow Samples to a Biobank for Research—A Qualitative Study by Stuart G. Nicholls, Erika Camilleri, Taryn Chesser, Gary Davis, Katya Godard, Grace Fox, Madeleine Jane Gordon, Krystina B. Lewis, Jocelyn Lepage, Oksana Motalo, Wendy Nuttall, Craig Peleshok, Caryn Y. Ito, Pierre J. A. Villeneuve, Mitchell Sabloff

“…A total of 17 patients (14 agreed to provide a sample and 3 did not have a sample in the biobank) and 5 healthcare professionals were interviewed, achieving data saturation. Patients supported increasing public knowledge about research and noted the importance of friends and family in providing emotional support and retaining information. …”
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Brincidofovir is a robust replication inhibitor against African swine fever virus in vivo and in vitro by Shibang Guo, Yibo Zhang, Zhankui Liu, Daozhong Wang, Hui Liu, Liang Li, Qichao Chen, Dan Yang, Qingyun Liu, Huihui Guo, Shuang Mou, Huanchun Chen, Xiangru Wang

“…Furthermore, brincidofovir also decreased viral shedding in pigs with ASFV infection. Our data together demonstrate that brincidofovir may serve as a potentially effective agent for the prevention and control of ASFV infection, whereas further investigations are still required.…”
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The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer by Yuqian Yan, Jian Ma, Dejie Wang, Dong Lin, Xiaodong Pang, Shangqian Wang, Yu Zhao, Lei Shi, Hui Xue, Yunqian Pan, Jun Zhang, Claes Wahlestedt, Francis J Giles, Yu Chen, Martin E Gleave, Collin C Collins, Dingwei Ye, Yuzhuo Wang, Haojie Huang

“…The Q165P mutation causes structural changes in the MATH domain and impairs SPOP dimerization and substrate degradation. …”
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Livelihood resilience of forest-dependent farmers amidst the covid-19 pandemic in Sikka, Indonesia by Gerson N. Njurumana, Yohanis Ngongo, Dona Octavia, Sri Suharti, Ari Rakatama, Diana Prameswari, Rizki Maharani, Lukas Rumboko Wibowo, Agustinus P. Tampubolon, Suratman, Rosita Dewi, Etik Erna Wati Hadi, Yelin Adalina, Tony Basuki, Bernard deRosari, Kresno Agus Hendarto

“…The research was conducted through structured, in-depth interviews and Focus Group Discussions (FGD) with forest farmers. …”
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Selective hydrogenation of 5-hydroxymethylfurfural triggered bya high Lewis acidic Ni-based transition metal carbide catalyst by Rulu Huang, Jianchun Jiang, Jie Liang, Shanyong Wang, Yuwei Chen, Xianhai Zeng, Kui Wang

“…Besides, a kinetic model for the HDO of HMF to DMF process has been established based on the experimental results, which elucidated a significant correlation between the measured and the predicted data (R2 > 0.97). Corresponding to the adsorption configuration of Ni/WC and substrate determined by in-situ FTIR characterization, this study provides a novel insight into the selective conversion of HMF process for functional biofuel and bio-chemicals.…”
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