USP7 V517F mutation as a mechanism of inhibitor resistance by Yu-Ling Miao, Fengying Fan, Yong-Jun Cheng, Li Jia, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Jian Ding, Xuekui Yu, Jin-Xue He

“…We discovered a key treatment-emergent heterozygous mutation (V517F) in USP7 in the binding pocket of compounds as the primary cause of resistance to the USP7 inhibitor USP7-797. Our structural analysis, supported by AlphaFold2 predictions, indicates that the V517F mutation altered the conformation of the compound binding pocket, causing steric hindrance and reducing the affinity between USP7 and its inhibitors. …”
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A hybrid CFD and machine learning study of energy performance of photovoltaic systems with a porous collector: Model development and validation by Yinling Wang, Lei Yu, Mazhar Ali, Imran Ali Khan, Tahir Maqsood, Haining Gao, Qi Wang, Xiaolei Guo

“…This study investigates the predictive modeling of temperature (T(K)) using a dataset of over 128,000 data points characterized by x, y, and z coordinates as inputs. …”
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Overcoming barriers to optimizing cash waqf linked sukuk: A DEMATEL-ANP approach by Muhamad Nafik Hadi Ryandono, Tika Widiastuti, Dian Filianti, Anidah Robani, Muhammad Ubaidillah Al Mustofa, Fitriah Dwi Susilowati, Ida Wijayanti, Eka Puspa Dewi, Nikmatul Atiya

“…This study investigates the factors behind low CWLS sales using the Decision Making Trial and Evaluation Laboratory (DEMATEL) and the Analytic Network Process (ANP) methods to analyze the interrelationships between various barriers to CWLS adoption. Primary data was collected from experts in Islamic finance, waqf management, and regulatory institutions through structured interviews and surveys. …”
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Determinants of ICT Adoption and Performance in Healthcare: The Role of Individual Attributes and Organizational Contextual Factors by Abey Jose, Alejandro F. Mac Cawley, Luis Enberg Gaete, Guilherme Luz Tortorella, Roberto Vassolo, Manisha Kumar, Nick Rich, Maneesh Kumar

“…We conducted a global survey involving healthcare professionals (n =204) to understand the role of various determinants in adopting ICTs and their implications for organizational performance. Data was analyzed using Partial Least Squares Structural Equation Modelling (PLS-SEM) and multiple regression for micro-level constructs. …”
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The Expression and Molecular Roles of MAMDC2 in MSS Colorectal Cancer with a High Tumor Stromal Ratio by Yiling Liu, Shengnan Qian, Jia Wei, Jianting He, Minghui Li, Xiaobing Gao, Hong Cai, Yiqing Wang, Yue Han, Tianyuan Tan, Minhui Yang

“…The meprin/A5/PTPmu (MAM) domain, a conserved structural motif in transmembrane proteins, remains undercharacterized in CRC pathogenesis. …”
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Perceptions of positive and negative clinician communication in obstetrical visits from the perspectives of pregnant patients who use substances by Abisola Olaniyan, Mary Hawk, Dara D. Mendez, Steven M. Albert, Natalie Stern, Sneha Patnaik, Judy C. Chang

“…Methods: We analyzed qualitative data from 85 semi-structured interviews with pregnant patients who reported or tested positive for substance use, which explored their interaction with obstetric providers during their first prenatal visit. …”
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Socio-Demographic Correlates of Health and Nutrition Among Rural and Plantation Communities of the western Dooars, Jalpaiguri district, West Bengal, India by Souraditya Chakraborty, Ayush Kumar Sah, Ayushman Pradhan, Keshab Sharma, Lalita Agarwal, Laxmi Pradhan, Mamta Sahu, Mausumi Roy, Monisha Khanam, Nabin Paul

“…A community-based cross-sectional study was done from September 2024 to January 2025. Data were collected from 156 adult participants (101 males, 55 females) using a pre-structured questionnaire through a multi-stage random sampling technique. …”
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Anthropogenic and natural influence on vegetation ecosystems from 1982 to 2023 by Teligeer Bao, Huaqiang Li, Yonghong Hao, Matthew Tom Harrison, Ke Liu, Gulnazar Ali

“…In addition, frequent land cover changes promoted the growth of greening trends (∼23%), which is linked to enhanced structural plasticity of vegetation. This effect has become more pronounced since 2000, with 92% of such changes occurring during this period. …”
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Linking Education, Culture and Community: A Proposal for an Intercultural Educational Triad by Gerardo Fuentes-Vilugrón, Eduardo Sandoval-Obando, Daniella Landeros-Guzmán, Lorena Elizabeth Pérez-Quinteros, Carlos Arriagada-Hernández, Felipe Caamaño-Navarrete, Paulo Etchegaray-Pezo, Pablo del Val Martín, Lorena Jara-Tomckowiack, Gerardo Muñoz-Troncoso, Flavio Muñoz-Troncoso

“…The study used a semi-structured interview script to collect data, and in the analysis plan the Grounded Theory (GT) was used, to conceptualize the emerging patterns in categorized concepts and theories. …”
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TET dioxygenases localize at splicing speckles and promote RNA splicing by Florian D. Hastert, Jasmin Weber, Christina Bauer, Andreas Zhadan, Deepanshu N. D. Singh, Thomas C. Dix, Roland Arnold, Sergey Bessonov, Matthias Soller, Heinrich Leonhardt, M. Cristina Cardoso, Maria Arroyo

“…This study explores the relationship between RNA splicing and the TET dioxygenase activity, shedding light on the role of hm5C (RNA 5-hydroxymethylcytosine), and TET proteins in RNA metabolism. Integrating data from mass spectrometry, AlphaFold structural modeling, microscopic analysis, and different functional assays, including in vitro splicing, TET proteins were found to regulate splicing. …”
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Visual Impairment Among Undergraduates: A Situational Analysis of Eye Health in Bowen University Iwo, Nigeria by Olumide Thomas Adeleke, Akinsola Aina, Adewumi Oluwafemi Oyabambi, Timothy Samson, Oludamola Victoria Adeleke, Temitayo Aderemi Olabode, Ifeoluwasemilojo Aina, Oluwaseun Awe

“…Materials and methods: A cross-sectional study was conducted among 1407 undergraduate students at the institution. Data obtained includes sociodemographic characteristics, vital signs, and visual acuity using a structured questionnaire. …”
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Determinants of digital health literacy among older adult patients with chronic diseases: a qualitative study by Yujiao Shao, Xiumu Yang, Xiumu Yang, Qin Chen, Hongyan Guo, Xiaocui Duan, Xuejun Xu, Jianxing Yue, Zeyu Zhang, Shuang Zhao, Shiqing Zhang

“…ObjectiveThis study aimed to identify the factors influencing digital health literacy in older adult patients with chronic diseases.MethodsA descriptive qualitative approach incorporated purposive and snowball sampling methods. Semi-structured interviews were conducted with 32 older adult patients with chronic diseases from three hospitals in Anhui Province between October 2023 and May 2024. …”
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Same same but different: Neuroanatomic and connectomic profiles of early-onset schizophrenia and autism spectrum disorder by Bin Lu, Xue Li, Xue-Ping Gao, Jing Chen, Yi Liu, Jian-Ping Lu, Siu-Ching Kat, Zeng-Hui Ma, Li-Yang Zhao, Ting-Ni Yin, Xing Su, Fan-Chao Meng, Ya-Ru Zhang, Shu-Xian Wu, Wen-Jie Yan, Ya-Song Du, Xue-Rong Luo, Jing Liu, Chao-Gan Yan

“…Conclusion: The neuro-profiles revealed that EOS and ASD exhibit overlapping as well as unique imaging characteristics; however, EOS exhibits greater structural variation, while ASD presents with more subtle connectomic abnormalities. …”
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Fluid characteristics, gas accumulation controlling factors and gas enrichment modes in coal reservoirs: A case study of the Upper Paleozoic in the central-eastern Ordos Basin, NW... by Shida CHEN, Dazhen TANG, Wei HOU, Daojun HUANG, Yongzhou LI, Jianling HU, Hao XU, Shu TAO, Song LI, Shuling TANG

“…Based on the test and experimental data from exploration well cores of the Upper Paleozoic in the central-eastern Ordos Basin, combined with structural, burial depth and fluid geochemistry analyses, this study reveals the fluid characteristics, gas accumulation control factors and accumulation modes in the Upper Paleozoic coal reservoirs. …”
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Rebuilding lives in Nagaya, a public housing for older victims of the great East Japan earthquake: An interview survey by Naomi Ito, Yurie Kobashi, Yuri Kinoshita, Nobuaki Moriyama, Toshiki Abe, Hiroaki Saito, Isamu Amir, Chika Yamamoto, Mika Sato, Masaharu Tsubokura

“…The current interview survey aimed to report the living conditions of such older victims in Nagaya and accordingly suggest strategies for supporting the older population who experience disasters. We conducted semi-structured interviews with 32 Nagaya residents, who relocated there due to the earthquake, and performed a thematic analysis of the data. …”
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Thai Guideline for Nuclear Medicine Investigations of Neurocognitive Disorders: Nuclear Medicine Society of Thailand, the Neurological Society of Thailand, and Thai Medical Physici... by Tawika Kaewchur, Tanyaluck Thientunyakit, Wichana Chamroonrat, Benjapa Khiewvan, Peerapon Kiatkittikul, Nantaporn Wongsurawat, Chanisa Chotipanich, Yuttachai Likitjaroen, Vorapun Senanarong, Panya Pasawang, Tanawat Sontrapornpol, Nucharee Poon-iad, Sasithorn Amnuaywattakorn, Supatporn Tepmongkol

“…By providing functional and molecular data via brain imaging, nuclear medicine investigations offer valuable insights that complement clinical evaluations and structural imaging in the early detection, diagnosis, and differentiation of various types of dementia, leading to more accurate diagnosis and personalized treatment planning. …”
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Telemedicine for under-resourced patients with systemic lupus erythematosus: a qualitative study exploring the views and experiences of patients and their healthcare team by Savannah Bowman, Sandeep K. Agarwal, Keshia C. Ferguson, Maryjo J. Maliekel, Maria A. Lopez-Olivo, Maria E. Suarez-Almazor, Maria I. Danila, Maria I. Danila, Jinoos Yazdany, Sebastian Bruera

“…Using Levesque's conceptual framework for healthcare access, semi-structured interviews and content analysis were used to explore benefits and limitations of telemedicine in under-resourced patients with SLE. …”
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Lived Experiences of Sexual and Gender Minorities in Solid Organ Transplantation: A Best-Fit Framework Synthesis and Inductive Thematic Analysis by Murdoch Leeies, Carmen Hrymak, David Collister, Emily Christie, Karen Doucette, Ogai Sherzoi, Tricia Carta, Ken Sutha, Cameron T. Whitley, Tzu-Hao Lee, Matthew J. Weiss, Sonny Dhanani, Julie Ho

“…Targets for improvement included (1) enhancements to shared decision-making between OTDT providers and patients, (2) transparent communication from OTDT organizations, (3) data-driven donor risk assessments, (4) expanded healthcare worker training, (5) inclusive physical care spaces, (6) recommendations for transgender and gender-diverse health system planning, (7) integrated sexual and reproductive healthcare services for transplant recipients, (8) increased SGM representation in medical education and care settings, (9) SGM and OTDT intersectional support networks, and (10) structural facilitation of SGM community advocacy efforts. …”
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Working memory related functional connectivity in adult ADHD and its amenability to training: A randomized controlled trial by Tuija Tolonen, Sami Leppämäki, Timo Roine, Kimmo Alho, Pekka Tani, Anniina Koski, Matti Laine, Juha Salmi

“…WM training did not modulate functional or structural connectivity compared with the active controls. …”
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Isolated Rapid Deployment Aortic Valve Replacement in Patients with Aortic Stenosis: Single-Center Retrospective Study by Ricardo Ferreira, Tiago R. Velho, João Gonçalves, André Sena, Beatriz Draiblate, Ana G. Almeida, Ângelo Nobre, Fausto Pinto

“…At a median follow-up of 6.7 years, no cases of structural valve deterioration and only one case of endocarditis were reported. …”
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