Hypoxia-inducible factors: details create a picture. Part I. HIF-1 by G. A. Ignatenko, N. N. Bondarenko, S. V. Tumanova, T. S. Ignatenko, A. A. Kaluga, Ya. S. Valigun

“…The review presents a comparative analysis of scientific data on the structural and functional characteristics of subunits (HIF-1α and HIF-1β) of hypoxia-inducible transcription factor-1 (HIF-1). …”
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Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines by Ye. O. Karpun, N. M. Polishchuk

“…The biological screening data indicate that the search among the given bis-1,2,4-triazole derivatives is promising. …”
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Validation of a questionnaire to assess complexity of palliative care needs in primary care in Malaga, Spain: a study protocol by Jose Miguel Morales-Asencio, Rafael Gomez-Garcia, Pilar Barnestein-Fonseca, Francisca Leiva-Fernandez, Auxiliadora Fernández-López, Maria Luisa Martín-Roselló, Virginia Patricia Aguiar-Leiva

“…A specific diagnostic tool to assess complexity in PC (IDC-Pal: Instrumento Diagnóstico de la Complejidad en Cuidados Paliativos, in Spanish) was created in community and hospital settings with 36 items to diagnose PC complexity, but its application in primary care is difficult.Aims (1) To generate an adapted version to primary care of the IDC-Pal tool to identify and stratify PC complexity in the adult population. (2) To determine face, content, criterion and construct validity and reliability of the new instrument.Methods and analysis There are three phases of clinimetric cross-sectional observational validation study: Phase 0: Review of the original tool structure suitability for its use in primary care setting by a committee (researchers and the original developer team). …”
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Experiment on physical and mechanical properties of tomato seedling pot for automatic vegetable transplanter by Liang Xifeng, Cai Yangyang, Wang Yongwei

“…However, automatic vegetable transplanter needs integrated knowledge and technology, the research on which should also combine the structural design with the physical and mechanical properties of vegetable seedling pot. …”
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Crocin improves post-thaw quality, fertility-associated gene expression and fertilization potential of buffalo bull sperm by Amjad Riaz, Ghulam S. Khan, Muhammad Zahid Tahir, Muhammad Yasir Zahoor, Hifz-ul-Rahman Hifz-ul-Rahman

“… Buffalo sperm suffer more cryoinjuries due to lipid peroxidation of their high structural polyunsaturated fatty acid contents than cattle. …”
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Extracorporeal Shock Waves Increase Markers of Cellular Proliferation in Bronchial Epithelium and in Primary Bronchial Fibroblasts of COPD Patients by Antonino Di Stefano, Roberto Frairia, Fabio L. M. Ricciardolo, Isabella Gnemmi, Antonella Marino Gammazza, Alessio Piraino, Francesco Cappello, Bruno Balbi, Maria Graziella Catalano

“…Chronic obstructive pulmonary disease (COPD) is due to structural changes and narrowing of small airways and parenchymal destruction (loss of the alveolar attachment as a result of pulmonary emphysema), which all lead to airflow limitation. …”
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Perceived social support and self-stigma as factors of COVID-19 booster vaccination behavior and intention via cognitive coping and emotion regulation among people infected with CO... by Xiaoying Zhang, Yiming Luan, Yihan Tang, Mason M. C. Lau, Yanqiu Yu, Jing Gu, Joseph T. F. Lau

“…The associations between the independent variables and BI-BV were tested by logistic regression analysis. A structural equation model (SEM) tested the indirect effects of the latent variables of self-stigma, active coping, and maladaptive emotion regulation between the latent variable of perceived social support and BI-BV. …”
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Geospatial Innovation Breakthroughs: A Study on the Impact of Talent Birthplace Diversity and Multidimensional Proximity by Jin Wenwan, He Xinyi, Zhu Shengjun, Zhang Xudong

“…However, the global distribution of technological innovation remains uneven, with a sustained "core-periphery" structure. From the perspective of evolutionary economic geography, technological development paths are closely linked to the local knowledge base, making it generally difficult to overcome spatial constraints. …”
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Taxonomic composition, distribution and resources of macrobenthos in Peter the Great Bay in 2011 by Victor A. Nadtochy, Nikolai V. Kolpakov

“…The same grid of samplings was used as in the previous survey in 2003. The data were averaged within 5 domains: Amur Bay, Ussuri Bay, the Western (westward from 131о30′ E), Central (131о30′-132о30′ E) and Eastern (eastward from 132о30′ E) areas. …”
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Synthesis and study of the anticancer activity of some new 7H-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazines by I. I. Myrko, T. I. Chaban, V. V. Ohurtsov, I. V. Drapak, V. S. Matiichuk

“…The reaction proceeds by heating the above reagents in alcohol with the closure of the thiadiazine ring and the formation of 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine systems. The structure of all synthesized compounds was confirmed by 1H NMR spectroscopy and elemental analysis data. …”
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Undeliverable by design? How excessive internal medicine commitments are compromising Group 1 specialty training across the UK by Hasaan Rafique, Sadaf Hasaan, Neil Fisher

“…Annualised adjustments were made for leave, and all data were validated with Trust staffing teams. Results: No DGH met the 75:25 training time split in any year, while only one university hospital achieved this benchmark. …”
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Device optimization of CsPbI2Br-based inorganic perovskite solar cells using different charge transport layers via SCAPS-1D by Muhammad Siddique, Muhammad Sultan, M.Shahid Iqbal Khan, Syed Hamza Safeer

“…We hope our findings will contribute to understanding the Perovskite solar cells (PSCs) structure with different hole transport layers, and ultimately lead to the development of more efficient, stable, and cost-effective perovskite solar cells for commercial applications.…”
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Asteroseismology of One of the Most Rapidly Rotating DBV Stars: EPIC 248705247 by Jiayi Zhang, Jianning Fu, Tianqi Cang, Jie Su, Yanhui Chen, Xiaoyu Ma, Gang Meng

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Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis by Min-Young Noh, Seong-il Oh, Young-Eun Kim, Sun Joo Cha, Wonjae Sung, Ki-Wook Oh, Yurim Park, Ji Young Mun, Chang-Seok Ki, Minyeop Nahm, Seung Hyun Kim

“…All three NEK1 variants exhibited abnormal primary ciliary structure, impaired sonic hedgehog signaling, and altered cell-cycle progression. …”
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Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model. by Emily A Kendall, Sourya Shrestha, Ted Cohen, Eric Nuermberger, Kelly E Dooley, Lice Gonzalez-Angulo, Gavin J Churchyard, Payam Nahid, Michael L Rich, Cathy Bansbach, Thomas Forissier, Christian Lienhardt, David W Dowdy

“…Limitations include sparse data on key model parameters and necessary simplifications to model structure and outcomes.…”
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Left bundle branch block in coronary artery disease: toward novel electrocardiographic markers by Yuri N. Fedulaev, Irina V. Makarova, Alisa V. Grigorieva, Dzhamilya R. Kapitonova, Gulfiya A. Khairetdinova

“…There were no significant differences in the mortality structure between groups. CONCLUSION: The presence of fragmented QRS complexes on electrocardiogram in patients with complete left bundle branch block is associated with further QRS widening and QTc prolongation, a trend toward reduced left ventricular ejection fraction, increased frequency of cardiovascular-related hospitalizations, and progression of heart failure severity. …”
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Environmental Impact of Physical Visits and Telemedicine in Nursing Care at Home: Comparative Life Cycle Assessment by Egid M van Bree, Lynn E Snijder, Hans C Ossebaard, Evelyn A Brakema

“…We collected anonymous user data in collaboration with a telemedicine service company, complemented by consulting staff members of four nursing organizations. …”
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Computational modelling reveals neurobiological contributions to static and dynamic functional connectivity patterns by Linnea Hoheisel, Linnea Hoheisel, Hannah Hacker, Gereon R Fink, Gereon R Fink, Silvia Daun, Silvia Daun, Joseph Kambeitz, Joseph Kambeitz

“…Recent advances in computational modelling allow us to investigate the relationship of both static FC (sFC) and dynamic FC (dFC) with neurobiology non-invasively.In this study, we modelled the brain activity of 200 healthy individuals based on empirical resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data. Simulations were conducted using a group-averaged structural connectome and four parameters guiding global integration and local excitation-inhibition balance: (i) G, a global coupling scaling parameter; (ii) Ji, an inhibitory coupling parameter; (iii) JN, the excitatory NMDA synaptic coupling parameter; and (iv) wp, the excitatory population recurrence weight. …”
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Optimal Airfoil Selection for Small Horizontal Axis Wind Turbine Blades: A Multi-Criteria Approach by Temesgen Batu, Hirpa G. Lemu, Besufekad Negash, Eaba Beyene, Dagim Tirfe, Eyob Hailemichael, Solomon Alemneh

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The Role of Exosome-Loaded Hydrogels in Improving Intervertebral Disc Degeneration: A Systematic Review and Meta-Analysis of Preclinical Animal Studies by Bowen Wang, Desheng Xie, Jianming Huang, Zheyuan Huang, Weizong Weng, Danlei Huang, Ying Zhang, Xiaolin Chen

“…Conclusions: Exosome-loaded hydrogels show potential for improving the structure and function of intervertebral discs in IDD treatment, potentially slowing degeneration by inhibiting matrix degradation and cellular aging. …”
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