Repurposing of compound libraries yields new inhibitors of NDM-1 metallo-β-lactamase with diverse zinc-binding moieties by Vid Kavaš, Philip Hinchliffe, Maša Zorman, Alen Krajnc, Matic Proj, Majda Golob, Martina Hrast Rambaher, James Spencer, Stanislav Gobec

“…This resulted in a compound (14a) with an IC50 of 20 μM, which crystallography shows binds to NDM-1 in two different poses. Using this structure as a starting point for in silico design, we developed a series of larger thiol-based compounds designed to occupy more space in the active site and to utilize other novel zinc-binding groups. …”
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Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrumResearch in context by Thuy-Dung Nguyen, Joeri J. Meijsen, Robert Sigström, Ralf Kuja-Halkola, Ying Xiong, Arvid Harder, Kaarina Kowalec, Joëlle A. Pasman, Carolina Scarpa, Elin Hörbeck, Lina Jonsson, Sara Hägg, Niamh Mullins, Kevin S. O’Connell, Christina Dalman, Dorte Helenius, Richard Zetterberg, Henrik Larsson, Paul Lichtenstein, Ole A. Andreassen, Thomas Werge, Alfonso Buil, Mikael Landén, Patrick F. Sullivan, Yi Lu

“…Methods: This population-based cohort study used Swedish and Danish registry data for over 5.1 M individuals born between 1958 and 1993/1996. …”
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Presenting the model of social entrepreneurship in the development of rural tourism in the target villages of Gilan province by Fatemeh Doozandeh Ziabari, hamed fallah tafti, Mir Mohammad Asadi, Mahdi Basouli

“…The results of the qualitative questionnaire and open interview with the sample members, after taking notes and transferring to the system, were analyzed using coding and the data-based method and Maxqda software, and the output and the final model were reported. …”
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Element Nucleosynthetic Origins from Abundance Spatial Distributions beyond the Milky Way by Zefeng Li, Mark R. Krumholz, Anna F. McLeod, A. Mark Swinbank, Emily Wisnioski, J. Trevor Mendel, Francesco Belfiore, Giovanni Cresci, Giacomo Venturi, Jia-Lai Kang

“…These findings both open a new avenue to test nucleosynthetic models and make predictions for the structure of stellar chemical abundance distributions.…”
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A 14-bp motif in the KIT active promoter region is critical for melanin accumulation in yaks, mice, and humans by Xinfeng Liu, Tongcheng Wang, Zeyu Zheng, Congcong Dong, Wenyu Liu, Zhimin Niu, Yingbo Yang, Xiaoyun Wu, Qiang Qiu, Yongzhi Yang, Kexin Li, Johannes A. Lenstra, Ping Yan, Minghui Kang, Bowen Li, Lingzhao Fang, Jianquan Liu

“…Results Using whole-genome sequencing data from 387 yaks, we analyzed the population genetic structure of all-white yaks and discovered that they clustered into two distinct genetic groups. …”
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The development and implementation of an innovative community-based intervention to strengthen community capacity for HIV prevention and care among Canadians of African Caribbean a... by Josephine Etowa, Notisha Massaquoi, Francisca Omorodion, Danielle Brown-Shreves, Ilene Hyman, Akalewold Gebremeskel, Hugues Loemba, Bishwajit Ghose, Egbe Etowa, Jennifer Rayner, Charles Dabone, Lounanjio Brown O’Sullivan, Azeeza Sule, Joseph Kiirya, Sanni Yaya, Wangari Tharao, Haoua Inoua, Angela Kaida, Apondi Odhiambo, Clinton Beckford

“…African, Caribbean, and Black (ACB) women are overrepresented among new HIV diagnoses due to social and structural factors. This study seeks to create, implement, and evaluate a community-based peer-led intervention to improve access to HIV prevention and care for ACB women in Canada. …”
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The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program by Michael P. Harms, Kang-Ik K. Cho, Alan Anticevic, Nicolas R. Bolo, Sylvain Bouix, Dylan Campbell, Tyrone D. Cannon, Guillermo Cecchi, Mathias Goncalves, Anastasia Haidar, Dylan E. Hughes, Igor Izyurov, Omar John, Tina Kapur, Nicholas Kim, Elana Kotler, Marek Kubicki, Joshua M. Kuperman, Kristen Laulette, Ulrich Lindberg, Christopher Markiewicz, Lipeng Ning, Russell A. Poldrack, Yogesh Rathi, Paul A. Romo, Zailyn Tamayo, Cassandra Wannan, Alana Wickham, Walid Yassin, Juan Helen Zhou, Jean Addington, Luis Alameda, Celso Arango, Nicholas J. K. Breitborde, Matthew R. Broome, Kristin S. Cadenhead, Monica E. Calkins, Eric Yu Hai Chen, Jimmy Choi, Philippe Conus, Cheryl M. Corcoran, Barbara A. Cornblatt, Covadonga M. Diaz-Caneja, Lauren M. Ellman, Paolo Fusar-Poli, Pablo A. Gaspar, Carla Gerber, Louise Birkedal Glenthøj, Leslie E. Horton, Christy Lai Ming Hui, Joseph Kambeitz, Lana Kambeitz-Ilankovic, Matcheri S. Keshavan, Sung-Wan Kim, Nikolaos Koutsouleris, Jun Soo Kwon, Kerstin Langbein, Daniel Mamah, Daniel H. Mathalon, Vijay A. Mittal, Merete Nordentoft, Godfrey D. Pearlson, Jesus Perez, Diana O. Perkins, Albert R. Powers, Jack Rogers, Fred W. Sabb, Jason Schiffman, Jai L. Shah, Steven M. Silverstein, Stefan Smesny, William S. Stone, Gregory P. Strauss, Judy L. Thompson, Rachel Upthegrove, Swapna K. Verma, Jijun Wang, Daniel H. Wolf, Rene S. Kahn, John M. Kane, Patrick D. McGorry, Barnaby Nelson, Scott W. Woods, Martha E. Shenton, Stephen J. Wood, Carrie E. Bearden, Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), Ofer Pasternak

“…For the SNR/CNR measures from the structural and fMRI scans, participant variance is the largest component (as desired; 40–76%). …”
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The Analysis and Prioritization of Social Sustainability of Rural Environments (Case Study: Ghal’eh Biaban District Darab Sub-Province) by Saeid Reza Akbarian Ronizi, Rana Shaykh-Baygloo

“…B) Demographic, including components such as population density, change of population structure, migration patterns among village and city and cultural issues. …”
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How to Implement Digital Clinical Consultations in UK Maternity Care: the ARM@DA Realist Review by Catrin Evans, Georgia Clancy, Kerry Evans, Andrew Booth, Benash Nazmeen, Candice Sunney, Mark Clowes, Nia Wyn Jones, Stephen Timmons, Helen Spiby

“…From the findings, four principles emerged for developing and using digital maternity consultations: Create an appropriate environment, structure and support for staff. For women, consultations need to be responsive and personalised to different needs and preferences. …”
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Results of a study of the effectiveness of direct coronary oxygen persufflation as a donor heart conditioning method by M. O. Zhulkov, D. A. Sirota, I. S. Zykov, A. K. Sabetov, K. A. Agaeva, А. G. Makaev, D. M. Osintsev, A. P. Nadeev, V. Е. Kliver, E. E. Kliver, A. M. Volkov, A. R. Tarkova, А. V. Fomichev, A. M. Chernyavsky

“…Objective: to evaluate the technical feasibility as well as functional, metabolic and structural integrity of donor heart myocardium after 4 hours of direct intracoronary oxygen persufflation in an experiment. …”
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The association between perceive social support and post-traumatic stress disorder symptoms among medical staff in Hubei, China: a chain mediating effect of resilience and positive... by Junjie Cao, Yifang Liu, Shijiao Yan, Zijun Xiong, Jing Wen, Zongju Chen, Pu Zhang, Jiaxin Tao, Jun Zhang, Ying Wang, Li Zou, Wenning Fu

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Prevalence of anxiety symptoms in a Ugandan population sample and psychometric properties of the Generalized Anxiety Disorder-7 scale (GAD-7) in Luganda and Runyoro by Leo Ziegel, Cristina Espinosa da Silva, Robert Bulamba, Alex Daama, Grace Kigozi, Amanda P. Miller, Godfrey Kigozi, Emmanuel Kyasanku, Stephen Mugamba, Anders Hammarberg, Anna Mia Ekström, Fred Nalugoda, Anna-Clara Hollander

“…The Runyoro-translated GAD-7 retained its one-factor structure (RMSEA = 0.097, CFI = 0.977, TLI = 0.966), had good internal consistency (omega total = 0.85), and correlated moderately with the PHQ-9 (r = 0.67, p < 0.01). …”
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The impact of COVID-19 fear during the later stages of the pandemic on maladaptive eating, psychological distress and body weight: a global cross-sectional study by Meeah Willig, Tomás Cabeza de Baca, Emma J. Stinson, Andrés M. Treviño-Alvarez, Theresa Rodzevik, Susanne B. Votruba, Coley C. Lameman, Jonathan Krakoff, Marci E. Gluck

“…General linear models, multinomial logistic regression modes, and structural equation modeling were used to analyze the data. …”
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TERT c.3150 G > C (p.K1050N): a founder Ashkenazi Jewish variant associated with telomere biology disorders by Kelvin César de Andrade, Emilia M. Pinto, Tianna Zhao, Logan P. Zeigler, Jung Kim, Neelam Giri, Jeremy S. Haley, Lisa J. McReynolds, Oscar Florez-Vargas, Aaron H. Phillips, Richard W. Kriwacki, Sherifa A. Akinniyi, Scott B. Cohen, Matthew R. Emerson, Diane T. Smelser, Gretchen M. Urban, Cintia Fridman, Gerard P. Zambetti, Tracy M. Bryan, David J. Carey, Christine Kim Garcia, Douglas R. Stewart, Sharon A. Savage

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Impact and elastic modulus of coal mining on terrestrial ecosystems by Jihong Dong, Wenting Dai, Jiren Xu, Hui Zhang, Yunpeng Li, Fei Xie

“…Abstract The energy consumption structure is gradually evolving into a "diversified energy structure" against the backdrop of the global implementation of energy-saving and low-carbon policies. …”
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Sealing and zero leakage characteristics of a high-pressure large-sized main drive based on active pressure compensation by Lifang ZHENG, Chao FANG, Fei MA, Tengfei CAI, Man YAO

“…Under a higher confining pressure, the new main drive seal structure exhibited better sealing ability, and under the pre-compensation mode, the sealing pressure reached 1.95 MPa at a compensation pressure of 7 MPa. …”
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Co-developing a health promotion programme for indigenous youths in Brazil: A concept mapping report. by Paulo T C Jardim, Josiliane M Dias, Antonio J Grande, André B Veras, Érika K Ferri, Fatima A A Quadros, Clayton Peixoto, Francielle C S Botelho, Maria I M G Oliveira, Ieda M A V Dias, Majella O'Keeffe, Christelle Elia, Paola Dazzan, Ingrid Wolfe, Seeromanie Harding

“…The little routinely collected population-level data from Indigenous communities in the region available shows stark inequities in health and well-being. …”
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Level of matrix metalloproteinase-9 and myocardium remodeling in patients with acute postinfarction aneurism of left ventricle by V. D. Syvolap, S. M. Kyselov

“…Level of matrix metalloproteinase-9, structural and functional indexes of myocardium remodeling were studied in patients with acute postinfarction aneurism of left ventricle. …”
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Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons by Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger

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A Study of the Effect of Temperature on the Capacitance Characteristics of a Metal-<i>μ</i>hemisphere Resonant Gyroscope by Xiangxian Yao, Hui Zhao, Zhong Su, Xibing Gu, Sirui Chu

“…In order to capture this nonlinear behavior, the experimental data were smoothed and fitted using the LOESS method, revealing a complex trend of the capacitance variation with temperature. …”
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