SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon-α and interferon-γ receptors by Naveen Thakur, Poushali Chakraborty, JoAnn M. Tufariello, Christopher F. Basler

“…ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 14 (Nsp14) possesses an N-terminal exonuclease (ExoN) domain that provides a proofreading function for the viral RNA-dependent RNA polymerase and a C-terminal N7-methyltransferase (N7-MTase) domain that methylates viral mRNA caps. …”
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Analysis of the dependence of survival in patients with gastric cancer on the location and characteristics of the tumor by O. M. Levyk, K. V. Barannikov

“…In addition to location of the tumor in the stomach data on such characteristics of malignant tumors as the degree of differentiation and histological structure of the tumor have been analyzed. …”
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The Intervened effect of place attachment on the relationship between community attachment and environmental behaviors (case study: Tajrish neighborhood) by Atousa Soleimani, Ahmad Nohegar

“…The participants were asked to fill out the research questionnaire whose reliability and validity were confirmed. The obtained data were statistically analyzed using the correlation analysis and structural equation modeling in SPSS-21 and AMOS-21. …”
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Molecular characterization and expression profiles of cytochrome P450 reductase gene in Sogatella furcifera (Hemiptera: Delphacidae) by YU Hang, LIU Su, ZHU Qingzi, ZHOU Wenwu, LIANG Qingmei, SHI Xiaoxiao, ZHU Zijie, ZHU Zengrong

“…The theoretical isoelectric point (pI) and calculated molecular mass of SfCPR protein are 5.48 and 76.762 ku, respectively. The secondary structure of SfCPR protein showed the marked features of typical CPRs, such as N-terminal transmembrane region, FMN-, FAD- and NADPH-binding domains and conserved catalytic residues. …”
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Manganese mitigates atrazine-induced oxidative stress and hepatorenal toxicity: insights from network pharmacology and in vivo experimentation by Solomon E. Owumi, Tella T. Adedayo, Joseph Chimezie, Bayode Oluwawibe, Harieme Agbarogie, Jesutosin O. Babalola, Oludare M. Ogunyemi, Uche O. Arunsi, Moses T. Otunla, Chioma E. Irozuru, Ahmad Altayyar, Eziuche A. Ugbogu

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Development and validation of a comprehensive tool to study the various elements influencing the utilization of E-learning among undergraduate health professions students by Archana Prabu Kumar, Prabu Kumar Chokkalingam Mani, Komal Atta, Abirami Omprakash, K. Maheshkumar, Hany Atwa, K. N. Maruthy, Padmavathi R.

“…Content validity was assessed using the Lawshe method, and the CKAPQ survey was conducted from 2014 to 2017 among medical and dental students at a South Indian tertiary care university. Data were analyzed using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) to validate the questionnaire structure and verify the theoretical framework. …”
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Real time counting method for coal mine drill pipes based on deep learning by Fukai ZHANG, Yiran SUN, Xufeng WU, Aijun LI, Peiyang LI, Dengke WANG, Guan YUAN, Shan ZHAO, Haiyan ZHANG

“…The Slim-Neck network structure is improved to balance the accuracy and complexity of the model, and the DDA Head module is designed to replace the detection head structure to enhance the attention of the model head to the multi-dimensional information of drilling rig targets; Finally, a pipe count inference method called Pipe Count is designed based on the principle of calculating the effective number of movements at the tail of the drilling rig using a two-level polygon judgment area. …”
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Metagenomic analysis reveals rumen microbiome enrichment and functional genes adjustment in carbohydrate metabolism induced by different sorting behavior in mid-lactation dairy cow... by Abdallah Alaa Mousa, Han Zhang, Hongwei Duan, Jiyou Zhang, Shengyong Mao

“…Abstract Background This study aimed to investigate differences in the structure and function of the rumen microbiome and its associated changes in rumen fermentation patterns and apparent nutrient digestibility in dairy cattle with different sorting behavior. …”
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Scaling climate information services and climate smart agriculture through bundled business models by Desire M. Kagabo, Livingstone Byandaga, Patrick Gatsinzi, Patrick Mvuyibwami, Yvonne U. Munyangeri, Nasson Ntwari, Mathieu Ouedraogo

“…Eleven CIS-CSA bundled business models with publicly available quantitative scaling readiness data (financial capacity, the number of customers, customer categories, and the number of beneficiaries) were used to quantitatively model how different CIS-CSA products and services bundling strategies, the revenue stream structure of a CIS-CSA business, and the structure of a CIS-CSA business’s stakeholder network (the diversity of its stakeholders) affect its scaling readiness. …”
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Impact of HIV-1 capsid polymorphisms on viral infectivity and susceptibility to lenacapavir by Derek Hansen, Matthew R. Hendricks, Silvia Chang, Arthur Cai, Jason K. Perry, Thomas Aeschbacher, Ross Martin, Tomas Cihlar, Stephen R. Yant

“…Here, we identified natural polymorphisms within the LEN-binding site and assessed each for their impact on viral infectivity and susceptibility to LEN. Using a co-crystal structure of LEN in complex with a CA hexamer, we identified 29 binding site residues within five angstroms of LEN and analyzed each for naturally occurring polymorphisms across a multiclade collection of >10,000 unique HIV-1 gag sequences. …”
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Aborto provocado: representações sociais de mulheres [Induced abortion: social representations of women] by Bárbara Angélica Gómez Pérez, Nadirlene Pereira Gomes, Maria de Fátima de Souza Santos, Normélia Maria Freire Diniz

“…A free word association test was used in 2007. Data was analyzed on the EVOC-2000 software. The structure of the representations is supported by elements of the central nucleus and by those of the peripheral nucleus. …”
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White matter integrity and functional connectivity in adolescents with a parental history of substance use disorder by Xiaofu He, Diana V. Rodriguez-Moreno, Yael M. Cycowicz, Keely Cheslack-Postava, Huilan Tang, Zhishun Wang, Lawrence V. Amsel, Megan Ryan, Lupo Geronazzo-Alman, George J. Musa, Adam Bisaga, Christina W. Hoven

“…We acquired diffusion tensor-imaging (DTI) and resting state fMRI data across the whole brain. Structural connectivity was examined by measuring fractional anisotropy (FA) using DTI, to indicate integrity of the white matter tracts. …”
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Genetic Diversity and Construction of Salt-Tolerant Core Germplasm in Maize (<i>Zea mays</i> L.) Based on Phenotypic Traits and SNP Markers by Yongfeng Song, Jiahao Wang, Yingwen Ma, Jiaxin Wang, Liangliang Bao, Dequan Sun, Hong Lin, Jinsheng Fan, Yu Zhou, Xing Zeng, Zhenhua Wang, Lin Zhang, Chunxiang Li, Hong Di

“…Whole-genome genotyping was conducted using the Maize6H-60K liquid phase chip. Population structure analysis, principal component analysis, and cluster analysis divided the 588 accessions into six subgroups. …”
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Research progress on immune mechanism and control strategy of dsRNA impurities in mRNA vaccine by Xinjun Liu, Chaoying Hu, Qian He, Yu Bai, Xuanxuan Zhang, Zhihao Fu, Xiao Ma, Miao Xu, Zhenglun Liang, Qunying Mao

“…Regulatory standards for dsRNA impurities in mRNA vaccines have also been discussed.Expert opinion dsRNA as a critical quality attribute (CQA), the structural heterogeneity of it (including length and structure) and its precise immunomodulatory mechanisms affecting vaccine safety are poorly understood. …”
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Robust Image Population Based Stain Color Normalization: How Many Reference Slides Are Enough? by Jose L. Agraz, Caleb M. Grenko, Andrew A. Chen, Angela N. Viaene, MacLean D. Nasrallah, Sarthak Pati, Tahsin Kurc, Joel Saltz, Michael D. Feldman, Hamed Akbari, Parth Sharma, Russell T. Shinohara, Spyridon Bakas

“…Histopathologic evaluation of Hematoxylin &amp; Eosin (H&amp;E) stained slides is essential for disease diagnosis, revealing tissue morphology, structure, and cellular composition. Variations in staining protocols and equipment result in images with color nonconformity. …”
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The alternative prey hypothesis revisited: Still valid for willow ptarmigan population dynamics. by Jo Inge Breisjøberget, Morten Odden, Per Wegge, Barbara Zimmermann, Harry Andreassen

“…In order to better understand the role of these potential changes in community structure on an alternative prey species, willow ptarmigan Lagopus lagopus, we analyzed nine years of population census data from SE Norway to investigate how community interactions affected their population dynamics. …”
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Raising Awareness of Canine, Feline and Human Dirofilariosis in Aveiro, Portugal: A One Health Perspective by Joana Esteves-Guimarães, José Alberto Montoya-Alonso, Jorge Isidoro Matos, Elmano Ramalheira, Elena Carretón, Ivan Rodríguez-Escolar, Alfonso Balmori-de la Puente, Manuel Collado-Cuadrado, Rodrigo Morchón, Ana Patrícia Fontes-Sousa

“…The coastal district of Aveiro, Portugal, marked by its unique hydrographic structure, Ria de Aveiro, and a concerning rise in heartworm disease, was the focus of our study. …”
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Martinostat as a novel HDAC inhibitor to overcome tyrosine kinase inhibitor resistance in chronic myeloid leukemia by Haeun Yang, Vladimir Li, Su Jung Park, Sang Won Cheon, Anne Lorant, Aloran Mazumder, Jin Young Lee, Barbora Orlikova-Boyer, Claudia Cerella, Christo Christov, Gilbert Kirsch, Dag Erlend Olberg, Guy Bormans, Hyoung Jin Kang, Byung Woo Han, Michael Schnekenburger, Marc Diederich

“…Methods and results Structural and biochemical analyses confirmed the efficient and selective binding of martinostat to HDAC isoenzyme ligand-binding pockets, resulting in histone and tubulin hyperacetylation in both imatinib-sensitive and resistant CML cells, outperforming vorinostat, a clinically used HDAC inhibitor (HDACi). …”
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PiezoSight: Coupling vision based tactile sensor neural network processing and piezoresistive stimulation for enhanced piezo-vision hybrid sensing by Abdullah Solayman, Hussain Sajwani, Oussama Abdul Hay, Rui Chang, Laith AbuAssi, Abdulla Ayyad, Yahya Zweiri, Yarjan Abdul Samad

“…A machine learning LSTM model was used to train the data for different designs for using such sensors in unsupervised environments.…”
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Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals by Timur Liwinski, Matthias K. Auer, Johanna Schröder, Ina Pieknik, Christian Casar, Dorothee Schwinge, Lara Henze, Günter K. Stalla, Undine E. Lang, Alina von Klitzing, Peer Briken, Thomas Hildebrandt, Jeanne C. Desbuleux, Sarah V. Biedermann, Paul-Martin Holterhus, Corinna Bang, Christoph Schramm, Johannes Fuss

“…Abstract Background Limited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. …”
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