Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation by Linhao Xu, Yanli Bi, Yizhou Xu, Yihao Wu, Xiaoxue Du, Yixuan Mou, Jian Chen

“…GSK2606414, a specific chemical inhibitor of the PERK pathway, reduced the expression of p-PERK, ATF-4, p-elf2α, and CHOP and rescued ER structure. In addition, Bax and Bak accumulated in the mitochondria after IH treatment, which induced cytochrome c release and initiated apoptosis. …”
Get full text

Potential to use of viral reverse transcriptase inhibitors in oncology by O. A. Vlasova, I. A. Antonova, Kh. M. Magomedova, M. A. Usolkina, K. I. Kirsanov, G. A. Belitsky, T. T. Valiev, M. G. Yakubovskaya

“…To date, reverse transcriptase inhibitors of viruses of nucleoside and non-nucleoside structure have been developed and are successfully used in the clinic. …”
Get full text

Literature review: potential non-thermal molecular effects of external radiofrequency electromagnetic fields on cancer by Anna Dieper, Stephan Scheidegger, Rudolf M. Füchslin, Paraskevi D. Veltsista, Ulrike Stein, Mathias Weyland, Dominik Gerster, Marcus Beck, Olof Bengtsson, Daniel Zips, Pirus Ghadjar

“…Among those, by reviewing the included publications, we identified RF-EMF-induced ion channel activation, altered gene expression, altered membrane potentials, membrane oscillations, and blebbing, as well as changes in cytoskeletal structure and cell morphology.Conclusion The existent literature points toward a yet untapped therapeutic potential of RF-EMF treatment, which might aid in damaging cancer cells through bio-electrical and electro-mechanical molecular mechanisms while minimizing adverse effects on healthy tissue cells. …”
Get full text

From disconnection to compassion: a phenomenological exploration of embodied empathy in a face-to-face interaction by Alejandro Troncoso, Antonia Zepeda, Vicente Soto, Ellen Riquelme, Sissi Fuentealba, Catherine Andreu, Ausiàs Cebolla, Ausiàs Cebolla, David Martínez-Pernía

“…Subsequently, micro-phenomenological interviews explored participants’ embodied experiences. Data underwent iterative inter-coder processing, and both qualitative and quantitative analyses were conducted. …”
Get full text

MiR-6721-5p as a natural regulator of Meta-VCL is upregulated in the serum of patients with coronary artery disease by Akram Gholipour, Ali Zahedmehr, Maedeh Arabian, Farshad Shakerian, Majid Maleki, Maziar Oveisee, Mahshid Malakootian

“…Meta-vinculin (meta-VCL), a large spliced isoform of VCL, co-localizes in muscular adhesive structures and plays significant roles in cardiac physiology and pathophysiology. …”
Get full text

Understanding crystallinity indexes benchmarking concept from optimized parametric ionic liquid pretreatment using 1-ethyl-3-methylimidazolium Acetate [EMIM]Ac on oil palm biomass by Amizon Azizan, Rosmaria Abu Darim, Intan Suhada Azmi, Rafidah Jalil, Shareena Fairuz Abdul Manaf

“…Thus, in this article, the crystallinity status, like the crystallinity index (CrI) from X-Ray Diffraction analysis, was used as a beneficial preliminary predictive index to describe the transformation of less ordered structures in lignocellulosic biomass as an early decisive point after pretreatment prior to any succeeding steps. …”
Get full text

Ultra-processed food intake and brain health in middle-aged and older adults by Jiawei Gu, Linli Chen, Yujia Bao, Xueer Yang, Xuhua Chen, Zheshen Han, Yibin Zhou, Xiaobei Deng, Yuhua Li, Jinjun Ran

“…Given the increasing prevalence of ultra-processed foods (UPFs) in modern diets and their links to various chronic diseases, this study investigates their associations with neurodegeneration and alterations in brain structure. Design: A prospective cohort study. Setting and participants: 58,423 participants aged 40–70 years from the UK Biobank cohort (enrolled from 2006 to 2010) were included to examine the associations between UPF intake and neurodegenerative diseases, with a subsample of 5,462 participants with neuroimaging data used to investigate associations with regional gray matter morphology, including volume, thickness, and surface area. …”
Get full text

Assessing Causes and Consequences of Winter Surface Water Dynamics in California's Central Valley Using Satellite Remote Sensing by Christine M. Albano, Christopher E. Soulard, Blake A. Minor, Jessica J. Walker, Britt W. Smith, Eric K. Waller, Michael D. Bartles, Thomas W. Corringham, Anthony T. O'Geen, Melissa M. Rohde, Anne M. Wein

“…Precipitation‐driven surface water occurrences are also common in leveed areas and outside flood boundaries designated by state and federal agencies where exposure of structures to inundation was larger in terms of their value. …”
Get full text

The spectrum of embodied intersubjective synchrony in empathy: from fully embodied to externally oriented engagement in Parkinson's disease by Antonia Zepeda, Alejandro Troncoso, Daniela Pizarro, Constanza Baquedano, Rodrigo Gomez, Silvia Barria, Kevin Blanco, David Martínez-Pernía, David Martínez-Pernía

“…Two primary empathic structures emerged: Embodied Resonance Empathy, marked by strong bodily and emotional connections with temporal synchronization to others' suffering through internal sensations, and Marginal Embodied Resonance Empathy, where bodily and emotional resonance is reduced or absent, relying mainly on external visual cues. …”
Get full text

Rapid Decrease in Dextrose Concentration After Intra-Articular Knee Injection: Implications for Mechanism of Action of Dextrose Prolotherapy by Kenneth Dean Reeves, Jordan R. Atkins, Clare R. Solso, Chin-I Cheng, Ian M. Thornell, King Hei Stanley Lam, Yung-Tsan Wu, Thomas Motyka, David Rabago

Get full text

Effects of Different Levels of Green Tea Powder on Performance, Antioxidant Activity, Egg Mass, Quality, and Cecal Microflora of Chickens by Wei Luo, Qisong Tan, Hui Li, Tao Ye, Tao Xiao, Xingzhou Tian, Weiwei Wang

“…The statistical software SPSS was used to perform a one-way analysis of variance (ANOVA) on the experimental data, and Duncan’s method was used to perform multiple comparisons among groups. …”
Get full text

MRI-based 3D models of cranial nerves in clinical care: a systematic review by Manon C. M. Moll, Luc H. E. Karssemakers, Milou Baarsma, Loes M. M. Braun, Leon C. ter Beek, Stevie van der Mierden, Baris Karakullukcu, Ludi E. Smeele, Maarten J. A. van Alphen, Matthijs H. Valstar

“…Abstract Background Technical advances in magnetic resonance imaging (MRI) acquisition and reconstruction have improved the visualization of anatomical structures such as cranial nerves (CNs) and enabled subsequent three-dimensional (3D) models for use in clinical care. …”
Get full text

Integrating Geodetector and GTWR to Unveil Spatiotemporal Heterogeneity in China’s Agricultural Carbon Emissions Under the Dual Carbon Goals by Huae Dang, Yuanjie Deng, Yifeng Hai, Hang Chen, Wenjing Wang, Miao Zhang, Xingyang Liu, Can Yang, Minghong Peng, Dingdi Jize, Mei Zhang, Long He

“…This study recommends formulating differentiated low-carbon agricultural policies based on regional characteristics, optimizing industrial structures, enhancing modernization levels, strengthening regional collaborative governance, and promoting the synergistic development of climate and agriculture. …”
Get full text

Combining ATAC-seq and RNA-seq reveals key genes for gonadal abnormalities in one-month-old XX-DSD pigs by Congying Yu, Bingzhou Zhong, Yuqiao Zhang, Haiquan Zhao, Jinhua Wu, Haiyi Yu, Hui Yu, Hua Li

“…Following this, we analyzed ATAC-seq data and identified 14,820 differential accessible chromatin peaks. …”
Get full text

Genomic Prediction in a Self-Fertilized Progenies of <i>Eucalyptus</i> spp. by Guilherme Ferreira Melchert, Filipe Manoel Ferreira, Fabiana Rezende Muniz, Jose Wilacildo de Matos, Thiago Romanos Benatti, Itaraju Junior Baracuhy Brum, Leandro de Siqueira, Evandro Vagner Tambarussi

“…However, its efficiency may be compromised due to the complex structures of breeding populations, which arise from the use of multiple parents from different species. …”
Get full text

Prevalence and distribution of Cryptosporidium spp. in cattle in central and western Inner Mongolia, China by Ziran Mo, Bin Xu, Jingwei Quan, Qinghan Meng, Xu Jiang, Junyan Li, Jia Wang, Yaping Xuan, Xingyu Ruan, Wenbin Yang, Xiaoping Luo, Wei Hu

“…Although Inner Mongolia is an important production and export base for beef, milk, and other cattle products, there is a paucity of comprehensive data on the prevalence of Cryptosporidium in cattle in the region. …”
Get full text

Psychometric properties of the Persian version of the training needs assessment for critical care nurses by Amir Jalali, Mostafa Bafandeh Zendeh, Azam Sharifi, Amirhossein Naghibzadeh, Leila Moradi, Jalal Karimi, Nazanin Mardani Taghvostani, Khalil Moradi

“…Results The results of the EFA and CFA confirmed the thirteen-factor structure with 66 items, explaining 62.337% of the total variance. …”
Get full text

Lipopolysaccharide and ARDS caused by new coronavirus infection: hypotheses and facts by I. A. Yatskov, V. A. Beloglazov, E. I. Ryapova

“…This review presents data from the literature that provide insight into the role of the lipopolysaccharide (LPS) of the Gram-negative bacteria in pathogenesis of acute respiratory distress syndrome (ARDS) caused by the novel SARS-CoV-2 coronavirus infection. …”
Get full text

Optimizing XGBoost Hyperparameters for Credit Scoring Classification Using Weighted Cognitive Avoidance Particle Swarm by Atul Vikas Lakra, Sudarson Jena, Kaushik Mishra

“…Weighted cognitive avoidance particle swarm optimization for the XGBoost (WCAPSO-XGB) model has been proposed for credit score classification. The structure of the XGBoost (XGB) model is determined by the hyperparameters, which must be initialized prior to model evaluation. …”
Get full text

Aligning the management of nature-based solutions to locally led adaptation principles: A case study of sand dams in Makueni County, Kenya by Judith Mulwa, Eric Kioko, Marie Ladekjaer Gravesen

“…It is the view of the authors’ that if better governance structures are pegged to the remaining LLA principles, then financing can flow more naturally to the water sector.…”
Get full text