Seropositive juvenile rheumatoid arthritis: analysis of the spectrum of clinical manifestations and therapy according to a retrospective study by М. I. Kaleda, I. P. Nikishina, E. S. Fedorov, S. V. Arsenyeva, A. N. Shapovalenko

“…Seropositive juvenile rheumatoid arthritis (JRA) is the rarest subtype of juvenile idiopathic arthritis (JIA) that is the equivalent of RA in adults and is manifested mainly by a symmetric polyarticular lesion, rapid structural disease progression with the formation of intraarticular erosions, the presence of positive rheumatoid factor (RF), and/or anti-cyclic citrullinated peptide (CCP) antibodies.Objective: to analyze demographic, clinical, and laboratory features of seropositive JRA and drug therapy according to a retrospective 10-year study.Patients and methods. …”
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Synovial cesys in children: clinical features, diagnostics, treatment (analytical review of the literature and own observation) by V.S. Konoplitskyi, Yu. Ye. Korobko, B.L. Pavlenko, H.M. Rudenko, O.A. Korobko, S.V. Klymenko

“…Synovial cysts are structurally mucinous pseudotumors that usually arise from the underlying joint capsule, bursa, tendon sheath, or subchondral bone. …”
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Clinical-pathagenetic, Age, Gender, Genetic Aspects of Non-alcoholic Fatty Liver Disease and Nonviral Chronic Hepatitis Without, and also with Comorbid Hypothyroidism; Improving of... by Prysyazhnyuk V., Voloshyn O.

“…The correlation between the cytokines plasma content and the biochemical markers of cytolytic, cholestatic, intoxication syndromes, lipid profile are indicative of their important role in pathogenesis of NAFLD and CH. Changes in the structural and functional parameters of the heart, increase of the left ventricle myocardium mass and its index, and ejection fraction reduction were determined with age among NAFLD patients and CH patients. …”
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Cryogenic Thermo-Optical Coefficient of SU-8 Measured Using a Racetrack Resonator at 850 nm by Salvador A. Medina-Rangel, Nicola Maraviglia, John O’Hara, Artem S. Vorobev, Simone Iadanza, Emanuele Pelucchi, Liam O’Faolain

“…SU-8 is an emerging polymer material for integrated optical circuits that has demonstrated good structural properties in a cryogenic environment. In this article, we investigate the thermo-optical properties of SU-8 for a wavelength <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>λ</mi><mo>=</mo><mn>850</mn><mtext> </mtext><mi mathvariant="normal">n</mi><mi mathvariant="normal">m</mi></mrow></semantics></math></inline-formula>, from room temperature to cryogenic temperature down to 14 K. …”
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Impact of medical school on quality of life and mental health in Brazil: a cross-sectional comparative study by Marina Silveira de Resende, Isabelle Martins Santos, Eduardo Cardoso de Moura, Renata de Almeida Pedro, Marcelo Gobbo

“…To address these challenges, this study investigates the specific impact of medical education on students’ mental health and QoL, aiming to identify potential structural changes that could mitigate these negative outcomes.Design A cross-sectional study was conducted in private higher education institutions in Brazil.Setting Data were collected online via the QuestionPro platform in August 2024, encompassing 32 units located across 14 states and 4 geographic regions in Brazil.Participants The sample included 10 844 students, 33.7% of whom were enrolled in medicine and 66.3% in other fields (administration, agronomy, agribusiness, systems analysis and development, architecture, architecture and urbanism, biomedicine, computer science, accounting, economics, social communication/advertising and propaganda, law, physical education, nursing, civil engineering, computer engineering, production engineering, electrical engineering, mechatronics engineering, aesthetics and cosmics, pharmacy, physics, physiotherapy, speech, speech therapy, environmental management, commercial management, human resources management, financial management, history, Portuguese-English literature, logistics, marketing, mathematics, veterinary medicine, nutrition, dentistry, pedagogy, management processes, psychology, advertising and propaganda, computer networks, social work, information systems and theology). …”
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Rule with an iron hand: powerful CEOs, influential shareholders and corporate performance in Russia by Marina Zavertiaeva, Tatiana Ershova

“…Design/methodology/approach – Managerial power is divided into structural, ownership, expert and prestige. The proposed power metrics include not only CEOs but also the board of directors' characteristics that may restrict or enhance CEO power. …”
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Prediction of methylphenidate treatment response for ADHD using conventional and radiomics T1 and DTI features: Secondary analysis of a randomized clinical trial by Mingshi Chen, Zarah van der Pal, Maarten G. Poirot, Anouk Schrantee, Marco Bottelier, Sandra J.J. Kooij, Henk A. Marquering, Liesbeth Reneman, Matthan W.A. Caan

“…Conclusion: While conventional and radiomics models performed equally well in predicting clinical improvement across children and adults during treatment, radiomics features offered enhanced structural information beyond conventional region-based volume and FA averages in children. …”
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Actions to Improve the Secondary Prevention of Fragility Fractures in Women with Postmenopausal Osteoporosis: A Social Return on Investment (SROI) Study by Olmo-Montes FJ, Caeiro-Rey JR, Peris P, Pérez del Río V, Etxebarria-Foronda Í, Cancio-Trujillo JM, Pareja T, Jódar E, Naranjo A, Moro-Álvarez MJ, García-Goñi M, Vergés J, Maratia S, Campos Tapias I, Prades M, Aceituno S

“…Unitary costs were sourced from scientific literature and official data, and intangible costs were estimated through surveys on women’s willingness to pay for better health-related quality of life. …”
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Measurement-guided therapeutic-dose prediction using multi-level gated modality-fusion model for volumetric-modulated arc radiotherapy by Changfei Gong, Changfei Gong, Changfei Gong, Yuling Huang, Yuling Huang, Yuling Huang, Junming Jian, Junming Jian, Junming Jian, Wenheng Zheng, Wenheng Zheng, Wenheng Zheng, Xiaoping Wang, Xiaoping Wang, Xiaoping Wang, Shenggou Ding, Shenggou Ding, Shenggou Ding, Yun Zhang, Yun Zhang, Yun Zhang

“…Quantitative experimental predictions show that the proposed model achieved the lowest values for the mean absolute error (37.99) and root mean square error (4.916), and the highest values for the peak signal-to-noise ratio (52.622), structural similarity (0.986) and universal quality index (0.932). …”
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Cross-species comparison of rodent and human decision-making in the Iowa Gambling Task in select neurological and psychiatric disorders: translational approach to examine age- and... by Varsha Singh, Manjari Tripathi, Sarat P. Chandra, Rohit Verma, Sushil Kumar Jha, Harvinder Singh Chhabra, Mrinmoy Chakravarty, Mrinmoy Chakravarty, Shambhovi Mitra, Indupriya B, Ankit Jha, Sakshi Sharma, Jyotsna Pandey, Divyanshi Pandey, Insha Shamshad, Ekta Ahlawat, Titli Saha, Chloé César, Suman Jain

“…This non-analogous structural–functional mapping of brain regions and cognitive deficits result in rodent models that fail to establish causal links of brain pathophysiology and clinical conditions, and the model remains a poor depiction of cognitive deficits experienced by humans. …”
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High-Dose Ceftriaxone in Elderly Patients with Enterococcal Infective Endocarditis: Population Pharmacokinetics of Free Ceftriaxone and Dose Optimization by Beatriz Fernández Rubio, Fernando Docobo Pérez, Laura Herrera Hidalgo, Luis Eduardo López-Cortés, Rafael Luque Márquez, José Manuel Lomas Cabezas, Luis Fernando López-Cortés, Marta Mejías Trueba, Ana Belén Guisado Gil, Alicia Gutiérrez Valencia, Arístides de Alarcón González, María Victoria Gil Navarro

“…Ceftriaxone free concentration was measured at three time-points: before the administration (C_min) and two and four hours after ceftriaxone administration (C₂ and C₄). Both structural and covariate population pharmacokinetic models were built. …”
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Ecological responses of Orientallactaga sibirica: Variations in body size and trophic niche across changing habitats by Qi-qige Buren, Xin Li, Guo-kang Chen, Guo-hui Ye, Shan-shan Sun, Yong-ling Jin, Ming-ming, He-Ping Fu, Shuai Yuan

“…The trophic niche width of O. sibirica varied across habitat types, being widest in the warm-temperate semi-humid zone and at mid-altitudes. Segmented structural equation modeling revealed that elevation and mean annual temperature exerted significant negative effects on O. sibirica body size by affecting FVC, whereas annual precipitation had a significant positive effect on body size, mediated through FVC. …”
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Comparative genetic mapping and a consensus interspecific genetic map reveal strong synteny and collinearity within the Citrus genus by Patrick Ollitrault, Patrick Ollitrault, Barbara Hufnagel, Barbara Hufnagel, Franck Curk, Aude Perdereau, Pierre Mournet, Pierre Mournet, Maëva Miranda, Maëva Miranda, Gilles Costantino, Yann Froelicher, Yann Froelicher, Mônica Alves, Maria Angeles Forner Giner, Malcolm W. Smith, Pablo Aleza, François Luro, Nelson A. Wulff, Leandro Peña, Raphaël Morillon, Raphaël Morillon, Arnaud Lemainque

“…The consensus genetic map is a useful tool to check the accuracy of genome assemblies, identify large structural variation and focus on analyzing potential relationships with phenotypic variations. …”
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Key Drivers Affecting the Future of Power Relations in Tehran Metropolis with a Scenario-Writing Approach by Afshin Mottaghi, Arash Ghorbani Sepehr, Joseph Saloukadz

“…The Delphi method was also used to screen the propellants. The data were analyzed using the MicMac and Scenario Wizard software. …”
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Design and analysis of spiral plating solution flow and rotating magnetic field device for electroplated diamond wire saw by Wei HUANG, Yanming HE, Jinbao XU, Zhenya SONG, Xiang HUANG, Yumeng SUN, Ximeng YU

“…The research focuses on solving three core problems: (1) the structural design of the spiral bath flow electroplating device and the optimization of flow rate and spiral speed of the spiral bath flow; (2) the structural design of the rotating magnetic field device and the optimization of rotation speed and magnetic field strength; (3) the optimal process parameters for electroplating diamond wire saws in the new composite field electroplating device, and the production of wire saws for silicon wafer cutting experiments.MethodsThe electroplating mixture spirals in the same direction around the baseline, which can improve the consistency of diamond particle concentration around the baseline circumference and enhance the uniformity of the mixed solution stirring. …”
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Abnormal Granger causal connectivity based on altered gray matter volume and associated neurotransmitters of adolescents with internet gaming disorder revealed by a multimodal neur... by Xiaoyu Niu, Mengzhe Zhang, Xinyu Gao, Jinghan Dang, Jieping Sun, Qiuying Tao, Yan Lang, Weijian Wang, Yarui Wei, Shaoqiang Han, Huayan Xu, Yingkun Guo, Jingliang Cheng, Yong Zhang

“…Therefore, we aimed to integrate structural, functional and molecular data to explore the GMV-based Granger causal connectivity abnormalities and their correlated neurotransmitter systems in IGD adolescents. …”
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Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular... by Louis Bherer, Louis Bherer, Louis Bherer, Tudor Vrinceanu, Emma Gabrielle Dupuy, Emma Gabrielle Dupuy, Mathieu Gayda, Thomas Vincent, Pierre-Olivier Magnan, Pierre-Olivier Magnan, Hanieh Mohammadi, Claudine Gauthier, Claudine Gauthier, Christine Gagnon, Simon Duchesne, Kirk I. Erickson, Daniel Gagnon, Frédéric Lesage, Sonia Lupien, Judes Poirier, Marie-Pierre Dubé, Éric Thorin, Martin Juneau, Juliana Breton, Sylvie Belleville, Sylvie Belleville, Guylaine Ferland, Guylaine Ferland, Flavie Gaudreau-Majeau, Flavie Gaudreau-Majeau, Caroll-Ann Blanchette, Caroll-Ann Blanchette, Paolo Vitali, Anil Nigam, Anil Nigam

“…Moreover, functional and structural cerebral mechanisms involved are still poorly documented. …”
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Antimicrobial resistance (AMR) and spread of New Delhi Metallo-β-Lactamase (NDM) in Italy: A call for policymakers by Gabriella Nucera

“…According to its Agenzia Regionale di Sanità (ARS) data, between November 2018 and 27 October 2019, NDM producing CREs have been identified in the blood of 129 patients and the rate of mortality in patients with sepsis was as 33% [13]. …”

Right atrial strain in Anderson–Fabry disease by Rosa Lillo, Rosa Lillo, Alessio Cianci, Maria Chiara Meucci, Giulia Iannaccone, Giulia Iannaccone, Claudio Di Brango, Filippo Tusa, Mario Marsilia, Gaetano Antonio Lanza, Gaetano Antonio Lanza, Antonella Lombardo, Antonella Lombardo, Francesco Burzotta, Francesco Burzotta, Francesca Graziani

“…BackgroundTo date, only limited data are available on right atrium (RA) morphofunctional remodeling in Fabry disease (FD).PurposeWe aimed to investigate RA structural and functional remodeling in patients with FD vs. healthy controls using 2D speckle tracking echocardiography (STE) and to explore whether any differences exist in FD patients with and without left ventricular hypertrophy (LVH).MethodsWe prospectively enrolled patients with FD and controls matched for age, sex, and cardiovascular risk factors. …”
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Multi-omics insights into functional alterations of the liver in growth-retarded offspring: transcriptomic, epigenetic and metabolomic profiles by Qun Lan, Sui Liufu, Xin Xu, Bohe Chen, Wenwu Chen, Kaiming Wang, Caihong Liu, Lanlin Xiao, Xiaolin Liu, Lei Yi, Jingwen Liu, Qiuchun Deng, Haiming Ma, Meng Kang

“…Compared to high weaning weight (HWW) piglets, the liver of low weaning weight (LWW) piglets was predominantly characterized by hepatic vacuolation and structural lesions. Transcriptomic analysis of the liver indicated that differentially expressed genes (DEGs) linked to amino acid metabolism (IDO1, DAO, and UROC1) and innate immune (ISG15, RSAD2, and IFIT1) showed significant upregulation in the high birth weight (HBW) piglets when compared to the low birth weight (LBW) piglets. …”
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