The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer by Yuqian Yan, Jian Ma, Dejie Wang, Dong Lin, Xiaodong Pang, Shangqian Wang, Yu Zhao, Lei Shi, Hui Xue, Yunqian Pan, Jun Zhang, Claes Wahlestedt, Francis J Giles, Yu Chen, Martin E Gleave, Collin C Collins, Dingwei Ye, Yuzhuo Wang, Haojie Huang

“…The Q165P mutation causes structural changes in the MATH domain and impairs SPOP dimerization and substrate degradation. …”
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New possibilities of using perampanel in children. Efficacy and tolerability of perampanel in the treatment of epilepsy (literature review and experience of Svt. Luka’s Association... by K. Yu. Mukhin, O. A. Pylaeva, M. Yu. Bobylova, L. Yu. Glukhova

“…This study included 270 patients aged 4 to 43 years (125 males and 145 females; 255 children and adolescents aged 4–18 years; 15 adult patients; mean age at the time of perampanel therapy initiation was 11.8 years) who received perampanel and for whom we managed to collect clinical data for at least 6 months.The study sample included 114 patients with structural and presumably structural focal epilepsy, 120 patients with genetic and presumably genetic epilepsy (including Dravet and Angelman syndromes, Lafora disease, mutations in genes PCDH19, PHACTR1, CDKL5, ARX, PING, SCN2A, KIAA2022, chromosomal microdeletions, etc.), and 36 patients with focal epilepsy of unknown etiology. …”
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Investigating The Performance Of Local And Indigenous Businesses In Times Of Economic Recession With Emphasis On Developing The Capabilities Of Cooperatives In Sistan And Baluchest... by Ali Asghar Tabavar, Abdoulnaser Derakhshan, Sahar Arefi

“…The first step in carrying out the estimation approach of vector error correction models is to check the meanness of the data. Therefore, the significance of all variables is checked and if some of them are insignificant, the significance variables are formed using measurement methods. …”
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Results of a study of the effectiveness of direct coronary oxygen persufflation as a donor heart conditioning method by M. O. Zhulkov, D. A. Sirota, I. S. Zykov, A. K. Sabetov, K. A. Agaeva, А. G. Makaev, D. M. Osintsev, A. P. Nadeev, V. Е. Kliver, E. E. Kliver, A. M. Volkov, A. R. Tarkova, А. V. Fomichev, A. M. Chernyavsky

“…Objective: to evaluate the technical feasibility as well as functional, metabolic and structural integrity of donor heart myocardium after 4 hours of direct intracoronary oxygen persufflation in an experiment. …”
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The association between perceive social support and post-traumatic stress disorder symptoms among medical staff in Hubei, China: a chain mediating effect of resilience and positive... by Junjie Cao, Yifang Liu, Shijiao Yan, Zijun Xiong, Jing Wen, Zongju Chen, Pu Zhang, Jiaxin Tao, Jun Zhang, Ying Wang, Li Zou, Wenning Fu

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The impact of COVID-19 fear during the later stages of the pandemic on maladaptive eating, psychological distress and body weight: a global cross-sectional study by Meeah Willig, Tomás Cabeza de Baca, Emma J. Stinson, Andrés M. Treviño-Alvarez, Theresa Rodzevik, Susanne B. Votruba, Coley C. Lameman, Jonathan Krakoff, Marci E. Gluck

“…General linear models, multinomial logistic regression modes, and structural equation modeling were used to analyze the data. …”
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The effects of active play interventions on children’s fundamental movement skills: a systematic review by Xinmiao Zhang, Changhao Tang, Miao Geng, Kai Li, Cong Liu, Yujun Cai

“…Active play (AP) holds significant potential for enhancing children’s FMS based on its free-choice and unstructured nature, as well as its ease of implementation and dissemination. …”
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Extracting Multifaceted Characteristics of Patients With Chronic Disease Comorbidity: Framework Development Using Large Language Models by Junyan Zhang, Junchen Zhou, Liqin Zhou, Zhichao Ba

“…In addition, we demonstrated the strengths and limitations of this framework. MethodsWe used data sourced from a grassroots community health service center in China. …”
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TERT c.3150 G > C (p.K1050N): a founder Ashkenazi Jewish variant associated with telomere biology disorders by Kelvin César de Andrade, Emilia M. Pinto, Tianna Zhao, Logan P. Zeigler, Jung Kim, Neelam Giri, Jeremy S. Haley, Lisa J. McReynolds, Oscar Florez-Vargas, Aaron H. Phillips, Richard W. Kriwacki, Sherifa A. Akinniyi, Scott B. Cohen, Matthew R. Emerson, Diane T. Smelser, Gretchen M. Urban, Cintia Fridman, Gerard P. Zambetti, Tracy M. Bryan, David J. Carey, Christine Kim Garcia, Douglas R. Stewart, Sharon A. Savage

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Co-developing a health promotion programme for indigenous youths in Brazil: A concept mapping report. by Paulo T C Jardim, Josiliane M Dias, Antonio J Grande, André B Veras, Érika K Ferri, Fatima A A Quadros, Clayton Peixoto, Francielle C S Botelho, Maria I M G Oliveira, Ieda M A V Dias, Majella O'Keeffe, Christelle Elia, Paola Dazzan, Ingrid Wolfe, Seeromanie Harding

“…The little routinely collected population-level data from Indigenous communities in the region available shows stark inequities in health and well-being. …”
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Level of matrix metalloproteinase-9 and myocardium remodeling in patients with acute postinfarction aneurism of left ventricle by V. D. Syvolap, S. M. Kyselov

“…Level of matrix metalloproteinase-9, structural and functional indexes of myocardium remodeling were studied in patients with acute postinfarction aneurism of left ventricle. …”
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Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons by Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger

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SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon-α and interferon-γ receptors by Naveen Thakur, Poushali Chakraborty, JoAnn M. Tufariello, Christopher F. Basler

“…ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 14 (Nsp14) possesses an N-terminal exonuclease (ExoN) domain that provides a proofreading function for the viral RNA-dependent RNA polymerase and a C-terminal N7-methyltransferase (N7-MTase) domain that methylates viral mRNA caps. …”
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The Intervened effect of place attachment on the relationship between community attachment and environmental behaviors (case study: Tajrish neighborhood) by Atousa Soleimani, Ahmad Nohegar

“…The participants were asked to fill out the research questionnaire whose reliability and validity were confirmed. The obtained data were statistically analyzed using the correlation analysis and structural equation modeling in SPSS-21 and AMOS-21. …”
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Manganese mitigates atrazine-induced oxidative stress and hepatorenal toxicity: insights from network pharmacology and in vivo experimentation by Solomon E. Owumi, Tella T. Adedayo, Joseph Chimezie, Bayode Oluwawibe, Harieme Agbarogie, Jesutosin O. Babalola, Oludare M. Ogunyemi, Uche O. Arunsi, Moses T. Otunla, Chioma E. Irozuru, Ahmad Altayyar, Eziuche A. Ugbogu

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Brain-derived neurotrophic factor as a target for the search of anti-addiction drugs by M. S. Khalimanov, E. M. Grigorevskikh, K. A. Zavadich, S. I. Sologov, D. A. Traschenkova, K. A. Tatzhikova, E. V. Polikarpov, S. S. Sologova, D. A. Kudlay, E. A. Smolyarchuk

“…This study analyzed the molecular mechanisms of the action of BDNF, including its biosynthesis, structural forms (BDNF and pro-BDNF), and functions and features of TrkB and LNGFR receptors. …”
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The issue of credibility between customers’ perceptions and the attitude toward Facebook advertising by Jassim Al-Gasawneh, Abdullah AlSokkar, Mahmoud Alghizzawi, Tahreer Abu Hmeidan, Deemah Alarabiat, Ahmed Alamro

“…This research was conducted in Amman, Jordan, and data were collected from undergraduate students enrolled in the Digital Marketing program at Applied Science Private University (ASU) in 2024 using purposive sampling methods via Google Forms. …”
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Geological Evaluation of In-Situ Pyrolysis Development of Oil-Rich Coal in Tiaohu Mining Area, Santanghu Basin, Xinjiang, China by Guangxiu Jing, Xiangquan Gao, Shuo Feng, Xin Li, Wenfeng Wang, Tianyin Zhang, Chenchen Li

“…., roof/floor lithology) and structural features (e.g., fault proximity) directly impact pyrolysis furnace sealing integrity, while environmental geological factors (e.g., hazardous element content in coal) determine environmental risk control effectiveness. …”
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Phthalate-Induced Liver Protection against Deleterious Effects of the Th1 Response: A Potentially Serious Health Hazard by Mostafa Z. Badr, Alexander Shnyra, Mikhail Zoubine, Maxim Norkin, Betty Herndon, Tim Quinn, Roberto N. Miranda, Michael L. Cunningham, Agostino Molteni

“…Animals with Th1 response (group II) showed a marked structural disruption in the hepatic lobule. Remarkably, these alterations were conspicuously absent in animals which received DEHP (group IV), despite noticeable accumulation of T cells in the periportal triads. …”
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Operational cost savings: Blockchain-driven back-office automation and syndicated loan growth in U.S. banks by Maksym Ivasenko, Serhiy Frolov, Mykhaylo Heyenko, Nataliia Kolodnenko, Viktoriia Datsenko

“…Using the Autoregressive Distributed Lag Model (ARDL) bounds testing approach, evidence of cointegration is found and long-run elasticity is estimated: a steady 1% increase in the volume of syndicated loans reduces the operating expense ratio by 0.147%, which means that almost doubling the volume of loans in the resulting sample leads to approximately 15% structural reduction in the burden on banks’ back offices. …”
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