Identification of Causal Genes and Potential Drug Targets for Restless Legs Syndrome: A Comprehensive Mendelian Randomization Study by Ruiyi Qian, Xue Zhao, Dongbin Lyu, Qingqing Xu, Kai Yuan, Xin Luo, Wanying Wang, Yang Wang, Yutong Liu, Yu Cheng, Yingting Tan, Fan Mou, Chengmei Yuan, Shunying Yu

“…Molecular docking was used to visualize the binding structure and fine affinity for <i>MAN1A2</i> and the drugs predicted by DSigDB. …”
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Genome-Wide Identification Analysis of the 4-Coumarate: Coa Ligase (4CL) Gene Family in <i>Brassica</i> U’s Triangle Species and Its Potential Role in the Accumulation of Flavonoid... by Mengzhen Zhang, Mengjiao Tian, Ziwuyun Weng, Yaping Yang, Nian Pan, Shulin Shen, Huiyan Zhao, Hai Du, Cunmin Qu, Nengwen Yin

“…Based on phylogenetics, gene structure, conserved motifs, chromosome localization and collinearity analysis, <i>4CLs</i> were relatively conserved in the evolution of <i>Brassica</i> U’s triangle species. …”
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Forest birds maintain body condition in Alder-leaf Birch (Betula alnoides) plantations in subtropical Asia by Wenyi Zhou, Alexandra A. Grossi, Daniel R. Gustafsson, Zhengzhen Wang, Zhuyang Zhang, Yuqing Han, Xinyi Wang, Anru Zuo, Miguel A. Acevedo, Yang Liu, Scott K. Robinson

“…Plantation forestry alters avian community assembly by creating homogeneous habitats with simplified vegetation structure. However, its effects on avian body condition remain poorly understood, despite the influence body condition has on survival and reproduction. …”
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Polar lights optimizer: A novel algorithm for accurate parameter estimation in proton exchange membrane fuel cells by Mohammad Aljaidi, Pradeep Jangir, Arpita, Sunilkumar P. Agrawal, Sundaram B. Pandya, Anil Parmar, G. Gulothungan, Ali Fayez Alkoradees, Mohammad Khishe, Reena Jangid

“…The complex multivariate structure together with nonlinear behavior of these systems makes it parameter estimation a challenging task, which negatively affects operational reliability and system lifespan. …”
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Academic response to improving value and reducing waste: A comprehensive framework for INcreasing QUality In patient-oriented academic clinical REsearch (INQUIRE). by Belinda von Niederhäusern, Gordon H Guyatt, Matthias Briel, Christiane Pauli-Magnus

“…The Delphi process ultimately achieved consensus on structure and content. The framework addresses 5 study stages (concept, planning and feasibility, conduct, analysis and interpretation, and reporting and knowledge translation) and includes the following dimensions: (i) protection of patient safety and rights, (ii) relevance/patient centeredness and involvement, (iii) minimization of bias (internal validity), (iv) precision, (v) transparency/access to data, and (vi) generalizability (external validity) of study results. …”
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Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study by Lu Liu, Qianyi Zhou, Tianbao Xu, Qiufeng Deng, Yuhao Sun, Jingxiang Fu, Muxuan Chen, Xiaojiao Chen, Zhenchao Ma, Quanbin Dong, Beining Ma, Yuwen Jiao, Yan Zhou, Tingting Wu, Huayiyang Zou, Jing Shi, Yifeng Wang, Yanhui Sheng, Liming Tang, Chao Zheng, Wei Wu, Wenjun Ma, Wei Sun, Shixian Hu, Hongwei Zhou, Yan He, Xiangqing Kong, Lianmin Chen

“…Abstract Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. …”
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Habitat conditions of reef-forming corals directly affect the spatial distribution and stability in fish and macroinvertebrate communities: A case study of Mischief Reef by Peng Xu, Jianfeng Gan, Lintao Huang, Danping Xie, Feilong Li, Hui Huang

“…We utilized eDNA baseline data from Mischief Reef to investigate changes in community structure and their underlying drivers within a small-scale habitat model. …”
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MSAN-Net: An End-to-End Multi-Scale Attention Network for Universal Industrial Defect Detection by Zelu Wang, Ming Luo, Xinghe Xie, Yue Sun, Xinyu Tian, Zhengxuan Chen, Junwei Xie, Qinquan Gao, Tong Tong, Yue Liu, Tao Tan

“…MSAN-Net was adopted an integrated architecture, deeply combining UnifiedViT, C2f modules, convolution operations, SPPF structure, and Bi-Level Routing Attention mechanism to achieve accurate identification of complex industrial defects. …”
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Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist by Jarosz-Biej Magdalena, Czapla Justyna, Ciepła Joanna, Smolarczyk Ryszard, Drzyzga Alina, Sprus-Lipka Dorota, Pilny Ewelina, Matuszczak Sybilla, Cichoń Tomasz

“…Despite studies conducted, there are no unambiguous data showing how IMQ affects the condition of tumor blood vessels. …”
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Inhibition Mechanism of Pleurotus citrinipileatus Sing. Ergothioneine on Pancreatic Lipase Activity by Zhangchen XIA, Xiaohui MENG, Ru FANG, Yanqing MAO, Junwen CHENG, Yanbin WANG, Juan XU, Liang HE

“…The UV spectrum indicated there was a π→π* transition produced by the peptide bond C=O group of PL as the mass concentration of PCEGT increased, which could reflect the reinforcement of polarity and hydrophilicity. Fluorescence spectra data revealed PCEGT could efficiently static-quench the intrinsic fluorescence of PL by changing its space structure. …”
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Comparative Genomics and Characterisation of the Role of <i>Saccharomyces cerevisiae</i> Respiration in the Fermentation of Chinese Steamed Bread by Yawen Gao, Yufeng Guo, Jianing Pang, Mingkai Liu, Tengdan Yuan, Qinhong Wang, Jingsheng Liu

“…At the micro level, CSBs 1, 25 and 33 showed a loose reticular structure with large holes and in which starch particles wrapped into gluten protein. …”
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Turbulent Transport Efficiency of Momentum and Sscalar over Forest Canopy in Southern Sichuan by Yi DING, Yu ZHANG, Demin FAN, Youqi SU, Qian ZHANG, Yanqi WANG, Yanqi WANG

“…The turbulent transport characteristics of momentum and scalar over the canopy were studied by using the three levels （20 m， 38 m and 56 m） turbulence data measured at the 60m forest micro meteorological tower in southern Sichuan from May 1 to June 30， 2021.Coherent structure is the main form of turbulent motion， which is composed of updraft （ejection） and downdraft （sweep）.In this paper， the quadrant analysis method is used to analyze the boundary of the roughness sublayer， roughness sublayer and constant flux layer above the forest canopy and the ejection-sweep motion characteristics of the constant flux layer， including the difference of ejection and sweep contribution to flux， the difference between momentum and scalar transport， and the difference between different scalar （T， q， CO2） transport.The results show that under unstable and stable conditions， the ejection dominates the scalar transport at all three levels， while the sweep is the main eddy current motion for scalar transport above the roughness sublayer under neutral conditions.For the momentum flux， under unstable conditions， the ejection dominates at all three levels.Under stable conditions， the ejection dominates at the roughness sublayer and the constant flux layer， while at the boundary of the roughness sublayer and the constant flux layer， the effect of the sweep is greater than that of the ejection.Under neutral conditions， the flux contribution of the sweep is greater than that of the ejection except for the roughness sublayer.The third-order cumulant expansion method （CEM） can more accurately express the flux contribution caused by ejection and sweep， while the incomplete cumulant expansion method （ICEM） is poor in simulating the temperature at the boundary of roughness sublayer and constant flux layer.Through the calculation of transmission efficiency， the difference between momentum and scalar transmission is further quantified.The turbulent transfer efficiency of momentum decreases with increasing instability， while the heat transfer efficiency is the opposite.Atmospheric stability is an important factor controlling momentum and scalar transfer， and the transfer efficiency of water vapor is less affected by atmospheric stability.Under the condition of strong instability， the heat transfer efficiency is more effective than other scalar transfer.…”
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A Hybrid Deep Learning Framework for Deepfake Detection Using Temporal and Spatial Features by Fazeel Zafar, Talha Ahmed Khan, Salas Akbar, Muhammad Talha Ubaid, Sameena Javaid, Kushsairy Abdul Kadir

“…Our research introduces a model for detecting deepfakes by utilizing an Enhanced EfficientNet B0 structure in conjunction with Temporal Convolutional Neural Networks (TempCNNs). …”
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Radiologic assessment of the optimal point for tube thoracostomy using the sternum as a landmark: a computed tomography‐based analysis by Jaeik Jang, Jae-Hyug Woo, Mina Lee, Woo Sung Choi, Yong Su Lim, Jin Seong Cho, Jae Ho Jang, Jea Yeon Choi, Sung Youl Hyun

“…Purpose This study aimed at developing a novel tube thoracostomy technique using the sternum, a fixed anatomical structure, as an indicator to reduce the possibility of incorrect chest tube positioning and complications in patients with chest trauma. …”
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Spatio-temporal dynamics of Isoberlinia-dominated woodlands in disturbance-prone landscapes over 15 years by Shègoun Eudes Idjigbèrou, Eméline Sêssi Pélagie Assédé, Séverin Biaou, Gérard Nounagnon Gouwakinnou, Armand Kuyema Natta, Samadori Sorotori Honoré Biaou

“…Productivity and disturbance influence species richness and structure, enhancing our understanding of vegetation dynamics and species coexistence over time. …”
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Atrophy of hypothalamic subregions increases migraine risk: cross-sectional study and mendelian randomization analysis by Zhonghua Xiong, Lei Zhao, Geyu Liu, Dong Qiu, Yanliang Mei, Xiaoshuang Li, Zhi Guo, Peng Zhang, Mantian Zhang, Tianshuang Gao, Jinju Sun, Xin Liu, Yonggang Wang

“…Abstract Background The hypothalamus is a versatile structure comprising several nuclei that play key roles in regulating various biological processes associated with migraine, including hormone secretion, metabolism, circadian rhythm, and autonomic nervous system functions. …”
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Wetland dynamics in northern Australia’s tropical savanna (1987–2024): a multi-index Google Earth Engine approach for long-term monitoring by Kaline de Mello, Edimilson Rodrigues dos Santos Junior, Erica A. Garcia, Anna E. Richards, Peter Scott Waugh, Jessica Huxley, Simon Linke

“…Wetlands were categorized into twelve classes based on hydrological regime and vegetation structure. Validation showed high accuracy (93 % ± 1 %), with class-level accuracy above 80 % for most wetland types, including water bodies, mangroves, salt flats, swamps, marshes, and floodplains. …”
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The multicenter observational non-interventional study of combination anti-tuberculosis drugs used in treatment of pulmonary tuberculosis patients by T. E. Tyulkova, I. V. Mokhireva, A. A. Starshinova, P. K. Yablonskiy, L. I. Аkhilgova, O. D. Baronova, A. V. Gromov, O. N. Otpuschenikova, G. S. Oganezova, M. V. Levchenko, I. A. Panova, O. A. Trushina, N. V. Yasinetskaya, E. A. Sakharitova

“…Descriptive statistics methods were used for statistical data processing.Results. Of all PP, 267 (54.6%) completed the main course of chemotherapy. …”
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Distinct effects of fine and coarse aerosols on microphysical processes of shallow-precipitation systems in summer over southern China by F. Chen, F. Chen, Y. Yang, L. Yu, Y. Li, W. Liu, Y. Liu, Y. Liu, S. Lolli

“…<p>Densely populated southern China, adjacent to the South China Sea, which is associated with shallow precipitation during summer, is an open-air natural laboratory for studying the impact of aerosol particles on shallow-precipitation events. Using 8 years of data from Dual-frequency Precipitation Radar measurements, aerosol reanalysis, and atmospheric reanalysis, this study investigates the potential influence of coarse and fine aerosol particles on the structure of the precipitation and the microphysical processes of shallow precipitation in southern China. …”
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Crystallinity integration of anatase (TiO2) nanocrystal by whole powder pattern fitting (WPPF) method: A Rietveld refinement study by Shanawaz Ahmed, Md. Khalid Hossain Shishir, Md. Tarikul Islam, Md. Ashikur Rahaman, Sahil Aman, Allah Rakha Aidid, Sumaiya Islam Sadia, Md. Masud Rana, Md. Ashraful Alam

“…This research advances the understanding of the controlled synthesis of anatase nanoparticles and demonstrates the effectiveness of characterizing their crystalline structure.…”
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