Theoretical–Cheminformatic Study of Four Indolylphytoquinones, Prospective Anticancer Candidates by Edgar Daniel Moyers-Montoya, María Jazmín Castañeda-Muñoz, Daniel Márquez-Olivas, René Miranda-Ruvalcaba, Carlos Alberto Martínez-Pérez, Perla E. García-Casillas, Wilber Montejo-López, María Inés Nicolás-Vázquez, René Gerardo Escobedo-González

“…Results: The results revealed that the studied structures possibly presented antineoplastic activity, in addition to the fact that the reactivity parameters showed that two of the evaluated compounds have the option to present IC₅₀ values lower than or similar to 25 mg/mL, activity like that of indolylisoperezone; moreover, they show molecular coupling to PARP-1. …”
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Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial by Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, Leah Holroyd, Christina Prechtl, Tom Preston, Mike J Lean, Waljit Dhillo, A Toby Prevost, and Douglas Morrison

“…Due to the COVID-19 lockdowns and pivot to collection of self-reported weight data, the ‘Principal weight’ measurement for the primary outcome consists of 38% self-reported weight data. …”
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Etiological mechanisms underlying the hazard factors and inflammatory bowel disease: a prospective cohort study by Yi Tao, Yongjia Li, Tianyi Zhou, Lei Zhao, Pan Li, Minghong Sun, Lijuan Zhang, Lihong Yang, Ting Chen, Xuemei Lian, Xiaoni Zhong

“…Finally, we constructed a structural equation model to elucidate the complex pathogenic mechanisms and interactions among genetic risks, lifestyle factors, dietary habits, comorbidities, and immune metabolism in the progression of IBD. …”
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High-temperature dolomite in the Lower Cretaceous Cupido Formation, Bustamante Canyon, northeast Mexico: petrologic, geochemical and microthermometric constraints by Gabriela Sara Guzzy-Arredondo, Gustavo Murillo-Muñetón, Dante Jaime Morán-Zenteno, José Manuel Grajales-Nishimura, Ricardo Martínez-Ibarra, Peter Schaaf

“…The high temperatures recorded in the Cupido Formation dolomites are the result of a regional thermal anomaly developed probably around salt structures. 87Sr/86Sr values, oxygen stable isotopes, and trace element composition of dolomite suggest that the dolomitizing fluid was perhaps a hot mixture of formation water (modified sea water) of the Cupido Formation and brines derived from the updip La Virgen Formation, a carbonate-evaporite succession equivalent in age to the Cupido Formation. …”
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Facial Expression Recognition and Digital Images Infosecurity for Prevention Care System Application in Sudden Infant Death Syndrome Monitoring by Chih-Te Tsai, Chia-Hung Lin, Hsiang-Yueh Lai, Yu-En Cheng, Ping-Tzan Huang, Neng-Sheng Pai, Chien-Ming Li

“…For image infosecurity testing, the number of pixel changing rate (NPCR), unified averaged changed intensity (UACI), and structural similarity index measurement (SSIM) were employed to evaluate the performances for encryption and decryption processes, ensuring confidentiality, recoverability, and availability of transmitted images. …”
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For-profit growth and academic decline: a retrospective nationwide assessment of Brazilian medical schools by Bruno B. Andrade, Bruno B. Andrade, Klauss Villalva-Serra, Klauss Villalva-Serra, Rodrigo C. Menezes, Rodrigo C. Menezes, Luiz F. Quintanilha, Katia de Miranda Avena, Katia de Miranda Avena

“…These patterns suggest a structural misalignment between the commercial logic of expansion and the core educational mission of medical training. …”
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Effects of different corticotomy approaches on anterior retraction with clear aligners: a finite element study by Hongyu Hou, Fang Yang, Hong He, Fang Hua, Zhengguo Cao, Hui Xiong

“…Abstract Background Corticotomy has been shown to influence the biomechanical behavior of dentoalveolar structures during anterior retraction. However, most research on corticotomy in orthodontics focused on fixed appliance models. …”
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Use of conjoint analysis to weight biosecurity practices on pasture-based dairy farms to develop a novel audit tool—BioscoreDairy by Siobhan M. O Donovan, Siobhan M. O Donovan, Conor G. McAloon, Conor G. McAloon, Luke O'Grady, Timothy Geraghty, Alison Burrell, Marie-Claire McCarthy, John Donlon, Jamie A. Tratalos, John F. Mee

“…However, a weakness is their failure to account for unique intra-national farming enterprise structures such as, for example, pasture-based dairying. …”
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EFFECTS OF PROLINE-RICH PEPTIDES OF THE INNATE IMMUNE SYSTEM ON DRUG-RESISTANT BACTERIAL STRAINS by M. S. Zharkova, P. M. Kopeykin, G. E. Afinogenov, D. S. Orlov, A. Yu. Artamonov, K. E. Safiullina, M. S. Sukhareva, E. V. Tsvetkova, B. L. Milman, A. G. Afinogenova, O. V. Shamova

“…Lack of hemolytic activity towards human red blood cells is an important benefit of the studied peptides when used at concentrations several times higher than those showing antimicrobial effects. The data obtained presume certain prospects for further investigations of proline-rich peptides, as well as their structural modifications, for the development of new combined drugs based on these compounds, in order to combat antibiotic-resistant microorganisms, e.g., medications for local applications, various components of medical devices, in particular, venous catheters, stents and wound dressings.…”
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The Middle to Late Triassic of Central Saudi Arabia with emphasis on the Jilh Formation. Part I: lithostratigraphy, facies and paleoenvironments, palaeontology and biostratigraphic... by Le Nindre, Yves-Michel, Vaslet, Denis, Vrielynck, Bruno, Krystyn, Leopold, Manivit, Jacques, Memesh, Abdullah, Davies, Roger Brett

“…Part II “Sequence stratigraphy, depositional and structural evolution, and regional correlations” exploits the results of Part I, providing a dynamic reconstruction and a renewed vision of the Middle to Late Triassic at the regional scale.The Jilh Formation at outcrop consists of a multilayer system of thinly bedded, mixed siliciclastics with subordinate carbonates and evaporites, representing non-marine to offshore settings. …”
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Characterization of Superoxide Dismutase (SOD) Gene Family and Their Responses to Salinity Stress and Fruit Development in Octoploid Strawberry by Yunting Zhang, Yan Chen, Weiliang Gao, Su Tian, Bangyu Lin, Xianjie Gu, Yuanxiu Lin, Mengyao Li, Yan Wang, Wen He, Yong Zhang, Qing Chen, Ya Luo, Xiaorong Wang, Haoru Tang

“…Each clade had similar motifs, and exon–intron structures, which in turn supported the evolutionary classification. …”
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Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations by Cristiane S. R. Fonteles, Julia Enterria-Rosales, Ying Lin, John W. Steele, Ramiro A. Villarreal-Leal, Jing Xiao, Daniel I. Idowu, Beck Burgelin, Bogdan J. Wlodarczyk, Richard H. Finnell, Bruna Corradetti

“…A physicochemical, structural, and molecular comparison was conducted with exosomes (EXOs) released from the same batch of cells. …”
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Metabolomic and Transcriptomic Analysis Revealed the Maturation Mechanism of White-Fleshed Strawberry by Linlin Xu, Xiaodong Chen, Qinglian Wang, Mizhen Zhao, Yushan Qiao, Zhaobiao Xie, Chuanwen Sun, Miao Sun, Weijian Cai

“…Further analysis revealed a co-expression of MYBs, bHLHs, NACs, and WRKYs with the structural genes mentioned. Overall, our findings uncovered a molecular mechanism regulating the maturation of white-fleshed strawberry, providing valuable insights for enhancing the flavor of white-fleshed strawberry through the gene-editing technique.…”
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Evaluating cutinase from Fusarium oxysporum as a biocatalyst for the degradation of nine synthetic polymer by Maycon Vinicius Damasceno de Oliveira, Gabriel Calandrini, Clauber Henrique Souza da Costa, Carlos Gabriel da Silva de Souza, Cláudio Nahum Alves, José Rogério A. Silva, Anderson H. Lima, Jerônimo Lameira

“…We demonstrated that important conserved regions, such as the Ser-Asp-His catalytic triad, exist in the enzyme’s catalytic site and that all Cut enzymes from different organisms have the same region to couple with the polymer structures.…”
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Trajectory optimization of a flapping-wing robot in a wind field by Xiaoyang WU, Zhiguo ZHANG, Wei HE, Jingyan QIN, Junhai ZHANG, Tingting MENG

“…In the simulation, the robot’s design is simplified, with some complex structures removed, to reduce computational costs and model complexity. …”
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The Application Status of Radiomics-Based Machine Learning in Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-Analysis by Lan Xu, Zian Chen, Dan Zhu, Yingjun Wang

“…Radiomics-based machine learning (ML) was mainly used to diagnose ICC (n=30), microvascular invasion (n=8), gene mutations (n=5), perineural invasion (PNI; n=2), lymph node (LN) positivity (n=2), and tertiary lymphoid structures (TLSs; n=2), and predict overall survival (n=6) and recurrence (n=9). …”
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Hypoxia-inducible factors: details create a picture. Part I. HIF-1 by G. A. Ignatenko, N. N. Bondarenko, S. V. Tumanova, T. S. Ignatenko, A. A. Kaluga, Ya. S. Valigun

“…The review presents a comparative analysis of scientific data on the structural and functional characteristics of subunits (HIF-1α and HIF-1β) of hypoxia-inducible transcription factor-1 (HIF-1). …”
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Antimicrobial and antifungal activity of new 4-(5-((5-(alkylthio)-4-R-4H-1,2,4-triazole-3-yl)thio)-1H-1,2,4-triazole-3-yl)pyridines by Ye. O. Karpun, N. M. Polishchuk

“…The biological screening data indicate that the search among the given bis-1,2,4-triazole derivatives is promising. …”
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Experiment on physical and mechanical properties of tomato seedling pot for automatic vegetable transplanter by Liang Xifeng, Cai Yangyang, Wang Yongwei

“…However, automatic vegetable transplanter needs integrated knowledge and technology, the research on which should also combine the structural design with the physical and mechanical properties of vegetable seedling pot. …”
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Crocin improves post-thaw quality, fertility-associated gene expression and fertilization potential of buffalo bull sperm by Amjad Riaz, Ghulam S. Khan, Muhammad Zahid Tahir, Muhammad Yasir Zahoor, Hifz-ul-Rahman Hifz-ul-Rahman

“… Buffalo sperm suffer more cryoinjuries due to lipid peroxidation of their high structural polyunsaturated fatty acid contents than cattle. …”
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