Insights into Keratinocyte and Immunologic Landscape in Cutaneous Graft-Versus-Host Disease through Single-Cell Transcriptomics by Amy J. Petty, Adela Rambi Cardones, Yingai Jane Jin, Vaibhav Jain, Emily Hocke, Harsh B. Pathak, Amrita Mitra, Simon G. Gregory, M. Angelica Selim, Jennifer Y. Zhang

“…Very little is understood about the underlying pathogenesis underpinning injury at this location, especially the contribution of keratinocytes and other structural skin cells. We performed single-cell RNA sequencing to compare the transcriptome of epidermal and dermal chronic GVHD samples with that of healthy control samples. …”
Get full text

Food parenting stress among caregivers receiving government food assistance: a study from the United States by Faith Hardy, Alison Tovar, Emily G. Elenio, Yarisbel Melo Herrera, Michelle Perry, Katherine W. Bauer, Maya K. Vadiveloo

“…Nutrition education should be paired with supports that address structural barriers.…”
Get full text

Perceived barriers to and facilitators of behavioural change towards a more active lifestyle in people with neuromuscular diseases: a qualitative study by Eric L. Voorn, Sander Oorschot, Roos Ritmeester, Lois de Zeeuw, Sandra de Morée, Fieke S. Koopman, Annerieke C. van Groenestijn, Judith G.M. Jelsma

“…Subjects: Nineteen subjects (63% females, age range 28–73 years), representing 4 different neuromuscular diseases. Methods: Data from a randomized controlled trial were used. …”
Get full text

5-Ene-2-arylaminothiazol-4(5<i>H</i>)-ones Induce Apoptosis in Breast Cancer Cells by Rostyslav Dudchak, Magdalena Podolak, Ivan Sydorenko, Robert Czarnomysy, Agnieszka Gornowicz, Olexandr Karpenko, Serhii Holota, Anna Bielawska, Krzysztof Bielawski, Roman Lesyk

“…The second approach fits the requirements of cost-effective methodologies and allows for the reduction of synthetic steps, reagents, and reaction time. The obtained data from in vitro research showed a potent cytotoxic activity of the novel structures in micromolar concentrations against MCF-7 breast cancer cells. …”
Get full text

On cyber sabotage risks in automated manufacturing of advanced composites by Saral Mittal, Hammond Pearce, Mark Yampolskiy, Ebrahim Oromiehie, B. Gangadhara Prusty

“…Recent advancements in the manufacturing of layered composite structures have seen the deployment of automated control systems, with computers used for both design protocols and control of manufacturing processes. …”
Get full text

ODEP-Based Robotic System for Micromanipulation and In-Flow Analysis of Primary Cells by Joanna Filippi, Paola Casti, Valentina Lacconi, Gianni Antonelli, Michele D’Orazio, Giorgia Curci, Carlo Ticconi, Rocco Rago, Massimiliano De Luca, Alessandro Pecora, Arianna Mencattini, Steven L. Neale, Luisa Campagnolo, Eugenio Martinelli

“…The induced responses obtained under time-variant ODEP stimulation reflect the cells’ chemical, morphological, and structural characteristics in an automated, flexible, and label-free manner. …”
Get full text

Evaluation of dengue virus seroprevalence in four boroughs of Mexico City among persons aged 5-35 years in 2022 by Eleazar Coba-Alcalá, Lilia Chihu-Amparán, Irma Yvonne Amaya-Larios, Susana Román-Pérez, Rene Santos-Luna, Lorena Suárez-Idueta, Sonia López-Álvarez, Cristal Morales-Trevizo, Jesús Felipe González-Roldán, Ruth Aralí Martínez-Vega, José Ramos-Castañeda

“…However, it is important to note that the structural conditions of the dwellings in these boroughs, which offer minimal barriers to vector infestation, could facilitate the establishment of local transmission under favorable conditions. …”
Get full text

Connecting the Small Solar Wind Transients Observed Remotely to Their In Situ Measurement near 1 au by Shaoyu Lyu, Yuming Wang, Christopher J. Owen

“…Based on the two-vantage observations by the COR2 coronagraphs on board the two STEREO spacecraft between 2010 January 1 and 2010 July 15, we reconstruct the three-dimensional (3D) structures of small solar wind transients in the extended corona and determine their velocities by using the CORrelation-Aided Reconstruction technique. …”
Get full text

The Relation between Solar Spicules and Magnetohydrodynamic Shocks by Sankalp Srivastava, Piyali Chatterjee, Sahel Dey, Robertus Erdélyi

“…In addition, we also find the presence of structures similar to propagating coronal disturbances (PCDs) in the simulation, linked with the spicules. …”
Get full text

Oral Small-Molecule GLP-1 Receptor Agonists: Mechanistic Insights and Emerging Therapeutic Strategies by Héctor Iván Saldívar-Cerón, Jorge Arturo Vargas-Camacho, Sonia León-Cabrera, Paola Briseño-Díaz, Ari Evelyn Castañeda-Ramírez, Axel Eduardo Muciño-Galicia, María Regina Díaz-Domínguez

“…Nevertheless, challenges persist regarding hepatic safety, pharmacodynamic variability, and limited long-term outcome data. This review integrates current structural, pharmacological, and clinical evidence, highlights key mechanistic innovations—including biased agonism, covalent binding strategies, and allosteric modulation—and discusses future directions for this rapidly evolving therapeutic class in metabolic disease management.…”
Get full text

Comprehensive Dissolution Study on Two Double Ce(IV) Phosphates with Evidence of Secondary CeO₂ Nanoparticle Formation by Anastasiia L. Listova, Anastasiia S. Kuzenkova, Mikhail A. Gerasimov, Elizaveta S. Kulikova, Roman D. Svetogorov, Daniil A. Novichkov, Alexei A. Averin, Vasiliy O. Yapaskurt, Anna Yu. Romanchuk, Stepan N. Kalmykov, Tatiana V. Plakhova

“…For the first time, experimental dissolution data were obtained for both compounds over a wide pH range (1.5–10) under long-term equilibration. …”
Get full text

Evidence of slab tearing on an inherited Mesozoic rift transfer fault in the Betic Cordillera by Antonio Pedrera, Juan Díaz-Alvarado, Antonio Azor, Andrés Folguera, Luis González-Menéndez, Jesús García-Senz, Pedro Pablo Hernaiz-Huerta, Ana Ruiz-Constán, Carlos Marín-Lechado, Adrià Ramos, Berta López-Mir, Carmen Rodríguez, Roberto Jiménez-Borrego, Károly Hidas

“…Our findings demonstrate how inherited rift-related structures can drive slab tearing and asthenospheric upwelling, shaping the spatial and temporal patterns of magmatism and high-temperature metamorphism in complex subduction systems.…”
Get full text

The nonglycosylated variant in therapeutic monoclonal antibodies preferentially forms large aggregates under typical thermal stresses used in forced degradation studies by Gao-Yuan Liu, Jenny Kim Kim, Shuli Tang, Yuetian Yan, Mandi Hopkins, Dalia Laredo, Teng-Chieh Yang, James Mutino, Douglas E. Kamen, Kenneth S. Graham, Mohammed Shameem, Shunhai Wang, Ning Li

“…Monoclonal antibodies (mAbs) feature a conserved N-linked glycosylation site in the CH2 domain, which exhibits heterogeneities in both occupancy and glycan structures. Previous studies have suggested that the unoccupied (nonglycosylated) variant exhibits decreased thermal stability, potentially impacting the overall stability of mAb products. …”
Get full text

USP7 V517F mutation as a mechanism of inhibitor resistance by Yu-Ling Miao, Fengying Fan, Yong-Jun Cheng, Li Jia, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Jian Ding, Xuekui Yu, Jin-Xue He

“…We discovered a key treatment-emergent heterozygous mutation (V517F) in USP7 in the binding pocket of compounds as the primary cause of resistance to the USP7 inhibitor USP7-797. Our structural analysis, supported by AlphaFold2 predictions, indicates that the V517F mutation altered the conformation of the compound binding pocket, causing steric hindrance and reducing the affinity between USP7 and its inhibitors. …”
Get full text

Mite Domatia and Associated Mite Density in a North American Eastern Deciduous Forest in Michigan by Carolyn D. K. Graham, Lillian R. Bailey, Ashley E. Cole, Anna M. Cress, Emma Dawson‐Glass, Bailee D. Duke, Liam J. Estill, Lauren D. Jones, Gabrielle R. Leon, Samantha Molino, Nia G. Paton, Abrianna J. Soule, Christopher A. Talbot, Addison L. Yerks, Marjorie G. Weber

“…We scored 16 common woody species in a wooded natural area for the presence and number of mite domatia—small structures on the underside of plant leaves that are known to house mutualistic mites. …”
Get full text

Determinants of ICT Adoption and Performance in Healthcare: The Role of Individual Attributes and Organizational Contextual Factors by Abey Jose, Alejandro F. Mac Cawley, Luis Enberg Gaete, Guilherme Luz Tortorella, Roberto Vassolo, Manisha Kumar, Nick Rich, Maneesh Kumar

“…We conducted a global survey involving healthcare professionals (n =204) to understand the role of various determinants in adopting ICTs and their implications for organizational performance. Data was analyzed using Partial Least Squares Structural Equation Modelling (PLS-SEM) and multiple regression for micro-level constructs. …”
Get full text

The Expression and Molecular Roles of MAMDC2 in MSS Colorectal Cancer with a High Tumor Stromal Ratio by Yiling Liu, Shengnan Qian, Jia Wei, Jianting He, Minghui Li, Xiaobing Gao, Hong Cai, Yiqing Wang, Yue Han, Tianyuan Tan, Minhui Yang

“…The meprin/A5/PTPmu (MAM) domain, a conserved structural motif in transmembrane proteins, remains undercharacterized in CRC pathogenesis. …”
Get full text

Anthropogenic and natural influence on vegetation ecosystems from 1982 to 2023 by Teligeer Bao, Huaqiang Li, Yonghong Hao, Matthew Tom Harrison, Ke Liu, Gulnazar Ali

“…In addition, frequent land cover changes promoted the growth of greening trends (∼23%), which is linked to enhanced structural plasticity of vegetation. This effect has become more pronounced since 2000, with 92% of such changes occurring during this period. …”
Get full text

TET dioxygenases localize at splicing speckles and promote RNA splicing by Florian D. Hastert, Jasmin Weber, Christina Bauer, Andreas Zhadan, Deepanshu N. D. Singh, Thomas C. Dix, Roland Arnold, Sergey Bessonov, Matthias Soller, Heinrich Leonhardt, M. Cristina Cardoso, Maria Arroyo

“…This study explores the relationship between RNA splicing and the TET dioxygenase activity, shedding light on the role of hm5C (RNA 5-hydroxymethylcytosine), and TET proteins in RNA metabolism. Integrating data from mass spectrometry, AlphaFold structural modeling, microscopic analysis, and different functional assays, including in vitro splicing, TET proteins were found to regulate splicing. …”
Get full text

Same same but different: Neuroanatomic and connectomic profiles of early-onset schizophrenia and autism spectrum disorder by Bin Lu, Xue Li, Xue-Ping Gao, Jing Chen, Yi Liu, Jian-Ping Lu, Siu-Ching Kat, Zeng-Hui Ma, Li-Yang Zhao, Ting-Ni Yin, Xing Su, Fan-Chao Meng, Ya-Ru Zhang, Shu-Xian Wu, Wen-Jie Yan, Ya-Song Du, Xue-Rong Luo, Jing Liu, Chao-Gan Yan

“…Conclusion: The neuro-profiles revealed that EOS and ASD exhibit overlapping as well as unique imaging characteristics; however, EOS exhibits greater structural variation, while ASD presents with more subtle connectomic abnormalities. …”
Get full text